WP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ITGB1 | Integrin beta-1 | [1] | 0.19[2] | 0.20[3] | 0.13[4] | 0.93[5] | 0.97[6] | -0.29[7] |
2 | RAP1B | Ras-related protein Rap-1b | [8] | -2.35[9] | -1.75[10] | -2.17[11] | -1.06[12] | -1.34[13] | -2.34[14] |
3 | JUN | Transcription factor AP-1 | [15] | -0.53[16] | -2.09[17] | -2.02[18] | -2.24[19] | -1.70[20] | -2.26[21] |
4 | FOS | Proto-oncogene c-Fos | [22] | -6.05[23] | -4.81[24] | -5.68[25] | -6.70[26] | -5.67[27] | -1.75[28] |
5 | STAT3 | Signal transducer and activator of transcription 3 | [29] | 0.51[30] | -1.01[31] | -0.47[32] | -0.29[33] | -1.05[34] | 1.96[35] |
6 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [36] | -0.97[37] | -1.32[38] | -0.94[39] | -1.08[40] | -0.60[41] | -1.64[42] |
7 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [43] | 0.01[44] | -0.33[45] | 0.34[46] | -1.38[47] | -0.93[48] | -2.15[49] |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [50] | 0.40[51] | 0.82[52] | 0.57[53] | 0.35[54] | 0.95[55] | 0.81[56] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [57] | 1.15[58] | 0.97[59] | 0.89[60] | 0.02[61] | -0.10[62] | -0.15[63] |
10 | CRK | Adapter molecule crk | [64] | -0.25[65] | -0.33[66] | -0.47[67] | -0.77[68] | -0.41[69] | 0.39[70] |
11 | RAP1A | Ras-related protein Rap-1A | [71] | -1.09[72] | -1.17[73] | -0.54[74] | -0.75[75] | -1.02[76] | -1.74[77] |
12 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [78] | -0.11[79] | 0.28[80] | 1.35[81] | -0.72[82] | 0.11[83] | 0.65[84] |
13 | MET | Hepatocyte growth factor receptor | [85] | 0.04[86] | 0.06[87] | 0.48[88] | 1.00[89] | -0.31[90] | 0.52[91] |
14 | HRAS | GTPase HRas | [92] | -1.05[93] | -1.77[94] | -2.77[95] | -1.48[96] | -1.73[97] | -3.11[98] |
15 | MAPK1 | Mitogen-activated protein kinase 1 | [99] | 1.67[100] | 1.79[101] | 1.41[102] | 1.32[103] | 0.93[104] | 1.32[105] |
16 | PXN | Paxillin | [106] | 0.96[107] | 0.66[108] | 0.49[109] | 1.58[110] | 1.51[111] | -0.80[112] |
17 | PTK2 | Focal adhesion kinase 1 | [113] | 0.69[114] | 1.16[115] | 1.34[116] | 1.41[117] | 0.58[118] | 0.31[119] |
18 | CRKL | Crk-like protein | [120] | 1.66[121] | 1.74[122] | 2.14[123] | 0.59[124] | 0.76[125] | 1.00[126] |
19 | MAPK8 | Mitogen-activated protein kinase 8 | [127] | -1.49[128] | -0.09[129] | -1.43[130] | -1.44[131] | -1.62[132] | -0.96[133] |
20 | SOS1 | Son of sevenless homolog 1 | [134] | -0.14[135] | 1.37[136] | 0.68[137] | 0.31[138] | -0.49[139] | 0.09[140] |
21 | ELK1 | ETS domain-containing protein Elk-1 | [141] | -0.36[142] | -2.51[143] | -0.29[144] | -0.26[145] | 0.29[146] | -0.62[147] |
22 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.58[148] | 0.80[149] | 0.79[150] | -1.10[151] | 0.12[152] | 2.03[153] | |
23 | ITGA1 | Integrin alpha-1 | [154] | -0.88[155] | 0.21[156] | 0.00[157] | -1.56[158] | -0.23[159] | 3.19[160] |
24 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [161] | 2.05[162] | 1.86[163] | 1.37[164] | 0.72[165] | 0.36[166] | 0.72[167] |
25 | MAPK3 | Mitogen-activated protein kinase 3 | [168] | 1.81[169] | 1.84[170] | 1.67[171] | -0.11[172] | -0.13[173] | -1.49[174] |
26 | SRC | Proto-oncogene tyrosine-protein kinase Src | [175] | 2.98[176] | 2.95[177] | 1.75[178] | 1.87[179] | 1.01[180] | -1.30[181] |
27 | RASA1 | Ras GTPase-activating protein 1 | [182] | 0.33[183] | 1.23[184] | 1.13[185] | 1.38[186] | 0.40[187] | 0.76[188] |
28 | DOCK1 | Dedicator of cytokinesis protein 1 | [189] | 1.94[190] | 2.46[191] | 2.24[192] | -3.18[193] | 1.59[194] | 2.07[195] |
29 | PAK1 | Serine/threonine-protein kinase PAK 1 | [196] | -0.05[197] | -0.83[198] | 1.38[199] | -2.39[200] | 1.35[201] | -0.18[202] |
30 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.42[203] | 1.20[204] | 1.18[205] | 0.60[206] | 0.76[207] | 1.46[208] | |
31 | PTK2B | Protein-tyrosine kinase 2-beta | [209] | -0.85[210] | 0.49[211] | 1.25[212] | -2.31[213] | 0.28[214] | 1.32[215] |
32 | GAB1 | GRB2-associated-binding protein 1 | [216] | 1.26[217] | 2.33[218] | 2.25[219] | 1.40[220] | 1.22[221] | 2.42[222] |
33 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | [223] | -2.44[224] | -0.74[225] | -1.58[226] | -0.68[227] | -2.12[228] | 0.88[229] |
34 | HGF | Hepatocyte growth factor | [230] | [231] | [232] | -1.91[233] | 4.06[234] | 1.05[235] | 8.44[236] |