WP_HEME_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALAS1 5-aminolevulinate synthase, nonspecific, mitochondrial [1] -0.74[2] -1.25[3] -0.47[4] -0.60[5] -0.68[6] 0.84[7]
2 UROD Uroporphyrinogen decarboxylase [8] 0.01[9] 0.15[10] -0.40[11] -0.35[12] 0.04[13] -1.10[14]
3 UROS Uroporphyrinogen-III synthase [15] -1.24[16] -1.52[17] -1.27[18] -1.92[19] -1.29[20] -2.18[21]
4 ALAD Delta-aminolevulinic acid dehydratase [22] -0.39[23] 0.51[24] 0.20[25] -0.30[26] 0.47[27] 0.32[28]
5 HMBS Porphobilinogen deaminase [29] 1.34[30] 1.39[31] 0.90[32] 1.35[33] 0.59[34] -0.53[35]
6 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [36] 1.46[37] 1.41[38] 2.01[39] 0.84[40] 1.28[41] -0.54[42]
7 FECH Ferrochelatase, mitochondrial [43] 2.17[44] 1.33[45] 1.05[46] 3.04[47] 1.94[48] 2.15[49]
8 PPOX Protoporphyrinogen oxidase [50] 0.80[51] 0.99[52] 1.44[53] 1.79[54] 0.85[55] -0.50[56]
9 ALAS2 5-aminolevulinate synthase, erythroid-specific, mitochondrial [57] -0.70[58] -3.82[59] -1.83[60] [61] -5.64[62] -0.49[63]
[1]
ref_hepatocyte ALAS1
Mean 47.5
Standard deviation 33
Values 55 55 94 11 22
[2]
HepG2 ALAS1
Mean 32.4
Standard deviation 1.9
Values 34 31
[3]
HepG2.C3A ALAS1
Mean 22.2
Standard deviation 3.9
Values 19 25
[4]
HuH.7 ALAS1
Mean 34.9
Standard deviation 9.3
Values 31 46 28
[5]
SNU475 ALAS1
Mean 23.5
Standard deviation 9.9
Values 30 17
[6]
THLE ALAS1
Mean 31.9
Standard deviation 2.3
Values 30 34
[7]
liver ALAS1
Mean 143
Standard deviation 85
Values 52 1.5e+02 1.1e+02 2.5e+02
[8]
ref_hepatocyte UROD
Mean 43.3
Standard deviation 13
Values 56 46 53 24 37
[9]
HepG2 UROD
Mean 49.6
Standard deviation 4.3
Values 53 47
[10]
HepG2.C3A UROD
Mean 53.3
Standard deviation 16
Values 65 42
[11]
HuH.7 UROD
Mean 33.5
Standard deviation 11
Values 44 22 35
[12]
SNU475 UROD
Mean 25.4
Standard deviation 2.6
Values 24 27
[13]
THLE UROD
Mean 47.7
Standard deviation 6.8
Values 43 52
[14]
liver UROD
Mean 33.9
Standard deviation 21
Values 13 18 53 52
[15]
ref_hepatocyte UROS
Mean 34
Standard deviation 34
Values 2.9 14 18 46 89
[16]
HepG2 UROS
Mean 16.4
Standard deviation 3.9
Values 19 14
[17]
HepG2.C3A UROS
Mean 13.2
Standard deviation 2.7
Values 15 11
[18]
HuH.7 UROS
Mean 14.4
Standard deviation 5.8
Values 19 7.8 17
[19]
SNU475 UROS
Mean 6.73
Standard deviation 4.2
Values 3.7 9.7
[20]
THLE UROS
Mean 14.9
Standard deviation 2
Values 13 16
[21]
liver UROS
Mean 12.6
Standard deviation 8.6
Values 5.4 5.1 22 18
[22]
ref_hepatocyte ALAD
Mean 20.2
Standard deviation 20
Values 2.9 49 34 8.7 6.8
[23]
HepG2 ALAD
Mean 17.6
Standard deviation 4.8
Values 21 14
[24]
HepG2.C3A ALAD
Mean 32
Standard deviation 11
Values 24 40
[25]
HuH.7 ALAD
Mean 23.7
Standard deviation 3.5
Values 23 28 21
[26]
SNU475 ALAD
Mean 12.3
Standard deviation 4
Values 9.4 15
[27]
THLE ALAD
Mean 29.9
Standard deviation 1.2
Values 31 29
[28]
liver ALAD
Mean 42.2
Standard deviation 15
Values 55 24 55 35
[29]
ref_hepatocyte HMBS
Mean 9.21
Standard deviation 3.5
Values 6.3 8.8 14 5.7 11
[30]
HepG2 HMBS
Mean 26.5
Standard deviation 0.29
Values 26 27
[31]
HepG2.C3A HMBS
Mean 26.9
Standard deviation 7.8
Values 32 21
[32]
HuH.7 HMBS
Mean 17.5
Standard deviation 8.5
Values 26 9 18
[33]
SNU475 HMBS
Mean 17.6
Standard deviation 1.4
Values 17 19
[34]
THLE HMBS
Mean 14.8
Standard deviation 0.63
Values 14 15
[35]
liver HMBS
Mean 10.7
Standard deviation 10
Values 1.6 1.8 20 19
[36]
ref_hepatocyte CPOX
Mean 8.09
Standard deviation 4.1
Values 3.2 8.7 7.5 14 6.6
[37]
HepG2 CPOX
Mean 25.5
Standard deviation 6
Values 30 21
[38]
HepG2.C3A CPOX
Mean 24
Standard deviation 4
Values 27 21
[39]
HuH.7 CPOX
Mean 33.2
Standard deviation 5.6
Values 36 27 37
[40]
SNU475 CPOX
Mean 10.8
Standard deviation 1.9
Values 12 9.5
[41]
THLE CPOX
Mean 21.1
Standard deviation 4.2
Values 18 24
[42]
liver CPOX
Mean 9.36
Standard deviation 2.1
Values 7.9 12 10 7.4
[43]
ref_hepatocyte FECH
Mean 3.81
Standard deviation 1.3
Values 2.2 4.7 4.4 2.6 5.1
[44]
HepG2 FECH
Mean 19.5
Standard deviation 4.1
Values 17 22
[45]
HepG2.C3A FECH
Mean 10.7
Standard deviation 3.1
Values 13 8.5
[46]
HuH.7 FECH
Mean 8.02
Standard deviation 1.9
Values 9.6 5.9 8.5
[47]
SNU475 FECH
Mean 23.5
Standard deviation 11
Values 16 31
[48]
THLE FECH
Mean 15.7
Standard deviation 1.5
Values 15 17
[49]
liver FECH
Mean 28.4
Standard deviation 7.8
Values 23 30 22 39
[50]
ref_hepatocyte PPOX
Mean 2.47
Standard deviation 1.4
Values 0.53 3.9 3.4 1.7 2.8
[51]
HepG2 PPOX
Mean 4.91
Standard deviation 0.76
Values 4.4 5.4
[52]
HepG2.C3A PPOX
Mean 5.46
Standard deviation 0.59
Values 5 5.9
[53]
HuH.7 PPOX
Mean 6.81
Standard deviation 2.6
Values 9 4 7.4
[54]
SNU475 PPOX
Mean 6.37
Standard deviation 0.37
Values 6.1 6.6
[55]
THLE PPOX
Mean 4.78
Standard deviation 0.24
Values 4.6 4.9
[56]
liver PPOX
Mean 2.92
Standard deviation 2.1
Values 1.3 0.93 4.7 4.7
[57]
ref_hepatocyte ALAS2
Mean 0.124
Standard deviation 0.17
Values 0 0.33 0.28 0 0
[58]
HepG2 ALAS2
Mean 0.0865
Standard deviation 0.09
Values 0.15 0.023
[59]
HepG2.C3A ALAS2
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[60]
HuH.7 ALAS2
Mean 0.0355
Standard deviation 0.024
Values 0.047 0.051 0.0082
[61]
SNU475 ALAS2
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE ALAS2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[63]
liver ALAS2
Mean 0.148
Standard deviation 0.22
Values 0 0.13 0 0.46