WP_G_PROTEIN_SIGNALING_PATHWAYS |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
CALM2 |
Calmodulin-2 |
[1] |
-1.31[2] |
-0.55[3] |
-1.93[4] |
-1.82[5] |
-1.47[6] |
-1.50[7] |
2 |
RHOA |
Transforming protein RhoA |
[8] |
-0.74[9] |
-1.34[10] |
-1.03[11] |
-1.29[12] |
-0.79[13] |
-1.11[14] |
3 |
GNAS |
Guanine nucleotide-binding protein
G(s) subunit alpha isoforms XLas |
0.63[15] |
0.56[16] |
0.31[17] |
0.78[18] |
0.07[19] |
-1.12[20] |
4 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-1.00[21] |
-0.93[22] |
-1.71[23] |
-1.88[24] |
-2.09[25] |
-1.37[26] |
5 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[27] |
0.28[28] |
0.29[29] |
0.53[30] |
-0.16[31] |
-0.21[32] |
0.81[33] |
6 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[34] |
1.22[35] |
1.12[36] |
0.74[37] |
1.21[38] |
1.06[39] |
-1.02[40] |
7 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[41] |
-0.40[42] |
-0.76[43] |
-0.33[44] |
-0.44[45] |
-0.33[46] |
-1.39[47] |
8 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-4.50[48] |
-4.32[49] |
-4.53[50] |
-3.88[51] |
-3.01[52] |
-4.13[53] |
9 |
GNAI2 |
Guanine nucleotide-binding protein G(i) subunit alpha-2 |
[54] |
0.27[55] |
-0.90[56] |
-0.64[57] |
-0.24[58] |
0.88[59] |
0.02[60] |
10 |
CALM1 |
Calmodulin-1 |
[61] |
0.28[62] |
0.20[63] |
0.76[64] |
1.51[65] |
0.84[66] |
1.83[67] |
11 |
AKAP12 |
A-kinase anchor protein 12 |
[68] |
1.17[69] |
0.12[70] |
-2.24[71] |
1.43[72] |
1.65[73] |
-0.13[74] |
12 |
AKAP1 |
A-kinase anchor protein 1, mitochondrial |
[75] |
1.58[76] |
1.62[77] |
1.40[78] |
-2.08[79] |
-1.18[80] |
1.19[81] |
13 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-4.55[82] |
-7.59[83] |
0.45[84] |
1.81[85] |
1.96[86] |
0.70[87] |
14 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[88] |
0.04[89] |
-0.25[90] |
-0.15[91] |
-0.54[92] |
0.10[93] |
-0.57[94] |
15 |
GNAI3 |
Guanine nucleotide-binding protein G(k) subunit alpha |
[95] |
0.33[96] |
0.76[97] |
0.95[98] |
1.03[99] |
0.72[100] |
0.45[101] |
16 |
NRAS |
GTPase NRas |
[102] |
0.83[103] |
1.15[104] |
1.66[105] |
0.93[106] |
0.55[107] |
-0.04[108] |
17 |
RRAS |
Ras-related protein R-Ras |
[109] |
-1.29[110] |
-2.38[111] |
-1.71[112] |
-0.35[113] |
-0.29[114] |
-1.97[115] |
18 |
GNA13 |
Guanine nucleotide-binding protein subunit alpha-13 |
[116] |
0.32[117] |
0.38[118] |
0.95[119] |
1.12[120] |
0.00[121] |
0.75[122] |
19 |
HRAS |
GTPase HRas |
[123] |
-0.81[124] |
-1.62[125] |
-2.32[126] |
-1.02[127] |
-1.18[128] |
-2.45[129] |
20 |
GNA11 |
Guanine nucleotide-binding protein subunit alpha-11 |
[130] |
-0.47[131] |
-0.65[132] |
-0.61[133] |
-1.25[134] |
-0.40[135] |
-1.04[136] |
21 |
KRAS |
GTPase KRas |
[137] |
-0.31[138] |
-0.44[139] |
1.25[140] |
0.73[141] |
0.44[142] |
0.89[143] |
22 |
PRKCZ |
Protein kinase C zeta type |
[144] |
0.67[145] |
0.95[146] |
-0.96[147] |
-2.37[148] |
-4.52[149] |
-1.43[150] |
23 |
PRKAR2A |
cAMP-dependent protein kinase type II-alpha regulatory subunit |
[151] |
0.25[152] |
-0.17[153] |
1.03[154] |
-0.36[155] |
-0.45[156] |
0.36[157] |
24 |
GNAI1 |
Guanine nucleotide-binding protein G(i) subunit alpha-1 |
[158] |
-1.45[159] |
-2.49[160] |
-0.26[161] |
1.15[162] |
0.57[163] |
1.05[164] |
25 |
ARHGEF1 |
Rho guanine nucleotide exchange factor 1 |
[165] |
1.12[166] |
1.33[167] |
1.74[168] |
0.85[169] |
1.17[170] |
0.60[171] |
26 |
PRKAR1B |
cAMP-dependent protein kinase type I-beta regulatory subunit |
[172] |
1.18[173] |
0.52[174] |
-1.18[175] |
-4.17[176] |
-1.32[177] |
0.04[178] |
27 |
PDE8A |
High affinity cAMP-specific and
IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
0.54[179] |
1.03[180] |
1.46[181] |
-0.35[182] |
0.22[183] |
1.75[184] |
28 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[185] |
0.30[186] |
0.23[187] |
1.34[188] |
0.72[189] |
0.89[190] |
1.10[191] |
29 |
GNA12 |
Guanine nucleotide-binding protein subunit alpha-12 |
[192] |
2.18[193] |
2.00[194] |
1.41[195] |
1.66[196] |
1.80[197] |
0.30[198] |
30 |
PRKCI |
Protein kinase C iota type |
[199] |
1.26[200] |
1.83[201] |
3.53[202] |
1.08[203] |
1.55[204] |
0.47[205] |
31 |
AKAP8 |
A-kinase anchor protein 8 |
[206] |
1.07[207] |
0.85[208] |
1.58[209] |
0.28[210] |
0.49[211] |
0.83[212] |
32 |
PPP3CC |
Serine/threonine-protein phosphatase
2B catalytic subunit gamma isoform |
-0.50[213] |
-0.47[214] |
-0.78[215] |
-1.16[216] |
-0.19[217] |
0.27[218] |
33 |
PRKCD |
Protein kinase C delta type |
[219] |
1.30[220] |
1.44[221] |
1.01[222] |
-0.57[223] |
0.63[224] |
-0.85[225] |
34 |
AKAP13 |
A-kinase anchor protein 13 |
[226] |
1.94[227] |
0.96[228] |
2.02[229] |
2.63[230] |
2.30[231] |
4.35[232] |
35 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
0.93[233] |
0.58[234] |
0.48[235] |
1.87[236] |
1.67[237] |
2.02[238] |
36 |
AKAP7 |
A-kinase anchor protein 7 isoform gamma |
[239] |
-0.72[240] |
-0.01[241] |
0.91[242] |
-0.86[243] |
-1.12[244] |
1.29[245] |
37 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[246] |
-0.63[247] |
0.03[248] |
1.41[249] |
2.16[250] |
1.07[251] |
1.92[252] |
38 |
ADCY9 |
Adenylate cyclase type 9 |
[253] |
2.82[254] |
1.90[255] |
2.42[256] |
0.89[257] |
0.48[258] |
2.63[259] |
39 |
GNAO1 |
Guanine nucleotide-binding protein G(o) subunit alpha |
[260] |
-6.23[261] |
-7.92[262] |
-6.98[263] |
-2.65[264] |
-6.47[265] |
0.70[266] |
40 |
PRKCA |
Protein kinase C alpha type |
[267] |
3.04[268] |
2.97[269] |
3.42[270] |
2.08[271] |
2.49[272] |
2.13[273] |
41 |
AKAP9 |
A-kinase anchor protein 9 |
[274] |
0.22[275] |
2.83[276] |
3.10[277] |
1.73[278] |
1.89[279] |
5.29[280] |
42 |
AKAP10 |
A-kinase anchor protein 10, mitochondrial |
[281] |
1.49[282] |
1.82[283] |
1.96[284] |
2.00[285] |
2.23[286] |
1.87[287] |
43 |
PRKD3 |
Serine/threonine-protein kinase D3 |
[288] |
2.00[289] |
2.42[290] |
2.35[291] |
3.11[292] |
2.85[293] |
2.45[294] |
44 |
GNAQ |
Guanine nucleotide-binding protein G(q) subunit alpha |
[295] |
0.28[296] |
0.95[297] |
1.55[298] |
1.52[299] |
1.79[300] |
1.65[301] |
45 |
ADCY6 |
Adenylate cyclase type 6 |
[302] |
2.25[303] |
2.61[304] |
2.66[305] |
2.44[306] |
3.16[307] |
2.85[308] |
46 |
GNAZ |
Guanine nucleotide-binding protein G(z) subunit alpha |
[309] |
2.10[310] |
2.45[311] |
1.82[312] |
-2.07[313] |
-1.59[314] |
-3.10[315] |
47 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[316] |
2.21[317] |
1.58[318] |
2.14[319] |
2.64[320] |
2.34[321] |
0.94[322] |
48 |
AKAP11 |
A-kinase anchor protein 11 |
[323] |
1.82[324] |
2.67[325] |
3.02[326] |
2.38[327] |
2.79[328] |
3.43[329] |
49 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-7.98[330] |
-8.09[331] |
-7.30[332] |
2.19[333] |
3.56[334] |
2.45[335] |
50 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
1.76[336] |
1.30[337] |
2.20[338] |
-2.31[339] |
-1.63[340] |
0.24[341] |
51 |
ADCY1 |
Adenylate cyclase type 1 |
[342] |
-0.63[343] |
-2.61[344] |
-2.72[345] |
-2.18[346] |
-2.14[347] |
5.21[348] |
52 |
PRKCE |
Protein kinase C epsilon type |
[349] |
0.84[350] |
-0.78[351] |
1.81[352] |
0.91[353] |
1.33[354] |
3.78[355] |
53 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
3.67[356] |
1.33[357] |
5.22[358] |
1.19[359] |
-0.88[360] |
-2.34[361] |
54 |
PDE7A |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
[362] |
2.19[363] |
2.68[364] |
3.26[365] |
3.70[366] |
2.40[367] |
2.41[368] |
55 |
PRKCH |
Protein kinase C eta type |
[369] |
-0.16[370] |
-4.08[371] |
-2.34[372] |
2.21[373] |
3.88[374] |
3.32[375] |
56 |
ADCY7 |
Adenylate cyclase type 7 |
[376] |
3.71[377] |
3.23[378] |
2.28[379] |
3.24[380] |
2.76[381] |
3.14[382] |
57 |
SLC9A1 |
Sodium/hydrogen exchanger 1 |
[383] |
3.20[384] |
2.01[385] |
0.97[386] |
4.06[387] |
4.02[388] |
0.95[389] |
58 |
PDE4C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
[390] |
3.17[391] |
2.50[392] |
1.10[393] |
-1.26[394] |
0.47[395] |
-0.65[396] |
59 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[397] |
3.34[398] |
3.12[399] |
4.36[400] |
2.78[401] |
3.70[402] |
4.86[403] |
60 |
AKAP3 |
A-kinase anchor protein 3 |
[404] |
-2.52[405] |
-3.27[406] |
0.18[407] |
-4.25[408] |
-3.29[409] |
-1.45[410] |
61 |
PDE4A |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
[411] |
3.32[412] |
2.15[413] |
3.61[414] |
0.53[415] |
3.41[416] |
1.72[417] |
62 |
PDE4B |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
[418] |
[419] |
[420] |
-5.57[421] |
0.71[422] |
3.42[423] |
2.65[424] |
63 |
GNA15 |
Guanine nucleotide-binding protein subunit alpha-15 |
[425] |
-3.18[426] |
-5.00[427] |
[428] |
-6.10[429] |
-2.49[430] |
0.31[431] |
64 |
PRKCB |
Protein kinase C beta type |
[432] |
-6.61[433] |
-5.52[434] |
[435] |
2.41[436] |
-2.84[437] |
3.75[438] |
65 |
GNA14 |
Guanine nucleotide-binding protein subunit alpha-14 |
[439] |
-5.86[440] |
-6.36[441] |
-5.11[442] |
-6.36[443] |
-3.22[444] |
3.45[445] |
66 |
AKAP5 |
A-kinase anchor protein 5 |
[446] |
1.28[447] |
1.62[448] |
1.99[449] |
4.05[450] |
2.46[451] |
2.41[452] |
67 |
GNAL |
Guanine nucleotide-binding protein G(olf) subunit alpha |
[453] |
2.04[454] |
2.74[455] |
3.10[456] |
2.03[457] |
2.06[458] |
2.75[459] |
68 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[460] |
[461] |
[462] |
-2.14[463] |
-6.76[464] |
0.32[465] |
69 |
AKAP6 |
A-kinase anchor protein 6 |
[466] |
1.50[467] |
0.16[468] |
1.92[469] |
5.20[470] |
1.42[471] |
4.04[472] |
70 |
PRKD1 |
Serine/threonine-protein kinase D1 |
[473] |
2.12[474] |
1.92[475] |
4.39[476] |
4.57[477] |
4.59[478] |
3.36[479] |
71 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-0.65[480] |
1.07[481] |
-1.06[482] |
-0.77[483] |
-1.03[484] |
0.13[485] |
72 |
PDE4D |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
[486] |
3.65[487] |
6.68[488] |
6.88[489] |
4.51[490] |
5.79[491] |
4.95[492] |
73 |
PRKAR2B |
cAMP-dependent protein kinase type II-beta regulatory subunit |
[493] |
-2.14[494] |
-0.42[495] |
3.95[496] |
5.02[497] |
3.58[498] |
3.53[499] |
74 |
ADCY3 |
Adenylate cyclase type 3 |
[500] |
1.66[501] |
0.31[502] |
3.73[503] |
4.67[504] |
6.25[505] |
3.73[506] |
75 |
PDE7B |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
[507] |
-2.05[508] |
-1.69[509] |
-0.63[510] |
4.63[511] |
6.24[512] |
4.99[513] |
76 |
ADCY2 |
Adenylate cyclase type 2 |
[514] |
-5.18[515] |
-3.36[516] |
-4.52[517] |
-2.80[518] |
-3.87[519] |
-3.91[520] |
77 |
PRKCQ |
Protein kinase C theta type |
[521] |
1.10[522] |
-2.56[523] |
[524] |
2.06[525] |
3.61[526] |
2.30[527] |
78 |
PDE1B |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1B |
-3.48[528] |
-4.56[529] |
[530] |
-0.89[531] |
-1.92[532] |
4.08[533] |
79 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[534] |
1.79[535] |
3.94[536] |
3.33[537] |
0.94[538] |
3.70[539] |
-1.47[540] |
80 |
PDE8B |
High affinity cAMP-specific and
IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
1.35[541] |
1.69[542] |
1.62[543] |
1.66[544] |
0.79[545] |
4.27[546] |
81 |
KCNJ3 |
G protein-activated inward rectifier potassium channel 1 |
[547] |
-1.90[548] |
0.77[549] |
4.87[550] |
-0.52[551] |
-1.83[552] |
4.95[553] |
82 |
ADCY5 |
Adenylate cyclase type 5 |
[554] |
0.35[555] |
1.24[556] |
2.37[557] |
0.58[558] |
1.75[559] |
6.59[560] |
83 |
PRKCG |
Protein kinase C gamma type |
[561] |
-0.62[562] |
-0.06[563] |
-2.34[564] |
-1.13[565] |
-1.17[566] |
[567] |
84 |
PDE1A |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1A |
[568] |
-0.63[569] |
4.16[570] |
6.05[571] |
2.56[572] |
6.82[573] |
85 |
ADCY4 |
Adenylate cyclase type 4 |
[574] |
0.29[575] |
-0.89[576] |
1.85[577] |
[578] |
[579] |
8.58[580] |
86 |
ENSG00000284797 |
[581] |
[582] |
[583] |
[584] |
[585] |
[586] |
[587] |
87 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[588] |
[589] |
[590] |
[591] |
[592] |
[593] |
88 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[594] |
[595] |
[596] |
[597] |
[598] |
[599] |
[600] |
89 |
MIR197 |
|
[601] |
[602] |
[603] |
[604] |
[605] |
[606] |
[607] |
90 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[608] |
[609] |
[610] |
[611] |
[612] |
[613] |
[614] |
91 |
AKAP4 |
A-kinase anchor protein 4 |
[615] |
[616] |
[617] |
[618] |
[619] |
[620] |
[621] |
92 |
ADCY8 |
Adenylate cyclase type 8 |
[622] |
[623] |
[624] |
[625] |
[626] |
[627] |
[628] |
93 |
PALM2AKAP2 |
[629] |
[630] |
[631] |
[632] |
[633] |
[634] |
[635] |
94 |
MIR7706 |
|
[636] |
[637] |
[638] |
[639] |
[640] |
[641] |
[642] |
95 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[643] |
[644] |
[645] |
[646] |
[647] |
[648] |
96 |
PDE1C |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1C |
[649] |
[650] |
[651] |
[652] |
[653] |
[654] |
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