WP_GLYCOSAMINOGLYCAN_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HYAL1 Hyaluronidase-1 [1] -1.03[2] -0.48[3] -6.17[4] -9.12[5] -7.10[6] -0.61[7]
2 HEXB Beta-hexosaminidase subunit beta [8] -0.75[9] -0.85[10] -0.18[11] -0.65[12] -0.07[13] -0.72[14]
3 GUSB Beta-glucuronidase [15] -2.13[16] -1.53[17] -0.92[18] -0.79[19] -1.49[20] -0.19[21]
4 GLB1 Beta-galactosidase [22] 0.13[23] 0.06[24] 1.20[25] -0.43[26] 0.17[27] -0.29[28]
5 HEXA Beta-hexosaminidase subunit alpha [29] 0.92[30] 0.54[31] 0.34[32] 0.95[33] 0.68[34] -0.16[35]
6 NAGLU Alpha-N-acetylglucosaminidase [36] -0.37[37] -0.39[38] 0.16[39] -0.95[40] -1.45[41] -0.67[42]
7 GNS N-acetylglucosamine-6-sulfatase [43] 1.26[44] 1.20[45] 2.06[46] 2.25[47] 2.33[48] 1.83[49]
8 IDS Iduronate 2-sulfatase [50] -0.31[51] -0.58[52] -1.03[53] 2.10[54] 1.08[55] 0.78[56]
9 HYAL2 Hyaluronidase-2 [57] 1.81[58] 2.33[59] 1.30[60] -0.26[61] 0.51[62] 0.71[63]
10 HGSNAT Heparan-alpha-glucosaminide N-acetyltransferase [64] -0.04[65] 0.07[66] 0.45[67] 0.69[68] 0.52[69] 0.81[70]
11 SGSH N-sulphoglucosamine sulphohydrolase [71] 1.21[72] 0.72[73] -0.68[74] 0.30[75] 0.19[76] 0.06[77]
12 GALNS N-acetylgalactosamine-6-sulfatase [78] 1.08[79] 0.48[80] 0.64[81] 0.77[82] 0.68[83] 0.36[84]
13 ARSB Arylsulfatase B [85] 3.11[86] 2.00[87] 1.48[88] 1.60[89] 1.90[90] 1.73[91]
14 IDUA Alpha-L-iduronidase [92] -2.92[93] -2.06[94] -1.59[95] 0.83[96] -1.03[97] -0.34[98]
15 HPSE Heparanase [99] -1.58[100] -1.22[101] -0.21[102] 2.26[103] 4.68[104] 1.23[105]
16 HYAL4 Hyaluronidase-4 [106] -4.84[107] -2.06[108] -3.66[109] 0.51[110] -3.71[111] -0.68[112]
17 HPSE2 Inactive heparanase-2 [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte HYAL1
Mean 53.9
Standard deviation 39
Values 36 1e+02 90 18 24
[2]
HepG2 HYAL1
Mean 83.6
Standard deviation 4.4
Values 87 81
[3]
HepG2.C3A HYAL1
Mean 88.6
Standard deviation 33
Values 65 1.1e+02
[4]
HuH.7 HYAL1
Mean 1.54
Standard deviation 0.96
Values 1 2.7 0.95
[5]
SNU475 HYAL1
Mean 0.168
Standard deviation 0.058
Values 0.13 0.21
[6]
THLE HYAL1
Mean 0.868
Standard deviation 0.069
Values 0.92 0.82
[7]
liver HYAL1
Mean 66.7
Standard deviation 12
Values 59 54 80 73
[8]
ref_hepatocyte HEXB
Mean 33.9
Standard deviation 11
Values 16 38 44 39 33
[9]
HepG2 HEXB
Mean 64.1
Standard deviation 5.9
Values 60 68
[10]
HepG2.C3A HEXB
Mean 43.4
Standard deviation 2.1
Values 42 45
[11]
HuH.7 HEXB
Mean 61.5
Standard deviation 15
Values 61 77 46
[12]
SNU475 HEXB
Mean 37.4
Standard deviation 0.5
Values 38 37
[13]
THLE HEXB
Mean 71.3
Standard deviation 17
Values 59 83
[14]
liver HEXB
Mean 39
Standard deviation 15
Values 22 34 42 57
[15]
ref_hepatocyte GUSB
Mean 25.3
Standard deviation 23
Values 11 49 52 7 7.5
[16]
HepG2 GUSB
Mean 18.3
Standard deviation 3.5
Values 16 21
[17]
HepG2.C3A GUSB
Mean 20.1
Standard deviation 2
Values 19 22
[18]
HuH.7 GUSB
Mean 27.5
Standard deviation 3.9
Values 32 25 26
[19]
SNU475 GUSB
Mean 25.3
Standard deviation 2.9
Values 27 23
[20]
THLE GUSB
Mean 20
Standard deviation 0.097
Values 20 20
[21]
liver GUSB
Mean 42.1
Standard deviation 30
Values 14 22 54 79
[22]
ref_hepatocyte GLB1
Mean 15.3
Standard deviation 5.7
Values 8.6 18 18 22 9.9
[23]
HepG2 GLB1
Mean 53.1
Standard deviation 4.7
Values 50 56
[24]
HepG2.C3A GLB1
Mean 36.7
Standard deviation 8.2
Values 31 42
[25]
HuH.7 GLB1
Mean 72.4
Standard deviation 9.9
Values 75 81 62
[26]
SNU475 GLB1
Mean 19.7
Standard deviation 1.4
Values 21 19
[27]
THLE GLB1
Mean 38.2
Standard deviation 4.9
Values 35 42
[28]
liver GLB1
Mean 23.6
Standard deviation 8.2
Values 16 20 23 35
[29]
ref_hepatocyte HEXA
Mean 15.3
Standard deviation 8.5
Values 6.1 24 25 11 11
[30]
HepG2 HEXA
Mean 91.6
Standard deviation 1.4
Values 91 93
[31]
HepG2.C3A HEXA
Mean 51.3
Standard deviation 2.1
Values 50 53
[32]
HuH.7 HEXA
Mean 39.8
Standard deviation 6.4
Values 47 35 37
[33]
SNU475 HEXA
Mean 51.2
Standard deviation 9
Values 45 58
[34]
THLE HEXA
Mean 54.1
Standard deviation 9.1
Values 48 61
[35]
liver HEXA
Mean 25.8
Standard deviation 15
Values 12 17 28 46
[36]
ref_hepatocyte NAGLU
Mean 11.6
Standard deviation 11
Values 5.1 24 22 4.4 2.3
[37]
HepG2 NAGLU
Mean 28.5
Standard deviation 0.22
Values 29 28
[38]
HepG2.C3A NAGLU
Mean 20.4
Standard deviation 4
Values 18 23
[39]
HuH.7 NAGLU
Mean 26.8
Standard deviation 6.6
Values 34 20 26
[40]
SNU475 NAGLU
Mean 10.4
Standard deviation 3.9
Values 7.6 13
[41]
THLE NAGLU
Mean 9.46
Standard deviation 2.1
Values 7.9 11
[42]
liver NAGLU
Mean 13.8
Standard deviation 2.3
Values 14 11 16 15
[43]
ref_hepatocyte GNS
Mean 10.7
Standard deviation 4.8
Values 4 8.4 12 17 13
[44]
HepG2 GNS
Mean 81.3
Standard deviation 7.9
Values 76 87
[45]
HepG2.C3A GNS
Mean 56.4
Standard deviation 4.7
Values 53 60
[46]
HuH.7 GNS
Mean 91.4
Standard deviation 13
Values 77 97 1e+02
[47]
SNU475 GNS
Mean 87.8
Standard deviation 16
Values 77 99
[48]
THLE GNS
Mean 119
Standard deviation 32
Values 96 1.4e+02
[49]
liver GNS
Mean 71.6
Standard deviation 24
Values 76 1e+02 44 66
[50]
ref_hepatocyte IDS
Mean 6.6
Standard deviation 4
Values 12 5.4 5 1.7 8.7
[51]
HepG2 IDS
Mean 16.9
Standard deviation 2.4
Values 15 19
[52]
HepG2.C3A IDS
Mean 10.2
Standard deviation 0.54
Values 11 9.8
[53]
HuH.7 IDS
Mean 6.65
Standard deviation 2.1
Values 5 9 5.9
[54]
SNU475 IDS
Mean 49.1
Standard deviation 1.7
Values 48 50
[55]
THLE IDS
Mean 30.9
Standard deviation 4
Values 28 34
[56]
liver IDS
Mean 21.3
Standard deviation 4.6
Values 22 15 27 22
[57]
ref_hepatocyte HYAL2
Mean 5.55
Standard deviation 2.1
Values 6.6 4.7 8.7 4.6 3.2
[58]
HepG2 HYAL2
Mean 61.5
Standard deviation 5.1
Values 58 65
[59]
HepG2.C3A HYAL2
Mean 64
Standard deviation 2.5
Values 62 66
[60]
HuH.7 HYAL2
Mean 28.1
Standard deviation 10
Values 39 18 28
[61]
SNU475 HYAL2
Mean 8
Standard deviation 0.042
Values 8 8
[62]
THLE HYAL2
Mean 17.5
Standard deviation 3.3
Values 15 20
[63]
liver HYAL2
Mean 17.2
Standard deviation 2.7
Values 18 13 18 19
[64]
ref_hepatocyte HGSNAT
Mean 4.04
Standard deviation 1.6
Values 2.6 5.8 4 5.4 2.4
[65]
HepG2 HGSNAT
Mean 12.5
Standard deviation 3.7
Values 15 9.8
[66]
HepG2.C3A HGSNAT
Mean 9.74
Standard deviation 2.6
Values 7.9 12
[67]
HuH.7 HGSNAT
Mean 11.4
Standard deviation 1.7
Values 9.4 12 12
[68]
SNU475 HGSNAT
Mean 11.2
Standard deviation 4.7
Values 7.9 15
[69]
THLE HGSNAT
Mean 12.8
Standard deviation 2.9
Values 11 15
[70]
liver HGSNAT
Mean 13.4
Standard deviation 1.5
Values 13 14 12 15
[71]
ref_hepatocyte SGSH
Mean 3.8
Standard deviation 3.4
Values 2.8 2.6 1.9 9.9 1.8
[72]
HepG2 SGSH
Mean 27.9
Standard deviation 0.23
Values 28 28
[73]
HepG2.C3A SGSH
Mean 14.4
Standard deviation 5.6
Values 10 18
[74]
HuH.7 SGSH
Mean 4.87
Standard deviation 0.69
Values 5.4 4.1 5.2
[75]
SNU475 SGSH
Mean 8.08
Standard deviation 1.6
Values 6.9 9.2
[76]
THLE SGSH
Mean 9.61
Standard deviation 1.2
Values 8.8 10
[77]
liver SGSH
Mean 7.46
Standard deviation 5.8
Values 3.6 2.3 15 9
[78]
ref_hepatocyte GALNS
Mean 2.75
Standard deviation 1
Values 2 3.7 4 2.3 1.7
[79]
HepG2 GALNS
Mean 18.4
Standard deviation 5.4
Values 15 22
[80]
HepG2.C3A GALNS
Mean 8.83
Standard deviation 1.2
Values 8 9.7
[81]
HuH.7 GALNS
Mean 8.79
Standard deviation 1.8
Values 9.9 6.7 9.7
[82]
SNU475 GALNS
Mean 8.1
Standard deviation 4.4
Values 5 11
[83]
THLE GALNS
Mean 9.76
Standard deviation 0.35
Values 9.5 10
[84]
liver GALNS
Mean 6.69
Standard deviation 2.6
Values 3.9 5.2 8.1 9.6
[85]
ref_hepatocyte ARSB
Mean 1.85
Standard deviation 1.5
Values 1.1 2.3 1.1 4.3 0.43
[86]
HepG2 ARSB
Mean 50.8
Standard deviation 1.2
Values 52 50
[87]
HepG2.C3A ARSB
Mean 17.1
Standard deviation 4.2
Values 20 14
[88]
HuH.7 ARSB
Mean 10.6
Standard deviation 2.5
Values 12 7.7 12
[89]
SNU475 ARSB
Mean 9.69
Standard deviation 3.6
Values 7.1 12
[90]
THLE ARSB
Mean 15.3
Standard deviation 3.2
Values 13 18
[91]
liver ARSB
Mean 11.6
Standard deviation 6.3
Values 21 11 7.9 6.6
[92]
ref_hepatocyte IDUA
Mean 1.21
Standard deviation 1.4
Values 0.69 2.1 3.2 0 0.052
[93]
HepG2 IDUA
Mean 0.506
Standard deviation 0.019
Values 0.52 0.49
[94]
HepG2.C3A IDUA
Mean 0.666
Standard deviation 0.49
Values 0.32 1
[95]
HuH.7 IDUA
Mean 0.828
Standard deviation 0.42
Values 0.85 1.2 0.39
[96]
SNU475 IDUA
Mean 3.72
Standard deviation 1.5
Values 2.7 4.8
[97]
THLE IDUA
Mean 1.31
Standard deviation 0.3
Values 1.5 1.1
[98]
liver IDUA
Mean 1.81
Standard deviation 0.66
Values 1.6 1.1 2.7 1.9
[99]
ref_hepatocyte HPSE
Mean 0.271
Standard deviation 0.14
Values 0.47 0.15 0.24 0.35 0.15
[100]
HepG2 HPSE
Mean 0.286
Standard deviation 0.017
Values 0.27 0.3
[101]
HepG2.C3A HPSE
Mean 0.267
Standard deviation 0.062
Values 0.31 0.22
[102]
HuH.7 HPSE
Mean 0.483
Standard deviation 0.063
Values 0.52 0.51 0.41
[103]
SNU475 HPSE
Mean 2.25
Standard deviation 0.14
Values 2.1 2.3
[104]
THLE HPSE
Mean 15.4
Standard deviation 1.3
Values 14 16
[105]
liver HPSE
Mean 1.2
Standard deviation 0.48
Values 1.1 1.8 0.63 1.2
[106]
ref_hepatocyte HYAL4
Mean 0.0841
Standard deviation 0.12
Values 0 0.033 0 0.29 0.098
[107]
HepG2 HYAL4
Mean 0.0093
Standard deviation 0.005
Values 0.013 0.0057
[108]
HepG2.C3A HYAL4
Mean 0.0463
Standard deviation 0.01
Values 0.054 0.039
[109]
HuH.7 HYAL4
Mean 0.0137
Standard deviation 0.014
Values 0.028 0.013 0
[110]
SNU475 HYAL4
Mean 0.208
Standard deviation 0.14
Values 0.3 0.11
[111]
THLE HYAL4
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[112]
liver HYAL4
Mean 0.0989
Standard deviation 0.088
Values 0.16 0.19 0 0.051
[113]
ref_hepatocyte HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 HPSE2
Mean 0.17
Standard deviation 0.13
Values 0.077 0.26
[115]
HepG2.C3A HPSE2
Mean 0.0302
Standard deviation 0.012
Values 0.021 0.039
[116]
HuH.7 HPSE2
Mean 2.68
Standard deviation 1.4
Values 3.1 1.1 3.7
[117]
SNU475 HPSE2
Mean 0.0173
Standard deviation 0.011
Values 0.025 0.0093
[118]
THLE HPSE2
Mean 0
Standard deviation 0
Values 0 0
[119]
liver HPSE2
Mean 0
Standard deviation 0
Values 0 0 0 0