WP_GLUTATHIONE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GSTA1 Glutathione S-transferase A1 [1] -4.46[2] -8.01[3] -2.01[4] -6.37[5] -9.98[6] -2.82[7]
2 GPX2 Glutathione peroxidase 2 [8] 0.32[9] -0.12[10] -2.48[11] -9.50[12] -8.47[13] 0.25[14]
3 GPX4 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [15] -0.63[16] -0.01[17] -0.53[18] -1.00[19] -0.19[20] -1.00[21]
4 GPX1 Glutathione peroxidase 1 [22] -0.35[23] -0.44[24] -0.29[25] -0.62[26] 1.57[27] -0.74[28]
5 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic [29] 0.66[30] 1.64[31] 2.49[32] 0.10[33] 0.32[34] 0.30[35]
6 GPX3 Glutathione peroxidase 3 [36] 1.48[37] 0.29[38] 0.04[39] -1.37[40] -4.85[41] 1.88[42]
7 ANPEP Aminopeptidase N [43] 0.17[44] 0.97[45] -2.15[46] -3.63[47] 0.22[48] 1.48[49]
8 GSR Glutathione reductase, mitochondrial [50] 1.70[51] 1.54[52] 1.79[53] 2.46[54] 2.09[55] -0.07[56]
9 GCLC Glutamate--cysteine ligase catalytic subunit [57] 0.82[58] 1.41[59] -0.02[60] 2.61[61] 1.10[62] 1.21[63]
10 GCLM Glutamate--cysteine ligase regulatory subunit [64] 0.20[65] -0.34[66] -0.09[67] 2.51[68] 1.90[69] -0.05[70]
11 GSS Glutathione synthetase [71] 1.87[72] 1.82[73] 0.94[74] 1.99[75] 2.59[76] 0.55[77]
12 GGT1 Glutathione hydrolase 1 proenzyme [78] 0.50[79] 0.46[80] 0.02[81] -0.53[82] -3.86[83] 1.51[84]
13 G6PD Glucose-6-phosphate 1-dehydrogenase [85] 3.86[86] 2.12[87] 1.64[88] 6.17[89] 4.34[90] -1.74[91]
14 OPLAH 5-oxoprolinase [92] 2.11[93] 2.40[94] 0.65[95] 1.24[96] 0.41[97] 2.46[98]
15 GSTT2 Glutathione S-transferase theta-2 [99] -6.15[100] -7.87[101] -8.93[102] -3.30[103] -0.44[104] -2.78[105]
16 GGTLC2 Glutathione hydrolase light chain 2 [106] [107] [108] -6.69[109] -5.85[110] -5.93[111] -6.57[112]
17 GSTM2 Glutathione S-transferase Mu 2 [113] 1.56[114] 0.55[115] 2.12[116] 3.13[117] 3.70[118] 0.80[119]
18 GSTM1 Glutathione S-transferase Mu 1 [120] -1.14[121] -2.19[122] 3.75[123] 5.75[124] -1.45[125] 7.35[126]
19 GGT5 Glutathione hydrolase 5 proenzyme [127] 5.75[128] 3.36[129] -1.73[130] 5.57[131] 6.92[132] 6.43[133]
20 GSTA5 Glutathione S-transferase A5 [134] -5.90[135] [136] -5.30[137] [138] [139] [140]
21 GGTLC1 Glutathione hydrolase light chain 1 [141] -2.15[142] 0.69[143] 0.38[144] 0.33[145] [146] 1.23[147]
22 GGT2 Inactive glutathione hydrolase 2 [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte GSTA1
Mean 456
Standard deviation 5.8e+02
Values 8.4 1.4e+03 4.8e+02 1.3e+02 2.2e+02
[2]
HepG2 GSTA1
Mean 20.3
Standard deviation 5.9
Values 24 16
[3]
HepG2.C3A GSTA1
Mean 1.31
Standard deviation 0.69
Values 1.8 0.83
[4]
HuH.7 GSTA1
Mean 93.3
Standard deviation 39
Values 1.3e+02 53 95
[5]
SNU475 GSTA1
Mean 3.21
Standard deviation 3.3
Values 0.88 5.5
[6]
THLE GSTA1
Mean 0.127
Standard deviation 0.11
Values 0.21 0.048
[7]
liver GSTA1
Mean 52.8
Standard deviation 52
Values 6.8 29 48 1.3e+02
[8]
ref_hepatocyte GPX2
Mean 224
Standard deviation 2.7e+02
Values 19 4.5e+02 5.9e+02 61 9.6
[9]
HepG2 GPX2
Mean 274
Standard deviation 26
Values 2.6e+02 2.9e+02
[10]
HepG2.C3A GPX2
Mean 153
Standard deviation 85
Values 2.1e+02 93
[11]
HuH.7 GPX2
Mean 33.1
Standard deviation 7.7
Values 38 24 37
[12]
SNU475 GPX2
Mean 0.18
Standard deviation 0.025
Values 0.2 0.16
[13]
THLE GPX2
Mean 0.178
Standard deviation 0.026
Values 0.16 0.2
[14]
liver GPX2
Mean 218
Standard deviation 2.6e+02
Values 6.4 30 2.6e+02 5.7e+02
[15]
ref_hepatocyte GPX4
Mean 223
Standard deviation 63
Values 2.2e+02 2.5e+02 2e+02 3.1e+02 1.4e+02
[16]
HepG2 GPX4
Mean 141
Standard deviation 10
Values 1.3e+02 1.5e+02
[17]
HepG2.C3A GPX4
Mean 164
Standard deviation 3.3
Values 1.6e+02 1.7e+02
[18]
HuH.7 GPX4
Mean 128
Standard deviation 29
Values 1.6e+02 1.1e+02 1.1e+02
[19]
SNU475 GPX4
Mean 64.8
Standard deviation 11
Values 57 73
[20]
THLE GPX4
Mean 54.8
Standard deviation 1.7
Values 54 56
[21]
liver GPX4
Mean 91.2
Standard deviation 88
Values 12 18 1.7e+02 1.6e+02
[22]
ref_hepatocyte GPX1
Mean 167
Standard deviation 1e+02
Values 2.7e+02 1.8e+02 2.5e+02 30 1e+02
[23]
HepG2 GPX1
Mean 128
Standard deviation 3.5
Values 1.3e+02 1.3e+02
[24]
HepG2.C3A GPX1
Mean 91.1
Standard deviation 33
Values 1.1e+02 67
[25]
HuH.7 GPX1
Mean 113
Standard deviation 55
Values 1.6e+02 55 1.2e+02
[26]
SNU475 GPX1
Mean 63.3
Standard deviation 6.4
Values 59 68
[27]
THLE GPX1
Mean 139
Standard deviation 16
Values 1.3e+02 1.5e+02
[28]
liver GPX1
Mean 81.8
Standard deviation 69
Values 19 25 1.4e+02 1.4e+02
[29]
ref_hepatocyte IDH1
Mean 120
Standard deviation 80
Values 23 1.8e+02 1.2e+02 2.1e+02 57
[30]
HepG2 IDH1
Mean 186
Standard deviation 83
Values 2.4e+02 1.3e+02
[31]
HepG2.C3A IDH1
Mean 278
Standard deviation 72
Values 3.3e+02 2.3e+02
[32]
HuH.7 IDH1
Mean 559
Standard deviation 1.1e+02
Values 6.5e+02 4.4e+02 5.8e+02
[33]
SNU475 IDH1
Mean 74.8
Standard deviation 19
Values 61 88
[34]
THLE IDH1
Mean 42.2
Standard deviation 1.1
Values 43 41
[35]
liver IDH1
Mean 121
Standard deviation 35
Values 74 1.2e+02 1.4e+02 1.5e+02
[36]
ref_hepatocyte GPX3
Mean 87.9
Standard deviation 1.1e+02
Values 47 76 2.8e+02 22 17
[37]
HepG2 GPX3
Mean 240
Standard deviation 69
Values 1.9e+02 2.9e+02
[38]
HepG2.C3A GPX3
Mean 79.8
Standard deviation 13
Values 71 89
[39]
HuH.7 GPX3
Mean 74.5
Standard deviation 41
Values 51 1.2e+02 51
[40]
SNU475 GPX3
Mean 19.7
Standard deviation 2.7
Values 22 18
[41]
THLE GPX3
Mean 0.86
Standard deviation 0.062
Values 0.82 0.9
[42]
liver GPX3
Mean 265
Standard deviation 2.9e+02
Values 35 1.2e+02 2.3e+02 6.8e+02
[43]
ref_hepatocyte ANPEP
Mean 59.7
Standard deviation 59
Values 24 1.2e+02 1.2e+02 13 14
[44]
HepG2 ANPEP
Mean 65.7
Standard deviation 12
Values 74 57
[45]
HepG2.C3A ANPEP
Mean 86.7
Standard deviation 36
Values 61 1.1e+02
[46]
HuH.7 ANPEP
Mean 11.1
Standard deviation 2.1
Values 9.3 13 11
[47]
SNU475 ANPEP
Mean 2.8
Standard deviation 2
Values 4.2 1.4
[48]
THLE ANPEP
Mean 19.6
Standard deviation 4.8
Values 16 23
[49]
liver ANPEP
Mean 137
Standard deviation 57
Values 1.1e+02 72 1.9e+02 1.8e+02
[50]
ref_hepatocyte GSR
Mean 31.7
Standard deviation 20
Values 29 12 16 63 38
[51]
HepG2 GSR
Mean 101
Standard deviation 36
Values 75 1.3e+02
[52]
HepG2.C3A GSR
Mean 68.4
Standard deviation 11
Values 77 60
[53]
HuH.7 GSR
Mean 90.7
Standard deviation 6
Values 95 84 93
[54]
SNU475 GSR
Mean 101
Standard deviation 25
Values 83 1.2e+02
[55]
THLE GSR
Mean 37.8
Standard deviation 6.5
Values 33 42
[56]
liver GSR
Mean 24.8
Standard deviation 7.4
Values 32 30 16 21
[57]
ref_hepatocyte GCLC
Mean 23.9
Standard deviation 11
Values 36 37 16 14 17
[58]
HepG2 GCLC
Mean 41.2
Standard deviation 0.21
Values 41 41
[59]
HepG2.C3A GCLC
Mean 47.1
Standard deviation 0.68
Values 47 48
[60]
HuH.7 GCLC
Mean 19.4
Standard deviation 7.4
Values 15 28 15
[61]
SNU475 GCLC
Mean 84.8
Standard deviation 9.1
Values 78 91
[62]
THLE GCLC
Mean 14.4
Standard deviation 0.55
Values 15 14
[63]
liver GCLC
Mean 45.3
Standard deviation 20
Values 64 59 37 22
[64]
ref_hepatocyte GCLM
Mean 20.7
Standard deviation 17
Values 32 5.2 8.4 12 45
[65]
HepG2 GCLM
Mean 23.3
Standard deviation 15
Values 13 34
[66]
HepG2.C3A GCLM
Mean 12.1
Standard deviation 3.1
Values 14 9.9
[67]
HuH.7 GCLM
Mean 16.1
Standard deviation 2.7
Values 13 19 16
[68]
SNU475 GCLM
Mean 68.3
Standard deviation 0.053
Values 68 68
[69]
THLE GCLM
Mean 21.6
Standard deviation 2.7
Values 20 24
[70]
liver GCLM
Mean 16.4
Standard deviation 8.1
Values 7 14 18 27
[71]
ref_hepatocyte GSS
Mean 17.2
Standard deviation 2.6
Values 20 17 20 14 16
[72]
HepG2 GSS
Mean 61.8
Standard deviation 7.1
Values 67 57
[73]
HepG2.C3A GSS
Mean 45
Standard deviation 7.3
Values 50 40
[74]
HuH.7 GSS
Mean 27.4
Standard deviation 7
Values 34 20 27
[75]
SNU475 GSS
Mean 39.8
Standard deviation 5.9
Values 36 44
[76]
THLE GSS
Mean 29.3
Standard deviation 2.5
Values 27 31
[77]
liver GSS
Mean 20.8
Standard deviation 9.9
Values 11 14 26 32
[78]
ref_hepatocyte GGT1
Mean 15.1
Standard deviation 12
Values 4.1 22 29 0.7 20
[79]
HepG2 GGT1
Mean 20.9
Standard deviation 6.9
Values 16 26
[80]
HepG2.C3A GGT1
Mean 15.5
Standard deviation 4.3
Values 12 19
[81]
HuH.7 GGT1
Mean 12.7
Standard deviation 3.6
Values 9.9 17 11
[82]
SNU475 GGT1
Mean 6.1
Standard deviation 1.7
Values 4.9 7.3
[83]
THLE GGT1
Mean 0.294
Standard deviation 0.0057
Values 0.29 0.3
[84]
liver GGT1
Mean 35.2
Standard deviation 23
Values 21 15 65 40
[85]
ref_hepatocyte G6PD
Mean 7
Standard deviation 9.9
Values 1.2 1.1 1.1 24 7.7
[86]
HepG2 G6PD
Mean 99.6
Standard deviation 38
Values 73 1.3e+02
[87]
HepG2.C3A G6PD
Mean 22.6
Standard deviation 2
Values 21 24
[88]
HuH.7 G6PD
Mean 18.1
Standard deviation 6.7
Values 19 11 24
[89]
SNU475 G6PD
Mean 293
Standard deviation 1.9e+02
Values 1.6e+02 4.3e+02
[90]
THLE G6PD
Mean 39.9
Standard deviation 6.1
Values 36 44
[91]
liver G6PD
Mean 1.72
Standard deviation 0.72
Values 1.6 1 1.6 2.7
[92]
ref_hepatocyte OPLAH
Mean 4.64
Standard deviation 4.4
Values 1.9 11 7.2 2.4 0.7
[93]
HepG2 OPLAH
Mean 19.7
Standard deviation 2.6
Values 18 22
[94]
HepG2.C3A OPLAH
Mean 18.1
Standard deviation 9.1
Values 12 25
[95]
HuH.7 OPLAH
Mean 6.03
Standard deviation 0.25
Values 6.2 5.7 6.2
[96]
SNU475 OPLAH
Mean 6.37
Standard deviation 3.8
Values 3.7 9.1
[97]
THLE OPLAH
Mean 1.73
Standard deviation 0.08
Values 1.7 1.8
[98]
liver OPLAH
Mean 21
Standard deviation 13
Values 40 19 14 10
[99]
ref_hepatocyte GSTT2
Mean 3.22
Standard deviation 3.2
Values 2.2 5.1 7.8 0 1.1
[100]
HepG2 GSTT2
Mean 0.0444
Standard deviation 0.022
Values 0.06 0.029
[101]
HepG2.C3A GSTT2
Mean 0.0102
Standard deviation 0.00071
Values 0.011 0.0097
[102]
HuH.7 GSTT2
Mean 0.00547
Standard deviation 0.0095
Values 0 0 0.016
[103]
SNU475 GSTT2
Mean 0.19
Standard deviation 0.13
Values 0.1 0.28
[104]
THLE GSTT2
Mean 0.671
Standard deviation 0.33
Values 0.44 0.9
[105]
liver GSTT2
Mean 0.384
Standard deviation 0.24
Values 0.29 0.16 0.73 0.36
[106]
ref_hepatocyte GGTLC2
Mean 1.21
Standard deviation 2.2
Values 0 5.1 0.99 0 0
[107]
HepG2 GGTLC2
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A GGTLC2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 GGTLC2
Mean 0.00975
Standard deviation 0.0086
Values 0 0.013 0.016
[110]
SNU475 GGTLC2
Mean 0.0122
Standard deviation 0.0042
Values 0.015 0.0093
[111]
THLE GGTLC2
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[112]
liver GGTLC2
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0
[113]
ref_hepatocyte GSTM2
Mean 0.961
Standard deviation 0.9
Values 0 1.7 1.3 1.9 0
[114]
HepG2 GSTM2
Mean 2.78
Standard deviation 0.68
Values 3.3 2.3
[115]
HepG2.C3A GSTM2
Mean 1.04
Standard deviation 0.29
Values 0.84 1.2
[116]
HuH.7 GSTM2
Mean 3.46
Standard deviation 0.18
Values 3.7 3.3 3.4
[117]
SNU475 GSTM2
Mean 4.89
Standard deviation 2.9
Values 2.8 7
[118]
THLE GSTM2
Mean 3.5
Standard deviation 0.29
Values 3.7 3.3
[119]
liver GSTM2
Mean 1.38
Standard deviation 0.62
Values 1.3 0.53 1.9 1.8
[120]
ref_hepatocyte GSTM1
Mean 0.404
Standard deviation 0.25
Values 0 0.36 0.52 0.52 0.62
[121]
HepG2 GSTM1
Mean 0.18
Standard deviation 0.14
Values 0.28 0.08
[122]
HepG2.C3A GSTM1
Mean 0.0657
Standard deviation 0.017
Values 0.054 0.078
[123]
HuH.7 GSTM1
Mean 4.5
Standard deviation 1.1
Values 4.7 3.3 5.5
[124]
SNU475 GSTM1
Mean 12.6
Standard deviation 6.3
Values 8.2 17
[125]
THLE GSTM1
Mean 0.0417
Standard deviation 0.0088
Values 0.035 0.048
[126]
liver GSTM1
Mean 54
Standard deviation 35
Values 38 15 93 70
[127]
ref_hepatocyte GGT5
Mean 0.17
Standard deviation 0.18
Values 0 0.3 0.41 0.15 0
[128]
HepG2 GGT5
Mean 8.97
Standard deviation 6.7
Values 4.3 14
[129]
HepG2.C3A GGT5
Mean 1.3
Standard deviation 0.47
Values 1.6 0.97
[130]
HuH.7 GGT5
Mean 0.0424
Standard deviation 0.034
Values 0.047 0.0064 0.074
[131]
SNU475 GGT5
Mean 4.71
Standard deviation 2.8
Values 6.7 2.7
[132]
THLE GGT5
Mean 5.79
Standard deviation 1.9
Values 4.5 7.1
[133]
liver GGT5
Mean 12
Standard deviation 7.3
Values 9.1 4.2 13 21
[134]
ref_hepatocyte GSTA5
Mean 0.13
Standard deviation 0.18
Values 0 0.33 0 0 0.32
[135]
HepG2 GSTA5
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[136]
HepG2.C3A GSTA5
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 GSTA5
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[138]
SNU475 GSTA5
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE GSTA5
Mean 0
Standard deviation 0
Values 0 0
[140]
liver GSTA5
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte GGTLC1
Mean 0.013
Standard deviation 0.029
Values 0 0.065 0 0 0
[142]
HepG2 GGTLC1
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[143]
HepG2.C3A GGTLC1
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[144]
HuH.7 GGTLC1
Mean 0.014
Standard deviation 0.013
Values 0 0.026 0.016
[145]
SNU475 GGTLC1
Mean 0.00949
Standard deviation 0.0063
Values 0.0051 0.014
[146]
THLE GGTLC1
Mean 0
Standard deviation 0
Values 0 0
[147]
liver GGTLC1
Mean 0.025
Standard deviation 0.016
Values 0.013 0.014 0.047 0.026
[148]
ref_hepatocyte GGT2
Missing
[149]
HepG2 GGT2
Missing
[150]
HepG2.C3A GGT2
Missing
[151]
HuH.7 GGT2
Missing
[152]
SNU475 GGT2
Missing
[153]
THLE GGT2
Missing
[154]
liver GGT2
Missing