WP_GLIOBLASTOMA_SIGNALING_PATHWAYS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ERRFI1 | ERBB receptor feedback inhibitor 1 | [1] | -0.71[2] | 0.38[3] | -2.03[4] | -2.55[5] | -1.29[6] | -0.72[7] |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [8] | -0.22[9] | -1.74[10] | -4.27[11] | -2.66[12] | -0.20[13] | -2.68[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.98[16] | -1.34[17] | -2.26[18] | -0.72[19] | -0.80[20] | -1.09[21] |
4 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [22] | -2.28[23] | -2.11[24] | -3.05[25] | -2.49[26] | -2.73[27] | -2.28[28] |
5 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [29] | -1.99[30] | -2.45[31] | -1.71[32] | -1.21[33] | -0.80[34] | -2.04[35] |
6 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [36] | -1.00[37] | -1.46[38] | -0.43[39] | -1.51[40] | -1.12[41] | -2.55[42] |
7 | CCND1 | G1/S-specific cyclin-D1 | [43] | 1.99[44] | -0.64[45] | 0.35[46] | 1.21[47] | -0.36[48] | 0.21[49] |
8 | GRB2 | Growth factor receptor-bound protein 2 | [50] | 0.14[51] | -0.16[52] | 0.12[53] | -0.11[54] | -0.30[55] | -0.55[56] |
9 | CDK4 | Cyclin-dependent kinase 4 | [57] | 0.27[58] | 0.73[59] | 0.51[60] | -0.49[61] | 0.06[62] | -1.68[63] |
10 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [64] | -1.12[65] | -0.85[66] | 0.58[67] | -0.85[68] | -0.09[69] | 0.25[70] |
11 | NRAS | GTPase NRas | [71] | -0.43[72] | -0.13[73] | 0.44[74] | 0.33[75] | -0.20[76] | -1.10[77] |
12 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [78] | -1.14[79] | -0.83[80] | -0.48[81] | -1.78[82] | -1.41[83] | -1.75[84] |
13 | MET | Hepatocyte growth factor receptor | [85] | -0.97[86] | -1.07[87] | -0.29[88] | 0.87[89] | -0.51[90] | 0.12[91] |
14 | ARAF | Serine/threonine-protein kinase A-Raf | [92] | -1.51[93] | -1.95[94] | -1.52[95] | -0.76[96] | -0.83[97] | 0.03[98] |
15 | CDK2 | Cyclin-dependent kinase 2 | [99] | -1.47[100] | -1.44[101] | -0.90[102] | -0.69[103] | -0.20[104] | -3.03[105] |
16 | HRAS | GTPase HRas | [106] | -2.07[107] | -2.90[108] | -3.54[109] | -1.62[110] | -1.93[111] | -3.51[112] |
17 | MSH6 | DNA mismatch repair protein Msh6 | [113] | -0.74[114] | -0.39[115] | -0.02[116] | 0.23[117] | 0.55[118] | -0.56[119] |
18 | MAPK1 | Mitogen-activated protein kinase 1 | [120] | 0.65[121] | 0.66[122] | 0.64[123] | 1.18[124] | 0.73[125] | 0.93[126] |
19 | AKT2 | RAC-beta serine/threonine-protein kinase | [127] | -0.10[128] | 0.05[129] | 0.33[130] | 0.19[131] | -0.12[132] | 0.28[133] |
20 | KRAS | GTPase KRas | [134] | -1.57[135] | -1.72[136] | 0.03[137] | 0.13[138] | -0.31[139] | -0.17[140] |
21 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [141] | 0.95[142] | 2.20[143] | 1.39[144] | -6.54[145] | -6.39[146] | 1.46[147] |
22 | PRKCZ | Protein kinase C zeta type | [148] | -0.59[149] | -0.34[150] | -2.18[151] | -2.97[152] | -5.27[153] | -2.49[154] |
23 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [155] | -1.53[156] | -1.54[157] | -0.29[158] | 1.40[159] | 0.80[160] | 2.15[161] |
24 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -1.60[162] | -0.33[163] | 0.02[164] | -1.23[165] | -0.08[166] | 1.63[167] | |
25 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [168] | 1.31[169] | 0.00[170] | 1.33[171] | 0.59[172] | 0.09[173] | -0.69[174] |
26 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [175] | 1.05[176] | 2.34[177] | -0.27[178] | -0.16[179] | 0.62[180] | 1.32[181] |
27 | EGFR | Epidermal growth factor receptor | [182] | -1.75[183] | -2.26[184] | 0.78[185] | -0.23[186] | 0.28[187] | 1.80[188] |
28 | TP53 | Cellular tumor antigen p53 | [189] | 0.58[190] | 0.01[191] | 0.93[192] | 0.62[193] | 0.19[194] | -0.89[195] |
29 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [196] | 0.82[197] | 0.91[198] | 1.67[199] | 0.04[200] | 0.50[201] | -1.14[202] |
30 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [203] | -0.35[204] | 0.15[205] | -0.49[206] | 0.54[207] | -0.16[208] | 0.22[209] |
31 | PRKCI | Protein kinase C iota type | [210] | 0.00[211] | 0.55[212] | 2.31[213] | 0.49[214] | 0.80[215] | -0.59[216] |
32 | MAPK3 | Mitogen-activated protein kinase 3 | [217] | 0.79[218] | 0.71[219] | 0.90[220] | -0.25[221] | -0.32[222] | -1.89[223] |
33 | CDK6 | Cyclin-dependent kinase 6 | [224] | 0.99[225] | 1.56[226] | 0.12[227] | 0.25[228] | 0.95[229] | 1.22[230] |
34 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [231] | -0.10[232] | -0.08[233] | 0.65[234] | -0.39[235] | 0.07[236] | -1.60[237] |
35 | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 | [238] | -1.50[239] | -1.40[240] | -0.23[241] | -1.43[242] | -1.13[243] | -1.30[244] |
36 | SRC | Proto-oncogene tyrosine-protein kinase Src | [245] | 1.97[246] | 1.82[247] | 0.98[248] | 1.73[249] | 0.81[250] | -1.70[251] |
37 | PRKCD | Protein kinase C delta type | [252] | 0.04[253] | 0.16[254] | -0.21[255] | -1.17[256] | -0.11[257] | -1.91[258] |
38 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [259] | 1.28[260] | 2.33[261] | 1.20[262] | 0.77[263] | 1.06[264] | 1.66[265] |
39 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.43[266] | 1.92[267] | 1.41[268] | 2.15[269] | 1.55[270] | -0.51[271] | |
40 | CCNE1 | G1/S-specific cyclin-E1 | [272] | 0.18[273] | 0.16[274] | -1.50[275] | -1.07[276] | -0.57[277] | -5.48[278] |
41 | SPRY2 | Protein sprouty homolog 2 | [279] | -1.65[280] | -1.63[281] | 0.94[282] | -2.94[283] | -1.01[284] | -0.67[285] |
42 | TSC2 | Tuberin | [286] | 0.76[287] | 0.15[288] | 1.00[289] | 0.53[290] | 0.96[291] | 1.23[292] |
43 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.15[293] | 0.53[294] | 0.85[295] | 0.38[296] | 0.44[297] | 0.31[298] | |
44 | RB1 | Retinoblastoma-associated protein | [299] | 0.16[300] | 0.53[301] | 1.25[302] | 1.61[303] | 1.83[304] | 0.63[305] |
45 | IRS1 | Insulin receptor substrate 1 | [306] | 1.03[307] | 0.35[308] | 1.93[309] | 1.04[310] | 0.52[311] | 1.27[312] |
46 | FOXO3 | Forkhead box protein O3 | [313] | -0.60[314] | -0.64[315] | 0.15[316] | -0.27[317] | 0.87[318] | 1.49[319] |
47 | PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | 0.61[320] | 2.05[321] | 2.35[322] | 2.38[323] | 1.58[324] | 2.81[325] | |
48 | E2F1 | Transcription factor E2F1 | [326] | 0.89[327] | 0.61[328] | 0.90[329] | 1.20[330] | 1.54[331] | -4.46[332] |
49 | EP300 | Histone acetyltransferase p300 | [333] | 1.67[334] | 1.13[335] | 2.18[336] | 1.90[337] | 1.86[338] | 1.91[339] |
50 | PRKCA | Protein kinase C alpha type | [340] | 1.78[341] | 1.69[342] | 2.21[343] | 1.48[344] | 1.74[345] | 1.07[346] |
51 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [347] | -0.69[348] | -5.29[349] | -1.28[350] | 0.49[351] | 0.69[352] | -2.93[353] |
52 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C | [354] | -0.83[355] | -0.36[356] | -0.05[357] | 1.51[358] | 1.54[359] | -1.66[360] |
53 | BRCA1 | Breast cancer type 1 susceptibility protein | [361] | 0.61[362] | 1.73[363] | 2.28[364] | 1.48[365] | 1.90[366] | 0.83[367] |
54 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.44[368] | 0.07[369] | 0.41[370] | 0.46[371] | 0.57[372] | 1.07[373] | |
55 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.83[374] | 1.79[375] | -1.87[376] | -0.39[377] | 0.28[378] | -0.55[379] | |
56 | TSC1 | Hamartin | [380] | 0.83[381] | 1.36[382] | 1.67[383] | 1.39[384] | 1.50[385] | 1.91[386] |
57 | FOXO1 | Forkhead box protein O1 | [387] | 0.64[388] | 0.17[389] | 0.46[390] | 0.51[391] | 2.43[392] | 2.24[393] |
58 | NF1 | Neurofibromin | [394] | 1.40[395] | 1.61[396] | 2.58[397] | 3.30[398] | 2.64[399] | 3.26[400] |
59 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [401] | -0.77[402] | -4.11[403] | 0.90[404] | 0.34[405] | -3.79[406] | -2.47[407] |
60 | FOXO4 | Forkhead box protein O4 | [408] | -0.33[409] | -0.06[410] | -0.07[411] | -0.50[412] | -0.39[413] | -1.54[414] |
61 | FGFR2 | Fibroblast growth factor receptor 2 | [415] | -3.57[416] | -2.49[417] | 1.61[418] | 0.79[419] | -4.15[420] | 2.58[421] |
62 | PIK3C2G | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma | -9.09[422] | [423] | -0.37[424] | -4.01[425] | -10.35[426] | 3.53[427] | |
63 | BRAF | Serine/threonine-protein kinase B-raf | [428] | -0.81[429] | -1.21[430] | 0.98[431] | 0.07[432] | -0.33[433] | 1.01[434] |
64 | ATM | Serine-protein kinase ATM | [435] | 1.97[436] | 3.45[437] | 3.33[438] | 3.49[439] | 2.87[440] | 4.14[441] |
65 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -2.34[442] | -8.22[443] | -0.61[444] | -3.40[445] | -2.35[446] | 1.87[447] | |
66 | MDM4 | Protein Mdm4 | [448] | 0.58[449] | 1.46[450] | 2.05[451] | 1.62[452] | 1.41[453] | 3.71[454] |
67 | FGFR1 | Fibroblast growth factor receptor 1 | [455] | 3.52[456] | 1.70[457] | 3.51[458] | 4.39[459] | 3.56[460] | 0.81[461] |
68 | GAB1 | GRB2-associated-binding protein 1 | [462] | 0.24[463] | 1.20[464] | 1.48[465] | 1.26[466] | 1.03[467] | 2.03[468] |
69 | IGF1R | Insulin-like growth factor 1 receptor | [469] | 3.68[470] | 2.86[471] | 1.69[472] | 3.80[473] | 3.25[474] | 1.24[475] |
70 | CCND2 | G1/S-specific cyclin-D2 | [476] | 2.08[477] | 0.54[478] | -5.51[479] | -5.12[480] | -2.31[481] | 1.01[482] |
71 | PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | 0.73[483] | -1.17[484] | 1.78[485] | 2.27[486] | -0.41[487] | 1.99[488] | |
72 | PRKCH | Protein kinase C eta type | [489] | -1.42[490] | -5.36[491] | -3.56[492] | 1.61[493] | 3.14[494] | 2.26[495] |
73 | CBL | E3 ubiquitin-protein ligase CBL | [496] | 3.39[497] | 2.20[498] | 2.58[499] | 4.47[500] | 3.85[501] | 2.91[502] |
74 | PDGFRA | Platelet-derived growth factor receptor alpha | [503] | -4.68[504] | -5.79[505] | 2.00[506] | -0.14[507] | 4.43[508] | 4.47[509] |
75 | PDGFRB | Platelet-derived growth factor receptor beta | [510] | 0.24[511] | 0.51[512] | -1.79[513] | 1.19[514] | 1.65[515] | 2.57[516] |
76 | AKT3 | RAC-gamma serine/threonine-protein kinase | [517] | -2.90[518] | -5.59[519] | -4.74[520] | 5.17[521] | 4.03[522] | 2.76[523] |
77 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [524] | 3.03[525] | 0.66[526] | 4.22[527] | 4.54[528] | 6.22[529] | -3.00[530] |
78 | PRKCB | Protein kinase C beta type | [531] | -7.87[532] | -6.81[533] | [534] | 1.81[535] | -3.59[536] | 2.69[537] |
79 | BRCA2 | Breast cancer type 2 susceptibility protein | [538] | 1.74[539] | 4.10[540] | 4.43[541] | 3.80[542] | 3.86[543] | 2.59[544] |
80 | PRKCQ | Protein kinase C theta type | [545] | -0.15[546] | -3.84[547] | [548] | 1.46[549] | 2.86[550] | 1.24[551] |
81 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [552] | [553] | [554] | 0.67[555] | -4.31[556] | 3.25[557] | |
82 | PRKCG | Protein kinase C gamma type | [558] | -1.88[559] | -1.34[560] | -3.56[561] | -1.73[562] | -1.92[563] | [564] |
83 | MIR1281 | [565] | [566] | [567] | [568] | [569] | [570] | [571] |