WP_GASTRIN_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | ANXA2 | Annexin A2 | [8] | -2.83[9] | -2.66[10] | -1.39[11] | 0.44[12] | -0.70[13] | -2.84[14] |
3 | RHOA | Transforming protein RhoA | [15] | -0.63[16] | -1.01[17] | -0.77[18] | -0.84[19] | -0.87[20] | -0.65[21] |
4 | ITGB1 | Integrin beta-1 | [22] | 0.54[23] | 0.69[24] | 0.84[25] | 1.84[26] | 1.44[27] | 0.84[28] |
5 | RHOB | Rho-related GTP-binding protein RhoB | [29] | -0.48[30] | -0.93[31] | -3.05[32] | -1.91[33] | -3.25[34] | 0.55[35] |
6 | CDC42 | Cell division control protein 42 homolog | [36] | -0.51[37] | 0.32[38] | -0.67[39] | -0.15[40] | -1.36[41] | -1.41[42] |
7 | SERPINE1 | Plasminogen activator inhibitor 1 | [43] | 1.45[44] | 1.78[45] | -4.93[46] | -3.43[47] | 2.77[48] | -3.20[49] |
8 | NFKBIA | NF-kappa-B inhibitor alpha | [50] | -0.74[51] | -2.42[52] | -2.78[53] | -3.14[54] | -1.74[55] | -0.46[56] |
9 | CLDN1 | Claudin-1 | [57] | -0.94[58] | -0.31[59] | 1.44[60] | -5.13[61] | -2.88[62] | 0.57[63] |
10 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [64] | -0.08[65] | -0.29[66] | 0.44[67] | 0.39[68] | -0.10[69] | -0.29[70] |
11 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [71] | -0.68[72] | -0.88[73] | -0.25[74] | -2.92[75] | -1.85[76] | -0.92[77] |
12 | JUN | Transcription factor AP-1 | [78] | -0.18[79] | -1.60[80] | -1.31[81] | -1.32[82] | -1.23[83] | -1.13[84] |
13 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [85] | 1.15[86] | -0.12[87] | -2.79[88] | -1.61[89] | 0.47[90] | -1.16[91] |
14 | FOS | Proto-oncogene c-Fos | [92] | -5.70[93] | -4.32[94] | -4.96[95] | -5.79[96] | -5.20[97] | -0.63[98] |
15 | RHOD | Rho-related GTP-binding protein RhoD | [99] | -5.35[100] | -3.56[101] | -1.84[102] | -2.42[103] | -4.72[104] | -1.30[105] |
16 | AKT1 | RAC-alpha serine/threonine-protein kinase | [106] | 0.39[107] | 0.28[108] | -0.78[109] | 0.33[110] | -0.13[111] | 0.43[112] |
17 | CTNNB1 | Catenin beta-1 | [113] | 1.93[114] | 1.54[115] | 2.46[116] | 1.13[117] | 0.88[118] | 1.78[119] |
18 | STAT3 | Signal transducer and activator of transcription 3 | [120] | 0.86[121] | -0.52[122] | 0.24[123] | 0.62[124] | -0.58[125] | 3.08[126] |
19 | MYC | Myc proto-oncogene protein | [127] | 0.74[128] | 0.52[129] | -1.49[130] | -2.41[131] | -0.52[132] | -1.32[133] |
20 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [134] | -0.62[135] | -0.83[136] | -0.23[137] | -0.16[138] | -0.14[139] | -0.52[140] |
21 | BCL2L1 | Bcl-2-like protein 1 | [141] | 2.45[142] | 1.96[143] | 2.94[144] | -0.24[145] | -0.33[146] | -0.14[147] |
22 | CCND1 | G1/S-specific cyclin-D1 | [148] | 3.36[149] | 0.98[150] | 1.83[151] | 2.26[152] | 0.30[153] | 1.73[154] |
23 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [155] | 0.76[156] | 1.31[157] | 1.28[158] | 1.27[159] | 1.42[160] | 1.93[161] |
24 | GRB2 | Growth factor receptor-bound protein 2 | [162] | 1.51[163] | 1.46[164] | 1.60[165] | 0.93[166] | 0.37[167] | 0.97[168] |
25 | YES1 | Tyrosine-protein kinase Yes | [169] | -0.55[170] | 1.06[171] | 1.30[172] | 0.83[173] | -0.19[174] | 0.80[175] |
26 | CRK | Adapter molecule crk | [176] | 0.11[177] | 0.16[178] | 0.25[179] | 0.14[180] | 0.06[181] | 1.52[182] |
27 | BAD | Bcl2-associated agonist of cell death | [183] | -1.36[184] | -1.11[185] | -2.04[186] | -0.69[187] | -0.76[188] | -0.74[189] |
28 | SHC1 | SHC-transforming protein 1 | [190] | 1.48[191] | 1.81[192] | 1.91[193] | 3.03[194] | 2.04[195] | 1.46[196] |
29 | RELA | Transcription factor p65 | [197] | 0.45[198] | 0.06[199] | 0.22[200] | 0.32[201] | -0.25[202] | -0.20[203] |
30 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [204] | 0.15[205] | 0.09[206] | 0.11[207] | -0.09[208] | 0.02[209] | -0.10[210] |
31 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [211] | -2.80[212] | -1.66[213] | -4.04[214] | -2.74[215] | 0.55[216] | -1.40[217] |
32 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [218] | 0.25[219] | 0.77[220] | 2.06[221] | 0.19[222] | 0.58[223] | 1.77[224] |
33 | VEGFA | Vascular endothelial growth factor A | [225] | 1.53[226] | 2.98[227] | 1.61[228] | 0.82[229] | 1.05[230] | 1.46[231] |
34 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [232] | 0.23[233] | 0.78[234] | 1.00[235] | -0.73[236] | -0.74[237] | -0.23[238] |
35 | CD44 | CD44 antigen | [239] | -6.75[240] | -8.14[241] | -1.69[242] | 2.14[243] | 2.12[244] | -0.61[245] |
36 | EGR1 | Early growth response protein 1 | [246] | -1.49[247] | -0.89[248] | -2.99[249] | -1.95[250] | -0.77[251] | 1.82[252] |
37 | CASP3 | Caspase-3 | [253] | 0.45[254] | 1.24[255] | -1.29[256] | -0.52[257] | 0.00[258] | -0.13[259] |
38 | CDH1 | Cadherin-1 | [260] | 1.43[261] | 2.03[262] | 2.58[263] | -2.79[264] | -7.52[265] | 2.24[266] |
39 | HRAS | GTPase HRas | [267] | -0.70[268] | -1.28[269] | -2.06[270] | -0.57[271] | -1.26[272] | -1.98[273] |
40 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | [274] | 1.40[275] | 1.46[276] | 1.11[277] | 0.52[278] | -0.09[279] | 1.13[280] |
41 | MAPK1 | Mitogen-activated protein kinase 1 | [281] | 2.02[282] | 2.28[283] | 2.13[284] | 2.23[285] | 1.40[286] | 2.45[287] |
42 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | [288] | 1.44[289] | 1.44[290] | 0.33[291] | 1.75[292] | 1.00[293] | 0.74[294] |
43 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [295] | 0.55[296] | 1.63[297] | 0.60[298] | 0.80[299] | 1.10[300] | 1.40[301] |
44 | PXN | Paxillin | [302] | 1.31[303] | 1.15[304] | 1.21[305] | 2.50[306] | 1.98[307] | 0.32[308] |
45 | KRAS | GTPase KRas | [309] | -0.20[310] | -0.11[311] | 1.51[312] | 1.18[313] | 0.36[314] | 1.35[315] |
46 | PTK2 | Focal adhesion kinase 1 | [316] | 1.05[317] | 1.65[318] | 2.05[319] | 2.33[320] | 1.05[321] | 1.44[322] |
47 | MAPK14 | Mitogen-activated protein kinase 14 | [323] | 1.79[324] | 1.97[325] | 1.57[326] | 2.06[327] | 1.06[328] | 1.96[329] |
48 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [330] | 0.95[331] | 2.12[332] | 2.37[333] | 1.16[334] | 0.45[335] | 1.70[336] |
49 | ARRB2 | Beta-arrestin-2 | [337] | 0.48[338] | 0.98[339] | 0.96[340] | -0.94[341] | -0.61[342] | -0.20[343] |
50 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [344] | -0.16[345] | 0.07[346] | 1.19[347] | 2.45[348] | 1.47[349] | 3.68[350] |
51 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [351] | 1.89[352] | 2.45[353] | 2.43[354] | 1.06[355] | 1.41[356] | -1.64[357] |
52 | MAPK8 | Mitogen-activated protein kinase 8 | [358] | -1.13[359] | 0.39[360] | -0.71[361] | -0.52[362] | -1.15[363] | 0.16[364] |
53 | KAT5 | Histone acetyltransferase KAT5 | [365] | -0.47[366] | 0.06[367] | -0.95[368] | -0.46[369] | -1.02[370] | -0.39[371] |
54 | SOS1 | Son of sevenless homolog 1 | [372] | 0.21[373] | 1.86[374] | 1.39[375] | 1.22[376] | -0.02[377] | 1.21[378] |
55 | ELK1 | ETS domain-containing protein Elk-1 | [379] | 0.00[380] | -2.02[381] | 0.42[382] | 0.65[383] | 0.76[384] | 0.51[385] |
56 | ROCK1 | Rho-associated protein kinase 1 | [386] | -0.64[387] | 1.00[388] | 1.79[389] | 1.74[390] | 0.61[391] | 2.26[392] |
57 | TJP1 | Tight junction protein ZO-1 | [393] | 0.77[394] | 1.10[395] | 0.90[396] | 2.08[397] | 1.06[398] | 2.51[399] |
58 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [400] | 0.98[401] | 0.78[402] | 0.59[403] | 0.13[404] | 0.56[405] | 1.13[406] |
59 | BMP2 | Bone morphogenetic protein 2 | [407] | -4.67[408] | -7.68[409] | 1.44[410] | -1.51[411] | -1.74[412] | -1.51[413] |
60 | EGFR | Epidermal growth factor receptor | [414] | -0.39[415] | -0.64[416] | 2.26[417] | 0.81[418] | 0.95[419] | 3.33[420] |
61 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [421] | 2.19[422] | 2.53[423] | 3.16[424] | 1.09[425] | 1.17[426] | 0.39[427] |
62 | ELAVL1 | ELAV-like protein 1 | [428] | 2.48[429] | 2.21[430] | 2.66[431] | 2.19[432] | 2.00[433] | 1.76[434] |
63 | KLF4 | Krueppel-like factor 4 | [435] | -1.89[436] | -5.52[437] | -2.81[438] | -3.78[439] | 0.11[440] | -1.26[441] |
64 | MAPK9 | Mitogen-activated protein kinase 9 | [442] | 1.54[443] | 1.88[444] | 1.96[445] | 2.09[446] | 1.07[447] | 1.19[448] |
65 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [449] | 1.30[450] | 2.00[451] | 1.13[452] | 0.86[453] | 0.89[454] | 1.57[455] |
66 | MAPK3 | Mitogen-activated protein kinase 3 | [456] | 2.16[457] | 2.32[458] | 2.39[459] | 0.80[460] | 0.34[461] | -0.36[462] |
67 | GSK3B | Glycogen synthase kinase-3 beta | [463] | 1.58[464] | 1.33[465] | 1.92[466] | 2.19[467] | 1.54[468] | 1.84[469] |
68 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [470] | 1.22[471] | 2.55[472] | 2.53[473] | 1.03[474] | 1.36[475] | 2.19[476] |
69 | SRC | Proto-oncogene tyrosine-protein kinase Src | [477] | 3.34[478] | 3.44[479] | 2.46[480] | 2.78[481] | 1.48[482] | -0.17[483] |
70 | PPARG | Peroxisome proliferator-activated receptor gamma | [484] | 0.23[485] | 1.95[486] | 2.49[487] | 1.22[488] | 0.71[489] | 0.30[490] |
71 | PRKCD | Protein kinase C delta type | [491] | 1.41[492] | 1.78[493] | 1.27[494] | -0.13[495] | 0.55[496] | -0.39[497] |
72 | SP1 | Transcription factor Sp1 | [498] | 2.13[499] | 2.49[500] | 3.58[501] | 3.05[502] | 2.25[503] | 2.83[504] |
73 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.80[505] | 3.54[506] | 2.89[507] | 3.20[508] | 2.21[509] | 1.02[510] | |
74 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [511] | 0.83[512] | 1.01[513] | 1.13[514] | 0.64[515] | 0.25[516] | 1.86[517] |
75 | MTOR | Serine/threonine-protein kinase mTOR | [518] | 2.85[519] | 3.98[520] | 3.56[521] | 3.06[522] | 2.66[523] | 4.13[524] |
76 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [525] | [526] | [527] | [528] | [529] | [530] | [531] |
77 | PRKD2 | Serine/threonine-protein kinase D2 | [532] | 1.20[533] | 0.84[534] | 1.93[535] | 1.58[536] | 0.99[537] | 0.57[538] |
78 | IRS1 | Insulin receptor substrate 1 | [539] | 2.40[540] | 1.96[541] | 3.41[542] | 2.08[543] | 1.19[544] | 2.79[545] |
79 | FOXO3 | Forkhead box protein O3 | [546] | 0.77[547] | 0.97[548] | 1.63[549] | 0.78[550] | 1.54[551] | 3.01[552] |
80 | JAG1 | Protein jagged-1 | [553] | 5.09[554] | 3.79[555] | 3.28[556] | 1.89[557] | 0.06[558] | 1.73[559] |
81 | PRKCA | Protein kinase C alpha type | [560] | 3.15[561] | 3.31[562] | 3.69[563] | 2.53[564] | 2.41[565] | 2.60[566] |
82 | MEF2D | Myocyte-specific enhancer factor 2D | [567] | 1.06[568] | 1.04[569] | 1.77[570] | 2.96[571] | 2.06[572] | 1.53[573] |
83 | PAK1 | Serine/threonine-protein kinase PAK 1 | [574] | 0.30[575] | -0.34[576] | 2.09[577] | -1.48[578] | 1.82[579] | 0.94[580] |
84 | FYN | Tyrosine-protein kinase Fyn | [581] | 1.26[582] | -7.23[583] | 1.36[584] | 1.85[585] | 2.90[586] | 1.65[587] |
85 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [588] | 0.39[589] | 1.28[590] | 1.82[591] | 1.97[592] | 1.71[593] | 2.12[594] |
86 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.07[595] | 1.69[596] | 1.90[597] | 1.51[598] | 1.23[599] | 2.59[600] | |
87 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [601] | 2.03[602] | 3.31[603] | 3.82[604] | 2.92[605] | 2.38[606] | 3.02[607] |
88 | FOXO1 | Forkhead box protein O1 | [608] | 2.00[609] | 1.79[610] | 1.95[611] | 1.55[612] | 3.09[613] | 3.76[614] |
89 | HDAC7 | Histone deacetylase 7 | [615] | 2.70[616] | 2.17[617] | 1.88[618] | 3.48[619] | 3.32[620] | 1.65[621] |
90 | SERPINB2 | Plasminogen activator inhibitor 2 | [622] | -2.75[623] | -6.33[624] | -5.78[625] | 0.15[626] | 4.30[627] | -7.89[628] |
91 | JAK2 | Tyrosine-protein kinase JAK2 | [629] | 0.54[630] | 0.65[631] | 0.23[632] | 1.14[633] | 1.26[634] | 3.38[635] |
92 | PRKCE | Protein kinase C epsilon type | [636] | 0.95[637] | -0.44[638] | 2.07[639] | 1.36[640] | 1.24[641] | 4.24[642] |
93 | ARRB1 | Beta-arrestin-1 | [643] | 3.90[644] | 3.82[645] | 3.14[646] | 2.53[647] | 1.86[648] | 3.95[649] |
94 | PRKCH | Protein kinase C eta type | [650] | -0.05[651] | -3.74[652] | -2.08[653] | 2.65[654] | 3.80[655] | 3.78[656] |
95 | MEF2B | Myocyte-specific enhancer factor 2B | [657] | -4.72[658] | -3.44[659] | -1.27[660] | [661] | [662] | -6.89[663] |
96 | SLC9A1 | Sodium/hydrogen exchanger 1 | [664] | 3.31[665] | 2.34[666] | 1.23[667] | 4.50[668] | 3.94[669] | 1.41[670] |
97 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [671] | 2.03[672] | 2.16[673] | 3.03[674] | 3.55[675] | 2.09[676] | 3.35[677] |
98 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [678] | 4.40[679] | 2.28[680] | 5.71[681] | 5.59[682] | 6.89[683] | -1.48[684] |
99 | TFF2 | Trefoil factor 2 | [685] | -1.51[686] | -6.34[687] | 1.76[688] | -4.09[689] | [690] | -4.37[691] |
100 | TCF4 | Transcription factor 4 | [692] | -1.93[693] | -0.87[694] | 5.52[695] | 5.71[696] | 4.69[697] | 5.99[698] |
101 | MMP7 | Matrilysin | [699] | 0.73[700] | -1.93[701] | [702] | 2.92[703] | -2.82[704] | 1.39[705] |
102 | HDC | Histidine decarboxylase | [706] | -5.07[707] | -4.53[708] | -4.36[709] | -2.28[710] | [711] | 2.23[712] |
103 | PRKD1 | Serine/threonine-protein kinase D1 | [713] | 2.23[714] | 2.25[715] | 4.65[716] | 5.02[717] | 4.51[718] | 3.82[719] |
104 | MEF2C | Myocyte-specific enhancer factor 2C | [720] | -2.80[721] | -1.55[722] | 3.43[723] | 5.99[724] | 1.50[725] | 5.96[726] |
105 | SLC9A3 | Sodium/hydrogen exchanger 3 | [727] | 0.15[728] | -0.34[729] | 0.73[730] | 0.91[731] | 2.20[732] | 0.23[733] |
106 | KIT | Mast/stem cell growth factor receptor Kit | [734] | -2.68[735] | -4.44[736] | [737] | 2.88[738] | -3.13[739] | 4.31[740] |
107 | PRKCQ | Protein kinase C theta type | [741] | 1.22[742] | -2.23[743] | [744] | 2.50[745] | 3.53[746] | 2.76[747] |
108 | PTGS2 | Prostaglandin G/H synthase 2 | [748] | [749] | -2.19[750] | -1.92[751] | 3.24[752] | 8.58[753] | 3.51[754] |
109 | CHGA | Chromogranin-A | [755] | -2.34[756] | -0.15[757] | [758] | 3.19[759] | -0.71[760] | 1.97[761] |
110 | IL2 | Interleukin-2 | [762] | [763] | [764] | [765] | [766] | [767] | [768] |
111 | CXCL8 | Interleukin-8 | [769] | [770] | [771] | [772] | [773] | [774] | [775] |
112 | GAST | Gastrin | [776] | [777] | [778] | [779] | [780] | [781] | [782] |
113 | CCKBR | Gastrin/cholecystokinin type B receptor | [783] | [784] | [785] | [786] | [787] | [788] | [789] |
114 | ARHGEF28 | Rho guanine nucleotide exchange factor 28 | [790] | [791] | [792] | [793] | [794] | [795] | [796] |