WP_G13_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PFN1 | Profilin-1 | [1] | -1.37[2] | -1.80[3] | -1.45[4] | -1.36[5] | -1.48[6] | -1.89[7] |
2 | CALM2 | Calmodulin-2 | [8] | -0.61[9] | 0.21[10] | -1.16[11] | -1.08[12] | -0.59[13] | -0.76[14] |
3 | CFL1 | Cofilin-1 | [15] | 0.63[16] | -0.43[17] | -0.35[18] | 0.20[19] | 0.47[20] | 0.01[21] |
4 | RHOA | Transforming protein RhoA | [22] | -0.04[23] | -0.58[24] | -0.26[25] | -0.55[26] | 0.10[27] | -0.37[28] |
5 | CDC42 | Cell division control protein 42 homolog | [29] | 0.07[30] | 0.74[31] | -0.16[32] | 0.14[33] | -0.39[34] | -1.13[35] |
6 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [36] | 0.50[37] | 0.13[38] | 0.94[39] | 0.68[40] | 0.87[41] | -0.01[42] |
7 | CFL2 | Cofilin-2 | [43] | 0.46[44] | -1.05[45] | 0.68[46] | 0.64[47] | -0.40[48] | 0.88[49] |
8 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [50] | 0.66[51] | 1.18[52] | 1.37[53] | 1.43[54] | 1.45[55] | 1.45[56] |
9 | CALM1 | Calmodulin-1 | [57] | 0.97[58] | 0.96[59] | 1.53[60] | 2.25[61] | 1.73[62] | 2.57[63] |
10 | DIAPH1 | Protein diaphanous homolog 1 | [64] | 1.51[65] | 1.12[66] | 1.65[67] | 0.59[68] | 1.21[69] | 1.88[70] |
11 | RTKN | Rhotekin | [71] | 0.70[72] | 1.49[73] | -0.25[74] | -2.44[75] | -2.34[76] | 0.89[77] |
12 | IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | [78] | 0.08[79] | 2.25[80] | 2.53[81] | -3.83[82] | -6.13[83] | 3.55[84] |
13 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [85] | 1.01[86] | 1.14[87] | 1.71[88] | 1.86[89] | 0.89[90] | 1.49[91] |
14 | CYFIP1 | Cytoplasmic FMR1-interacting protein 1 | [92] | 2.17[93] | 1.71[94] | 1.45[95] | 1.79[96] | 1.75[97] | 2.28[98] |
15 | PKN1 | Serine/threonine-protein kinase N1 | [99] | 2.92[100] | 1.84[101] | 2.99[102] | 1.54[103] | 2.42[104] | 0.40[105] |
16 | WASL | Neural Wiskott-Aldrich syndrome protein | [106] | 0.41[107] | 1.44[108] | 1.94[109] | 1.77[110] | 1.13[111] | 2.08[112] |
17 | ROCK1 | Rho-associated protein kinase 1 | [113] | -0.06[114] | 1.42[115] | 2.30[116] | 2.03[117] | 1.57[118] | 2.54[119] |
18 | ARHGDIB | Rho GDP-dissociation inhibitor 2 | [120] | -4.15[121] | -4.40[122] | -5.25[123] | -0.93[124] | -0.31[125] | 1.68[126] |
19 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [127] | 1.82[128] | 2.09[129] | 2.51[130] | 1.59[131] | 2.06[132] | 1.34[133] |
20 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [134] | 2.77[135] | 2.95[136] | 3.66[137] | 1.38[138] | 2.14[139] | 0.66[140] |
21 | ROCK2 | Rho-associated protein kinase 2 | [141] | 2.37[142] | 3.57[143] | 2.14[144] | 3.30[145] | 1.27[146] | 2.88[147] |
22 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [148] | 2.75[149] | 2.25[150] | 2.77[151] | 4.64[152] | 4.68[153] | 2.98[154] |
23 | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | [155] | 2.54[156] | 1.76[157] | 1.93[158] | 2.93[159] | 2.08[160] | 2.25[161] |
24 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [162] | [163] | [164] | [165] | [166] | [167] | [168] |
25 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.11[169] | 2.57[170] | 2.83[171] | 1.72[172] | 2.08[173] | 2.11[174] | |
26 | RHPN2 | Rhophilin-2 | [175] | 2.50[176] | 2.57[177] | 4.25[178] | 1.62[179] | 0.45[180] | 2.75[181] |
27 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | [182] | 1.85[183] | 2.48[184] | 1.72[185] | 1.53[186] | 2.02[187] | 2.35[188] |
28 | LIMK1 | LIM domain kinase 1 | [189] | 3.20[190] | 2.05[191] | 1.73[192] | 4.18[193] | 2.61[194] | -0.54[195] |
29 | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1 | [196] | 2.20[197] | 1.17[198] | 2.46[199] | 1.40[200] | 2.78[201] | 2.31[202] |
30 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.52[203] | 2.11[204] | 2.40[205] | 1.80[206] | 2.20[207] | 2.87[208] | |
31 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.78[209] | 3.83[210] | 0.12[211] | 0.95[212] | 1.91[213] | 1.25[214] | |
32 | TNK2 | Activated CDC42 kinase 1 | [215] | 1.88[216] | 1.88[217] | 1.52[218] | 1.69[219] | 2.71[220] | 1.50[221] |
33 | WAS | Wiskott-Aldrich syndrome protein | [222] | -4.82[223] | -4.32[224] | -0.78[225] | -2.84[226] | -3.68[227] | 0.54[228] |
34 | CIT | Citron Rho-interacting kinase | [229] | 5.15[230] | 5.59[231] | 6.62[232] | 5.96[233] | 6.79[234] | 3.00[235] |
35 | PAK3 | Serine/threonine-protein kinase PAK 3 | [236] | -5.51[237] | [238] | [239] | -0.93[240] | 0.99[241] | 1.74[242] |
36 | MYL1 | Myosin light chain 1/3, skeletal muscle isoform | [243] | [244] | [245] | [246] | -4.03[247] | [248] | -0.86[249] |
37 | MYBPH | Myosin-binding protein H | [250] | 6.80[251] | 0.86[252] | -1.24[253] | 11.29[254] | -1.03[255] | [256] |
38 | MAPK10 | Mitogen-activated protein kinase 10 | [257] | -0.59[258] | [259] | [260] | 9.58[261] | 5.51[262] | 8.20[263] |
39 | MIR1178 | [264] | [265] | [266] | [267] | [268] | [269] | [270] | |
40 | ARHGDIG | Rho GDP-dissociation inhibitor 3 | [271] | [272] | [273] | [274] | [275] | [276] | [277] |