WP_FTO_OBESITY_VARIANT_MECHANISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO [1] 0.24[2] -0.79[3] -0.55[4] -0.73[5] 0.04[6] -0.85[7]
2 PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha -2.04[8] 0.06[9] -10.51[10] -0.78[11] -4.00[12] 1.07[13]
3 ARID5B AT-rich interactive domain-containing protein 5B [14] 0.23[15] 1.05[16] 0.90[17] 1.40[18] 1.05[19] -0.17[20]
4 TBX1 T-box transcription factor TBX1 [21] -1.10[22] -4.83[23] -2.34[24] -5.15[25] -4.71[26] -4.03[27]
5 IRX3 Iroquois-class homeodomain protein IRX-3 [28] 2.34[29] 1.80[30] 3.20[31] 1.74[32] 2.08[33] -2.98[34]
6 PRDM16 PR domain zinc finger protein 16 [35] 2.17[36] -1.64[37] 6.09[38] -1.17[39] -1.64[40] 1.03[41]
7 IRX5 Iroquois-class homeodomain protein IRX-5 [42] [43] [44] [45] [46] [47] [48]
8 UCP1 Mitochondrial brown fat uncoupling protein 1 [49] [50] [51] [52] [53] [54] [55]
[1]
ref_hepatocyte FTO
Mean 3.84
Standard deviation 2.2
Values 2.3 2.9 3 7.7 3.3
[2]
HepG2 FTO
Mean 19.4
Standard deviation 2
Values 18 21
[3]
HepG2.C3A FTO
Mean 14.6
Standard deviation 4.2
Values 12 18
[4]
HuH.7 FTO
Mean 14.4
Standard deviation 2.1
Values 13 14 17
[5]
SNU475 FTO
Mean 12.4
Standard deviation 2.6
Values 11 14
[6]
THLE FTO
Mean 22.3
Standard deviation 1.1
Values 21 23
[7]
liver FTO
Mean 15.6
Standard deviation 2.9
Values 15 18 12 18
[8]
ref_hepatocyte PPARGC1A
Mean 1.87
Standard deviation 1.7
Values 0.25 1.6 3.2 4 0.26
[9]
HepG2 PPARGC1A
Mean 1.94
Standard deviation 0.37
Values 2.2 1.7
[10]
HepG2.C3A PPARGC1A
Mean 12.8
Standard deviation 3.6
Values 10 15
[11]
HuH.7 PPARGC1A
Mean 0.00701
Standard deviation 0.0065
Values 0 0.013 0.0082
[12]
SNU475 PPARGC1A
Mean 5.83
Standard deviation 1.4
Values 4.9 6.8
[13]
THLE PPARGC1A
Mean 0.662
Standard deviation 0.1
Values 0.73 0.59
[14]
liver PPARGC1A
Mean 28.7
Standard deviation 18
Values 26 54 20 15
[15]
ref_hepatocyte ARID5B
Mean 1.26
Standard deviation 0.89
Values 1.3 0.45 0.52 2.6 1.3
[16]
HepG2 ARID5B
Mean 6.34
Standard deviation 0.84
Values 6.9 5.7
[17]
HepG2.C3A ARID5B
Mean 17.1
Standard deviation 6.4
Values 13 22
[18]
HuH.7 ARID5B
Mean 12.9
Standard deviation 3
Values 9.5 15 14
[19]
SNU475 ARID5B
Mean 17.8
Standard deviation 6.5
Values 13 22
[20]
THLE ARID5B
Mean 14.8
Standard deviation 1.2
Values 14 16
[21]
liver ARID5B
Mean 8.19
Standard deviation 4.5
Values 5.1 5.7 15 7.1
[22]
ref_hepatocyte TBX1
Mean 0.133
Standard deviation 0.2
Values 0 0.041 0.14 0 0.48
[23]
HepG2 TBX1
Mean 0.265
Standard deviation 0.29
Values 0.06 0.47
[24]
HepG2.C3A TBX1
Mean 0.0307
Standard deviation 0.0021
Values 0.032 0.029
[25]
HuH.7 TBX1
Mean 0.143
Standard deviation 0.043
Values 0.12 0.19 0.11
[26]
SNU475 TBX1
Mean 0.0201
Standard deviation 0.022
Values 0.035 0.0046
[27]
THLE TBX1
Mean 0.0287
Standard deviation 0.018
Values 0.041 0.016
[28]
liver TBX1
Mean 0.0593
Standard deviation 0.035
Values 0.04 0.071 0.024 0.1
[29]
ref_hepatocyte IRX3
Mean 0.128
Standard deviation 0.15
Values 0.13 0.033 0.37 0.1 0
[30]
HepG2 IRX3
Mean 2.76
Standard deviation 1.3
Values 1.9 3.7
[31]
HepG2.C3A IRX3
Mean 2.93
Standard deviation 2
Values 1.5 4.3
[32]
HuH.7 IRX3
Mean 6.42
Standard deviation 0.39
Values 6.9 6.3 6.1
[33]
SNU475 IRX3
Mean 2.29
Standard deviation 0.18
Values 2.4 2.2
[34]
THLE IRX3
Mean 3.05
Standard deviation 0.044
Values 3 3.1
[35]
liver IRX3
Mean 0.118
Standard deviation 0.082
Values 0.19 0.16 0 0.13
[36]
ref_hepatocyte PRDM16
Mean 0.014
Standard deviation 0.016
Values 0 0 0.017 0.04 0.013
[37]
HepG2 PRDM16
Mean 0.27
Standard deviation 0.097
Values 0.2 0.34
[38]
HepG2.C3A PRDM16
Mean 0.0297
Standard deviation 0.027
Values 0.011 0.049
[39]
HuH.7 PRDM16
Mean 5.23
Standard deviation 0.95
Values 4.3 5.2 6.2
[40]
SNU475 PRDM16
Mean 0.0333
Standard deviation 0.018
Values 0.02 0.046
[41]
THLE PRDM16
Mean 0.0254
Standard deviation 0.0059
Values 0.03 0.021
[42]
liver PRDM16
Mean 0.21
Standard deviation 0.11
Values 0.28 0.13 0.33 0.1
[43]
ref_hepatocyte IRX5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[44]
HepG2 IRX5
Mean 0
Standard deviation 0
Values 0 0
[45]
HepG2.C3A IRX5
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 IRX5
Mean 0.447
Standard deviation 0.13
Values 0.56 0.3 0.48
[47]
SNU475 IRX5
Mean 0.438
Standard deviation 0.055
Values 0.48 0.4
[48]
THLE IRX5
Mean 0.0928
Standard deviation 0.011
Values 0.1 0.085
[49]
liver IRX5
Mean 0
Standard deviation 0
Values 0 0 0 0
[50]
ref_hepatocyte UCP1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[51]
HepG2 UCP1
Mean 0.0329
Standard deviation 0.01
Values 0.026 0.04
[52]
HepG2.C3A UCP1
Mean 0.0823
Standard deviation 0.02
Values 0.097 0.068
[53]
HuH.7 UCP1
Mean 0.121
Standard deviation 0.027
Values 0.094 0.15 0.12
[54]
SNU475 UCP1
Mean 0
Standard deviation 0
Values 0 0
[55]
THLE UCP1
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[56]
liver UCP1
Mean 0.00918
Standard deviation 0.011
Values 0.013 0 0.024 0