WP_FRAGILE_X_SYNDROME |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
EEF1A1 |
Elongation factor 1-alpha 1 |
[1] |
0.37[2] |
0.59[3] |
0.61[4] |
-0.44[5] |
-0.07[6] |
-0.47[7] |
2 |
EIF4A1 |
Eukaryotic initiation factor 4A-I |
[8] |
[9] |
[10] |
[11] |
[12] |
[13] |
[14] |
3 |
CLTA |
Clathrin light chain A |
[15] |
-2.54[16] |
-3.20[17] |
-3.34[18] |
-2.37[19] |
-2.21[20] |
-3.28[21] |
4 |
RHEB |
GTP-binding protein Rheb |
[22] |
-2.61[23] |
-2.51[24] |
-2.84[25] |
-1.01[26] |
-1.11[27] |
-1.11[28] |
5 |
EIF4G1 |
Eukaryotic translation initiation factor 4 gamma 1 |
[29] |
0.22[30] |
-1.06[31] |
-0.90[32] |
0.47[33] |
0.66[34] |
1.03[35] |
6 |
APP |
Amyloid-beta A4 protein |
[36] |
-0.28[37] |
-1.31[38] |
-0.91[39] |
0.87[40] |
1.07[41] |
0.12[42] |
7 |
ABAT |
4-aminobutyrate aminotransferase, mitochondrial |
[43] |
-1.21[44] |
-1.96[45] |
-3.94[46] |
-9.28[47] |
-7.66[48] |
1.15[49] |
8 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[50] |
-0.58[51] |
-0.94[52] |
-1.05[53] |
0.00[54] |
-0.31[55] |
0.57[56] |
9 |
CLTB |
Clathrin light chain B |
[57] |
-1.23[58] |
-3.71[59] |
-4.15[60] |
-2.56[61] |
-2.40[62] |
-2.31[63] |
10 |
ALDH3A2 |
Fatty aldehyde dehydrogenase |
[64] |
-0.67[65] |
-1.24[66] |
-2.03[67] |
-0.62[68] |
-1.68[69] |
0.40[70] |
11 |
PPP1CA |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
[71] |
-0.68[72] |
-1.44[73] |
-0.48[74] |
1.62[75] |
-0.98[76] |
-0.97[77] |
12 |
AP2M1 |
AP-2 complex subunit mu |
[78] |
-0.44[79] |
-1.12[80] |
-1.87[81] |
1.07[82] |
1.37[83] |
-0.18[84] |
13 |
AP2S1 |
AP-2 complex subunit sigma |
[85] |
-2.28[86] |
-2.78[87] |
-2.33[88] |
-0.65[89] |
-0.43[90] |
-1.04[91] |
14 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[92] |
-0.58[93] |
-1.29[94] |
-2.62[95] |
0.04[96] |
-0.15[97] |
-0.26[98] |
15 |
TECR |
Very-long-chain enoyl-CoA reductase |
[99] |
-1.50[100] |
-2.37[101] |
-0.87[102] |
-1.69[103] |
-1.16[104] |
-0.43[105] |
16 |
CLTC |
Clathrin heavy chain 1 |
[106] |
0.96[107] |
0.57[108] |
0.50[109] |
1.77[110] |
1.70[111] |
2.44[112] |
17 |
MAP2K1 |
Dual specificity mitogen-activated protein kinase kinase 1 |
[113] |
-1.59[114] |
-2.40[115] |
-2.07[116] |
-0.45[117] |
-0.15[118] |
-1.21[119] |
18 |
MAP2K2 |
Dual specificity mitogen-activated protein kinase kinase 2 |
[120] |
-0.61[121] |
-1.41[122] |
-0.79[123] |
-0.75[124] |
-0.47[125] |
-1.72[126] |
19 |
DUSP3 |
Dual specificity protein phosphatase 3 |
[127] |
0.11[128] |
-0.96[129] |
-0.68[130] |
-0.59[131] |
-0.79[132] |
1.39[133] |
20 |
PTPN11 |
Tyrosine-protein phosphatase non-receptor type 11 |
[134] |
-0.21[135] |
-0.26[136] |
-0.56[137] |
0.98[138] |
1.40[139] |
1.24[140] |
21 |
GRB2 |
Growth factor receptor-bound protein 2 |
[141] |
0.54[142] |
-0.11[143] |
-0.24[144] |
0.65[145] |
0.35[146] |
0.28[147] |
22 |
ABCD3 |
ATP-binding cassette sub-family D member 3 |
[148] |
-0.82[149] |
-0.45[150] |
-0.65[151] |
-0.09[152] |
-0.38[153] |
1.69[154] |
23 |
SHC1 |
SHC-transforming protein 1 |
[155] |
0.50[156] |
0.24[157] |
0.07[158] |
2.74[159] |
2.02[160] |
0.76[161] |
24 |
AKT1S1 |
Proline-rich AKT1 substrate 1 |
[162] |
-1.12[163] |
-1.76[164] |
-1.66[165] |
-0.66[166] |
-0.25[167] |
-1.21[168] |
25 |
SLC16A1 |
Monocarboxylate transporter 1 |
[169] |
0.30[170] |
0.65[171] |
0.64[172] |
0.76[173] |
1.24[174] |
1.16[175] |
26 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[176] |
-0.82[177] |
-1.48[178] |
-1.73[179] |
-0.38[180] |
0.00[181] |
-0.80[182] |
27 |
RAF1 |
RAF proto-oncogene serine/threonine-protein kinase |
[183] |
-0.72[184] |
-0.80[185] |
0.22[186] |
-0.09[187] |
0.56[188] |
1.08[189] |
28 |
EIF4E |
Eukaryotic translation initiation factor 4E |
[190] |
-0.52[191] |
-0.17[192] |
-1.06[193] |
-0.18[194] |
0.64[195] |
0.15[196] |
29 |
ALDH5A1 |
Succinate-semialdehyde dehydrogenase, mitochondrial |
[197] |
-0.90[198] |
-1.23[199] |
-3.32[200] |
-1.68[201] |
-4.04[202] |
0.53[203] |
30 |
EIF4EBP2 |
Eukaryotic translation initiation factor 4E-binding protein 2 |
[204] |
0.15[205] |
0.74[206] |
0.63[207] |
1.67[208] |
0.74[209] |
2.26[210] |
31 |
DNM2 |
Dynamin-2 |
[211] |
1.35[212] |
-0.20[213] |
-0.18[214] |
1.05[215] |
1.11[216] |
0.75[217] |
32 |
SH3GL1 |
Endophilin-A2 |
[218] |
0.41[219] |
0.32[220] |
-0.77[221] |
0.63[222] |
0.76[223] |
-0.45[224] |
33 |
ARAF |
Serine/threonine-protein kinase A-Raf |
[225] |
-1.12[226] |
-1.90[227] |
-1.88[228] |
0.00[229] |
-0.18[230] |
0.86[231] |
34 |
DAG1 |
Dystroglycan |
[232] |
2.05[233] |
0.17[234] |
0.32[235] |
2.11[236] |
1.17[237] |
1.27[238] |
35 |
MAPK1 |
Mitogen-activated protein kinase 1 |
[239] |
1.05[240] |
0.71[241] |
0.28[242] |
1.94[243] |
1.38[244] |
1.76[245] |
36 |
CYFIP1 |
Cytoplasmic FMR1-interacting protein 1 |
[246] |
0.61[247] |
-0.28[248] |
-0.90[249] |
1.22[250] |
0.76[251] |
1.31[252] |
37 |
CPT1A |
Carnitine O-palmitoyltransferase 1, liver isoform |
[253] |
0.80[254] |
-1.25[255] |
-0.73[256] |
2.33[257] |
0.82[258] |
2.91[259] |
38 |
AP2A1 |
AP-2 complex subunit alpha-1 |
[260] |
0.55[261] |
-0.27[262] |
0.31[263] |
1.49[264] |
1.36[265] |
0.94[266] |
39 |
MLST8 |
Target of rapamycin complex subunit LST8 |
[267] |
-0.83[268] |
-0.99[269] |
-0.86[270] |
-0.88[271] |
-0.74[272] |
-0.58[273] |
40 |
CAMK1 |
Calcium/calmodulin-dependent protein kinase type 1 |
[274] |
-1.91[275] |
-0.95[276] |
-1.27[277] |
-1.37[278] |
-0.95[279] |
-0.98[280] |
41 |
AP2B1 |
AP-2 complex subunit beta |
[281] |
1.58[282] |
0.83[283] |
2.30[284] |
2.64[285] |
2.29[286] |
0.92[287] |
42 |
KRAS |
GTPase KRas |
[288] |
-1.17[289] |
-1.68[290] |
-0.33[291] |
0.89[292] |
0.34[293] |
0.66[294] |
43 |
SOS1 |
Son of sevenless homolog 1 |
[295] |
-0.76[296] |
0.29[297] |
-0.45[298] |
0.94[299] |
-0.04[300] |
0.52[301] |
44 |
TBC1D7 |
TBC1 domain family member 7 |
[302] |
-1.53[303] |
-2.05[304] |
-1.94[305] |
-0.04[306] |
-0.92[307] |
-0.97[308] |
45 |
TARBP2 |
RISC-loading complex subunit TARBP2 |
[309] |
-0.61[310] |
-0.36[311] |
-0.91[312] |
-0.25[313] |
-0.31[314] |
-0.52[315] |
46 |
PTEN |
Phosphatidylinositol
3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
-1.20[316] |
-0.29[317] |
-0.34[318] |
-0.47[319] |
0.57[320] |
2.46[321] |
47 |
RAP1GAP |
Rap1 GTPase-activating protein 1 |
[322] |
0.54[323] |
0.75[324] |
-1.91[325] |
-1.12[326] |
-4.80[327] |
-0.10[328] |
48 |
GPHN |
Gephyrin |
[329] |
-1.35[330] |
-1.30[331] |
-2.00[332] |
-0.95[333] |
-0.95[334] |
1.92[335] |
49 |
FMR1 |
Synaptic functional regulator FMR1 |
[336] |
-0.81[337] |
-0.19[338] |
-0.27[339] |
1.47[340] |
0.85[341] |
1.06[342] |
50 |
PICK1 |
PRKCA-binding protein |
[343] |
-0.77[344] |
-1.17[345] |
-1.95[346] |
-1.44[347] |
-0.72[348] |
-0.09[349] |
51 |
MECP2 |
Methyl-CpG-binding protein 2 |
[350] |
0.07[351] |
-0.13[352] |
-0.17[353] |
1.68[354] |
1.57[355] |
0.81[356] |
52 |
SLC6A1 |
Sodium- and chloride-dependent GABA transporter 1 |
[357] |
-12.16[358] |
[359] |
-12.73[360] |
-11.31[361] |
-11.46[362] |
2.83[363] |
53 |
MKNK1 |
MAP kinase-interacting serine/threonine-protein kinase 1 |
[364] |
-0.29[365] |
-1.15[366] |
-0.88[367] |
0.44[368] |
-0.17[369] |
0.68[370] |
54 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[371] |
2.36[372] |
1.87[373] |
0.62[374] |
2.49[375] |
1.46[376] |
-0.87[377] |
55 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
2.83[378] |
1.97[379] |
1.05[380] |
2.91[381] |
2.20[382] |
0.32[383] |
56 |
TTI1 |
TELO2-interacting protein 1 homolog |
[384] |
1.19[385] |
0.53[386] |
0.50[387] |
1.92[388] |
1.54[389] |
1.25[390] |
57 |
MTOR |
Serine/threonine-protein kinase mTOR |
[391] |
1.87[392] |
2.41[393] |
1.72[394] |
2.78[395] |
2.65[396] |
3.43[397] |
58 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
0.07[398] |
-0.65[399] |
-1.10[400] |
2.04[401] |
1.57[402] |
1.79[403] |
59 |
TSC2 |
Tuberin |
[404] |
1.16[405] |
0.20[406] |
0.64[407] |
1.29[408] |
1.61[409] |
2.06[410] |
60 |
RPS6KB1 |
Ribosomal protein S6 kinase beta-1 |
[411] |
[412] |
[413] |
[414] |
[415] |
[416] |
[417] |
61 |
PIK3CB |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
0.55[418] |
0.58[419] |
0.49[420] |
1.14[421] |
1.09[422] |
1.14[423] |
62 |
TELO2 |
Telomere length regulation protein TEL2 homolog |
[424] |
0.51[425] |
0.27[426] |
-0.57[427] |
0.56[428] |
1.28[429] |
1.09[430] |
63 |
DEPTOR |
DEP domain-containing mTOR-interacting protein |
[431] |
-3.98[432] |
-3.28[433] |
0.52[434] |
-4.16[435] |
-1.73[436] |
0.84[437] |
64 |
DICER1 |
Endoribonuclease Dicer |
[438] |
1.03[439] |
1.69[440] |
0.20[441] |
3.23[442] |
1.86[443] |
3.91[444] |
65 |
PRKCA |
Protein kinase C alpha type |
[445] |
2.18[446] |
1.74[447] |
1.85[448] |
2.24[449] |
2.39[450] |
1.90[451] |
66 |
PPP2R5B |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit beta isoform |
0.12[452] |
-0.60[453] |
-1.50[454] |
0.38[455] |
1.34[456] |
0.08[457] |
67 |
FYN |
Tyrosine-protein kinase Fyn |
[458] |
0.28[459] |
-8.80[460] |
-0.48[461] |
1.56[462] |
2.88[463] |
0.95[464] |
68 |
CYFIP2 |
Cytoplasmic FMR1-interacting protein 2 |
[465] |
2.46[466] |
1.63[467] |
-6.08[468] |
0.20[469] |
-0.89[470] |
3.00[471] |
69 |
RPTOR |
Regulatory-associated protein of mTOR |
[472] |
2.43[473] |
1.18[474] |
1.03[475] |
1.94[476] |
1.97[477] |
2.32[478] |
70 |
PDK1 |
[Pyruvate dehydrogenase
(acetyl-transferring)] kinase isozyme 1, mitochondrial |
1.71[479] |
1.94[480] |
1.31[481] |
2.71[482] |
0.73[483] |
2.05[484] |
71 |
TSC1 |
Hamartin |
[485] |
1.23[486] |
1.41[487] |
1.31[488] |
2.15[489] |
2.15[490] |
2.74[491] |
72 |
CREB1 |
Cyclic AMP-responsive element-binding protein 1 |
[492] |
1.06[493] |
1.74[494] |
1.98[495] |
2.63[496] |
2.37[497] |
2.32[498] |
73 |
NF1 |
Neurofibromin |
[499] |
1.80[500] |
1.65[501] |
2.22[502] |
4.06[503] |
3.29[504] |
4.09[505] |
74 |
MAP1B |
Microtubule-associated protein 1B |
[506] |
1.99[507] |
0.95[508] |
-3.18[509] |
6.17[510] |
3.81[511] |
2.15[512] |
75 |
BRAF |
Serine/threonine-protein kinase B-raf |
[513] |
-0.41[514] |
-1.16[515] |
0.62[516] |
0.83[517] |
0.32[518] |
1.83[519] |
76 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[520] |
2.13[521] |
3.28[522] |
2.45[523] |
0.87[524] |
1.15[525] |
2.47[526] |
77 |
HOMER1 |
Homer protein homolog 1 |
[527] |
0.77[528] |
1.22[529] |
1.71[530] |
1.62[531] |
1.12[532] |
-0.54[533] |
78 |
GAB1 |
GRB2-associated-binding protein 1 |
[534] |
0.64[535] |
1.25[536] |
1.12[537] |
2.03[538] |
1.68[539] |
2.86[540] |
79 |
MMP9 |
Matrix metalloproteinase-9 |
[541] |
-3.38[542] |
-4.91[543] |
-7.56[544] |
-1.34[545] |
-4.11[546] |
-0.16[547] |
80 |
CLTCL1 |
Clathrin heavy chain 2 |
[548] |
1.42[549] |
0.49[550] |
0.09[551] |
2.00[552] |
1.23[553] |
1.73[554] |
81 |
CAMK2B |
Calcium/calmodulin-dependent protein kinase type II subunit beta |
[555] |
-3.20[556] |
-5.00[557] |
-8.21[558] |
-2.77[559] |
-2.34[560] |
1.13[561] |
82 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[562] |
2.48[563] |
1.88[564] |
2.79[565] |
2.94[566] |
3.60[567] |
4.63[568] |
83 |
ARHGAP32 |
Rho GTPase-activating protein 32 |
[569] |
3.07[570] |
2.39[571] |
1.20[572] |
4.57[573] |
2.92[574] |
4.15[575] |
84 |
CDKN2A |
Cyclin-dependent kinase inhibitor 2A |
[576] |
3.42[577] |
0.71[578] |
3.86[579] |
5.30[580] |
6.87[581] |
-2.17[582] |
85 |
DLG4 |
Disks large homolog 4 |
[583] |
2.12[584] |
1.93[585] |
0.43[586] |
2.05[587] |
4.06[588] |
1.68[589] |
86 |
EPS8L1 |
Epidermal growth factor receptor kinase substrate 8-like protein 1 |
[590] |
1.96[591] |
1.99[592] |
-0.39[593] |
1.12[594] |
-4.80[595] |
-0.75[596] |
87 |
AKAP5 |
A-kinase anchor protein 5 |
[597] |
0.42[598] |
0.39[599] |
0.41[600] |
4.22[601] |
2.36[602] |
2.18[603] |
88 |
DNM1 |
Dynamin-1 |
[604] |
1.58[605] |
-0.73[606] |
0.73[607] |
5.69[608] |
4.97[609] |
1.92[610] |
89 |
AGAP2 |
Arf-GAP with GTPase, ANK repeat and
PH domain-containing protein 2 |
2.08[611] |
2.63[612] |
0.05[613] |
-3.33[614] |
0.80[615] |
0.97[616] |
90 |
SYNGAP1 |
Ras/Rap GTPase-activating protein SynGAP |
[617] |
2.53[618] |
2.02[619] |
1.82[620] |
4.97[621] |
5.19[622] |
1.86[623] |
91 |
GAD1 |
Glutamate decarboxylase 1 |
[624] |
0.15[625] |
-0.01[626] |
3.10[627] |
-1.17[628] |
-0.21[629] |
-3.81[630] |
92 |
ARC |
Activity-regulated cytoskeleton-associated protein |
[631] |
-3.07[632] |
-1.37[633] |
-5.85[634] |
-1.27[635] |
2.17[636] |
-3.53[637] |
93 |
BDNF |
Brain-derived neurotrophic factor |
[638] |
-2.32[639] |
-5.57[640] |
-3.89[641] |
6.84[642] |
5.39[643] |
2.08[644] |
94 |
KCND2 |
Potassium voltage-gated channel subfamily D member 2 |
[645] |
[646] |
[647] |
-4.91[648] |
-0.99[649] |
2.78[650] |
-0.08[651] |
95 |
GABRD |
Gamma-aminobutyric acid receptor subunit delta |
[652] |
-3.21[653] |
-5.09[654] |
-5.91[655] |
-4.82[656] |
-5.00[657] |
-1.08[658] |
96 |
DLGAP3 |
Disks large-associated protein 3 |
[659] |
-0.82[660] |
-5.04[661] |
-1.96[662] |
-0.44[663] |
0.76[664] |
1.08[665] |
97 |
EPHA4 |
Ephrin type-A receptor 4 |
[666] |
-5.46[667] |
-5.01[668] |
-4.59[669] |
2.40[670] |
6.34[671] |
4.73[672] |
98 |
CAMK4 |
Calcium/calmodulin-dependent protein kinase type IV |
[673] |
[674] |
-2.90[675] |
-3.82[676] |
1.54[677] |
3.39[678] |
4.23[679] |
99 |
GRIN2B |
Glutamate receptor ionotropic, NMDA 2B |
[680] |
-3.12[681] |
[682] |
[683] |
1.18[684] |
-1.84[685] |
1.84[686] |
100 |
GRIP1 |
Glutamate receptor-interacting protein 1 |
[687] |
2.75[688] |
0.33[689] |
-0.04[690] |
8.01[691] |
5.32[692] |
4.26[693] |
101 |
HCN1 |
Potassium/sodium
hyperpolarization-activated cyclic nucleotide-gated channel 1 |
0.23[694] |
-0.97[695] |
0.23[696] |
[697] |
-1.36[698] |
2.75[699] |
102 |
GRIP2 |
Glutamate receptor-interacting protein 2 |
[700] |
3.65[701] |
0.81[702] |
-2.01[703] |
1.26[704] |
1.37[705] |
3.93[706] |
103 |
GRIA1 |
Glutamate receptor 1 |
[707] |
-2.99[708] |
[709] |
[710] |
-0.56[711] |
-0.33[712] |
0.12[713] |
104 |
PTPN5 |
Tyrosine-protein phosphatase non-receptor type 5 |
[714] |
-0.99[715] |
-1.12[716] |
-3.50[717] |
-1.86[718] |
[719] |
[720] |
105 |
GRIN2A |
Glutamate receptor ionotropic, NMDA 2A |
[721] |
[722] |
[723] |
-2.00[724] |
9.15[725] |
1.47[726] |
8.01[727] |
106 |
GRM1 |
Metabotropic glutamate receptor 1 |
[728] |
1.60[729] |
[730] |
-0.98[731] |
5.66[732] |
3.19[733] |
3.11[734] |
107 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[735] |
[736] |
[737] |
[738] |
[739] |
[740] |
[741] |
108 |
SHANK1 |
SH3 and multiple ankyrin repeat domains protein 1 |
[742] |
[743] |
[744] |
[745] |
[746] |
[747] |
[748] |
109 |
AGO2 |
Protein argonaute-2 |
[749] |
[750] |
[751] |
[752] |
[753] |
[754] |
[755] |
110 |
KCNC1 |
Potassium voltage-gated channel subfamily C member 1 |
[756] |
[757] |
[758] |
[759] |
[760] |
[761] |
[762] |
111 |
HOXB8 |
Homeobox protein Hox-B8 |
[763] |
[764] |
[765] |
[766] |
[767] |
[768] |
[769] |
112 |
GABRB2 |
Gamma-aminobutyric acid receptor subunit beta-2 |
[770] |
[771] |
[772] |
[773] |
[774] |
[775] |
[776] |
113 |
NTRK2 |
BDNF/NT-3 growth factors receptor |
[777] |
[778] |
[779] |
[780] |
[781] |
[782] |
[783] |
114 |
GRIA2 |
Glutamate receptor 2 |
[784] |
[785] |
[786] |
[787] |
[788] |
[789] |
[790] |
115 |
MIR639 |
|
[791] |
[792] |
[793] |
[794] |
[795] |
[796] |
[797] |
116 |
GRM5 |
Metabotropic glutamate receptor 5 |
[798] |
[799] |
[800] |
[801] |
[802] |
[803] |
[804] |
117 |
CNR1 |
Cannabinoid receptor 1 |
[805] |
[806] |
[807] |
[808] |
[809] |
[810] |
[811] |
118 |
GRIN1 |
Glutamate receptor ionotropic, NMDA 1 |
[812] |
[813] |
[814] |
[815] |
[816] |
[817] |
[818] |
119 |
SH3GL3 |
Endophilin-A3 |
[819] |
[820] |
[821] |
[822] |
[823] |
[824] |
[825] |
120 |
GABRG2 |
Gamma-aminobutyric acid receptor subunit gamma-2 |
[826] |
[827] |
[828] |
[829] |
[830] |
[831] |
[832] |
121 |
MIR5004 |
|
[833] |
[834] |
[835] |
[836] |
[837] |
[838] |
[839] |
122 |
GABRA1 |
Gamma-aminobutyric acid receptor subunit alpha-1 |
[840] |
[841] |
[842] |
[843] |
[844] |
[845] |
[846] |
|
|
|
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