WP_FOLLICLE_STIMULATING_HORMONE_FSH_SIGNALING_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RPS6 40S ribosomal protein S6 [1] [2] [3] [4] [5] [6] [7]
2 RHEB GTP-binding protein Rheb [8] -0.07[9] 0.33[10] 0.13[11] 0.90[12] 0.77[13] 0.73[14]
3 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 [15] 0.88[16] 0.39[17] 0.87[18] -1.29[19] 0.01[20] 0.23[21]
4 AKT1 RAC-alpha serine/threonine-protein kinase [22] 1.95[23] 1.55[24] 0.34[25] 1.96[26] 1.73[27] 1.58[28]
5 RPS6KB2 Ribosomal protein S6 kinase beta-2 [29] [30] [31] [32] [33] [34] [35]
6 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [36] 1.71[37] 1.36[38] 1.23[39] 1.54[40] 1.88[41] 1.05[42]
7 RAF1 RAF proto-oncogene serine/threonine-protein kinase [43] 1.81[44] 2.05[45] 3.18[46] 1.82[47] 2.44[48] 2.92[49]
8 MAPK1 Mitogen-activated protein kinase 1 [50] 3.58[51] 3.55[52] 3.25[53] 3.86[54] 3.25[55] 3.60[56]
9 SGK1 Serine/threonine-protein kinase Sgk1 [57] 0.82[58] -0.31[59] 3.62[60] 1.63[61] 3.02[62] 2.92[63]
10 MAPK14 Mitogen-activated protein kinase 14 [64] 3.35[65] 3.25[66] 2.69[67] 3.69[68] 2.91[69] 3.11[70]
11 AREG Amphiregulin [71] -0.99[72] -4.40[73] -6.29[74] -7.69[75] 2.36[76] -8.48[77]
12 APPL1 DCC-interacting protein 13-alpha [78] 1.92[79] 2.94[80] 2.04[81] 2.78[82] 3.02[83] 3.62[84]
13 MAPK3 Mitogen-activated protein kinase 3 [85] 3.72[86] 3.60[87] 3.51[88] 2.43[89] 2.20[90] 0.79[91]
14 SRC Proto-oncogene tyrosine-protein kinase Src [92] 4.90[93] 4.71[94] 3.58[95] 4.41[96] 3.33[97] 0.98[98]
15 GRK6 G protein-coupled receptor kinase 6 [99] 3.04[100] 2.97[101] 3.75[102] 2.75[103] 3.28[104] 1.51[105]
16 MTOR Serine/threonine-protein kinase mTOR [106] 4.41[107] 5.25[108] 4.69[109] 4.69[110] 4.52[111] 5.28[112]
17 TSC2 Tuberin [113] 3.69[114] 3.04[115] 3.60[116] 3.21[117] 3.48[118] 3.91[119]
18 RPS6KB1 Ribosomal protein S6 kinase beta-1 [120] [121] [122] [123] [124] [125] [126]
19 PRKCA Protein kinase C alpha type [127] 4.71[128] 4.58[129] 4.81[130] 4.16[131] 4.27[132] 3.74[133]
20 CREB1 Cyclic AMP-responsive element-binding protein 1 [134] 3.60[135] 4.58[136] 4.94[137] 4.55[138] 4.24[139] 4.17[140]
21 FOXO1 Forkhead box protein O1 [141] 3.57[142] 3.06[143] 3.07[144] 3.18[145] 4.95[146] 4.91[147]
22 CYP19A1 Aromatase [148] 3.81[149] 4.65[150] -1.93[151] 0.36[152] -2.35[153] -4.51[154]
23 CGA Glycoprotein hormones alpha chain [155] [156] [157] -0.78[158] -1.51[159] -3.07[160] -2.28[161]
24 BDNF Brain-derived neurotrophic factor [162] 0.21[163] -2.73[164] -0.93[165] 8.75[166] 7.26[167] 3.92[168]
25 FSHR Follicle-stimulating hormone receptor [169] [170] [171] [172] [173] [174] [175]
26 FSHB Follitropin subunit beta [176] [177] [178] [179] [180] [181] [182]
27 H3-4 [183] [184] [185] [186] [187] [188] [189]
[1]
ref_hepatocyte RPS6
Mean 819
Standard deviation 2.5e+02
Values 9e+02 7.2e+02 1.2e+03 6.5e+02 6.1e+02
[2]
HepG2 RPS6
Missing
[3]
HepG2.C3A RPS6
Missing
[4]
HuH.7 RPS6
Missing
[5]
SNU475 RPS6
Missing
[6]
THLE RPS6
Missing
[7]
liver RPS6
Missing
[8]
ref_hepatocyte RHEB
Mean 67.3
Standard deviation 38
Values 1.1e+02 33 29 64 96
[9]
HepG2 RHEB
Mean 38.6
Standard deviation 1.7
Values 37 40
[10]
HepG2.C3A RHEB
Mean 51.2
Standard deviation 9.4
Values 58 45
[11]
HuH.7 RHEB
Mean 46.6
Standard deviation 5.3
Values 53 44 44
[12]
SNU475 RHEB
Mean 57.5
Standard deviation 1.9
Values 56 59
[13]
THLE RHEB
Mean 69.7
Standard deviation 5.7
Values 66 74
[14]
liver RHEB
Mean 44.9
Standard deviation 28
Values 18 25 77 59
[15]
ref_hepatocyte EIF4EBP1
Mean 48.7
Standard deviation 38
Values 90 20 87 11 35
[16]
HepG2 EIF4EBP1
Mean 54.1
Standard deviation 26
Values 36 72
[17]
HepG2.C3A EIF4EBP1
Mean 38.6
Standard deviation 15
Values 28 49
[18]
HuH.7 EIF4EBP1
Mean 56.5
Standard deviation 22
Values 73 32 64
[19]
SNU475 EIF4EBP1
Mean 9.08
Standard deviation 1.3
Values 10 8.2
[20]
THLE EIF4EBP1
Mean 29.8
Standard deviation 5
Values 33 26
[21]
liver EIF4EBP1
Mean 22.9
Standard deviation 28
Values 4.4 3.1 62 22
[22]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[23]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[24]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[25]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[26]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[27]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[28]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[29]
ref_hepatocyte RPS6KB2
Mean 17
Standard deviation 4.8
Values 15 13 15 17 25
[30]
HepG2 RPS6KB2
Missing
[31]
HepG2.C3A RPS6KB2
Missing
[32]
HuH.7 RPS6KB2
Missing
[33]
SNU475 RPS6KB2
Missing
[34]
THLE RPS6KB2
Missing
[35]
liver RPS6KB2
Missing
[36]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 11 23 27 7.6 11
[37]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 33 29
[38]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 22 27
[39]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[40]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 19 23
[41]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[42]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 8.9 8.8 18 16
[43]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[44]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[45]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[46]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[47]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[48]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[49]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[50]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[51]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[52]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[53]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[54]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[55]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[56]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[57]
ref_hepatocyte SGK1
Mean 9.78
Standard deviation 9
Values 6.9 6.8 25 10 0.53
[58]
HepG2 SGK1
Mean 10.4
Standard deviation 8
Values 16 4.7
[59]
HepG2.C3A SGK1
Mean 4.78
Standard deviation 1.7
Values 3.6 6
[60]
HuH.7 SGK1
Mean 76.3
Standard deviation 7.9
Values 69 85 75
[61]
SNU475 SGK1
Mean 13.8
Standard deviation 1.6
Values 13 15
[62]
THLE SGK1
Mean 48.3
Standard deviation 15
Values 37 59
[63]
liver SGK1
Mean 29.6
Standard deviation 5.6
Values 34 22 30 32
[64]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 7.2 8.3 7.5 12 8.5
[65]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 60 47
[66]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[67]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 34 36 37
[68]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 51 52
[69]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[70]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 37 38 24 22
[71]
ref_hepatocyte AREG
Mean 5.24
Standard deviation 9.3
Values 1.7 0.4 0.57 1.7 22
[72]
HepG2 AREG
Mean 1.59
Standard deviation 1.3
Values 0.67 2.5
[73]
HepG2.C3A AREG
Mean 0.15
Standard deviation 0.061
Values 0.19 0.11
[74]
HuH.7 AREG
Mean 0.0425
Standard deviation 0.021
Values 0.019 0.051 0.057
[75]
SNU475 AREG
Mean 0.0116
Standard deviation 0.016
Values 0 0.023
[76]
THLE AREG
Mean 16.4
Standard deviation 1.7
Values 15 18
[77]
liver AREG
Mean 0.00588
Standard deviation 0.012
Values 0 0 0.024 0
[78]
ref_hepatocyte APPL1
Mean 4.53
Standard deviation 2.5
Values 4.2 3 1.9 5 8.5
[79]
HepG2 APPL1
Mean 10.4
Standard deviation 4.1
Values 13 7.5
[80]
HepG2.C3A APPL1
Mean 21
Standard deviation 2.9
Values 23 19
[81]
HuH.7 APPL1
Mean 11.8
Standard deviation 2
Values 9.5 13 13
[82]
SNU475 APPL1
Mean 14.2
Standard deviation 0.14
Values 14 14
[83]
THLE APPL1
Mean 22.4
Standard deviation 0.84
Values 23 22
[84]
liver APPL1
Mean 22.4
Standard deviation 5.5
Values 20 30 18 21
[85]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[86]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[87]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[88]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[89]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[90]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[91]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[92]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[93]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[94]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[95]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[96]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[97]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[98]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[99]
ref_hepatocyte GRK6
Mean 3.54
Standard deviation 1.6
Values 6.3 2.4 2.7 3 3.3
[100]
HepG2 GRK6
Mean 17.6
Standard deviation 5.1
Values 14 21
[101]
HepG2.C3A GRK6
Mean 16.8
Standard deviation 0.62
Values 16 17
[102]
HuH.7 GRK6
Mean 30.3
Standard deviation 8.1
Values 33 21 37
[103]
SNU475 GRK6
Mean 10.9
Standard deviation 0.25
Values 11 11
[104]
THLE GRK6
Mean 20.9
Standard deviation 1.5
Values 20 22
[105]
liver GRK6
Mean 4.05
Standard deviation 2
Values 6.6 4.3 3.5 1.8
[106]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 4.3 3.2 3.5 2.6 3.1
[107]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 47 38
[108]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 65 89
[109]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 41 50 73
[110]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 40 39
[111]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[112]
liver MTOR
Mean 51.8
Standard deviation 18
Values 62 72 34 39
[113]
ref_hepatocyte TSC2
Mean 3.2
Standard deviation 0.13
Values 3.2 3.4 3.2 3.1 3.1
[114]
HepG2 TSC2
Mean 24.9
Standard deviation 3.4
Values 22 27
[115]
HepG2.C3A TSC2
Mean 16
Standard deviation 4.7
Values 13 19
[116]
HuH.7 TSC2
Mean 24.6
Standard deviation 4
Values 21 24 29
[117]
SNU475 TSC2
Mean 13.5
Standard deviation 5
Values 10 17
[118]
THLE TSC2
Mean 21.8
Standard deviation 1.7
Values 21 23
[119]
liver TSC2
Mean 19.2
Standard deviation 2.2
Values 22 19 17 18
[120]
ref_hepatocyte RPS6KB1
Mean 3.19
Standard deviation 1.6
Values 1.9 2.1 2 5.1 4.9
[121]
HepG2 RPS6KB1
Missing
[122]
HepG2.C3A RPS6KB1
Missing
[123]
HuH.7 RPS6KB1
Missing
[124]
SNU475 RPS6KB1
Missing
[125]
THLE RPS6KB1
Missing
[126]
liver RPS6KB1
Missing
[127]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 1.1 1.2 1.2 2.7 6
[128]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 43 35
[129]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 39 32
[130]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 33 44 54
[131]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 23 17
[132]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[133]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 21 17 11 4.7
[134]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 1.5 0.81 0.96 3.7 2.1
[135]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 15 11
[136]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 28 24
[137]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 31 36 38
[138]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[139]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[140]
liver CREB1
Mean 13
Standard deviation 3.1
Values 15 16 12 9.3
[141]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 2 2.6 1.9 0.71 1.7
[142]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 14 11
[143]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 7.9 10
[144]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 7.6 10 10
[145]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 6 8.6
[146]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[147]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 29 19 25 13
[148]
ref_hepatocyte CYP19A1
Mean 1.13
Standard deviation 2.3
Values 0.28 0 0 5.3 0.08
[149]
HepG2 CYP19A1
Mean 9.51
Standard deviation 0.87
Values 10 8.9
[150]
HepG2.C3A CYP19A1
Mean 17.1
Standard deviation 5.6
Values 13 21
[151]
HuH.7 CYP19A1
Mean 0.188
Standard deviation 0.27
Values 0.047 0.5 0.016
[152]
SNU475 CYP19A1
Mean 0.66
Standard deviation 0.58
Values 1.1 0.25
[153]
THLE CYP19A1
Mean 0.135
Standard deviation 0.018
Values 0.15 0.12
[154]
liver CYP19A1
Mean 0.0199
Standard deviation 0.04
Values 0.079 0 0 0
[155]
ref_hepatocyte CGA
Mean 0.0776
Standard deviation 0.17
Values 0 0 0.39 0 0
[156]
HepG2 CGA
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A CGA
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 CGA
Mean 0.0287
Standard deviation 0.011
Values 0.037 0.032 0.016
[159]
SNU475 CGA
Mean 0.0125
Standard deviation 0.011
Values 0.02 0.0046
[160]
THLE CGA
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[161]
liver CGA
Mean 0.00642
Standard deviation 0.013
Values 0 0 0 0.026
[162]
ref_hepatocyte BDNF
Mean 0.0532
Standard deviation 0.065
Values 0.095 0.024 0.15 0 0
[163]
HepG2 BDNF
Mean 0.0372
Standard deviation 0.0041
Values 0.034 0.04
[164]
HepG2.C3A BDNF
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[165]
HuH.7 BDNF
Mean 0.0177
Standard deviation 0.024
Values 0 0.045 0.0082
[166]
SNU475 BDNF
Mean 10.5
Standard deviation 1.7
Values 12 9.3
[167]
THLE BDNF
Mean 4.97
Standard deviation 1.1
Values 5.7 4.2
[168]
liver BDNF
Mean 0.324
Standard deviation 0.17
Values 0.3 0.57 0.19 0.23
[169]
ref_hepatocyte FSHR
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 FSHR
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A FSHR
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 FSHR
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 FSHR
Mean 0
Standard deviation 0
Values 0 0
[174]
THLE FSHR
Mean 0
Standard deviation 0
Values 0 0
[175]
liver FSHR
Mean 0.00993
Standard deviation 0.02
Values 0.04 0 0 0
[176]
ref_hepatocyte FSHB
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 FSHB
Mean 0
Standard deviation 0
Values 0 0
[178]
HepG2.C3A FSHB
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 FSHB
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 FSHB
Mean 0
Standard deviation 0
Values 0 0
[181]
THLE FSHB
Mean 0
Standard deviation 0
Values 0 0
[182]
liver FSHB
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[183]
ref_hepatocyte H3-4
Missing
[184]
HepG2 H3-4
Missing
[185]
HepG2.C3A H3-4
Missing
[186]
HuH.7 H3-4
Missing
[187]
SNU475 H3-4
Missing
[188]
THLE H3-4
Missing
[189]
liver H3-4
Missing