WP_FOLATEALCOHOL_AND_CANCER_PATHWAY_HYPOTHESES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -11.46[2] -11.27[3] -10.10[4] -14.43[5] -10.54[6] 0.00[7]
2 ALDH1A1 Retinal dehydrogenase 1 [8] 1.53[9] 1.03[10] 1.99[11] 2.13[12] -3.92[13] -0.99[14]
3 ADH5 Alcohol dehydrogenase class-3 [15] 2.75[16] 3.06[17] 1.51[18] 0.92[19] 3.52[20] 0.04[21]
4 CBS Cystathionine beta-synthase [22] 1.54[23] 2.10[24] 1.59[25] -1.62[26] 2.22[27] 1.36[28]
5 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase [29] -1.09[30] -9.35[31] -12.41[32] -6.04[33] -3.53[34] 1.38[35]
6 CEBPB CCAAT/enhancer-binding protein beta [36] 1.86[37] 1.57[38] -0.48[39] 0.58[40] 3.85[41] -1.28[42]
7 CREB1 Cyclic AMP-responsive element-binding protein 1 [43] 4.75[44] 6.26[45] 4.66[46] 4.54[47] 6.81[48] 2.74[49]
8 MTR Methionine synthase [50] 5.30[51] 6.33[52] 4.40[53] 5.15[54] 6.81[55] 3.76[56]
9 MTHFR Methylenetetrahydrofolate reductase [57] 4.36[58] 6.07[59] 4.24[60] 4.70[61] 5.80[62] 4.21[63]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 90 4.1e+03 2.7e+03 0 4.6
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.06 0.21
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0 0.21
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.99 1.3 0.67
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.025 0.032
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 6.9e+02 1e+03 2.6e+03 1.7e+03
[8]
ref_hepatocyte ALDH1A1
Mean 382
Standard deviation 2.7e+02
Values 20 4.3e+02 2.8e+02 4.1e+02 7.6e+02
[9]
HepG2 ALDH1A1
Mean 298
Standard deviation 51
Values 3.3e+02 2.6e+02
[10]
HepG2.C3A ALDH1A1
Mean 148
Standard deviation 48
Values 1.8e+02 1.1e+02
[11]
HuH.7 ALDH1A1
Mean 1.17e+03
Standard deviation 3.9e+02
Values 1.4e+03 7.1e+02 1.4e+03
[12]
SNU475 ALDH1A1
Mean 768
Standard deviation 3.3e+02
Values 5.4e+02 1e+03
[13]
THLE ALDH1A1
Mean 2.59
Standard deviation 1.5
Values 3.6 1.6
[14]
liver ALDH1A1
Mean 207
Standard deviation 1.4e+02
Values 68 2.8e+02 1.2e+02 3.6e+02
[15]
ref_hepatocyte ADH5
Mean 65.9
Standard deviation 32
Values 19 1.1e+02 61 84 59
[16]
HepG2 ADH5
Mean 119
Standard deviation 17
Values 1.3e+02 1.1e+02
[17]
HepG2.C3A ADH5
Mean 104
Standard deviation 26
Values 1.2e+02 86
[18]
HuH.7 ADH5
Mean 144
Standard deviation 17
Values 1.6e+02 1.4e+02 1.3e+02
[19]
SNU475 ADH5
Mean 57.2
Standard deviation 13
Values 48 66
[20]
THLE ADH5
Mean 77.4
Standard deviation 11
Values 69 85
[21]
liver ADH5
Mean 73.2
Standard deviation 37
Values 43 49 1.2e+02 76
[22]
ref_hepatocyte CBS
Mean 54.1
Standard deviation 52
Values 21 1.2e+02 96 7.7 22
[23]
HepG2 CBS
Mean 42.6
Standard deviation 25
Values 25 60
[24]
HepG2.C3A CBS
Mean 44
Standard deviation 22
Values 28 60
[25]
HuH.7 CBS
Mean 125
Standard deviation 32
Values 1.5e+02 89 1.4e+02
[26]
SNU475 CBS
Mean 8.06
Standard deviation 1.8
Values 6.8 9.3
[27]
THLE CBS
Mean 25.8
Standard deviation 4.2
Values 29 23
[28]
liver CBS
Mean 150
Standard deviation 40
Values 1.3e+02 1.1e+02 2e+02 1.6e+02
[29]
ref_hepatocyte ALDH1L1
Mean 53.8
Standard deviation 57
Values 4.3 1.3e+02 1.1e+02 22 12
[30]
HepG2 ALDH1L1
Mean 6.81
Standard deviation 2.3
Values 5.2 8.4
[31]
HepG2.C3A ALDH1L1
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[32]
HuH.7 ALDH1L1
Mean 0.00761
Standard deviation 0.0083
Values 0 0.0064 0.016
[33]
SNU475 ALDH1L1
Mean 0.375
Standard deviation 0.16
Values 0.49 0.26
[34]
THLE ALDH1L1
Mean 0.478
Standard deviation 0.039
Values 0.45 0.51
[35]
liver ALDH1L1
Mean 151
Standard deviation 64
Values 90 1.5e+02 1.2e+02 2.4e+02
[36]
ref_hepatocyte CEBPB
Mean 37.2
Standard deviation 25
Values 24 62 65 9 26
[37]
HepG2 CEBPB
Mean 36.4
Standard deviation 26
Values 18 55
[38]
HepG2.C3A CEBPB
Mean 20.9
Standard deviation 13
Values 12 30
[39]
HuH.7 CEBPB
Mean 20.5
Standard deviation 6.4
Values 23 25 13
[40]
SNU475 CEBPB
Mean 25.6
Standard deviation 11
Values 33 18
[41]
THLE CEBPB
Mean 55
Standard deviation 10
Values 48 62
[42]
liver CEBPB
Mean 16.5
Standard deviation 5.6
Values 22 16 18 9.1
[43]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 1.5 0.81 0.96 3.7 2.1
[44]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 15 11
[45]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 28 24
[46]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 31 36 38
[47]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[48]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[49]
liver CREB1
Mean 13
Standard deviation 3.1
Values 15 16 12 9.3
[50]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 1.2 0.48 0.53 2.9 2.1
[51]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 18 12
[52]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 21 22
[53]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 20 21 29
[54]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 18 29
[55]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[56]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 24 34 12 14
[57]
ref_hepatocyte MTHFR
Mean 0.857
Standard deviation 0.14
Values 0.91 0.6 0.95 0.9 0.92
[58]
HepG2 MTHFR
Mean 4.76
Standard deviation 0.36
Values 5 4.5
[59]
HepG2.C3A MTHFR
Mean 10.9
Standard deviation 2
Values 9.5 12
[60]
HuH.7 MTHFR
Mean 12.4
Standard deviation 3.7
Values 9.7 17 11
[61]
SNU475 MTHFR
Mean 10.2
Standard deviation 3.7
Values 7.6 13
[62]
THLE MTHFR
Mean 4.9
Standard deviation 0.19
Values 5 4.8
[63]
liver MTHFR
Mean 17.1
Standard deviation 4.4
Values 19 21 17 11