WP_FLUOROPYRIMIDINE_ACTIVITY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CES1 | Liver carboxylesterase 1 | [1] | -1.68[2] | -8.16[3] | -8.97[4] | -1.73[5] | -9.35[6] | -0.97[7] |
2 | CYP2A6 | Cytochrome P450 2A6 | [8] | -15.98[9] | [10] | -7.81[11] | -11.24[12] | -13.43[13] | -1.09[14] |
3 | DPYS | Dihydropyrimidinase | [15] | [16] | [17] | -13.67[18] | -10.97[19] | [20] | 1.27[21] |
4 | TYMP | Thymidine phosphorylase | [22] | -2.73[23] | -1.88[24] | -4.75[25] | -6.91[26] | -4.18[27] | -1.65[28] |
5 | GGH | Gamma-glutamyl hydrolase | [29] | 0.99[30] | 0.66[31] | 1.48[32] | 0.01[33] | 0.79[34] | -0.08[35] |
6 | CES2 | Cocaine esterase | [36] | 0.87[37] | 1.69[38] | -0.44[39] | -0.37[40] | -0.50[41] | 1.82[42] |
7 | SLC22A7 | Solute carrier family 22 member 7 | [43] | -4.34[44] | -0.71[45] | -3.13[46] | -10.84[47] | [48] | 1.93[49] |
8 | UPB1 | Beta-ureidopropionase | [50] | -6.57[51] | -3.94[52] | -2.18[53] | -6.41[54] | -11.33[55] | 0.56[56] |
9 | CDA | Cytidine deaminase | [57] | -0.25[58] | -1.63[59] | -4.39[60] | -2.92[61] | -4.05[62] | -1.70[63] |
10 | TYMS | Thymidylate synthase | [64] | 0.60[65] | 1.27[66] | 1.18[67] | 0.73[68] | 1.03[69] | -5.40[70] |
11 | FPGS | Folylpolyglutamate synthase, mitochondrial | [71] | 1.19[72] | 0.93[73] | 0.44[74] | 1.31[75] | 1.09[76] | 0.31[77] |
12 | SLC29A1 | Equilibrative nucleoside transporter 1 | [78] | 2.78[79] | 2.79[80] | 1.76[81] | 2.02[82] | 1.06[83] | -1.00[84] |
13 | ABCC3 | Canalicular multispecific organic anion transporter 2 | [85] | 2.96[86] | 2.52[87] | 0.97[88] | 2.30[89] | 1.95[90] | 3.17[91] |
14 | UPP1 | Uridine phosphorylase 1 | [92] | -0.62[93] | -0.44[94] | -0.07[95] | 0.26[96] | 1.39[97] | -1.66[98] |
15 | SMUG1 | Single-strand selective monofunctional uracil DNA glycosylase | [99] | 1.10[100] | 1.58[101] | 1.71[102] | 1.45[103] | 1.23[104] | -0.07[105] |
16 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | [106] | 3.45[107] | 3.84[108] | 3.41[109] | 4.14[110] | 4.42[111] | -0.31[112] |
17 | UCK1 | Uridine-cytidine kinase 1 | [113] | 1.08[114] | 2.16[115] | 1.66[116] | 1.30[117] | 2.27[118] | 0.72[119] |
18 | RRM1 | Ribonucleoside-diphosphate reductase large subunit | [120] | 3.35[121] | 3.13[122] | 3.91[123] | 4.08[124] | 4.44[125] | 0.62[126] |
19 | TK1 | Thymidine kinase, cytosolic | [127] | 3.78[128] | 3.30[129] | 2.99[130] | 3.28[131] | 3.69[132] | -1.02[133] |
20 | DHFR | Dihydrofolate reductase | [134] | 3.42[135] | 4.38[136] | 4.80[137] | 3.29[138] | 4.39[139] | 0.65[140] |
21 | TDG | G/T mismatch-specific thymine DNA glycosylase | [141] | 1.55[142] | 2.83[143] | 2.65[144] | 3.55[145] | 3.16[146] | 0.44[147] |
22 | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)] | [148] | -3.09[149] | -1.88[150] | 3.84[151] | 2.77[152] | 2.33[153] | 3.91[154] |
23 | TP53 | Cellular tumor antigen p53 | [155] | 3.51[156] | 3.32[157] | 4.16[158] | 3.33[159] | 3.23[160] | 0.49[161] |
24 | UMPS | Uridine 5'-monophosphate synthase | [162] | 3.41[163] | 3.92[164] | 3.49[165] | 2.57[166] | 3.43[167] | 2.16[168] |
25 | UCK2 | Uridine-cytidine kinase 2 | [169] | 3.32[170] | 3.45[171] | 3.57[172] | 3.89[173] | 4.08[174] | 0.74[175] |
26 | ERCC2 | TFIIH basal transcription factor complex helicase XPD subunit | [176] | 2.99[177] | 3.30[178] | 3.81[179] | 3.35[180] | 3.51[181] | -0.30[182] |
27 | PPAT | Amidophosphoribosyltransferase | [183] | 3.11[184] | 3.91[185] | 4.10[186] | 2.77[187] | 3.57[188] | 0.81[189] |
28 | ABCG2 | ATP-binding cassette sub-family G member 2 | [190] | 1.93[191] | 2.06[192] | 3.29[193] | 1.68[194] | 0.81[195] | 0.80[196] |
29 | ABCC4 | Multidrug resistance-associated protein 4 | [197] | 3.67[198] | 3.00[199] | 5.32[200] | 4.73[201] | 4.48[202] | 1.00[203] |
30 | ABCC5 | Multidrug resistance-associated protein 5 | [204] | 4.43[205] | 4.73[206] | 4.47[207] | 4.49[208] | 4.77[209] | 2.55[210] |
31 | UPP2 | Uridine phosphorylase 2 | [211] | -5.60[212] | [213] | -2.83[214] | [215] | -6.20[216] | 1.91[217] |
32 | MTHFR | Methylenetetrahydrofolate reductase | [218] | 3.21[219] | 4.82[220] | 5.15[221] | 4.74[222] | 3.75[223] | 4.34[224] |
33 | XRCC3 | DNA repair protein XRCC3 | [225] | 4.92[226] | 5.35[227] | 5.13[228] | 5.22[229] | 5.91[230] | 2.24[231] |
34 | MIR3658 | [232] | [233] | [234] | [235] | [236] | [237] | [238] |