WP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -1.28[2] -1.29[3] -3.46[4] -2.49[5] 0.86[6] -2.09[7]
2 SPP1 Osteopontin [8] 1.05[9] 1.20[10] -6.78[11] 1.39[12] -5.88[13] -1.33[14]
3 CCND1 G1/S-specific cyclin-D1 [15] 0.93[16] -0.19[17] 1.16[18] 1.38[19] 0.69[20] 0.80[21]
4 NFKB2 Nuclear factor NF-kappa-B p100 subunit [22] -2.89[23] -1.21[24] -0.24[25] -1.88[26] -0.24[27] -3.27[28]
5 FAM20C Extracellular serine/threonine protein kinase FAM20C [29] -4.35[30] -2.10[31] -2.48[32] -2.86[33] -0.65[34] -0.82[35]
6 ALPL Alkaline phosphatase, tissue-nonspecific isozyme [36] -2.39[37] -6.41[38] -8.77[39] -5.04[40] -6.19[41] 0.54[42]
7 FGFR3 Fibroblast growth factor receptor 3 [43] 0.61[44] 1.90[45] 2.75[46] -3.80[47] -1.66[48] 0.20[49]
8 NFKB1 Nuclear factor NF-kappa-B p105 subunit [50] -1.45[51] -0.39[52] -0.08[53] -0.75[54] 0.95[55] 0.20[56]
9 ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 -1.12[57] 1.31[58] 1.80[59] -0.71[60] -2.19[61] 2.63[62]
10 FGFR2 Fibroblast growth factor receptor 2 [63] -4.63[64] -2.05[65] 2.42[66] 0.95[67] -3.10[68] 3.17[69]
11 CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [70] 6.02[71] 2.53[72] -2.59[73] 3.60[74] -2.41[75] -7.35[76]
12 KL Klotho [77] -8.18[78] [79] [80] -1.89[81] -6.35[82] 0.00[83]
13 SLC34A1 Sodium-dependent phosphate transport protein 2A [84] -8.37[85] -4.71[86] -1.21[87] -4.55[88] [89] -0.29[90]
14 SLC34A3 Sodium-dependent phosphate transport protein 2C [91] -1.09[92] 2.34[93] -3.04[94] -2.54[95] -1.46[96] -2.11[97]
15 PHEX Phosphate-regulating neutral endopeptidase [98] -4.22[99] -2.26[100] 4.97[101] 3.34[102] -0.16[103] -2.42[104]
16 GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3 [105] -3.18[106] -1.88[107] 2.00[108] -2.02[109] 2.94[110] 2.89[111]
17 CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [112] 0.56[113] 3.37[114] 3.29[115] 0.69[116] 2.21[117] 1.42[118]
18 ROS1 Proto-oncogene tyrosine-protein kinase ROS [119] 0.55[120] 1.87[121] 7.36[122] 5.20[123] 11.00[124] 0.70[125]
19 FGF23 Fibroblast growth factor 23 [126] [127] [128] [129] [130] [131] [132]
20 PTH Parathyroid hormone [133] [134] [135] [136] [137] [138] [139]
21 DMP1 Dentin matrix acidic phosphoprotein 1 [140] [141] [142] [143] [144] [145] [146]
22 CYP11B2 Cytochrome P450 11B2, mitochondrial [147] [148] [149] [150] [151] [152] [153]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 76 5.7 52 19 48
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.2e+02 1.9e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 57 51
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 7.3 10 6.5
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 24 13
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 16 26
[8]
ref_hepatocyte SPP1
Mean 27.3
Standard deviation 57
Values 2.8 0.34 4.2 1.3e+02 0.47
[9]
HepG2 SPP1
Mean 545
Standard deviation 86
Values 6.1e+02 4.8e+02
[10]
HepG2.C3A SPP1
Mean 206
Standard deviation 2e+02
Values 3.5e+02 63
[11]
HuH.7 SPP1
Mean 0.548
Standard deviation 0.18
Values 0.35 0.71 0.59
[12]
SNU475 SPP1
Mean 187
Standard deviation 1.3e+02
Values 2.8e+02 97
[13]
THLE SPP1
Mean 0.781
Standard deviation 0.3
Values 0.57 0.99
[14]
liver SPP1
Mean 18.4
Standard deviation 23
Values 5.7 3.1 52 12
[15]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 19 12 11 44 28
[16]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 3.9e+02 4.5e+02
[17]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 74 58
[18]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.2e+02 79 1.4e+02
[19]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 2e+02 1.1e+02
[20]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[21]
liver CCND1
Mean 67.8
Standard deviation 49
Values 25 1.1e+02 26 1.1e+02
[22]
ref_hepatocyte NFKB2
Mean 16.8
Standard deviation 20
Values 49 3 4.1 3.6 24
[23]
HepG2 NFKB2
Mean 21.8
Standard deviation 8.1
Values 16 28
[24]
HepG2.C3A NFKB2
Mean 23.9
Standard deviation 12
Values 16 32
[25]
HuH.7 NFKB2
Mean 31.3
Standard deviation 3.8
Values 29 36 29
[26]
SNU475 NFKB2
Mean 11.9
Standard deviation 3
Values 14 9.7
[27]
THLE NFKB2
Mean 24
Standard deviation 2.2
Values 22 26
[28]
liver NFKB2
Mean 2.95
Standard deviation 1.2
Values 4.5 3.3 2.1 1.8
[29]
ref_hepatocyte FAM20C
Mean 16.5
Standard deviation 12
Values 5.1 28 29 17 3.8
[30]
HepG2 FAM20C
Mean 7.78
Standard deviation 1.7
Values 6.6 9
[31]
HepG2.C3A FAM20C
Mean 12.7
Standard deviation 4.6
Values 9.5 16
[32]
HuH.7 FAM20C
Mean 6.49
Standard deviation 0.57
Values 6.3 7.1 6
[33]
SNU475 FAM20C
Mean 5.95
Standard deviation 4.4
Values 9 2.9
[34]
THLE FAM20C
Mean 17.8
Standard deviation 0.6
Values 17 18
[35]
liver FAM20C
Mean 15.9
Standard deviation 9.5
Values 13 8.4 30 12
[36]
ref_hepatocyte ALPL
Mean 15.9
Standard deviation 20
Values 3.5 39 36 0.36 0.049
[37]
HepG2 ALPL
Mean 29.2
Standard deviation 32
Values 6.4 52
[38]
HepG2.C3A ALPL
Mean 0.615
Standard deviation 0.2
Values 0.47 0.76
[39]
HuH.7 ALPL
Mean 0.0798
Standard deviation 0.02
Values 0.1 0.071 0.066
[40]
SNU475 ALPL
Mean 1.26
Standard deviation 0.34
Values 1 1.5
[41]
THLE ALPL
Mean 0.368
Standard deviation 0.17
Values 0.49 0.24
[42]
liver ALPL
Mean 39.1
Standard deviation 18
Values 16 36 44 60
[43]
ref_hepatocyte FGFR3
Mean 7.46
Standard deviation 9.2
Values 0.18 6.4 4.6 23 2.7
[44]
HepG2 FGFR3
Mean 109
Standard deviation 1.1
Values 1.1e+02 1.1e+02
[45]
HepG2.C3A FGFR3
Mean 91.5
Standard deviation 12
Values 83 1e+02
[46]
HuH.7 FGFR3
Mean 110
Standard deviation 12
Values 1.2e+02 97 1.2e+02
[47]
SNU475 FGFR3
Mean 1.4
Standard deviation 0.25
Values 1.2 1.6
[48]
THLE FGFR3
Mean 3.99
Standard deviation 0.31
Values 3.8 4.2
[49]
liver FGFR3
Mean 14.5
Standard deviation 8.7
Values 25 18 9.3 5.8
[50]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 12 4.7 5.3 3 6.7
[51]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 26 18
[52]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 17 15
[53]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 13 12 14
[54]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 10 9.6
[55]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[56]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 17 15 9.7 7.2
[57]
ref_hepatocyte ENPP1
Mean 6.12
Standard deviation 3.9
Values 1.4 9.9 6.7 9.8 2.9
[58]
HepG2 ENPP1
Mean 27.1
Standard deviation 7.8
Values 33 22
[59]
HepG2.C3A ENPP1
Mean 50
Standard deviation 14
Values 40 60
[60]
HuH.7 ENPP1
Mean 46.7
Standard deviation 8.1
Values 39 55 46
[61]
SNU475 ENPP1
Mean 9.73
Standard deviation 5.5
Values 5.8 14
[62]
THLE ENPP1
Mean 2.26
Standard deviation 0.11
Values 2.2 2.3
[63]
liver ENPP1
Mean 64.2
Standard deviation 27
Values 61 56 1e+02 38
[64]
ref_hepatocyte FGFR2
Mean 1.34
Standard deviation 1.4
Values 0.084 3.2 2.4 0.47 0.46
[65]
HepG2 FGFR2
Mean 0.519
Standard deviation 0.3
Values 0.73 0.3
[66]
HepG2.C3A FGFR2
Mean 1.07
Standard deviation 0.3
Values 1.3 0.86
[67]
HuH.7 FGFR2
Mean 15.7
Standard deviation 0.71
Values 16 15 16
[68]
SNU475 FGFR2
Mean 6.74
Standard deviation 6.4
Values 2.2 11
[69]
THLE FGFR2
Mean 0.263
Standard deviation 0.0039
Values 0.27 0.26
[70]
liver FGFR2
Mean 20.4
Standard deviation 8
Values 32 19 18 13
[71]
ref_hepatocyte CYP24A1
Mean 0.344
Standard deviation 0.69
Values 0 0 0 1.6 0.15
[72]
HepG2 CYP24A1
Mean 215
Standard deviation 90
Values 1.5e+02 2.8e+02
[73]
HepG2.C3A CYP24A1
Mean 6.56
Standard deviation 2.9
Values 8.6 4.5
[74]
HuH.7 CYP24A1
Mean 0.126
Standard deviation 0.11
Values 0.019 0.24 0.11
[75]
SNU475 CYP24A1
Mean 10.9
Standard deviation 10
Values 18 3.8
[76]
THLE CYP24A1
Mean 0.109
Standard deviation 0.079
Values 0.053 0.16
[77]
liver CYP24A1
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[78]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0.4 0.69 0.2 0 0
[79]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0.017 0
[80]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.16 0.2
[83]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[84]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.9 0.31 0.38 0.15
[85]
ref_hepatocyte SLC34A1
Mean 0.198
Standard deviation 0.28
Values 0 0.61 0.38 0 0
[86]
HepG2 SLC34A1
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[87]
HepG2.C3A SLC34A1
Mean 0.0248
Standard deviation 0.02
Values 0.011 0.039
[88]
HuH.7 SLC34A1
Mean 0.188
Standard deviation 0.097
Values 0.084 0.28 0.21
[89]
SNU475 SLC34A1
Mean 0.0219
Standard deviation 0.0048
Values 0.025 0.019
[90]
THLE SLC34A1
Mean 0
Standard deviation 0
Values 0 0
[91]
liver SLC34A1
Mean 0.273
Standard deviation 0.18
Values 0.29 0.16 0.52 0.13
[92]
ref_hepatocyte SLC34A3
Mean 0.155
Standard deviation 0.35
Values 0 0 0 0.78 0
[93]
HepG2 SLC34A3
Mean 0.702
Standard deviation 0.02
Values 0.72 0.69
[94]
HepG2.C3A SLC34A3
Mean 2.58
Standard deviation 0.57
Values 3 2.2
[95]
HuH.7 SLC34A3
Mean 0.0415
Standard deviation 0.027
Values 0.037 0.071 0.016
[96]
SNU475 SLC34A3
Mean 0.0694
Standard deviation 0.026
Values 0.051 0.088
[97]
THLE SLC34A3
Mean 0.0949
Standard deviation 0.0087
Values 0.089 0.1
[98]
liver SLC34A3
Mean 0.0609
Standard deviation 0.081
Values 0.17 0.071 0 0
[99]
ref_hepatocyte PHEX
Mean 0.104
Standard deviation 0.17
Values 0.4 0 0 0 0.12
[100]
HepG2 PHEX
Mean 0.0537
Standard deviation 0.003
Values 0.056 0.052
[101]
HepG2.C3A PHEX
Mean 0.0716
Standard deviation 0.005
Values 0.075 0.068
[102]
HuH.7 PHEX
Mean 7.18
Standard deviation 3.1
Values 4.1 10 7.1
[103]
SNU475 PHEX
Mean 2.75
Standard deviation 0.44
Values 2.4 3.1
[104]
THLE PHEX
Mean 0.157
Standard deviation 0.063
Values 0.11 0.2
[105]
liver PHEX
Mean 0.0329
Standard deviation 0.033
Values 0.079 0.029 0.024 0
[106]
ref_hepatocyte GALNT3
Mean 0.0838
Standard deviation 0.064
Values 0 0.081 0.086 0.18 0.073
[107]
HepG2 GALNT3
Mean 0.0888
Standard deviation 0.028
Values 0.069 0.11
[108]
HepG2.C3A GALNT3
Mean 0.0749
Standard deviation 0.045
Values 0.043 0.11
[109]
HuH.7 GALNT3
Mean 0.738
Standard deviation 0.11
Values 0.71 0.85 0.65
[110]
SNU475 GALNT3
Mean 0.0538
Standard deviation 0.017
Values 0.066 0.042
[111]
THLE GALNT3
Mean 1.08
Standard deviation 0.21
Values 1.2 0.93
[112]
liver GALNT3
Mean 1.05
Standard deviation 0.16
Values 1.1 0.81 1.2 1.1
[113]
ref_hepatocyte CYP27B1
Mean 0.0505
Standard deviation 0.082
Values 0.19 0.065 0 0 0
[114]
HepG2 CYP27B1
Mean 0.715
Standard deviation 0.14
Values 0.81 0.62
[115]
HepG2.C3A CYP27B1
Mean 1.72
Standard deviation 0.25
Values 1.5 1.9
[116]
HuH.7 CYP27B1
Mean 1.08
Standard deviation 0.18
Values 1.3 0.89 1.1
[117]
SNU475 CYP27B1
Mean 0.211
Standard deviation 0.1
Values 0.28 0.14
[118]
THLE CYP27B1
Mean 0.395
Standard deviation 0.14
Values 0.5 0.29
[119]
liver CYP27B1
Mean 0.228
Standard deviation 0.17
Values 0.24 0.14 0.071 0.46
[120]
ref_hepatocyte ROS1
Mean 0.00473
Standard deviation 0.007
Values 0 0.0081 0 0 0.016
[121]
HepG2 ROS1
Mean 0.0666
Standard deviation 0.076
Values 0.013 0.12
[122]
HepG2.C3A ROS1
Mean 0.057
Standard deviation 0.026
Values 0.075 0.039
[123]
HuH.7 ROS1
Mean 1.71
Standard deviation 1.6
Values 0.56 3.5 1.1
[124]
SNU475 ROS1
Mean 0.453
Standard deviation 0.074
Values 0.4 0.51
[125]
THLE ROS1
Mean 16.3
Standard deviation 5.4
Values 20 12
[126]
liver ROS1
Mean 0.013
Standard deviation 0.015
Values 0 0.029 0.024 0
[127]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0.0094 0 0
[131]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.36 0.67 0.59 1.1
[134]
ref_hepatocyte PTH
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 PTH
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A PTH
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 PTH
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 PTH
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE PTH
Mean 0
Standard deviation 0
Values 0 0
[140]
liver PTH
Mean 0.026
Standard deviation 0.0021
Values 0.026 0.029 0.024 0.026
[141]
ref_hepatocyte DMP1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 DMP1
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A DMP1
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 DMP1
Mean 0.0119
Standard deviation 0.01
Values 0 0.019 0.016
[145]
SNU475 DMP1
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[146]
THLE DMP1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[147]
liver DMP1
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte CYP11B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 CYP11B2
Missing
[150]
HepG2.C3A CYP11B2
Missing
[151]
HuH.7 CYP11B2
Missing
[152]
SNU475 CYP11B2
Missing
[153]
THLE CYP11B2
Missing
[154]
liver CYP11B2
Missing