WP_FERROPTOSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FTL | Ferritin light chain | [1] | -0.69[2] | -1.38[3] | -1.21[4] | 0.00[5] | -1.34[6] | -0.65[7] |
2 | TF | Serotransferrin | [8] | 0.25[9] | 1.27[10] | 0.47[11] | -9.13[12] | -8.09[13] | 0.48[14] |
3 | FTH1 | Ferritin heavy chain | [15] | 0.39[16] | -1.04[17] | 0.59[18] | 0.57[19] | 1.80[20] | -0.57[21] |
4 | AKR1C1 | Aldo-keto reductase family 1 member C1 | [22] | -1.21[23] | -1.82[24] | -5.04[25] | -1.45[26] | -5.24[27] | -3.62[28] |
5 | HSPB1 | Heat shock protein beta-1 | [29] | -1.95[30] | -3.05[31] | -1.81[32] | 0.02[33] | -1.16[34] | -3.19[35] |
6 | SAT1 | Diamine acetyltransferase 1 | [36] | -0.53[37] | -0.85[38] | -0.50[39] | -2.66[40] | -0.05[41] | -0.91[42] |
7 | CP | Ceruloplasmin | [43] | -2.02[44] | 0.80[45] | -0.22[46] | -3.91[47] | -8.65[48] | 2.34[49] |
8 | AKR1C3 | Aldo-keto reductase family 1 member C3 | [50] | -0.73[51] | -0.39[52] | -6.54[53] | 1.79[54] | -4.28[55] | -1.58[56] |
9 | GPX4 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | [57] | -0.26[58] | -0.15[59] | 0.03[60] | -1.25[61] | -0.66[62] | -1.18[63] |
10 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | [64] | -0.48[65] | -3.23[66] | -2.12[67] | -3.54[68] | 0.62[69] | 2.88[70] |
11 | TXNRD1 | Thioredoxin reductase 1, cytoplasmic | [71] | 0.95[72] | -0.14[73] | 0.20[74] | 2.88[75] | 2.58[76] | -1.45[77] |
12 | AKR1C2 | Aldo-keto reductase family 1 member C2 | [78] | 0.66[79] | -1.67[80] | -3.81[81] | 0.90[82] | -4.05[83] | -0.55[84] |
13 | PCBP1 | Poly(rC)-binding protein 1 | [85] | 1.01[86] | 0.35[87] | 0.96[88] | -0.18[89] | 0.60[90] | -1.51[91] |
14 | SLC39A14 | Zinc transporter ZIP14 | [92] | 1.06[93] | 1.77[94] | 2.65[95] | -1.26[96] | 1.57[97] | 2.95[98] |
15 | POR | NADPH--cytochrome P450 reductase | [99] | 0.62[100] | 0.91[101] | 0.17[102] | -0.37[103] | -0.39[104] | 1.97[105] |
16 | FDFT1 | Squalene synthase | [106] | -0.22[107] | 1.45[108] | 1.50[109] | -2.36[110] | -0.31[111] | -0.34[112] |
17 | SAT2 | Diamine acetyltransferase 2 | [113] | -1.40[114] | -1.28[115] | -0.44[116] | -2.41[117] | -1.37[118] | -1.41[119] |
18 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | [120] | 1.12[121] | 0.93[122] | 0.45[123] | 0.68[124] | 1.56[125] | -1.40[126] |
19 | PCBP2 | Poly(rC)-binding protein 2 | [127] | 1.84[128] | 1.68[129] | 2.52[130] | 1.27[131] | 2.40[132] | -0.54[133] |
20 | SLC3A2 | 4F2 cell-surface antigen heavy chain | [134] | 1.49[135] | 0.12[136] | 0.74[137] | 0.56[138] | 2.13[139] | -1.44[140] |
21 | CBS | Cystathionine beta-synthase | [141] | 0.06[142] | -0.01[143] | 2.04[144] | -2.21[145] | 0.30[146] | 1.57[147] |
22 | NCOA4 | Nuclear receptor coactivator 4 | [148] | 2.50[149] | 3.21[150] | 2.23[151] | 1.68[152] | 2.23[153] | 1.88[154] |
23 | VDAC3 | Voltage-dependent anion-selective channel protein 3 | [155] | 0.90[156] | 0.51[157] | 1.03[158] | 0.04[159] | 0.88[160] | -0.62[161] |
24 | HMOX1 | Heme oxygenase 1 | [162] | 1.06[163] | -0.14[164] | -0.77[165] | -0.19[166] | 0.57[167] | -1.47[168] |
25 | SLC40A1 | Solute carrier family 40 member 1 | [169] | 1.81[170] | 1.41[171] | 1.99[172] | -0.29[173] | -2.09[174] | 2.50[175] |
26 | STEAP3 | Metalloreductase STEAP3 | [176] | 0.07[177] | -0.92[178] | -2.62[179] | 0.02[180] | 0.12[181] | 2.32[182] |
27 | ACSL5 | Long-chain-fatty-acid--CoA ligase 5 | [183] | 1.79[184] | 1.42[185] | -1.52[186] | -1.99[187] | -3.54[188] | 1.71[189] |
28 | LPCAT3 | Lysophospholipid acyltransferase 5 | [190] | 0.86[191] | 0.42[192] | 1.00[193] | -1.03[194] | 0.41[195] | 0.75[196] |
29 | GCLC | Glutamate--cysteine ligase catalytic subunit | [197] | 1.19[198] | 1.27[199] | 0.54[200] | 2.36[201] | 0.64[202] | 1.03[203] |
30 | GCLM | Glutamate--cysteine ligase regulatory subunit | [204] | 0.57[205] | -0.48[206] | 0.47[207] | 2.26[208] | 1.43[209] | -0.23[210] |
31 | CTH | Cystathionine gamma-lyase | [211] | -0.88[212] | -1.91[213] | 0.47[214] | -3.19[215] | -1.68[216] | 0.55[217] |
32 | CHMP5 | Charged multivesicular body protein 5 | [218] | 0.97[219] | 1.23[220] | 1.22[221] | 0.95[222] | 2.33[223] | -0.25[224] |
33 | DPP4 | Dipeptidyl peptidase 4 | [225] | 1.49[226] | 2.72[227] | 3.23[228] | 0.40[229] | 2.64[230] | 0.05[231] |
34 | MAP1LC3 | Microtubule-associated proteins 1A/1B light chain 3B | [232] | 2.27[233] | 1.72[234] | 0.96[235] | 1.56[236] | 3.17[237] | 0.06[238] |
35 | PRNP | Major prion protein | [239] | 3.01[240] | 2.46[241] | -3.50[242] | 2.80[243] | 4.46[244] | 0.68[245] |
36 | ACSL3 | Long-chain-fatty-acid--CoA ligase 3 | [246] | 1.64[247] | 3.51[248] | 3.17[249] | 1.62[250] | 2.11[251] | 1.33[252] |
37 | GSS | Glutathione synthetase | [253] | 2.24[254] | 1.67[255] | 1.50[256] | 1.74[257] | 2.13[258] | 0.37[259] |
38 | GCH1 | GTP cyclohydrolase 1 | [260] | -0.16[261] | 0.49[262] | 1.07[263] | -1.23[264] | 1.04[265] | 1.39[266] |
39 | TFRC | Transferrin receptor protein 1 | [267] | 4.98[268] | 4.19[269] | 4.80[270] | 2.86[271] | 5.34[272] | 2.19[273] |
40 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [274] | 0.98[275] | 3.46[276] | 4.21[277] | 1.10[278] | 1.79[279] | 1.99[280] |
41 | CISD1 | CDGSH iron-sulfur domain-containing protein 1 | [281] | 0.56[282] | 1.57[283] | 1.75[284] | 0.61[285] | 1.43[286] | 0.95[287] |
42 | CHMP6 | Charged multivesicular body protein 6 | [288] | 1.18[289] | 1.00[290] | -0.49[291] | 0.58[292] | 0.82[293] | 0.27[294] |
43 | AIFM2 | Apoptosis-inducing factor 2 | [295] | 3.80[296] | 2.93[297] | -0.45[298] | 1.65[299] | 2.49[300] | 0.36[301] |
44 | ACSL4 | Long-chain-fatty-acid--CoA ligase 4 | [302] | 4.26[303] | 5.71[304] | 6.49[305] | 2.96[306] | 4.79[307] | 1.58[308] |
45 | SLC39A8 | Zinc transporter ZIP8 | [309] | -3.13[310] | -5.22[311] | 1.43[312] | 0.73[313] | 4.51[314] | 1.69[315] |
46 | IREB2 | Iron-responsive element-binding protein 2 | [316] | 1.88[317] | 2.78[318] | 3.72[319] | 2.79[320] | 3.35[321] | 1.72[322] |
47 | MAP1LC3 | Microtubule-associated proteins 1A/1B light chain 3A | [323] | -7.49[324] | -9.23[325] | -8.11[326] | -1.83[327] | 1.12[328] | -0.33[329] |
48 | SLC11A2 | Natural resistance-associated macrophage protein 2 | [330] | 3.21[331] | 3.72[332] | 2.36[333] | 1.41[334] | 3.17[335] | 2.29[336] |
49 | ATG5 | Autophagy protein 5 | [337] | 1.32[338] | 2.07[339] | 2.22[340] | 2.19[341] | 2.93[342] | 1.45[343] |
50 | SLC1A5 | Neutral amino acid transporter B(0) | [344] | 5.16[345] | 4.08[346] | 4.49[347] | 4.61[348] | 4.80[349] | -1.32[350] |
51 | SLC38A1 | Sodium-coupled neutral amino acid transporter 1 | [351] | 3.84[352] | 4.34[353] | 4.83[354] | 2.97[355] | 5.59[356] | 2.18[357] |
52 | TP53 | Cellular tumor antigen p53 | [358] | 3.18[359] | 2.46[360] | 3.71[361] | 2.70[362] | 3.36[363] | 0.57[364] |
53 | COQ2 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial | [365] | 0.76[366] | 0.53[367] | 0.61[368] | -0.40[369] | 2.14[370] | 0.33[371] |
54 | PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | [372] | 2.16[373] | 2.34[374] | 2.23[375] | 0.98[376] | 2.56[377] | 1.48[378] |
55 | BACH1 | Transcription regulator protein BACH1 | [379] | 2.59[380] | 2.63[381] | 3.57[382] | 3.53[383] | 3.76[384] | 3.24[385] |
56 | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7 | [386] | 2.54[387] | 1.77[388] | 2.99[389] | 2.09[390] | 3.95[391] | 2.37[392] |
57 | CYBB | Cytochrome b-245 heavy chain | [393] | [394] | [395] | -8.47[396] | -3.06[397] | -7.62[398] | 3.66[399] |
58 | SLC7A11 | Cystine/glutamate transporter | [400] | 4.21[401] | 4.78[402] | 5.11[403] | 6.29[404] | 6.09[405] | -0.41[406] |
59 | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 | [407] | 1.48[408] | 3.57[409] | 1.44[410] | 0.14[411] | 0.58[412] | 3.63[413] |
60 | NOX4 | NADPH oxidase 4 | [414] | -1.69[415] | 0.80[416] | 1.49[417] | -1.18[418] | 1.05[419] | 2.71[420] |
61 | MAP1LC3 | Microtubule-associated proteins 1A/1B light chain 3C | [421] | 0.54[422] | 1.35[423] | 2.21[424] | 4.28[425] | 1.96[426] | 3.61[427] |
62 | ALOX15 | Arachidonate 15-lipoxygenase | [428] | 3.16[429] | -1.19[430] | 3.87[431] | -0.35[432] | 1.09[433] | -0.33[434] |
63 | NOX1 | NADPH oxidase 1 | [435] | 1.90[436] | 0.85[437] | 6.50[438] | 1.35[439] | 3.73[440] | 1.45[441] |
64 | FTMT | Ferritin, mitochondrial | [442] | [443] | [444] | [445] | [446] | [447] | [448] |
65 | MIR4651 | [449] | [450] | [451] | [452] | [453] | [454] | [455] |