WP_FATTY_ACID_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ECHS1 Enoyl-CoA hydratase, mitochondrial [1] -1.43[2] -1.87[3] -2.54[4] -1.75[5] -1.62[6] -1.08[7]
2 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial [8] -1.90[9] -2.85[10] -3.52[11] -1.50[12] -1.32[13] -0.09[14]
3 SCD Acyl-CoA desaturase [15] 0.59[16] 1.41[17] 1.75[18] -0.72[19] -1.71[20] -0.40[21]
4 ACSL1 Long-chain-fatty-acid--CoA ligase 1 [22] -0.81[23] -4.28[24] -4.09[25] -2.69[26] 0.40[27] 1.36[28]
5 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [29] -1.32[30] -1.44[31] -1.03[32] -0.74[33] -1.31[34] -0.74[35]
6 DECR1 2,4-dienoyl-CoA reductase, mitochondrial [36] -1.95[37] -3.22[38] -3.11[39] -0.98[40] -1.39[41] -1.48[42]
7 ECHDC2 Enoyl-CoA hydratase domain-containing protein 2, mitochondrial [43] -3.22[44] -3.10[45] -3.81[46] -2.19[47] -2.29[48] -1.31[49]
8 ECHDC3 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial [50] -11.25[51] -11.47[52] -3.33[53] -0.69[54] -5.30[55] -1.09[56]
9 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [57] -1.17[58] -1.32[59] -1.99[60] -0.63[61] -0.31[62] -0.79[63]
10 PC Pyruvate carboxylase, mitochondrial [64] -0.05[65] -0.85[66] -0.10[67] 0.69[68] -1.85[69] 1.24[70]
11 ACLY ATP-citrate synthase [71] 2.40[72] 1.06[73] 1.54[74] 3.32[75] 3.01[76] -1.25[77]
12 ACSL5 Long-chain-fatty-acid--CoA ligase 5 [78] 1.47[79] 0.37[80] -3.50[81] -1.14[82] -3.76[83] 0.19[84]
13 PECR Peroxisomal trans-2-enoyl-CoA reductase [85] -0.19[86] 0.36[87] -0.96[88] -1.10[89] -1.06[90] -1.27[91]
14 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic [92] -0.46[93] 0.20[94] -0.53[95] 0.58[96] 0.11[97] -0.89[98]
15 ECHDC1 Ethylmalonyl-CoA decarboxylase [99] 0.03[100] 0.33[101] -1.71[102] 0.93[103] 1.34[104] -0.99[105]
16 ACSL3 Long-chain-fatty-acid--CoA ligase 3 [106] 1.32[107] 2.45[108] 1.20[109] 2.48[110] 1.89[111] -0.18[112]
17 FASN Fatty acid synthase [113] 3.62[114] 3.25[115] 3.37[116] 3.00[117] 2.95[118] 1.60[119]
18 ACSL4 Long-chain-fatty-acid--CoA ligase 4 [120] 3.94[121] 4.66[122] 4.52[123] 3.81[124] 4.57[125] 0.06[126]
19 ACACB Acetyl-CoA carboxylase 2 [127] 0.35[128] 0.32[129] 0.00[130] 0.50[131] 0.71[132] 3.28[133]
20 MECR Enoyl-[acyl-carrier-protein] reductase, mitochondrial [134] 1.60[135] 0.32[136] -0.32[137] 1.81[138] 2.18[139] -0.62[140]
21 ACACA Acetyl-CoA carboxylase 1 [141] 3.67[142] 3.00[143] 3.48[144] 4.85[145] 3.96[146] 2.45[147]
22 ACSL6 Long-chain-fatty-acid--CoA ligase 6 [148] 1.15[149] 2.52[150] -0.54[151] 1.00[152] 0.36[153] 2.12[154]
[1]
ref_hepatocyte ECHS1
Mean 234
Standard deviation 2.7e+02
Values 36 6.2e+02 4.2e+02 50 41
[2]
HepG2 ECHS1
Mean 82.5
Standard deviation 19
Values 96 69
[3]
HepG2.C3A ECHS1
Mean 108
Standard deviation 1.4
Values 1.1e+02 1.1e+02
[4]
HuH.7 ECHS1
Mean 88.7
Standard deviation 28
Values 1.1e+02 59 93
[5]
SNU475 ECHS1
Mean 26.6
Standard deviation 2.9
Values 25 29
[6]
THLE ECHS1
Mean 34.4
Standard deviation 3
Values 32 37
[7]
liver ECHS1
Mean 293
Standard deviation 2.8e+02
Values 63 64 6.2e+02 4.2e+02
[8]
ref_hepatocyte ACAA2
Mean 210
Standard deviation 2e+02
Values 18 4.1e+02 4.5e+02 88 86
[9]
HepG2 ACAA2
Mean 53.5
Standard deviation 13
Values 63 44
[10]
HepG2.C3A ACAA2
Mean 49.4
Standard deviation 11
Values 57 42
[11]
HuH.7 ACAA2
Mean 40.6
Standard deviation 2.8
Values 43 38 41
[12]
SNU475 ACAA2
Mean 28.4
Standard deviation 3.9
Values 26 31
[13]
THLE ACAA2
Mean 37.9
Standard deviation 3
Values 36 40
[14]
liver ACAA2
Mean 525
Standard deviation 3.7e+02
Values 2.5e+02 2.2e+02 1e+03 6.2e+02
[15]
ref_hepatocyte SCD
Mean 184
Standard deviation 1.7e+02
Values 35 3.1e+02 1.3e+02 4.1e+02 33
[16]
HepG2 SCD
Mean 263
Standard deviation 44
Values 2.9e+02 2.3e+02
[17]
HepG2.C3A SCD
Mean 832
Standard deviation 2.9e+02
Values 6.3e+02 1e+03
[18]
HuH.7 SCD
Mean 1.37e+03
Standard deviation 3.6e+02
Values 1e+03 1.7e+03 1.4e+03
[19]
SNU475 SCD
Mean 42.8
Standard deviation 2.4
Values 41 45
[20]
THLE SCD
Mean 25.4
Standard deviation 2.3
Values 24 27
[21]
liver SCD
Mean 369
Standard deviation 2.8e+02
Values 1.4e+02 5.6e+02 1.1e+02 6.7e+02
[22]
ref_hepatocyte ACSL1
Mean 173
Standard deviation 2.2e+02
Values 13 5e+02 3.2e+02 17 17
[23]
HepG2 ACSL1
Mean 93.9
Standard deviation 14
Values 84 1e+02
[24]
HepG2.C3A ACSL1
Mean 15.2
Standard deviation 4.9
Values 12 19
[25]
HuH.7 ACSL1
Mean 22.4
Standard deviation 13
Values 14 38 15
[26]
SNU475 ACSL1
Mean 10.3
Standard deviation 0.5
Values 11 9.9
[27]
THLE ACSL1
Mean 103
Standard deviation 35
Values 1.3e+02 78
[28]
liver ACSL1
Mean 1.18e+03
Standard deviation 2.6e+02
Values 1.6e+03 1.1e+03 9.5e+02 1.1e+03
[29]
ref_hepatocyte ECH1
Mean 142
Standard deviation 1.5e+02
Values 19 3.3e+02 2.9e+02 40 31
[30]
HepG2 ECH1
Mean 54.1
Standard deviation 0.98
Values 53 55
[31]
HepG2.C3A ECH1
Mean 88.9
Standard deviation 28
Values 69 1.1e+02
[32]
HuH.7 ECH1
Mean 153
Standard deviation 37
Values 1.8e+02 1.1e+02 1.7e+02
[33]
SNU475 ECH1
Mean 32.6
Standard deviation 11
Values 25 40
[34]
THLE ECH1
Mean 26
Standard deviation 2.4
Values 28 24
[35]
liver ECH1
Mean 226
Standard deviation 2.1e+02
Values 47 43 3.5e+02 4.6e+02
[36]
ref_hepatocyte DECR1
Mean 82.4
Standard deviation 85
Values 15 1.9e+02 1.6e+02 19 29
[37]
HepG2 DECR1
Mean 20.2
Standard deviation 6.1
Values 25 16
[38]
HepG2.C3A DECR1
Mean 15.1
Standard deviation 2.9
Values 17 13
[39]
HuH.7 DECR1
Mean 21
Standard deviation 4
Values 25 17 21
[40]
SNU475 DECR1
Mean 15.9
Standard deviation 10
Values 8.9 23
[41]
THLE DECR1
Mean 14.2
Standard deviation 1.9
Values 13 16
[42]
liver DECR1
Mean 78.5
Standard deviation 62
Values 23 28 1.2e+02 1.4e+02
[43]
ref_hepatocyte ECHDC2
Mean 59.5
Standard deviation 64
Values 20 1.3e+02 1.3e+02 8.1 11
[44]
HepG2 ECHDC2
Mean 6.05
Standard deviation 0.53
Values 5.7 6.4
[45]
HepG2.C3A ECHDC2
Mean 11.8
Standard deviation 6
Values 7.5 16
[46]
HuH.7 ECHDC2
Mean 9.37
Standard deviation 2.3
Values 11 9.7 6.9
[47]
SNU475 ECHDC2
Mean 4.98
Standard deviation 2.1
Values 3.5 6.5
[48]
THLE ECHDC2
Mean 5.48
Standard deviation 1.6
Values 6.6 4.3
[49]
liver ECHDC2
Mean 63.8
Standard deviation 32
Values 42 31 86 96
[50]
ref_hepatocyte ECHDC3
Mean 42.3
Standard deviation 37
Values 16 77 82 0 36
[51]
HepG2 ECHDC3
Mean 0.0165
Standard deviation 0.0071
Values 0.021 0.011
[52]
HepG2.C3A ECHDC3
Mean 0.0253
Standard deviation 0.0055
Values 0.021 0.029
[53]
HuH.7 ECHDC3
Mean 9.3
Standard deviation 1.4
Values 10 10 7.7
[54]
SNU475 ECHDC3
Mean 10
Standard deviation 5.7
Values 6 14
[55]
THLE ECHDC3
Mean 0.483
Standard deviation 0.11
Values 0.4 0.56
[56]
liver ECHDC3
Mean 52.8
Standard deviation 25
Values 27 35 77 72
[57]
ref_hepatocyte HADH
Mean 40.9
Standard deviation 39
Values 2.9 93 70 29 9.1
[58]
HepG2 HADH
Mean 17.3
Standard deviation 4.6
Values 21 14
[59]
HepG2.C3A HADH
Mean 27.7
Standard deviation 5.6
Values 32 24
[60]
HuH.7 HADH
Mean 22.8
Standard deviation 5.7
Values 28 17 23
[61]
SNU475 HADH
Mean 10.1
Standard deviation 2
Values 8.7 12
[62]
THLE HADH
Mean 14.8
Standard deviation 0.91
Values 14 15
[63]
liver HADH
Mean 62.8
Standard deviation 48
Values 15 29 1e+02 1e+02
[64]
ref_hepatocyte PC
Mean 39.5
Standard deviation 46
Values 3.9 93 87 8 5.6
[65]
HepG2 PC
Mean 36.2
Standard deviation 7.4
Values 31 41
[66]
HepG2.C3A PC
Mean 37.2
Standard deviation 8
Values 32 43
[67]
HuH.7 PC
Mean 81.4
Standard deviation 7.4
Values 77 77 90
[68]
SNU475 PC
Mean 24.3
Standard deviation 13
Values 15 33
[69]
THLE PC
Mean 4.93
Standard deviation 0.64
Values 4.5 5.4
[70]
liver PC
Mean 248
Standard deviation 63
Values 2.4e+02 2.7e+02 1.7e+02 3.2e+02
[71]
ref_hepatocyte ACLY
Mean 28.9
Standard deviation 24
Values 33 4.3 9.2 64 33
[72]
HepG2 ACLY
Mean 145
Standard deviation 3.8
Values 1.4e+02 1.5e+02
[73]
HepG2.C3A ACLY
Mean 102
Standard deviation 23
Values 86 1.2e+02
[74]
HuH.7 ACLY
Mean 185
Standard deviation 35
Values 1.8e+02 1.5e+02 2.2e+02
[75]
SNU475 ACLY
Mean 111
Standard deviation 0.23
Values 1.1e+02 1.1e+02
[76]
THLE ACLY
Mean 105
Standard deviation 22
Values 89 1.2e+02
[77]
liver ACLY
Mean 32.1
Standard deviation 9.8
Values 46 32 25 26
[78]
ref_hepatocyte ACSL5
Mean 28.5
Standard deviation 4.5
Values 21 29 32 31 30
[79]
HepG2 ACSL5
Mean 74.6
Standard deviation 45
Values 43 1.1e+02
[80]
HepG2.C3A ACSL5
Mean 62.5
Standard deviation 11
Values 55 70
[81]
HuH.7 ACSL5
Mean 5.57
Standard deviation 4.2
Values 3 10 3.3
[82]
SNU475 ACSL5
Mean 4.95
Standard deviation 0.24
Values 5.1 4.8
[83]
THLE ACSL5
Mean 0.948
Standard deviation 0.26
Values 0.76 1.1
[84]
liver ACSL5
Mean 86.6
Standard deviation 32
Values 1.3e+02 90 46 84
[85]
ref_hepatocyte PECR
Mean 28
Standard deviation 28
Values 1.2 70 30 34 4.9
[86]
HepG2 PECR
Mean 23.3
Standard deviation 4.2
Values 26 20
[87]
HepG2.C3A PECR
Mean 60.8
Standard deviation 2
Values 59 62
[88]
HuH.7 PECR
Mean 31.9
Standard deviation 3.6
Values 36 30 29
[89]
SNU475 PECR
Mean 5
Standard deviation 1.8
Values 3.7 6.3
[90]
THLE PECR
Mean 6.05
Standard deviation 0.43
Values 5.7 6.4
[91]
liver PECR
Mean 30.8
Standard deviation 12
Values 32 19 47 26
[92]
ref_hepatocyte ACSS2
Mean 25.9
Standard deviation 16
Values 11 48 27 33 11
[93]
HepG2 ACSS2
Mean 17.9
Standard deviation 3.4
Values 20 16
[94]
HepG2.C3A ACSS2
Mean 50.5
Standard deviation 28
Values 31 70
[95]
HuH.7 ACSS2
Mean 39.6
Standard deviation 8.6
Values 36 49 33
[96]
SNU475 ACSS2
Mean 14.8
Standard deviation 2.6
Values 13 17
[97]
THLE ACSS2
Mean 12.6
Standard deviation 0.71
Values 13 12
[98]
liver ACSS2
Mean 37.1
Standard deviation 10
Values 42 34 24 48
[99]
ref_hepatocyte ECHDC1
Mean 24.1
Standard deviation 11
Values 8.1 38 22 21 31
[100]
HepG2 ECHDC1
Mean 23.3
Standard deviation 9.2
Values 30 17
[101]
HepG2.C3A ECHDC1
Mean 51.5
Standard deviation 16
Values 63 40
[102]
HuH.7 ECHDC1
Mean 16.2
Standard deviation 3.2
Values 19 13 17
[103]
SNU475 ECHDC1
Mean 17.5
Standard deviation 0.3
Values 17 18
[104]
THLE ECHDC1
Mean 27.5
Standard deviation 1.2
Values 27 28
[105]
liver ECHDC1
Mean 32.2
Standard deviation 19
Values 13 20 46 50
[106]
ref_hepatocyte ACSL3
Mean 17.7
Standard deviation 9.8
Values 21 12 10 33 11
[107]
HepG2 ACSL3
Mean 41.8
Standard deviation 11
Values 49 34
[108]
HepG2.C3A ACSL3
Mean 164
Standard deviation 67
Values 1.2e+02 2.1e+02
[109]
HuH.7 ACSL3
Mean 89.4
Standard deviation 16
Values 74 1.1e+02 89
[110]
SNU475 ACSL3
Mean 37.6
Standard deviation 1.8
Values 39 36
[111]
THLE ACSL3
Mean 29.6
Standard deviation 1.5
Values 29 31
[112]
liver ACSL3
Mean 41.4
Standard deviation 11
Values 37 50 28 50
[113]
ref_hepatocyte FASN
Mean 16.9
Standard deviation 11
Values 11 22 17 31 3.5
[114]
HepG2 FASN
Mean 197
Standard deviation 11
Values 2e+02 1.9e+02
[115]
HepG2.C3A FASN
Mean 273
Standard deviation 1.4e+02
Values 1.7e+02 3.7e+02
[116]
HuH.7 FASN
Mean 387
Standard deviation 1.1e+02
Values 2.9e+02 3.8e+02 5e+02
[117]
SNU475 FASN
Mean 51.5
Standard deviation 12
Values 43 60
[118]
THLE FASN
Mean 59
Standard deviation 19
Values 46 72
[119]
liver FASN
Mean 136
Standard deviation 1e+02
Values 2.8e+02 1.2e+02 92 54
[120]
ref_hepatocyte ACSL4
Mean 8.43
Standard deviation 12
Values 4.9 1.3 2.5 30 3.6
[121]
HepG2 ACSL4
Mean 122
Standard deviation 39
Values 1.5e+02 95
[122]
HepG2.C3A ACSL4
Mean 362
Standard deviation 36
Values 3.4e+02 3.9e+02
[123]
HuH.7 ACSL4
Mean 426
Standard deviation 72
Values 3.5e+02 4.5e+02 4.8e+02
[124]
SNU475 ACSL4
Mean 45.3
Standard deviation 4
Values 48 42
[125]
THLE ACSL4
Mean 90.2
Standard deviation 2.5
Values 92 88
[126]
liver ACSL4
Mean 23.4
Standard deviation 10
Values 28 34 11 20
[127]
ref_hepatocyte ACACB
Mean 5.46
Standard deviation 5.5
Values 1.1 13 9.6 1.7 1.8
[128]
HepG2 ACACB
Mean 6.6
Standard deviation 0.54
Values 7 6.2
[129]
HepG2.C3A ACACB
Mean 11.5
Standard deviation 0.088
Values 12 11
[130]
HuH.7 ACACB
Mean 12.1
Standard deviation 1.9
Values 9.8 13 13
[131]
SNU475 ACACB
Mean 2.94
Standard deviation 0.034
Values 2.9 3
[132]
THLE ACACB
Mean 4.04
Standard deviation 0.24
Values 4.2 3.9
[133]
liver ACACB
Mean 141
Standard deviation 89
Values 2.6e+02 1.6e+02 90 59
[134]
ref_hepatocyte MECR
Mean 3.89
Standard deviation 1.8
Values 2.4 3.9 6 1.9 5.3
[135]
HepG2 MECR
Mean 11.2
Standard deviation 1.8
Values 9.9 12
[136]
HepG2.C3A MECR
Mean 8.21
Standard deviation 0.45
Values 7.9 8.5
[137]
HuH.7 MECR
Mean 6.9
Standard deviation 3
Values 8.8 3.5 8.4
[138]
SNU475 MECR
Mean 5.2
Standard deviation 0.82
Values 4.6 5.8
[139]
THLE MECR
Mean 7.95
Standard deviation 0.16
Values 8.1 7.8
[140]
liver MECR
Mean 6.74
Standard deviation 5
Values 2.8 4 6.3 14
[141]
ref_hepatocyte ACACA
Mean 3.02
Standard deviation 0.95
Values 1.7 2.7 3.2 4.3 3.2
[142]
HepG2 ACACA
Mean 36.5
Standard deviation 4.8
Values 40 33
[143]
HepG2.C3A ACACA
Mean 41.2
Standard deviation 13
Values 32 50
[144]
HuH.7 ACACA
Mean 74.7
Standard deviation 16
Values 57 78 89
[145]
SNU475 ACACA
Mean 33.2
Standard deviation 14
Values 23 43
[146]
THLE ACACA
Mean 21.2
Standard deviation 5
Values 18 25
[147]
liver ACACA
Mean 44
Standard deviation 21
Values 50 70 21 35
[148]
ref_hepatocyte ACSL6
Mean 0.236
Standard deviation 0.16
Values 0.038 0.48 0.21 0.27 0.19
[149]
HepG2 ACSL6
Mean 0.499
Standard deviation 0.21
Values 0.65 0.35
[150]
HepG2.C3A ACSL6
Mean 2.3
Standard deviation 0.03
Values 2.3 2.3
[151]
HuH.7 ACSL6
Mean 0.36
Standard deviation 0.036
Values 0.34 0.34 0.4
[152]
SNU475 ACSL6
Mean 0.181
Standard deviation 0.046
Values 0.21 0.15
[153]
THLE ACSL6
Mean 0.137
Standard deviation 0.017
Values 0.12 0.15
[154]
liver ACSL6
Mean 2.73
Standard deviation 1.7
Values 4.2 1.6 4.2 0.87