WP_FARNESOID_X_RECEPTOR_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SULT2A1 Bile salt sulfotransferase [1] 0.23[2] 0.34[3] -0.76[4] -7.96[5] -9.23[6] -0.67[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -8.25[9] -9.19[10] -10.73[11] -11.87[12] -11.79[13] -0.23[14]
3 UGT2B4 UDP-glucuronosyltransferase 2B4 [15] -5.95[16] -6.95[17] -1.53[18] -6.45[19] -11.41[20] -0.19[21]
4 SLC27A5 Bile acyl-CoA synthetase [22] -1.94[23] -1.52[24] -2.94[25] -2.83[26] -6.80[27] -0.33[28]
5 BAAT Bile acid-CoA:amino acid N-acyltransferase [29] -2.02[30] -2.22[31] -4.40[32] -3.60[33] -6.38[34] 0.79[35]
6 SLC10A1 Sodium/bile acid cotransporter [36] -6.31[37] -7.51[38] -8.81[39] -7.32[40] -10.15[41] -1.36[42]
7 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [43] -4.72[44] -3.00[45] -6.75[46] -5.33[47] -8.63[48] 1.49[49]
8 NR0B2 Nuclear receptor subfamily 0 group B member 2 [50] 3.07[51] 3.53[52] -3.00[53] -4.92[54] -6.64[55] -1.02[56]
9 SLCO2B1 Solute carrier organic anion transporter family member 2B1 [57] 1.93[58] 2.53[59] 3.73[60] 4.01[61] -5.19[62] 0.77[63]
10 NR1H4 Bile acid receptor [64] 1.90[65] 1.67[66] 3.63[67] -3.40[68] -4.90[69] -0.44[70]
11 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 [71] 3.05[72] 1.96[73] 0.39[74] 3.57[75] 5.35[76] 1.16[77]
12 RXRA Retinoic acid receptor RXR-alpha [78] 3.44[79] 2.43[80] 3.44[81] 4.66[82] 2.87[83] 1.19[84]
13 ABCB4 Phosphatidylcholine translocator ABCB4 [85] 1.64[86] 1.66[87] 2.61[88] -0.71[89] -6.00[90] 2.62[91]
14 CYP7A1 Cholesterol 7-alpha-monooxygenase [92] -0.84[93] -4.00[94] -7.36[95] -5.32[96] [97] -3.92[98]
15 IP6K3 Inositol hexakisphosphate kinase 3 [99] 1.23[100] -2.79[101] -6.11[102] 0.82[103] 4.19[104] -0.94[105]
16 IRS2 Insulin receptor substrate 2 [106] -2.15[107] [108] 0.05[109] 3.98[110] 6.35[111] 1.42[112]
17 ABCB11 Bile salt export pump [113] -3.29[114] [115] -2.64[116] -0.87[117] [118] 3.83[119]
18 PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 2.41[120] 4.48[121] -6.13[122] 5.41[123] 0.64[124] 2.47[125]
19 FGF19 Fibroblast growth factor 19 [126] 1.44[127] 1.77[128] 8.68[129] 5.48[130] 0.54[131] [132]
[1]
ref_hepatocyte SULT2A1
Mean 281
Standard deviation 2.8e+02
Values 7.2 3e+02 6.4e+02 4.5e+02 5.2
[2]
HepG2 SULT2A1
Mean 64.4
Standard deviation 29
Values 85 44
[3]
HepG2.C3A SULT2A1
Mean 109
Standard deviation 37
Values 83 1.4e+02
[4]
HuH.7 SULT2A1
Mean 43.5
Standard deviation 18
Values 38 64 29
[5]
SNU475 SULT2A1
Mean 0.0827
Standard deviation 0.012
Values 0.091 0.074
[6]
THLE SULT2A1
Mean 0.106
Standard deviation 0.0079
Values 0.1 0.11
[7]
liver SULT2A1
Mean 489
Standard deviation 2.7e+02
Values 2.3e+02 2.9e+02 8.1e+02 6.3e+02
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[15]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 15 5e+02 4.6e+02 0.056 68
[16]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.37 0.96
[17]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.69 0.36
[18]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 12 34 11
[19]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.15 0.2
[20]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[21]
liver UGT2B4
Mean 509
Standard deviation 93
Values 4.3e+02 5.3e+02 4.5e+02 6.3e+02
[22]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 6 2.7e+02 1.4e+02 0.8 1.2
[23]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 3.8 4.7
[24]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 8.2 9.7
[25]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 3.5 2.7 2.3
[26]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.89 0.83
[27]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[28]
liver SLC27A5
Mean 184
Standard deviation 60
Values 1.6e+02 1.1e+02 2.2e+02 2.5e+02
[29]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 17 84 89 1.6 59
[30]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 3 1.9
[31]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.1 3.5
[32]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.18 1.6 0.098
[33]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.11 0.49
[34]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[35]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 1.1e+02 1.7e+02 4.1e+02 2.7e+02
[36]
ref_hepatocyte SLC10A1
Mean 41.6
Standard deviation 64
Values 1.5 1.5e+02 60 0 0
[37]
HepG2 SLC10A1
Mean 0.102
Standard deviation 0.08
Values 0.16 0.046
[38]
HepG2.C3A SLC10A1
Mean 0.0701
Standard deviation 0.038
Values 0.043 0.097
[39]
HuH.7 SLC10A1
Mean 0.0242
Standard deviation 0.015
Values 0.019 0.013 0.041
[40]
SNU475 SLC10A1
Mean 0.019
Standard deviation 0.013
Values 0.01 0.028
[41]
THLE SLC10A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[42]
liver SLC10A1
Mean 44.8
Standard deviation 22
Values 29 22 64 63
[43]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 6.4 86 79 1.2 0.33
[44]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.4 0.11
[45]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 0.98 1.7
[46]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.066 0.096 0.09
[47]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.066 0.06
[48]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[49]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 2.2e+02 1.3e+02 4.2e+02 3e+02
[50]
ref_hepatocyte NR0B2
Mean 23.4
Standard deviation 25
Values 16 44 55 0.37 1.2
[51]
HepG2 NR0B2
Mean 38.6
Standard deviation 7.8
Values 44 33
[52]
HepG2.C3A NR0B2
Mean 83
Standard deviation 18
Values 71 95
[53]
HuH.7 NR0B2
Mean 0.766
Standard deviation 0.29
Values 1 0.82 0.45
[54]
SNU475 NR0B2
Mean 0.0568
Standard deviation 0.034
Values 0.081 0.032
[55]
THLE NR0B2
Mean 0.0532
Standard deviation 3.6e-05
Values 0.053 0.053
[56]
liver NR0B2
Mean 32
Standard deviation 38
Values 3.3 5 86 34
[57]
ref_hepatocyte SLCO2B1
Mean 21.2
Standard deviation 24
Values 1.8 53 41 7.8 2.1
[58]
HepG2 SLCO2B1
Mean 15.8
Standard deviation 6.6
Values 20 11
[59]
HepG2.C3A SLCO2B1
Mean 37.6
Standard deviation 6.7
Values 33 42
[60]
HuH.7 SLCO2B1
Mean 73.5
Standard deviation 12
Values 63 87 71
[61]
SNU475 SLCO2B1
Mean 24.9
Standard deviation 6.3
Values 20 29
[62]
THLE SLCO2B1
Mean 0.131
Standard deviation 0.018
Values 0.12 0.14
[63]
liver SLCO2B1
Mean 100
Standard deviation 31
Values 84 98 75 1.4e+02
[64]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 3.8 33 43 15 9.3
[65]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 20 11
[66]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 21 19
[67]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 58 82 62
[68]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.17 0.12
[69]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[70]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 39 37 59 35
[71]
ref_hepatocyte FKBP5
Mean 18.4
Standard deviation 11
Values 7.4 15 31 10 28
[72]
HepG2 FKBP5
Mean 29.7
Standard deviation 0.56
Values 30 29
[73]
HepG2.C3A FKBP5
Mean 22
Standard deviation 6.9
Values 27 17
[74]
HuH.7 FKBP5
Mean 6.3
Standard deviation 3.2
Values 7.5 2.7 8.7
[75]
SNU475 FKBP5
Mean 16
Standard deviation 1.5
Values 15 17
[76]
THLE FKBP5
Mean 170
Standard deviation 22
Values 1.5e+02 1.9e+02
[77]
liver FKBP5
Mean 114
Standard deviation 13
Values 1.1e+02 98 1.1e+02 1.3e+02
[78]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 9.4 18 22 15 7.5
[79]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 29 33
[80]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 20 28
[81]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 30 51 42
[82]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 21 33
[83]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[84]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.2e+02 72 1.3e+02 49
[85]
ref_hepatocyte ABCB4
Mean 8.09
Standard deviation 7.8
Values 1.4 12 20 3 4
[86]
HepG2 ABCB4
Mean 4.92
Standard deviation 0.38
Values 5.2 4.7
[87]
HepG2.C3A ABCB4
Mean 7.87
Standard deviation 1.3
Values 6.9 8.8
[88]
HuH.7 ABCB4
Mean 12.9
Standard deviation 0.78
Values 12 14 13
[89]
SNU475 ABCB4
Mean 0.362
Standard deviation 0.12
Values 0.27 0.45
[90]
THLE ABCB4
Mean 0.0287
Standard deviation 0.018
Values 0.041 0.016
[91]
liver ABCB4
Mean 138
Standard deviation 90
Values 2.6e+02 1.5e+02 55 89
[92]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 0 9.7 0.69 9.8 0
[93]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.77 0.11
[94]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.097 0.058
[95]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[96]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.01 0.0046
[97]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[98]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 0.079 0.94 1.1 0.82
[99]
ref_hepatocyte IP6K3
Mean 2.42
Standard deviation 2.8
Values 4.1 0.62 6.6 0.35 0.43
[100]
HepG2 IP6K3
Mean 1.11
Standard deviation 0.92
Values 0.46 1.8
[101]
HepG2.C3A IP6K3
Mean 0.108
Standard deviation 0.015
Values 0.12 0.097
[102]
HuH.7 IP6K3
Mean 0.00915
Standard deviation 0.0097
Values 0 0.019 0.0082
[103]
SNU475 IP6K3
Mean 0.312
Standard deviation 0.061
Values 0.35 0.27
[104]
THLE IP6K3
Mean 10
Standard deviation 2.2
Values 12 8.5
[105]
liver IP6K3
Mean 3.51
Standard deviation 2.7
Values 6.9 1.1 4.3 1.7
[106]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 1.4 2.9 5.7 0.019 0.61
[107]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.043 0.14
[108]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.17 1.4 0.2
[110]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.8 2.1
[111]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[112]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 17 11 29 6.3
[113]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 1.8 4.1 3 0 1
[114]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.021 0.057
[115]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.037 0.096 0.11
[117]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.11 0.051
[118]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[119]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 71 1.9e+02 17 36
[120]
ref_hepatocyte PPARGC1A
Mean 1.87
Standard deviation 1.7
Values 0.25 1.6 3.2 4 0.26
[121]
HepG2 PPARGC1A
Mean 1.94
Standard deviation 0.37
Values 2.2 1.7
[122]
HepG2.C3A PPARGC1A
Mean 12.8
Standard deviation 3.6
Values 10 15
[123]
HuH.7 PPARGC1A
Mean 0.00701
Standard deviation 0.0065
Values 0 0.013 0.0082
[124]
SNU475 PPARGC1A
Mean 5.83
Standard deviation 1.4
Values 4.9 6.8
[125]
THLE PPARGC1A
Mean 0.662
Standard deviation 0.1
Values 0.73 0.59
[126]
liver PPARGC1A
Mean 28.7
Standard deviation 18
Values 26 54 20 15
[127]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0.61 0 0 0 0
[128]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.06 0.069
[129]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[130]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 12 17 11
[131]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.29 0.51
[132]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[133]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0