WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_4 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 APOA2 Apolipoprotein A-II [1] -0.51[2] -0.32[3] -0.33[4] -6.66[5] -6.61[6] -0.83[7]
2 APOA1 Apolipoprotein A-I [8] -0.49[9] -0.07[10] -1.69[11] -7.17[12] -7.51[13] 0.15[14]
3 APOA5 Apolipoprotein A-V [15] 1.10[16] 1.95[17] 0.82[18] -5.37[19] -4.27[20] 3.47[21]
4 LCAT Phosphatidylcholine-sterol acyltransferase [22] -0.28[23] 1.00[24] -1.48[25] 0.33[26] 1.75[27] 0.81[28]
5 DGAT2 Diacylglycerol O-acyltransferase 2 [29] 3.08[30] 1.35[31] 1.47[32] 2.36[33] 3.52[34] 1.78[35]
6 LIPC Hepatic triacylglycerol lipase [36] 1.56[37] 0.82[38] 3.83[39] -2.50[40] -3.24[41] 0.98[42]
7 APOA4 Apolipoprotein A-IV [43] 1.10[44] 1.99[45] -2.99[46] -5.79[47] -7.41[48] 2.59[49]
8 MTTP Microsomal triglyceride transfer protein large subunit [50] 1.61[51] 4.03[52] 6.02[53] -0.49[54] 0.21[55] 3.14[56]
9 GCKR Glucokinase regulatory protein [57] -0.51[58] 1.45[59] -0.89[60] -1.64[61] 0.70[62] 2.25[63]
10 SEL1L Protein sel-1 homolog 1 [64] 4.07[65] 3.64[66] 4.58[67] 7.85[68] 7.36[69] 4.12[70]
11 LDLR Low-density lipoprotein receptor [71] 3.94[72] 3.92[73] 5.94[74] 5.99[75] 7.00[76] 2.53[77]
12 LRP1 Prolow-density lipoprotein receptor-related protein 1 [78] 7.58[79] 5.01[80] 7.01[81] 9.24[82] 9.03[83] 6.44[84]
13 FAS Tumor necrosis factor receptor superfamily member 6 [85] 2.15[86] 2.07[87] -4.93[88] 5.14[89] 5.48[90] -0.43[91]
14 PLTP Phospholipid transfer protein [92] 5.25[93] 4.23[94] 6.64[95] 3.47[96] 8.07[97] 2.92[98]
15 ACSS1 Acetyl-coenzyme A synthetase 2-like, mitochondrial [99] 6.45[100] 4.19[101] -3.90[102] 3.78[103] 4.22[104] 3.39[105]
16 LMF1 Lipase maturation factor 1 [106] 2.88[107] 2.13[108] 4.31[109] 2.69[110] 3.57[111] 2.24[112]
17 CETP Cholesteryl ester transfer protein [113] 2.83[114] 2.59[115] -4.83[116] 6.99[117] 0.89[118] 1.10[119]
18 GCK Glucokinase [120] -4.21[121] -3.06[122] -5.24[123] -0.04[124] 1.73[125] 3.22[126]
19 LPL Lipoprotein lipase [127] [128] [129] -3.51[130] 7.46[131] 3.64[132] 1.06[133]
20 PDIA2 Protein disulfide-isomerase A2 [134] 7.28[135] 8.63[136] 1.99[137] 4.04[138] 6.52[139] -0.60[140]
21 GPIHBP1 Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 [141] 0.60[142] [143] 3.63[144] 3.48[145] 6.46[146]
22 MIR6886 [147] [148] [149] [150] [151] [152] [153]
[1]
ref_hepatocyte APOA2
Mean 7.33e+03
Standard deviation 9.4e+03
Values 1.6e+03 2e+04 1.5e+04 2.3e+02 92
[2]
HepG2 APOA2
Mean 848
Standard deviation 2.9e+02
Values 1.1e+03 6.5e+02
[3]
HepG2.C3A APOA2
Mean 1.56e+03
Standard deviation 1.1e+02
Values 1.5e+03 1.6e+03
[4]
HuH.7 APOA2
Mean 738
Standard deviation 1.6e+02
Values 9.2e+02 6.4e+02 6.5e+02
[5]
SNU475 APOA2
Mean 1.12
Standard deviation 0.32
Values 1.4 0.9
[6]
THLE APOA2
Mean 1.48
Standard deviation 0.8
Values 2 0.91
[7]
liver APOA2
Mean 2.39e+03
Standard deviation 2.6e+03
Values 1.8e+02 2.2e+02 5.4e+03 3.7e+03
[8]
ref_hepatocyte APOA1
Mean 5.54e+03
Standard deviation 5.9e+03
Values 9e+02 1.5e+04 7.3e+03 4.7e+03 1.6e+02
[9]
HepG2 APOA1
Mean 647
Standard deviation 1.1e+02
Values 7.2e+02 5.7e+02
[10]
HepG2.C3A APOA1
Mean 1.4e+03
Standard deviation 4.2e+02
Values 1.1e+03 1.7e+03
[11]
HuH.7 APOA1
Mean 217
Standard deviation 31
Values 2.3e+02 2.4e+02 1.8e+02
[12]
SNU475 APOA1
Mean 0.596
Standard deviation 0.16
Values 0.71 0.48
[13]
THLE APOA1
Mean 0.598
Standard deviation 0.26
Values 0.78 0.41
[14]
liver APOA1
Mean 3.55e+03
Standard deviation 3.2e+03
Values 7.4e+02 8.6e+02 6.9e+03 5.7e+03
[15]
ref_hepatocyte APOA5
Mean 59
Standard deviation 65
Values 14 1e+02 1.5e+02 27 0.62
[16]
HepG2 APOA5
Mean 20.8
Standard deviation 0.15
Values 21 21
[17]
HepG2.C3A APOA5
Mean 60.4
Standard deviation 19
Values 47 74
[18]
HuH.7 APOA5
Mean 13.1
Standard deviation 8.4
Values 9.7 23 7
[19]
SNU475 APOA5
Mean 0.0222
Standard deviation 0.012
Values 0.03 0.014
[20]
THLE APOA5
Mean 0.0603
Standard deviation 0.04
Values 0.089 0.032
[21]
liver APOA5
Mean 379
Standard deviation 1.6e+02
Values 3.5e+02 2.1e+02 3.7e+02 5.9e+02
[22]
ref_hepatocyte LCAT
Mean 41.5
Standard deviation 53
Values 9.2 1.2e+02 72 6 0.26
[23]
HepG2 LCAT
Mean 5.64
Standard deviation 1.4
Values 6.6 4.7
[24]
HepG2.C3A LCAT
Mean 22.1
Standard deviation 4.3
Values 19 25
[25]
HuH.7 LCAT
Mean 1.88
Standard deviation 0.21
Values 1.8 2.1 1.7
[26]
SNU475 LCAT
Mean 0.81
Standard deviation 0.048
Values 0.78 0.84
[27]
THLE LCAT
Mean 2.75
Standard deviation 1.3
Values 3.7 1.8
[28]
liver LCAT
Mean 42
Standard deviation 38
Values 18 8.9 94 46
[29]
ref_hepatocyte DGAT2
Mean 37.5
Standard deviation 34
Values 30 92 44 8 14
[30]
HepG2 DGAT2
Mean 52.1
Standard deviation 17
Values 64 40
[31]
HepG2.C3A DGAT2
Mean 25.5
Standard deviation 7.2
Values 31 20
[32]
HuH.7 DGAT2
Mean 13.1
Standard deviation 1.5
Values 12 15 12
[33]
SNU475 DGAT2
Mean 3
Standard deviation 1.1
Values 3.8 2.2
[34]
THLE DGAT2
Mean 8.53
Standard deviation 0.85
Values 7.9 9.1
[35]
liver DGAT2
Mean 74.5
Standard deviation 63
Values 65 23 1.6e+02 45
[36]
ref_hepatocyte LIPC
Mean 37.4
Standard deviation 43
Values 4 1.1e+02 52 16 9.2
[37]
HepG2 LIPC
Mean 18.2
Standard deviation 4
Values 21 15
[38]
HepG2.C3A LIPC
Mean 17.6
Standard deviation 9.2
Values 11 24
[39]
HuH.7 LIPC
Mean 67.2
Standard deviation 17
Values 61 86 55
[40]
SNU475 LIPC
Mean 0.103
Standard deviation 0.027
Values 0.12 0.083
[41]
THLE LIPC
Mean 0.0784
Standard deviation 0.002
Values 0.077 0.08
[42]
liver LIPC
Mean 42.7
Standard deviation 5.7
Values 36 44 40 50
[43]
ref_hepatocyte APOA4
Mean 25.6
Standard deviation 28
Values 28 8.8 74 11 5.3
[44]
HepG2 APOA4
Mean 9
Standard deviation 5.6
Values 5 13
[45]
HepG2.C3A APOA4
Mean 27
Standard deviation 5.6
Values 23 31
[46]
HuH.7 APOA4
Mean 0.405
Standard deviation 0.074
Values 0.41 0.47 0.33
[47]
SNU475 APOA4
Mean 0.00717
Standard deviation 0.003
Values 0.0051 0.0093
[48]
THLE APOA4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[49]
liver APOA4
Mean 89
Standard deviation 1.1e+02
Values 44 21 2.5e+02 39
[50]
ref_hepatocyte MTTP
Mean 24.5
Standard deviation 20
Values 0.63 44 29 43 6.3
[51]
HepG2 MTTP
Mean 12.3
Standard deviation 2.3
Values 14 11
[52]
HepG2.C3A MTTP
Mean 106
Standard deviation 10
Values 1.1e+02 99
[53]
HuH.7 MTTP
Mean 201
Standard deviation 24
Values 1.8e+02 2.3e+02 1.9e+02
[54]
SNU475 MTTP
Mean 0.27
Standard deviation 0.034
Values 0.29 0.25
[55]
THLE MTTP
Mean 0.56
Standard deviation 0.15
Values 0.67 0.45
[56]
liver MTTP
Mean 125
Standard deviation 22
Values 1.5e+02 1.3e+02 1.3e+02 95
[57]
ref_hepatocyte GCKR
Mean 17.6
Standard deviation 16
Values 13 29 39 4.2 3.1
[58]
HepG2 GCKR
Mean 2.03
Standard deviation 0.6
Values 1.6 2.5
[59]
HepG2.C3A GCKR
Mean 12.8
Standard deviation 7.2
Values 7.7 18
[60]
HuH.7 GCKR
Mean 1.2
Standard deviation 0.91
Values 0.85 2.2 0.52
[61]
SNU475 GCKR
Mean 0.0876
Standard deviation 0.091
Values 0.15 0.023
[62]
THLE GCKR
Mean 0.564
Standard deviation 0.11
Values 0.64 0.49
[63]
liver GCKR
Mean 48.3
Standard deviation 16
Values 31 41 56 66
[64]
ref_hepatocyte SEL1L
Mean 15.3
Standard deviation 6
Values 14 17 23 6.6 15
[65]
HepG2 SEL1L
Mean 42.2
Standard deviation 13
Values 51 33
[66]
HepG2.C3A SEL1L
Mean 50.8
Standard deviation 5.2
Values 54 47
[67]
HuH.7 SEL1L
Mean 46.1
Standard deviation 17
Values 30 64 45
[68]
SNU475 SEL1L
Mean 54.8
Standard deviation 20
Values 40 69
[69]
THLE SEL1L
Mean 49.6
Standard deviation 0.3
Values 49 50
[70]
liver SEL1L
Mean 154
Standard deviation 39
Values 1.7e+02 2e+02 1.1e+02 1.4e+02
[71]
ref_hepatocyte LDLR
Mean 13.7
Standard deviation 8.6
Values 27 4.3 16 7.7 14
[72]
HepG2 LDLR
Mean 34.6
Standard deviation 16
Values 23 46
[73]
HepG2.C3A LDLR
Mean 55.1
Standard deviation 38
Values 29 82
[74]
HuH.7 LDLR
Mean 106
Standard deviation 31
Values 78 1.4e+02 1e+02
[75]
SNU475 LDLR
Mean 13.5
Standard deviation 6.6
Values 8.9 18
[76]
THLE LDLR
Mean 34.7
Standard deviation 13
Values 25 44
[77]
liver LDLR
Mean 45.8
Standard deviation 27
Values 84 24 45 30
[78]
ref_hepatocyte LRP1
Mean 12.6
Standard deviation 14
Values 1.8 29 26 4.1 2.3
[79]
HepG2 LRP1
Mean 396
Standard deviation 1.6e+02
Values 2.8e+02 5.1e+02
[80]
HepG2.C3A LRP1
Mean 108
Standard deviation 18
Values 95 1.2e+02
[81]
HuH.7 LRP1
Mean 204
Standard deviation 59
Values 1.4e+02 2.4e+02 2.4e+02
[82]
SNU475 LRP1
Mean 118
Standard deviation 49
Values 83 1.5e+02
[83]
THLE LRP1
Mean 130
Standard deviation 35
Values 1.1e+02 1.6e+02
[84]
liver LRP1
Mean 635
Standard deviation 3.6e+02
Values 1e+03 8.3e+02 3.4e+02 3.3e+02
[85]
ref_hepatocyte FAS
Mean 10.9
Standard deviation 10
Values 13 3.1 5 5.6 28
[86]
HepG2 FAS
Mean 7.93
Standard deviation 5
Values 11 4.4
[87]
HepG2.C3A FAS
Mean 12.1
Standard deviation 8.5
Values 18 6.1
[88]
HuH.7 FAS
Mean 0.0451
Standard deviation 0.028
Values 0.075 0.019 0.041
[89]
SNU475 FAS
Mean 5.96
Standard deviation 1.8
Values 7.2 4.7
[90]
THLE FAS
Mean 9.58
Standard deviation 1.5
Values 11 8.5
[91]
liver FAS
Mean 4.68
Standard deviation 1.2
Values 3.7 4.1 6.4 4.5
[92]
ref_hepatocyte PLTP
Mean 3.71
Standard deviation 2
Values 4.1 5.1 5.3 3.6 0.39
[93]
HepG2 PLTP
Mean 23.2
Standard deviation 9.5
Values 17 30
[94]
HepG2.C3A PLTP
Mean 18.5
Standard deviation 5
Values 15 22
[95]
HuH.7 PLTP
Mean 46.5
Standard deviation 9.6
Values 46 37 57
[96]
SNU475 PLTP
Mean 0.639
Standard deviation 0.45
Values 0.96 0.32
[97]
THLE PLTP
Mean 19.7
Standard deviation 1.5
Values 21 19
[98]
liver PLTP
Mean 16.2
Standard deviation 5.3
Values 21 8.7 17 19
[99]
ref_hepatocyte ACSS1
Mean 3.12
Standard deviation 4.7
Values 1.2 1.4 1.4 11 0.2
[100]
HepG2 ACSS1
Mean 44.9
Standard deviation 0.52
Values 45 45
[101]
HepG2.C3A ACSS1
Mean 15.1
Standard deviation 1.4
Values 14 16
[102]
HuH.7 ACSS1
Mean 0.0263
Standard deviation 0.013
Values 0.019 0.019 0.041
[103]
SNU475 ACSS1
Mean 0.664
Standard deviation 0.15
Values 0.56 0.77
[104]
THLE ACSS1
Mean 1.15
Standard deviation 0.53
Values 1.5 0.77
[105]
liver ACSS1
Mean 18.9
Standard deviation 24
Values 56 5.8 7.8 6.5
[106]
ref_hepatocyte LMF1
Mean 2.34
Standard deviation 1.9
Values 0.7 4.6 4.3 0.63 1.5
[107]
HepG2 LMF1
Mean 2.83
Standard deviation 1
Values 2.1 3.5
[108]
HepG2.C3A LMF1
Mean 2.72
Standard deviation 2.3
Values 1.1 4.4
[109]
HuH.7 LMF1
Mean 5.84
Standard deviation 1.1
Values 5 5.4 7.1
[110]
SNU475 LMF1
Mean 0.234
Standard deviation 0.19
Values 0.1 0.37
[111]
THLE LMF1
Mean 0.547
Standard deviation 0.089
Values 0.61 0.48
[112]
liver LMF1
Mean 6.38
Standard deviation 2.5
Values 5.4 3.6 9.7 6.8
[113]
ref_hepatocyte CETP
Mean 1.89
Standard deviation 2.7
Values 0 6.1 3.2 0.14 0
[114]
HepG2 CETP
Mean 2.21
Standard deviation 1.2
Values 1.4 3.1
[115]
HepG2.C3A CETP
Mean 3.02
Standard deviation 1.9
Values 1.7 4.4
[116]
HuH.7 CETP
Mean 0.00839
Standard deviation 0.0095
Values 0.019 0.0064 0
[117]
SNU475 CETP
Mean 3.72
Standard deviation 1.8
Values 5 2.4
[118]
THLE CETP
Mean 0.0692
Standard deviation 0.023
Values 0.053 0.085
[119]
liver CETP
Mean 2.35
Standard deviation 1.5
Values 0.85 1.4 2.9 4.2
[120]
ref_hepatocyte GCK
Mean 0.642
Standard deviation 1.1
Values 0 2.5 0.7 0 0
[121]
HepG2 GCK
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[122]
HepG2.C3A GCK
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[123]
HuH.7 GCK
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[124]
SNU475 GCK
Mean 0.00971
Standard deviation 0.00061
Values 0.01 0.0093
[125]
THLE GCK
Mean 0.042
Standard deviation 0.00081
Values 0.041 0.043
[126]
liver GCK
Mean 3.47
Standard deviation 6.5
Values 0.38 0.17 13 0.13
[127]
ref_hepatocyte LPL
Mean 0.193
Standard deviation 0.37
Values 0.86 0 0.043 0 0.065
[128]
HepG2 LPL
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A LPL
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 LPL
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[131]
SNU475 LPL
Mean 0.525
Standard deviation 0.3
Values 0.74 0.31
[132]
THLE LPL
Mean 0.0473
Standard deviation 0.0083
Values 0.041 0.053
[133]
liver LPL
Mean 0.233
Standard deviation 0.16
Values 0.44 0.057 0.28 0.15
[134]
ref_hepatocyte PDIA2
Mean 0.0273
Standard deviation 0.061
Values 0 0 0 0.14 0
[135]
HepG2 PDIA2
Mean 0.7
Standard deviation 0.49
Values 0.36 1
[136]
HepG2.C3A PDIA2
Mean 2.87
Standard deviation 1.9
Values 1.5 4.2
[137]
HuH.7 PDIA2
Mean 0.0137
Standard deviation 0.014
Values 0.028 0.013 0
[138]
SNU475 PDIA2
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[139]
THLE PDIA2
Mean 0.0494
Standard deviation 0.047
Values 0.083 0.016
[140]
liver PDIA2
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0
[141]
ref_hepatocyte GPIHBP1
Mean 0.0121
Standard deviation 0.027
Values 0 0 0.06 0 0
[142]
HepG2 GPIHBP1
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A GPIHBP1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[144]
HuH.7 GPIHBP1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 GPIHBP1
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[146]
THLE GPIHBP1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[147]
liver GPIHBP1
Mean 0.614
Standard deviation 0.21
Values 0.5 0.6 0.92 0.44
[148]
ref_hepatocyte MIR6886
Missing
[149]
HepG2 MIR6886
Missing
[150]
HepG2.C3A MIR6886
Missing
[151]
HuH.7 MIR6886
Missing
[152]
SNU475 MIR6886
Missing
[153]
THLE MIR6886
Missing
[154]
liver MIR6886
Missing