WP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -10.82[2] -11.23[3] -8.14[4] -12.76[5] -11.29[6] 0.01[7]
2 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [8] 2.75[9] 2.15[10] 2.58[11] 3.13[12] 3.55[13] -0.78[14]
3 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [15] 3.73[16] 3.14[17] 3.86[18] 2.83[19] 3.23[20] -1.29[21]
4 NFE2L2 Nuclear factor erythroid 2-related factor 2 [22] 4.44[23] 5.11[24] 4.56[25] 4.13[26] 4.28[27] 0.58[28]
5 MAFF Transcription factor MafF [29] 2.73[30] 3.22[31] 3.13[32] 1.04[33] 3.51[34] -2.60[35]
6 MAPK8 Mitogen-activated protein kinase 8 [36] 2.23[37] 3.38[38] 2.10[39] 2.77[40] 2.54[41] -0.10[42]
7 MAFK Transcription factor MafK [43] 4.04[44] 3.20[45] 2.55[46] 2.09[47] 2.96[48] -1.74[49]
8 MAFG Transcription factor MafG [50] 5.89[51] 5.73[52] 4.77[53] 6.64[54] 5.54[55] 1.08[56]
9 SP1 Transcription factor Sp1 [57] 5.49[58] 5.47[59] 6.39[60] 6.34[61] 5.94[62] 2.57[63]
10 PRKCQ Protein kinase C theta type [64] 4.58[65] 0.76[66] [67] 5.80[68] 7.21[69] 2.50[70]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 90 4.1e+03 2.7e+03 0 4.6
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.06 0.21
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0 0.21
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.99 1.3 0.67
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.025 0.032
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 6.9e+02 1e+03 2.6e+03 1.7e+03
[8]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[9]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[10]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[11]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[12]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[13]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[14]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[15]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[16]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[17]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[18]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[19]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[20]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[21]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[22]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[23]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[24]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[25]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[26]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[27]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[28]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[29]
ref_hepatocyte MAFF
Mean 8.23
Standard deviation 13
Values 31 0.54 5.2 1.8 2.7
[30]
HepG2 MAFF
Mean 9.43
Standard deviation 6.1
Values 5.1 14
[31]
HepG2.C3A MAFF
Mean 14.1
Standard deviation 11
Values 6.7 22
[32]
HuH.7 MAFF
Mean 14.2
Standard deviation 3.3
Values 14 18 11
[33]
SNU475 MAFF
Mean 2.45
Standard deviation 1.4
Values 3.4 1.5
[34]
THLE MAFF
Mean 16.2
Standard deviation 0.39
Values 16 16
[35]
liver MAFF
Mean 1.44
Standard deviation 0.045
Values 1.5 1.5 1.4 1.4
[36]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 15 4.7 3.8 6.5 5.6
[37]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 6.5 5.1
[38]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 17 11
[39]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 5.2 6.2 6.5
[40]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 6.6 7.3
[41]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[42]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.6 7.8 7.3 5.6
[43]
ref_hepatocyte MAFK
Mean 6.99
Standard deviation 6
Values 17 0.9 3.6 6.1 7.7
[44]
HepG2 MAFK
Mean 19.8
Standard deviation 11
Values 12 28
[45]
HepG2.C3A MAFK
Mean 11.9
Standard deviation 6.7
Values 7.1 17
[46]
HuH.7 MAFK
Mean 8.06
Standard deviation 2.2
Values 6.6 11 7.1
[47]
SNU475 MAFK
Mean 4.3
Standard deviation 0.066
Values 4.3 4.3
[48]
THLE MAFK
Mean 9.37
Standard deviation 1.2
Values 8.5 10
[49]
liver MAFK
Mean 2.24
Standard deviation 2.1
Values 4.3 3.8 0.56 0.28
[50]
ref_hepatocyte MAFG
Mean 3.89
Standard deviation 2.8
Values 4.9 0.46 1.5 6.4 6.2
[51]
HepG2 MAFG
Mean 40.1
Standard deviation 17
Values 28 52
[52]
HepG2.C3A MAFG
Mean 38.2
Standard deviation 11
Values 30 46
[53]
HuH.7 MAFG
Mean 21
Standard deviation 4.1
Values 20 26 18
[54]
SNU475 MAFG
Mean 55.9
Standard deviation 10
Values 49 63
[55]
THLE MAFG
Mean 31.1
Standard deviation 0.12
Values 31 31
[56]
liver MAFG
Mean 8.79
Standard deviation 2.6
Values 11 11 6.3 6.8
[57]
ref_hepatocyte SP1
Mean 3.57
Standard deviation 0.42
Values 4.3 3.6 3.5 3.2 3.3
[58]
HepG2 SP1
Mean 27.8
Standard deviation 1
Values 29 27
[59]
HepG2.C3A SP1
Mean 29.3
Standard deviation 0.25
Values 29 29
[60]
HuH.7 SP1
Mean 58.8
Standard deviation 12
Values 46 59 71
[61]
SNU475 SP1
Mean 41.7
Standard deviation 2.6
Values 40 44
[62]
THLE SP1
Mean 37.5
Standard deviation 7.4
Values 32 43
[63]
liver SP1
Mean 22.6
Standard deviation 13
Values 36 31 14 9.1
[64]
ref_hepatocyte PRKCQ
Mean 0.0639
Standard deviation 0.072
Values 0 0.16 0.043 0 0.11
[65]
HepG2 PRKCQ
Mean 0.264
Standard deviation 0.11
Values 0.18 0.34
[66]
HepG2.C3A PRKCQ
Mean 0.0199
Standard deviation 0.013
Values 0.011 0.029
[67]
HuH.7 PRKCQ
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 PRKCQ
Mean 0.513
Standard deviation 0.44
Values 0.83 0.2
[69]
THLE PRKCQ
Mean 1.63
Standard deviation 0.3
Values 1.8 1.4
[70]
liver PRKCQ
Mean 0.386
Standard deviation 0.17
Values 0.54 0.3 0.19 0.51