WP_ESTROGEN_SIGNALING_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0.18[1] 0.22[2] 0.08[3] 0.38[4] -0.09[5] -0.93[6]
2 JUN Transcription factor AP-1 [7] -0.73[8] -2.28[9] -1.80[10] -2.17[11] -1.31[12] -1.40[13]
3 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [14] 0.77[15] 0.79[16] 0.51[17] 0.82[18] 0.90[19] -0.83[20]
4 FOS Proto-oncogene c-Fos [21] -6.26[22] -4.99[23] -5.46[24] -6.63[25] -5.28[26] -0.90[27]
5 AKT1 RAC-alpha serine/threonine-protein kinase [28] -0.16[29] -0.40[30] -1.27[31] -0.52[32] -0.21[33] 0.16[34]
6 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [35] -1.17[36] -1.50[37] -0.72[38] -1.01[39] -0.21[40] -0.79[41]
7 IKBKG NF-kappa-B essential modulator [42] -1.13[43] -0.99[44] -3.03[45] -1.31[46] -2.24[47] -0.20[48]
8 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [49] -0.41[50] -0.58[51] -0.38[52] -0.93[53] -0.06[54] -0.38[55]
9 MAPK1 Mitogen-activated protein kinase 1 [56] 1.46[57] 1.60[58] 1.63[59] 1.38[60] 1.32[61] 2.18[62]
10 MAPK14 Mitogen-activated protein kinase 14 [63] 1.23[64] 1.30[65] 1.08[66] 1.22[67] 0.98[68] 1.69[69]
11 ELK1 ETS domain-containing protein Elk-1 [70] -0.56[71] -2.69[72] -0.07[73] -0.19[74] 0.68[75] 0.24[76]
12 NFKB1 Nuclear factor NF-kappa-B p105 subunit [77] 0.43[78] 0.10[79] 0.09[80] -0.71[81] 0.48[82] 0.86[83]
13 MAPK9 Mitogen-activated protein kinase 9 [84] 0.98[85] 1.21[86] 1.47[87] 1.25[88] 0.99[89] 0.91[90]
14 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [91] 0.66[92] 1.88[93] 2.04[94] 0.19[95] 1.29[96] 1.92[97]
15 SP1 Transcription factor Sp1 [98] 1.58[99] 1.82[100] 3.09[101] 2.21[102] 2.18[103] 2.56[104]
16 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [105] 0.28[106] 0.34[107] 0.64[108] -0.21[109] 0.17[110] 1.59[111]
17 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.62[112] 1.01[113] 1.40[114] 0.66[115] 1.15[116] 2.32[117]
18 CREB1 Cyclic AMP-responsive element-binding protein 1 [118] 1.48[119] 2.64[120] 3.33[121] 2.08[122] 2.31[123] 2.75[124]
19 ESR1 Estrogen receptor [125] -7.55[126] [127] -5.83[128] -4.63[129] -6.61[130] 2.80[131]
20 BRAF Serine/threonine-protein kinase B-raf [132] 0.00[133] -0.27[134] 1.97[135] 0.28[136] 0.26[137] 2.26[138]
21 BCL2 Apoptosis regulator Bcl-2 [139] -3.10[140] 2.31[141] -4.90[142] 1.31[143] 1.31[144] 3.64[145]
22 GPER1 G-protein coupled estrogen receptor 1 [146] [147] [148] [149] [150] [151] [152]
23 GNGT1 Guanine nucleotide-binding protein G(T) subunit gamma-T1 [153] [154] [155] [156] [157] [158] [159]
[1]
ref_hepatocyte GNAS
Mean 120
Standard deviation 56
Values 61 1.7e+02 1.7e+02 1.4e+02 60
[2]
HepG2 GNAS
Mean 357
Standard deviation 65
Values 3.1e+02 4e+02
[3]
HepG2.C3A GNAS
Mean 326
Standard deviation 53
Values 2.9e+02 3.6e+02
[4]
HuH.7 GNAS
Mean 246
Standard deviation 32
Values 2.7e+02 2.1e+02 2.5e+02
[5]
SNU475 GNAS
Mean 397
Standard deviation 89
Values 3.3e+02 4.6e+02
[6]
THLE GNAS
Mean 262
Standard deviation 20
Values 2.5e+02 2.8e+02
[7]
liver GNAS
Mean 67.5
Standard deviation 15
Values 56 54 84 76
[8]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 66 20 73 26 30
[9]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 42 93
[10]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 13 28
[11]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 14 46 11
[12]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 27 21
[13]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[14]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 12 24 25 8.4
[15]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 53 24 31 44 60
[16]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 1.8e+02 2e+02
[17]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[18]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.2e+02 93 1.4e+02
[19]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 1.8e+02 2e+02
[20]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[21]
liver GNB1
Mean 25.7
Standard deviation 5
Values 27 25 31 19
[22]
ref_hepatocyte FOS
Mean 40
Standard deviation 67
Values 9 27 1.6e+02 4 0.65
[23]
HepG2 FOS
Mean 1.37
Standard deviation 1
Values 0.66 2.1
[24]
HepG2.C3A FOS
Mean 2.92
Standard deviation 1.9
Values 1.6 4.3
[25]
HuH.7 FOS
Mean 1.77
Standard deviation 0.38
Values 2.2 1.6 1.5
[26]
SNU475 FOS
Mean 1.02
Standard deviation 0.13
Values 1.1 0.93
[27]
THLE FOS
Mean 2.4
Standard deviation 0.3
Values 2.2 2.6
[28]
liver FOS
Mean 23
Standard deviation 32
Values 5.7 4.8 71 10
[29]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[30]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[31]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[32]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[33]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[34]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[35]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[36]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[37]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[38]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[39]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[40]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[41]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[42]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[43]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 37 10 24 7.4 36
[44]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 23 31
[45]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 24 30
[46]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 6.7 4.1 5.4
[47]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 26 21
[48]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[49]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 13 22 20 29
[50]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 11 23 27 7.6 11
[51]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 33 29
[52]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 22 27
[53]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[54]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 19 23
[55]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[56]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 8.9 8.8 18 16
[57]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[58]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[59]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[60]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[61]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[62]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[63]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[64]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 7.2 8.3 7.5 12 8.5
[65]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 60 47
[66]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[67]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 34 36 37
[68]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 51 52
[69]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[70]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 37 38 24 22
[71]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 7.5 4.4 8.5 1.7 12
[72]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 11 13
[73]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 1.9 3
[74]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 13 11 14
[75]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[76]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[77]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 7.1 6 10 11
[78]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 12 4.7 5.3 3 6.7
[79]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 26 18
[80]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 17 15
[81]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 13 12 14
[82]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 10 9.6
[83]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[84]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 17 15 9.7 7.2
[85]
ref_hepatocyte MAPK9
Mean 4.45
Standard deviation 2.7
Values 1.4 3.3 3.7 8.6 5.3
[86]
HepG2 MAPK9
Mean 23
Standard deviation 4.4
Values 26 20
[87]
HepG2.C3A MAPK9
Mean 24
Standard deviation 3.3
Values 26 22
[88]
HuH.7 MAPK9
Mean 24
Standard deviation 2.9
Values 25 21 26
[89]
SNU475 MAPK9
Mean 26.8
Standard deviation 2.4
Values 25 29
[90]
THLE MAPK9
Mean 20.6
Standard deviation 0.2
Values 21 21
[91]
liver MAPK9
Mean 9.01
Standard deviation 3.1
Values 11 12 7.1 5.7
[92]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 2.3 4.1 3.4 4.2 5.7
[93]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 21 12
[94]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 43 25
[95]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 32 28 34
[96]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 12 11
[97]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[98]
liver CHUK
Mean 16
Standard deviation 3.3
Values 15 21 13 15
[99]
ref_hepatocyte SP1
Mean 3.57
Standard deviation 0.42
Values 4.3 3.6 3.5 3.2 3.3
[100]
HepG2 SP1
Mean 27.8
Standard deviation 1
Values 29 27
[101]
HepG2.C3A SP1
Mean 29.3
Standard deviation 0.25
Values 29 29
[102]
HuH.7 SP1
Mean 58.8
Standard deviation 12
Values 46 59 71
[103]
SNU475 SP1
Mean 41.7
Standard deviation 2.6
Values 40 44
[104]
THLE SP1
Mean 37.5
Standard deviation 7.4
Values 32 43
[105]
liver SP1
Mean 22.6
Standard deviation 13
Values 36 31 14 9.1
[106]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 4.2 2.5 3.5 2.9 4.3
[107]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[108]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 9.5 11
[109]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 12 8.4 11
[110]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 6.4 8.9
[111]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[112]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 12 11 11 11
[113]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[114]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[115]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[116]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[117]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[118]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[119]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[120]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 1.5 0.81 0.96 3.7 2.1
[121]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 15 11
[122]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 28 24
[123]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 31 36 38
[124]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[125]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[126]
liver CREB1
Mean 13
Standard deviation 3.1
Values 15 16 12 9.3
[127]
ref_hepatocyte ESR1
Mean 1.54
Standard deviation 2.3
Values 0 5.3 2.2 0 0.17
[128]
HepG2 ESR1
Mean 0.0215
Standard deviation 0.018
Values 0.0086 0.034
[129]
HepG2.C3A ESR1
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 ESR1
Mean 0.0525
Standard deviation 0.047
Values 0.019 0.032 0.11
[131]
SNU475 ESR1
Mean 0.157
Standard deviation 0.14
Values 0.25 0.06
[132]
THLE ESR1
Mean 0.0367
Standard deviation 0.0067
Values 0.041 0.032
[133]
liver ESR1
Mean 11.5
Standard deviation 7
Values 22 11 7.2 6.1
[134]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 2.3 0.67 0.67 0.56 1.2
[135]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 3.2 2.4
[136]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 2.5 1.6
[137]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 3.4 15 6.4
[138]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.4 3.2
[139]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[140]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 7.9 8 3.1 2.9
[141]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.15 0.2 0.12 0.019 0
[142]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.026 0.034
[143]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 0.99 1.3
[144]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[145]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.68 0.55
[146]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[147]
liver BCL2
Mean 1.31
Standard deviation 1
Values 2.5 1.8 0.49 0.49
[148]
ref_hepatocyte GPER1
Missing
[149]
HepG2 GPER1
Missing
[150]
HepG2.C3A GPER1
Missing
[151]
HuH.7 GPER1
Missing
[152]
SNU475 GPER1
Missing
[153]
THLE GPER1
Missing
[154]
liver GPER1
Missing
[155]
ref_hepatocyte GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 GNGT1
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A GNGT1
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 GNGT1
Mean 0.0409
Standard deviation 0.035
Values 0.037 0.077 0.0082
[159]
SNU475 GNGT1
Mean 0.0679
Standard deviation 0.0043
Values 0.071 0.065
[160]
THLE GNGT1
Mean 0
Standard deviation 0
Values 0 0
[161]
liver GNGT1
Mean 0
Standard deviation 0
Values 0 0 0 0