WP_ESTROGEN_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GSTA1 Glutathione S-transferase A1 [1] -3.65[2] -7.30[3] -0.71[4] -7.10[5] -9.30[6] -2.78[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -9.76[9] -9.76[10] -11.09[11] -15.59[12] -11.43[13] 1.57[14]
3 UGT1A6 UDP-glucuronosyltransferase 1-6 [15] -6.85[16] -14.46[17] -8.19[18] -6.94[19] -10.16[20] -3.05[21]
4 UGT2B7 UDP-glucuronosyltransferase 2B7 [22] -1.36[23] -1.08[24] -6.17[25] -11.39[26] -10.34[27] 0.32[28]
5 SULT1A1 Sulfotransferase 1A1 [29] 0.48[30] 1.25[31] -1.85[32] -2.67[33] 0.02[34] -1.32[35]
6 CYP1A2 Cytochrome P450 1A2 [36] -8.94[37] -7.51[38] -7.79[39] -9.15[40] -6.96[41] -0.81[42]
7 UGT1A1 UDP-glucuronosyltransferase 1-1 [43] -4.38[44] -10.51[45] -4.97[46] -1.41[47] -8.80[48] 0.79[49]
8 CYP1A1 Cytochrome P450 1A1 [50] -2.48[51] -3.94[52] 0.10[53] -4.56[54] -2.48[55] -4.96[56]
9 NQO1 NAD(P)H dehydrogenase [quinone] 1 [57] 4.73[58] 4.55[59] 4.54[60] 5.02[61] 3.80[62] -4.40[63]
10 COMT Catechol O-methyltransferase [64] 1.35[65] 2.08[66] 0.29[67] -0.81[68] 1.86[69] 1.20[70]
11 UGT1A9 UDP-glucuronosyltransferase 1-9 [71] -5.73[72] -10.47[73] -6.28[74] -5.75[75] -8.39[76] 0.20[77]
12 ARSD Arylsulfatase D [78] 1.79[79] 1.21[80] 3.21[81] 1.29[82] 1.89[83] 2.92[84]
13 UGT1A3 UDP-glucuronosyltransferase 1-3 [85] -0.98[86] [87] -7.13[88] -5.49[89] -7.98[90] 2.08[91]
14 SULT1E1 Estrogen sulfotransferase [92] -0.88[93] 1.92[94] 2.78[95] -7.26[96] 4.06[97] 1.92[98]
15 CYP1B1 Cytochrome P450 1B1 [99] -5.07[100] -4.37[101] 0.12[102] 2.44[103] 7.66[104] 1.85[105]
16 STS Steryl-sulfatase [106] 2.13[107] 1.73[108] 3.29[109] 0.36[110] 5.15[111] 2.95[112]
17 GSTM1 Glutathione S-transferase Mu 1 [113] -0.33[114] -1.48[115] 5.05[116] 5.02[117] -0.77[118] 7.39[119]
18 ARSL [120] [121] [122] [123] [124] [125] [126]
19 MIR4761 [127] [128] [129] [130] [131] [132] [133]
[1]
ref_hepatocyte GSTA1
Mean 456
Standard deviation 5.8e+02
Values 8.4 1.4e+03 4.8e+02 1.3e+02 2.2e+02
[2]
HepG2 GSTA1
Mean 20.3
Standard deviation 5.9
Values 24 16
[3]
HepG2.C3A GSTA1
Mean 1.31
Standard deviation 0.69
Values 1.8 0.83
[4]
HuH.7 GSTA1
Mean 93.3
Standard deviation 39
Values 1.3e+02 53 95
[5]
SNU475 GSTA1
Mean 3.21
Standard deviation 3.3
Values 0.88 5.5
[6]
THLE GSTA1
Mean 0.127
Standard deviation 0.11
Values 0.21 0.048
[7]
liver GSTA1
Mean 52.8
Standard deviation 52
Values 6.8 29 48 1.3e+02
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[15]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 11 5.9e+02 4.3e+02 0.45 1.7e+02
[16]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 0.56 1.8
[17]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[18]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.14 0.65 0.041
[19]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 1.8 2
[20]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[21]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 8.2 34 9 42
[22]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 5.3 4.3e+02 1.6e+02 3.3 8.1
[23]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 20 33
[24]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 35 17
[25]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.34 1.1 0.3
[26]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.051 0.037
[27]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[28]
liver UGT2B7
Mean 121
Standard deviation 61
Values 61 77 1.7e+02 1.7e+02
[29]
ref_hepatocyte SULT1A1
Mean 97.6
Standard deviation 1.2e+02
Values 6 3e+02 1.2e+02 27 33
[30]
HepG2 SULT1A1
Mean 76.1
Standard deviation 9
Values 70 82
[31]
HepG2.C3A SULT1A1
Mean 105
Standard deviation 7.6
Values 1e+02 1.1e+02
[32]
HuH.7 SULT1A1
Mean 9.1
Standard deviation 2.4
Values 12 6.8 8.9
[33]
SNU475 SULT1A1
Mean 14.8
Standard deviation 8.6
Values 8.8 21
[34]
THLE SULT1A1
Mean 17.4
Standard deviation 0.098
Values 17 17
[35]
liver SULT1A1
Mean 31.2
Standard deviation 17
Values 17 16 44 47
[36]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.97 3e+02 71 0.4 18
[37]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.13 0.052
[38]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.15 0.24
[39]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.15 0.1 0.11
[40]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.2 0.07
[41]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[42]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 19 12 55 58
[43]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 15 96 2.1e+02 0.52 12
[44]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.7 1.9
[45]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[46]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.31 1.3 0.57
[47]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 9.8 39
[48]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[49]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 34 83 1.1e+02 1.4e+02
[50]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 0.06 82 17 77 43
[51]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 2.6 6.2
[52]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.2 1.4
[53]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 17 17 14
[54]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 3.1 0.49
[55]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[56]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.8 0.47 1.2 0.92
[57]
ref_hepatocyte NQO1
Mean 42.1
Standard deviation 85
Values 1.6 0.37 1.4 1.9e+02 13
[58]
HepG2 NQO1
Mean 625
Standard deviation 2.7e+02
Values 4.3e+02 8.1e+02
[59]
HepG2.C3A NQO1
Mean 447
Standard deviation 1.2e+02
Values 5.3e+02 3.6e+02
[60]
HuH.7 NQO1
Mean 329
Standard deviation 90
Values 4e+02 2.3e+02 3.5e+02
[61]
SNU475 NQO1
Mean 1.32e+03
Standard deviation 2.1e+02
Values 1.2e+03 1.5e+03
[62]
THLE NQO1
Mean 103
Standard deviation 3.8
Values 1.1e+02 1e+02
[63]
liver NQO1
Mean 1.58
Standard deviation 1.1
Values 0.97 1.8 0.49 3.1
[64]
ref_hepatocyte COMT
Mean 41.6
Standard deviation 29
Values 14 83 61 24 25
[65]
HepG2 COMT
Mean 59.3
Standard deviation 6.8
Values 55 64
[66]
HepG2.C3A COMT
Mean 80
Standard deviation 0.37
Values 80 80
[67]
HuH.7 COMT
Mean 17.1
Standard deviation 2.6
Values 19 18 14
[68]
SNU475 COMT
Mean 22.9
Standard deviation 4.5
Values 20 26
[69]
THLE COMT
Mean 26.6
Standard deviation 0.81
Values 26 27
[70]
liver COMT
Mean 76.3
Standard deviation 82
Values 20 20 1.9e+02 71
[71]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 2.6 27 26 0 21
[72]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.12 0.2
[73]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[74]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.0094 0.12 0.066
[75]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.03 0.51
[76]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[77]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 3 22 8.7 22
[78]
ref_hepatocyte ARSD
Mean 4.64
Standard deviation 4.4
Values 2.2 11 6.8 2 0.92
[79]
HepG2 ARSD
Mean 8.98
Standard deviation 0.4
Values 9.3 8.7
[80]
HepG2.C3A ARSD
Mean 4.87
Standard deviation 1.5
Values 3.8 5.9
[81]
HuH.7 ARSD
Mean 14.4
Standard deviation 1.2
Values 13 16 14
[82]
SNU475 ARSD
Mean 11
Standard deviation 1.7
Values 9.8 12
[83]
THLE ARSD
Mean 3.03
Standard deviation 0.034
Values 3 3.1
[84]
liver ARSD
Mean 28
Standard deviation 11
Values 39 21 35 17
[85]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0.37 11 7.9 0 2.3
[86]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.1 1.3
[87]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0094 0.013 0.0082
[89]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.071 0.11
[90]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[91]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 5.8 21 2.5 28
[92]
ref_hepatocyte SULT1E1
Mean 2.69
Standard deviation 3.5
Values 0.15 8.5 3.3 0.8 0.67
[93]
HepG2 SULT1E1
Mean 0.821
Standard deviation 0.16
Values 0.93 0.71
[94]
HepG2.C3A SULT1E1
Mean 4.62
Standard deviation 1.2
Values 5.5 3.8
[95]
HuH.7 SULT1E1
Mean 6.19
Standard deviation 1.8
Values 6.3 7.9 4.4
[96]
SNU475 SULT1E1
Mean 0.0169
Standard deviation 0.0024
Values 0.015 0.019
[97]
THLE SULT1E1
Mean 7.92
Standard deviation 1.1
Values 7.1 8.7
[98]
liver SULT1E1
Mean 8.11
Standard deviation 8.7
Values 4.8 2.4 21 4.2
[99]
ref_hepatocyte CYP1B1
Mean 2.62
Standard deviation 3.2
Values 0.92 1.4 2.7 0.024 8
[100]
HepG2 CYP1B1
Mean 0.0437
Standard deviation 0.019
Values 0.03 0.057
[101]
HepG2.C3A CYP1B1
Mean 0.0575
Standard deviation 0.04
Values 0.086 0.029
[102]
HuH.7 CYP1B1
Mean 0.95
Standard deviation 0.082
Values 0.95 1 0.87
[103]
SNU475 CYP1B1
Mean 13.6
Standard deviation 3.1
Values 11 16
[104]
THLE CYP1B1
Mean 93
Standard deviation 14
Values 1e+02 83
[105]
liver CYP1B1
Mean 7.5
Standard deviation 1.4
Values 6.2 7.4 6.9 9.5
[106]
ref_hepatocyte STS
Mean 1.2
Standard deviation 0.64
Values 1.2 1.8 1.9 0.53 0.62
[107]
HepG2 STS
Mean 2.95
Standard deviation 1.7
Values 4.2 1.7
[108]
HepG2.C3A STS
Mean 1.81
Standard deviation 1.1
Values 2.6 1
[109]
HuH.7 STS
Mean 3.93
Standard deviation 0.79
Values 3.7 3.3 4.8
[110]
SNU475 STS
Mean 1.49
Standard deviation 0.27
Values 1.7 1.3
[111]
THLE STS
Mean 7.51
Standard deviation 0.018
Values 7.5 7.5
[112]
liver STS
Mean 7.39
Standard deviation 1.4
Values 8.9 6.4 8.2 6
[113]
ref_hepatocyte GSTM1
Mean 0.404
Standard deviation 0.25
Values 0 0.36 0.52 0.52 0.62
[114]
HepG2 GSTM1
Mean 0.18
Standard deviation 0.14
Values 0.28 0.08
[115]
HepG2.C3A GSTM1
Mean 0.0657
Standard deviation 0.017
Values 0.054 0.078
[116]
HuH.7 GSTM1
Mean 4.5
Standard deviation 1.1
Values 4.7 3.3 5.5
[117]
SNU475 GSTM1
Mean 12.6
Standard deviation 6.3
Values 8.2 17
[118]
THLE GSTM1
Mean 0.0417
Standard deviation 0.0088
Values 0.035 0.048
[119]
liver GSTM1
Mean 54
Standard deviation 35
Values 38 15 93 70
[120]
ref_hepatocyte ARSL
Missing
[121]
HepG2 ARSL
Missing
[122]
HepG2.C3A ARSL
Missing
[123]
HuH.7 ARSL
Missing
[124]
SNU475 ARSL
Missing
[125]
THLE ARSL
Missing
[126]
liver ARSL
Missing
[127]
ref_hepatocyte MIR4761
Missing
[128]
HepG2 MIR4761
Missing
[129]
HepG2.C3A MIR4761
Missing
[130]
HuH.7 MIR4761
Missing
[131]
SNU475 MIR4761
Missing
[132]
THLE MIR4761
Missing
[133]
liver MIR4761
Missing