WP_ERK_PATHWAY_IN_HUNTINGTONS_DISEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAF1 RAF proto-oncogene serine/threonine-protein kinase [1] -0.69[2] -0.46[3] 0.32[4] -0.98[5] -0.13[6] 0.01[7]
2 CASP3 Caspase-3 [8] -0.50[9] 0.00[10] -3.03[11] -1.69[12] -0.71[13] -1.89[14]
3 HRAS GTPase HRas [15] -1.64[16] -2.52[17] -3.79[18] -1.74[19] -1.98[20] -3.75[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 1.08[23] 1.04[24] 0.39[25] 1.05[26] 0.69[27] 0.69[28]
5 CASP7 Caspase-7 [29] -0.94[30] -1.48[31] -1.52[32] -1.69[33] -1.50[34] -1.57[35]
6 ELK1 ETS domain-containing protein Elk-1 [36] -0.94[37] -3.26[38] -1.32[39] -0.52[40] 0.05[41] -1.25[42]
7 EGFR Epidermal growth factor receptor [43] -1.33[44] -1.88[45] 0.52[46] -0.36[47] 0.24[48] 1.57[49]
8 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 [50] 0.33[51] 0.31[52] 0.39[53] -0.51[54] 0.02[55] -1.84[56]
9 HTT Huntingtin [57] 2.86[58] 2.72[59] 3.00[60] 3.00[61] 2.24[62] 2.74[63]
10 CREB1 Cyclic AMP-responsive element-binding protein 1 [64] 1.09[65] 2.07[66] 2.08[67] 1.75[68] 1.67[69] 1.26[70]
11 RPS6KA5 Ribosomal protein S6 kinase alpha-5 [71] [72] [73] [74] [75] [76] [77]
12 BDNF Brain-derived neurotrophic factor [78] -2.29[79] -5.23[80] -3.79[81] 5.95[82] 4.69[83] 1.01[84]
13 EGF Pro-epidermal growth factor [85] 1.34[86] 2.95[87] 6.08[88] 8.23[89] 5.63[90] 0.49[91]
14 GRM1 Metabotropic glutamate receptor 1 [92] 1.63[93] [94] -0.87[95] 4.78[96] 2.50[97] 2.04[98]
15 NTRK2 BDNF/NT-3 growth factors receptor [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[2]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[3]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[4]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[5]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[6]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[7]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[8]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 6.8 5.1 4.9 33 13
[9]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 36 25
[10]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 59 27
[11]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 7.8 7.5 5.9
[12]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 12 13
[13]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[14]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 6.1 9 9.5 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 11 8.8 7.4 4 27
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 12 14
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 7.9 6
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 5.6 2.4 3.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 1.4 1.1 4.1 3.8
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[29]
ref_hepatocyte CASP7
Mean 10
Standard deviation 4.1
Values 15 6 7.6 7.8 14
[30]
HepG2 CASP7
Mean 17.9
Standard deviation 4
Values 21 15
[31]
HepG2.C3A CASP7
Mean 12.4
Standard deviation 4
Values 15 9.5
[32]
HuH.7 CASP7
Mean 16.1
Standard deviation 1.8
Values 18 15 15
[33]
SNU475 CASP7
Mean 9.89
Standard deviation 0.26
Values 9.7 10
[34]
THLE CASP7
Mean 12.8
Standard deviation 0.29
Values 13 13
[35]
liver CASP7
Mean 10.2
Standard deviation 3.1
Values 10 6.6 14 9.7
[36]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 7.5 4.4 8.5 1.7 12
[37]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 11 13
[38]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 1.9 3
[39]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 13 11 14
[40]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[41]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[42]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 7.1 6 10 11
[43]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 11 3.5 3.5 0.94 8.5
[44]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 8.2 6.9
[45]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 4.7 5.7
[46]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 15 63 32
[47]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 14 13
[48]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[49]
liver EGFR
Mean 49.4
Standard deviation 14
Values 42 69 39 47
[50]
ref_hepatocyte MAP2K7
Mean 3.82
Standard deviation 2
Values 6.2 3 5.7 2.7 1.5
[51]
HepG2 MAP2K7
Mean 16.4
Standard deviation 3.3
Values 14 19
[52]
HepG2.C3A MAP2K7
Mean 16.2
Standard deviation 4
Values 13 19
[53]
HuH.7 MAP2K7
Mean 23.1
Standard deviation 1.5
Values 23 22 24
[54]
SNU475 MAP2K7
Mean 8.53
Standard deviation 0.26
Values 8.7 8.3
[55]
THLE MAP2K7
Mean 14
Standard deviation 0.17
Values 14 14
[56]
liver MAP2K7
Mean 3.21
Standard deviation 0.87
Values 4.4 3 3.1 2.3
[57]
ref_hepatocyte HTT
Mean 2.27
Standard deviation 0.72
Values 2.1 1.8 1.6 3.5 2.3
[58]
HepG2 HTT
Mean 56.3
Standard deviation 7.8
Values 62 51
[59]
HepG2.C3A HTT
Mean 51.5
Standard deviation 0.11
Values 52 51
[60]
HuH.7 HTT
Mean 83.9
Standard deviation 22
Values 68 74 1.1e+02
[61]
SNU475 HTT
Mean 57.8
Standard deviation 12
Values 49 66
[62]
THLE HTT
Mean 38.8
Standard deviation 6.7
Values 34 44
[63]
liver HTT
Mean 45.8
Standard deviation 18
Values 62 62 31 28
[64]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 1.5 0.81 0.96 3.7 2.1
[65]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 15 11
[66]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 28 24
[67]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 31 36 38
[68]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[69]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[70]
liver CREB1
Mean 13
Standard deviation 3.1
Values 15 16 12 9.3
[71]
ref_hepatocyte RPS6KA5
Mean 0.385
Standard deviation 0.19
Values 0.65 0.46 0.18 0.21 0.42
[72]
HepG2 RPS6KA5
Missing
[73]
HepG2.C3A RPS6KA5
Missing
[74]
HuH.7 RPS6KA5
Missing
[75]
SNU475 RPS6KA5
Missing
[76]
THLE RPS6KA5
Missing
[77]
liver RPS6KA5
Missing
[78]
ref_hepatocyte BDNF
Mean 0.0532
Standard deviation 0.065
Values 0.095 0.024 0.15 0 0
[79]
HepG2 BDNF
Mean 0.0372
Standard deviation 0.0041
Values 0.034 0.04
[80]
HepG2.C3A BDNF
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[81]
HuH.7 BDNF
Mean 0.0177
Standard deviation 0.024
Values 0 0.045 0.0082
[82]
SNU475 BDNF
Mean 10.5
Standard deviation 1.7
Values 12 9.3
[83]
THLE BDNF
Mean 4.97
Standard deviation 1.1
Values 5.7 4.2
[84]
liver BDNF
Mean 0.324
Standard deviation 0.17
Values 0.3 0.57 0.19 0.23
[85]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0 0 0 0.021
[86]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.026 0.046
[87]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.17 0.049
[88]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 1.1 1.8 0.97
[89]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 3.6 4.3
[90]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[91]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0.013 0.057 0 0
[92]
ref_hepatocyte GRM1
Mean 0.00109
Standard deviation 0.0024
Values 0.0054 0 0 0 0
[93]
HepG2 GRM1
Mean 0.0115
Standard deviation 0.016
Values 0 0.023
[94]
HepG2.C3A GRM1
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 GRM1
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[96]
SNU475 GRM1
Mean 0.0949
Standard deviation 0.063
Values 0.051 0.14
[97]
THLE GRM1
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[98]
liver GRM1
Mean 0.0135
Standard deviation 0.019
Values 0.04 0.014 0 0
[99]
ref_hepatocyte NTRK2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 NTRK2
Mean 0.0201
Standard deviation 0.028
Values 0 0.04
[101]
HepG2.C3A NTRK2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 NTRK2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 NTRK2
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[104]
THLE NTRK2
Mean 0
Standard deviation 0
Values 0 0
[105]
liver NTRK2
Mean 1.46
Standard deviation 0.52
Values 2 1.2 0.89 1.8