WP_ERBB_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [1] | -1.80[2] | -2.03[3] | -1.42[4] | -3.83[5] | -2.29[6] | -2.04[7] |
2 | JUN | Transcription factor AP-1 | [8] | -1.30[9] | -2.75[10] | -2.48[11] | -2.23[12] | -1.67[13] | -2.25[14] |
3 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [15] | 0.03[16] | -1.27[17] | -3.95[18] | -2.52[19] | 0.04[20] | -2.28[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | -0.73[23] | -0.87[24] | -1.94[25] | -0.58[26] | -0.56[27] | -0.69[28] |
5 | MYC | Myc proto-oncogene protein | [29] | -0.38[30] | -0.62[31] | -2.65[32] | -3.32[33] | -0.95[34] | -2.44[35] |
6 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [36] | -1.74[37] | -1.97[38] | -1.39[39] | -1.07[40] | -0.57[41] | -1.64[42] |
7 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [43] | -0.76[44] | -0.98[45] | -0.11[46] | -1.37[47] | -0.89[48] | -2.15[49] |
8 | CCND1 | G1/S-specific cyclin-D1 | [50] | 2.24[51] | -0.17[52] | 0.67[53] | 1.35[54] | -0.13[55] | 0.61[56] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [57] | 0.39[58] | 0.32[59] | 0.44[60] | 0.02[61] | -0.07[62] | -0.15[63] |
10 | CRK | Adapter molecule crk | [64] | -1.01[65] | -0.98[66] | -0.92[67] | -0.77[68] | -0.38[69] | 0.40[70] |
11 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [71] | [72] | [73] | [74] | [75] | [76] | [77] |
12 | BAD | Bcl2-associated agonist of cell death | [78] | -2.48[79] | -2.26[80] | -3.20[81] | -1.60[82] | -1.20[83] | -1.86[84] |
13 | SHC1 | SHC-transforming protein 1 | [85] | 0.35[86] | 0.67[87] | 0.75[88] | 2.12[89] | 1.60[90] | 0.34[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | -0.87[93] | -0.37[94] | 0.90[95] | -0.72[96] | 0.15[97] | 0.65[98] |
15 | NRAS | GTPase NRas | [99] | -0.18[100] | 0.35[101] | 0.76[102] | 0.47[103] | 0.03[104] | -0.69[105] |
16 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [106] | -0.90[107] | -0.36[108] | -0.16[109] | -1.64[110] | -1.18[111] | -1.35[112] |
17 | ARAF | Serine/threonine-protein kinase A-Raf | [113] | -1.27[114] | -1.48[115] | -1.20[116] | -0.63[117] | -0.60[118] | 0.43[119] |
18 | HRAS | GTPase HRas | [120] | -1.82[121] | -2.43[122] | -3.22[123] | -1.48[124] | -1.70[125] | -3.10[126] |
19 | NCK1 | Cytoplasmic protein NCK1 | [127] | -2.41[128] | -2.21[129] | -2.10[130] | -1.09[131] | -0.99[132] | -0.91[133] |
20 | PAK2 | Serine/threonine-protein kinase PAK 2 | [134] | 0.64[135] | 0.48[136] | 0.77[137] | 0.22[138] | 0.77[139] | 0.92[140] |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [141] | 0.90[142] | 1.13[143] | 0.96[144] | 1.32[145] | 0.96[146] | 1.33[147] |
22 | AKT2 | RAC-beta serine/threonine-protein kinase | [148] | 0.15[149] | 0.52[150] | 0.65[151] | 0.33[152] | 0.12[153] | 0.69[154] |
23 | SHC2 | SHC-transforming protein 2 | [155] | -2.19[156] | -1.74[157] | -2.59[158] | -5.20[159] | -4.83[160] | -0.82[161] |
24 | KRAS | GTPase KRas | [162] | -1.33[163] | -1.25[164] | 0.35[165] | 0.27[166] | -0.07[167] | 0.23[168] |
25 | PTK2 | Focal adhesion kinase 1 | [169] | -0.08[170] | 0.51[171] | 0.89[172] | 1.42[173] | 0.61[174] | 0.32[175] |
26 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [176] | 1.19[177] | 2.67[178] | 1.71[179] | -6.40[180] | -6.16[181] | 1.86[182] |
27 | CRKL | Crk-like protein | [183] | 0.89[184] | 1.08[185] | 1.69[186] | 0.59[187] | 0.79[188] | 1.01[189] |
28 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [190] | -1.28[191] | -1.07[192] | 0.02[193] | 1.54[194] | 1.03[195] | 2.56[196] |
29 | MAPK8 | Mitogen-activated protein kinase 8 | [197] | -2.26[198] | -0.75[199] | -1.88[200] | -1.43[201] | -1.58[202] | -0.96[203] |
30 | SOS1 | Son of sevenless homolog 1 | [204] | -0.91[205] | 0.71[206] | 0.22[207] | 0.31[208] | -0.46[209] | 0.09[210] |
31 | ELK1 | ETS domain-containing protein Elk-1 | [211] | -1.13[212] | -3.17[213] | -0.74[214] | -0.26[215] | 0.33[216] | -0.61[217] |
32 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [218] | 1.56[219] | 0.48[220] | 1.65[221] | 0.72[222] | 0.33[223] | -0.29[224] |
33 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [225] | 1.30[226] | 2.81[227] | 0.05[228] | -0.02[229] | 0.85[230] | 1.72[231] |
34 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [232] | -0.68[233] | -0.28[234] | 1.25[235] | 0.14[236] | -0.67[237] | 0.97[238] |
35 | EGFR | Epidermal growth factor receptor | [239] | -1.51[240] | -1.79[241] | 1.10[242] | -0.10[243] | 0.52[244] | 2.21[245] |
36 | TP53 | Cellular tumor antigen p53 | [246] | 0.83[247] | 0.48[248] | 1.25[249] | 0.76[250] | 0.42[251] | -0.49[252] |
37 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [253] | 1.06[254] | 1.38[255] | 1.99[256] | 0.18[257] | 0.73[258] | -0.73[259] |
38 | AREG | Amphiregulin | [260] | -3.67[261] | -6.82[262] | -8.58[263] | -10.23[264] | 0.07[265] | -10.75[266] |
39 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [267] | -0.11[268] | 0.62[269] | -0.18[270] | 0.67[271] | 0.07[272] | 0.62[273] |
40 | NCK2 | Cytoplasmic protein NCK2 | [274] | -0.01[275] | -0.33[276] | -1.92[277] | -0.86[278] | -0.12[279] | -1.27[280] |
41 | PAK4 | Serine/threonine-protein kinase PAK 4 | [281] | 0.08[282] | 0.22[283] | 0.92[284] | 0.49[285] | 0.21[286] | -0.77[287] |
42 | MAPK9 | Mitogen-activated protein kinase 9 | [288] | 0.42[289] | 0.74[290] | 0.80[291] | 1.18[292] | 0.64[293] | 0.07[294] |
43 | MAPK3 | Mitogen-activated protein kinase 3 | [295] | 1.04[296] | 1.18[297] | 1.22[298] | -0.11[299] | -0.09[300] | -1.48[301] |
44 | GSK3B | Glycogen synthase kinase-3 beta | [302] | 0.46[303] | 0.19[304] | 0.76[305] | 1.28[306] | 1.11[307] | 0.72[308] |
45 | ABL1 | Tyrosine-protein kinase ABL1 | [309] | 1.42[310] | 0.91[311] | 1.71[312] | 1.54[313] | 2.22[314] | 0.50[315] |
46 | STAT5B | Signal transducer and activator of transcription 5B | [316] | 0.55[317] | 0.27[318] | 0.97[319] | 1.02[320] | 0.16[321] | 1.18[322] |
47 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [323] | 0.15[324] | 0.40[325] | 0.97[326] | -0.25[327] | 0.30[328] | -1.20[329] |
48 | SRC | Proto-oncogene tyrosine-protein kinase Src | [330] | 2.21[331] | 2.29[332] | 1.29[333] | 1.87[334] | 1.04[335] | -1.29[336] |
49 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [337] | 1.52[338] | 2.81[339] | 1.52[340] | 0.91[341] | 1.30[342] | 2.06[343] |
50 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.68[344] | 2.39[345] | 1.73[346] | 2.29[347] | 1.78[348] | -0.10[349] | |
51 | MTOR | Serine/threonine-protein kinase mTOR | [350] | 1.72[351] | 2.83[352] | 2.40[353] | 2.15[354] | 2.23[355] | 3.01[356] |
52 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [357] | [358] | [359] | [360] | [361] | [362] | [363] |
53 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.40[364] | 1.00[365] | 1.17[366] | 0.52[367] | 0.67[368] | 0.71[369] | |
54 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | -0.04[370] | 1.27[371] | 0.89[372] | 1.15[373] | 0.71[374] | 0.51[375] | |
55 | SOS2 | Son of sevenless homolog 2 | [376] | -0.84[377] | 0.38[378] | -0.38[379] | 1.16[380] | 1.02[381] | 1.40[382] |
56 | PRKCA | Protein kinase C alpha type | [383] | 2.03[384] | 2.16[385] | 2.52[386] | 1.62[387] | 1.98[388] | 1.47[389] |
57 | STAT5A | Signal transducer and activator of transcription 5A | [390] | -2.76[391] | -1.49[392] | -2.42[393] | -1.38[394] | -0.62[395] | -0.21[396] |
58 | PAK1 | Serine/threonine-protein kinase PAK 1 | [397] | -0.82[398] | -1.49[399] | 0.92[400] | -2.39[401] | 1.39[402] | -0.18[403] |
59 | CBLB | E3 ubiquitin-protein ligase CBL-B | [404] | -1.46[405] | -0.12[406] | 0.31[407] | 0.25[408] | 1.11[409] | 0.93[410] |
60 | TGFA | Protransforming growth factor alpha | [411] | 0.98[412] | 2.14[413] | -8.91[414] | -1.49[415] | -2.72[416] | -0.84[417] |
61 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.19[418] | 0.54[419] | 0.73[420] | 0.60[421] | 0.80[422] | 1.47[423] | |
62 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.08[424] | 2.26[425] | -1.55[426] | -0.25[427] | 0.51[428] | -0.15[429] | |
63 | HBEGF | Proheparin-binding EGF-like growth factor | [430] | -1.80[431] | -2.51[432] | -3.58[433] | -0.23[434] | -0.54[435] | -2.87[436] |
64 | FOXO1 | Forkhead box protein O1 | [437] | 0.88[438] | 0.64[439] | 0.78[440] | 0.64[441] | 2.66[442] | 2.64[443] |
65 | BCL2L11 | Bcl-2-like protein 11 | [444] | 0.69[445] | 0.80[446] | 1.13[447] | 1.33[448] | 0.31[449] | 1.54[450] |
66 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [451] | -0.48[452] | -6.52[453] | -3.63[454] | 1.52[455] | -5.96[456] | 0.33[457] |
67 | ABL2 | Abelson tyrosine-protein kinase 2 | [458] | 1.26[459] | 1.38[460] | 2.32[461] | 3.35[462] | 3.55[463] | 2.48[464] |
68 | BRAF | Serine/threonine-protein kinase B-raf | [465] | -0.56[466] | -0.74[467] | 1.30[468] | 0.21[469] | -0.10[470] | 1.41[471] |
69 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -2.09[472] | -7.74[473] | -0.29[474] | -3.27[475] | -2.12[476] | 2.27[477] | |
70 | BTC | Probetacellulin | [478] | -8.95[479] | -9.25[480] | -5.02[481] | -3.41[482] | -3.44[483] | -3.36[484] |
71 | GAB1 | GRB2-associated-binding protein 1 | [485] | 0.49[486] | 1.67[487] | 1.80[488] | 1.40[489] | 1.26[490] | 2.43[491] |
72 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [492] | -3.35[493] | -4.57[494] | -7.53[495] | -3.39[496] | -2.76[497] | 0.70[498] |
73 | NRG4 | Pro-neuregulin-4, membrane-bound isoform | [499] | -4.90[500] | -1.93[501] | -1.98[502] | -0.25[503] | -2.45[504] | -1.38[505] |
74 | CBL | E3 ubiquitin-protein ligase CBL | [506] | 3.64[507] | 2.68[508] | 2.90[509] | 4.60[510] | 4.08[511] | 3.31[512] |
75 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [513] | 0.91[514] | 1.02[515] | 1.86[516] | 2.64[517] | 1.65[518] | 2.23[519] |
76 | AKT3 | RAC-gamma serine/threonine-protein kinase | [520] | -2.65[521] | -5.12[522] | -4.43[523] | 5.31[524] | 4.26[525] | 3.16[526] |
77 | PRKCB | Protein kinase C beta type | [527] | -7.62[528] | -6.33[529] | [530] | 1.95[531] | -3.36[532] | 3.09[533] |
78 | EREG | Proepiregulin | [534] | 0.94[535] | 0.96[536] | -3.45[537] | -2.10[538] | 3.15[539] | -1.92[540] |
79 | PAK3 | Serine/threonine-protein kinase PAK 3 | [541] | -7.22[542] | [543] | [544] | -2.13[545] | -0.41[546] | 0.34[547] |
80 | PAK6 | Serine/threonine-protein kinase PAK 6 | [548] | -2.49[549] | [550] | 0.34[551] | 1.67[552] | 0.78[553] | -1.52[554] |
81 | SHC4 | SHC-transforming protein 4 | [555] | -3.07[556] | [557] | -2.42[558] | 2.00[559] | 2.37[560] | -1.14[561] |
82 | SHC3 | SHC-transforming protein 3 | [562] | 1.30[563] | 3.77[564] | -3.72[565] | 2.93[566] | 6.83[567] | 1.37[568] |
83 | PRKCG | Protein kinase C gamma type | [569] | -1.63[570] | -0.86[571] | -3.24[572] | -1.59[573] | -1.69[574] | [575] |
84 | EGF | Pro-epidermal growth factor | [576] | 1.16[577] | 3.04[578] | 6.66[579] | 8.49[580] | 5.91[581] | 1.13[582] |
85 | MAPK10 | Mitogen-activated protein kinase 10 | [583] | -2.29[584] | [585] | [586] | 8.38[587] | 4.11[588] | 6.80[589] |
86 | NRG3 | Pro-neuregulin-3, membrane-bound isoform | [590] | [591] | [592] | [593] | [594] | [595] | [596] |
87 | NRG2 | Pro-neuregulin-2, membrane-bound isoform | [597] | [598] | [599] | [600] | [601] | [602] | [603] |
88 | PAK5 | Serine/threonine-protein kinase PAK 5 | [604] | [605] | [606] | [607] | [608] | [609] | [610] |
89 | BUB1B-PA | BUB1B-PAK6 readthrough (Fragment) | [611] | [612] | [613] | [614] | [615] | [616] | [617] |
90 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [618] | [619] | [620] | [621] | [622] | [623] | [624] |
91 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [625] | [626] | [627] | [628] | [629] | [630] | [631] |