WP_EPO_RECEPTOR_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.61[2] -0.68[3] -1.94[4] -1.03[5] -0.55[6] -1.17[7]
2 STAT3 Signal transducer and activator of transcription 3 [8] -0.14[9] -1.47[10] -0.92[11] -0.74[12] -1.01[13] 1.48[14]
3 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [15] -1.62[16] -1.78[17] -1.39[18] -1.52[19] -0.56[20] -2.12[21]
4 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [22] -0.64[23] -0.79[24] -0.11[25] -1.82[26] -0.88[27] -2.63[28]
5 GRB2 Growth factor receptor-bound protein 2 [29] 0.50[30] 0.51[31] 0.45[32] -0.43[33] -0.05[34] -0.63[35]
6 STAT1 Signal transducer and activator of transcription 1-alpha/beta [36] -0.77[37] -1.52[38] -0.59[39] 1.55[40] -0.26[41] 0.02[42]
7 SHC1 SHC-transforming protein 1 [43] 0.47[44] 0.86[45] 0.75[46] 1.67[47] 1.61[48] -0.15[49]
8 RAF1 RAF proto-oncogene serine/threonine-protein kinase [50] -0.75[51] -0.18[52] 0.90[53] -1.16[54] 0.16[55] 0.17[56]
9 MAPK1 Mitogen-activated protein kinase 1 [57] 1.02[58] 1.32[59] 0.97[60] 0.87[61] 0.98[62] 0.85[63]
10 SOS1 Son of sevenless homolog 1 [64] -0.79[65] 0.91[66] 0.23[67] -0.13[68] -0.44[69] -0.39[70]
11 CISH Cytokine-inducible SH2-containing protein [71] -3.60[72] -3.25[73] -3.22[74] -3.63[75] -4.61[76] 0.17[77]
12 EPO Erythropoietin [78] -1.82[79] 0.50[80] -3.53[81] -10.65[82] -12.07[83] -0.94[84]
13 MAPK3 Mitogen-activated protein kinase 3 [85] 1.16[86] 1.37[87] 1.23[88] -0.56[89] -0.08[90] -1.97[91]
14 STAT5B Signal transducer and activator of transcription 5B [92] 0.67[93] 0.46[94] 0.98[95] 0.57[96] 0.17[97] 0.70[98]
15 SRC Proto-oncogene tyrosine-protein kinase Src [99] 2.33[100] 2.48[101] 1.30[102] 1.42[103] 1.05[104] -1.78[105]
16 IRS1 Insulin receptor substrate 1 [106] 1.40[107] 1.01[108] 2.25[109] 0.73[110] 0.76[111] 1.19[112]
17 RASA1 Ras GTPase-activating protein 1 [113] -0.31[114] 0.77[115] 0.68[116] 0.94[117] 0.45[118] 0.29[119]
18 STAT5A Signal transducer and activator of transcription 5A [120] -2.64[121] -1.30[122] -2.41[123] -1.83[124] -0.61[125] -0.69[126]
19 IRS2 Insulin receptor substrate 2 [127] -6.34[128] [129] -3.50[130] -1.64[131] 2.64[132] 1.46[133]
20 SOCS1 Suppressor of cytokine signaling 1 [134] -2.14[135] -1.11[136] -1.02[137] -2.77[138] -3.70[139] -2.39[140]
21 PTPRU Receptor-type tyrosine-protein phosphatase U [141] 3.49[142] 1.56[143] 1.26[144] -2.55[145] 0.33[146] 0.70[147]
22 PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1.68[148] 2.56[149] 1.99[150] 1.63[151] 0.32[152] 1.14[153]
23 PTPRC Receptor-type tyrosine-protein phosphatase C [154] [155] [156] [157] -0.61[158] -9.07[159] 2.22[160]
24 JAK2 Tyrosine-protein kinase JAK2 [161] -0.46[162] -0.30[163] -0.93[164] -0.22[165] 0.84[166] 1.78[167]
25 EPOR Erythropoietin receptor [168] 0.57[169] 1.86[170] 2.70[171] 0.19[172] 1.48[173] 1.66[174]
26 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [175] [176] [177] 0.36[178] -4.07[179] 3.17[180]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 18 36 46 26 25
[9]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 1e+02 90
[10]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 27 34
[11]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 35 65 47
[12]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 57 74
[13]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[14]
liver STAT3
Mean 227
Standard deviation 42
Values 2e+02 2.3e+02 1.9e+02 2.8e+02
[15]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[16]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[17]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[18]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[19]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[20]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[21]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[22]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[23]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[24]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[25]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[26]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[27]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[28]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[29]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 20 17 14 27 26
[30]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1.1e+02 1e+02
[31]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[32]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 93 78 89
[33]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 57 55
[34]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[35]
liver GRB2
Mean 36.1
Standard deviation 16
Values 22 22 50 50
[36]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 19 18 12 17 35
[37]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 49 36
[38]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 25 15
[39]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 40 38 47
[40]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 1.1e+02 3.2e+02
[41]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[42]
liver STAT1
Mean 55.8
Standard deviation 15
Values 38 69 49 67
[43]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 19 16 26 5.8 17
[44]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[45]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 93 77
[46]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 85 84 89
[47]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 1.7e+02 2.2e+02
[48]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[49]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 37 56
[50]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[51]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[52]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[53]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[54]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[55]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[56]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[57]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[58]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[59]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[60]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[61]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[62]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[63]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[64]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 2.2 1.5 1.3 27 1.9
[65]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 19 9.4
[66]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 33 39
[67]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 15 37 22
[68]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 20 25
[69]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[70]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 16 18 13 9.3
[71]
ref_hepatocyte CISH
Mean 4.68
Standard deviation 5.7
Values 3 4.7 14 0.89 0.45
[72]
HepG2 CISH
Mean 1.38
Standard deviation 0.087
Values 1.4 1.3
[73]
HepG2.C3A CISH
Mean 1.4
Standard deviation 0.43
Values 1.1 1.7
[74]
HuH.7 CISH
Mean 1.55
Standard deviation 0.25
Values 1.3 1.7 1.7
[75]
SNU475 CISH
Mean 1.37
Standard deviation 0.36
Values 1.1 1.6
[76]
THLE CISH
Mean 0.567
Standard deviation 0.027
Values 0.59 0.55
[77]
liver CISH
Mean 14.3
Standard deviation 12
Values 11 1.8 31 13
[78]
ref_hepatocyte EPO
Mean 4.3
Standard deviation 5.9
Values 0.32 6.2 14 1.1 0
[79]
HepG2 EPO
Mean 4.34
Standard deviation 2.9
Values 6.4 2.3
[80]
HepG2.C3A EPO
Mean 17.3
Standard deviation 2.6
Values 19 15
[81]
HuH.7 EPO
Mean 1.15
Standard deviation 0.76
Values 0.72 2 0.71
[82]
SNU475 EPO
Mean 0.00971
Standard deviation 0.00061
Values 0.01 0.0093
[83]
THLE EPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[84]
liver EPO
Mean 6.05
Standard deviation 8
Values 0.3 2.9 3.1 18
[85]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[86]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[87]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[88]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[89]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[90]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[91]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[92]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 2.3 5.6 4.6 4.1 3.3
[93]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 18 27
[94]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 13 18
[95]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 26 22 25
[96]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 19 24
[97]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[98]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 22 21 13 14
[99]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[100]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[101]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[102]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[103]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[104]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[105]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[106]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 2.7 4.7 2.1 4.3 1.5
[107]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 23 35
[108]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 13 22
[109]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 37 48 49
[110]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 22 15
[111]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[112]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 22 18 23 12
[113]
ref_hepatocyte RASA1
Mean 2.68
Standard deviation 1.4
Values 1.6 2.4 1.4 3.2 4.9
[114]
HepG2 RASA1
Mean 7.68
Standard deviation 3
Values 9.8 5.6
[115]
HepG2.C3A RASA1
Mean 12.9
Standard deviation 0.039
Values 13 13
[116]
HuH.7 RASA1
Mean 13.3
Standard deviation 0.87
Values 12 14 14
[117]
SNU475 RASA1
Mean 18.6
Standard deviation 2.3
Values 17 20
[118]
THLE RASA1
Mean 10.8
Standard deviation 0.049
Values 11 11
[119]
liver RASA1
Mean 8.83
Standard deviation 3.2
Values 8 13 7.7 6.2
[120]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 5 0.95 1.5 1.8 2.7
[121]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.3 1.4
[122]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.9 2.6
[123]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.2 1.8 1.1
[124]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.3 2.5
[125]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[126]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 6.2 3.5 3 3.3
[127]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 1.4 2.9 5.7 0.019 0.61
[128]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.043 0.14
[129]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.17 1.4 0.2
[131]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.8 2.1
[132]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[133]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 17 11 29 6.3
[134]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.3 3.4 4.7 1.1 0
[135]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.6 1.8
[136]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 1.9 3.7
[137]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 5.3 1 3.3
[138]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 0.95 1.3
[139]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[140]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 2.2 0.27 1.1 0.8
[141]
ref_hepatocyte PTPRU
Mean 1.91
Standard deviation 0.89
Values 3.2 1.3 1.7 2.4 1
[142]
HepG2 PTPRU
Mean 76.4
Standard deviation 37
Values 50 1e+02
[143]
HepG2.C3A PTPRU
Mean 16
Standard deviation 1.8
Values 15 17
[144]
HuH.7 PTPRU
Mean 14.1
Standard deviation 2.2
Values 13 13 17
[145]
SNU475 PTPRU
Mean 1.18
Standard deviation 0.38
Values 1.4 0.91
[146]
THLE PTPRU
Mean 7.08
Standard deviation 3.3
Values 9.4 4.8
[147]
liver PTPRU
Mean 8.38
Standard deviation 4.8
Values 15 8 4.3 6
[148]
ref_hepatocyte PDK1
Mean 1.82
Standard deviation 1.1
Values 0.89 2.1 1.1 3.7 1.3
[149]
HepG2 PDK1
Mean 20.7
Standard deviation 5.2
Values 24 17
[150]
HepG2.C3A PDK1
Mean 30.3
Standard deviation 3.9
Values 33 28
[151]
HuH.7 PDK1
Mean 22.3
Standard deviation 0.9
Values 21 22 23
[152]
SNU475 PDK1
Mean 20.4
Standard deviation 4.6
Values 17 24
[153]
THLE PDK1
Mean 6.71
Standard deviation 0.29
Values 6.5 6.9
[154]
liver PDK1
Mean 10.8
Standard deviation 3
Values 7.1 12 10 14
[155]
ref_hepatocyte PTPRC
Mean 1.02
Standard deviation 1.6
Values 0.46 3.8 0.76 0 0.047
[156]
HepG2 PTPRC
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A PTPRC
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 PTPRC
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 PTPRC
Mean 2.42
Standard deviation 0.6
Values 2 2.9
[160]
THLE PTPRC
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[161]
liver PTPRC
Mean 12.8
Standard deviation 4
Values 16 17 8.5 10
[162]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 0.62 0.5 0.18 1.3 1.3
[163]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 2.9 1
[164]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 2.2 1.3
[165]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 0.9 1.6 1.2
[166]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.4 2.3
[167]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[168]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 9.8 11 4.7 2.9
[169]
ref_hepatocyte EPOR
Mean 0.552
Standard deviation 0.22
Values 0.53 0.82 0.69 0.24 0.48
[170]
HepG2 EPOR
Mean 2.93
Standard deviation 0.93
Values 2.3 3.6
[171]
HepG2.C3A EPOR
Mean 5.68
Standard deviation 2.7
Values 3.8 7.6
[172]
HuH.7 EPOR
Mean 11.1
Standard deviation 0.46
Values 11 11 11
[173]
SNU475 EPOR
Mean 2.28
Standard deviation 0.26
Values 2.5 2.1
[174]
THLE EPOR
Mean 4.55
Standard deviation 0.058
Values 4.5 4.6
[175]
liver EPOR
Mean 4.7
Standard deviation 1.7
Values 3.1 3.4 6.5 5.7
[176]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0.29 0.026 0 0
[177]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[178]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.37 0.22
[181]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[182]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 1.6 1.9 0.94 1.7