WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2C8 Cytochrome P450 2C8 [1] -11.22[2] -7.99[3] -6.67[4] -7.90[5] [6] -0.19[7]
2 CYP4A11 Cytochrome P450 4A11 [8] -9.39[9] -8.27[10] -11.02[11] -6.72[12] -7.45[13] 0.18[14]
3 CYP2C18 Cytochrome P450 2C18 [15] -6.19[16] -9.18[17] -4.21[18] -7.73[19] -5.51[20] -1.16[21]
4 EPHX2 Bifunctional epoxide hydrolase 2 [22] 1.99[23] 2.29[24] 2.85[25] -0.25[26] 0.27[27] 0.24[28]
5 CYP4F2 Phylloquinone omega-hydroxylase CYP4F2 [29] -1.35[30] 0.76[31] -11.82[32] -7.94[33] -5.76[34] 0.12[35]
6 CYP4F12 Cytochrome P450 4F12 [36] 2.57[37] 2.40[38] 2.70[39] 0.67[40] -3.10[41] -0.51[42]
7 PPARA Peroxisome proliferator-activated receptor alpha [43] 5.94[44] 5.42[45] 5.39[46] 5.65[47] 5.10[48] 3.45[49]
8 PPARG Peroxisome proliferator-activated receptor gamma [50] 5.18[51] 5.29[52] 4.92[53] 6.45[54] 6.71[55] -1.08[56]
9 CYP4A22 Cytochrome P450 4A22 [57] [58] [59] [60] [61] [62] 1.56[63]
[1]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 19 9.1e+02 7.1e+02 0 1.2
[2]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[3]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.24 0.14
[4]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.3 2 0.16
[5]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.066 0.037
[6]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[7]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 2e+02 6.2e+02 6.8e+02 1.2e+03
[8]
ref_hepatocyte CYP4A11
Mean 109
Standard deviation 1.6e+02
Values 4 3.4e+02 2e+02 0 0
[9]
HepG2 CYP4A11
Mean 0.0093
Standard deviation 0.005
Values 0.013 0.0057
[10]
HepG2.C3A CYP4A11
Mean 0.0511
Standard deviation 0.0036
Values 0.054 0.049
[11]
HuH.7 CYP4A11
Mean 0.0135
Standard deviation 0.0098
Values 0.0094 0.0064 0.025
[12]
SNU475 CYP4A11
Mean 0.039
Standard deviation 0.0093
Values 0.046 0.032
[13]
THLE CYP4A11
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[14]
liver CYP4A11
Mean 286
Standard deviation 2.2e+02
Values 1.3e+02 87 5.7e+02 3.6e+02
[15]
ref_hepatocyte CYP2C18
Mean 43
Standard deviation 35
Values 18 56 51 0 90
[16]
HepG2 CYP2C18
Mean 0.0336
Standard deviation 0.017
Values 0.021 0.046
[17]
HepG2.C3A CYP2C18
Mean 0.0107
Standard deviation 0.015
Values 0.021 0
[18]
HuH.7 CYP2C18
Mean 0.593
Standard deviation 0.1
Values 0.53 0.71 0.53
[19]
SNU475 CYP2C18
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[20]
THLE CYP2C18
Mean 0.0325
Standard deviation 0.029
Values 0.012 0.053
[21]
liver CYP2C18
Mean 44.5
Standard deviation 13
Values 31 57 36 54
[22]
ref_hepatocyte EPHX2
Mean 31.5
Standard deviation 40
Values 2.2 93 51 6.6 5.1
[23]
HepG2 EPHX2
Mean 7.16
Standard deviation 2
Values 8.5 5.8
[24]
HepG2.C3A EPHX2
Mean 22.2
Standard deviation 4
Values 19 25
[25]
HuH.7 EPHX2
Mean 58
Standard deviation 2.7
Values 61 55 58
[26]
SNU475 EPHX2
Mean 0.995
Standard deviation 0.55
Values 0.61 1.4
[27]
THLE EPHX2
Mean 1.31
Standard deviation 0.13
Values 1.4 1.2
[28]
liver EPHX2
Mean 85.8
Standard deviation 57
Values 40 42 1.6e+02 1e+02
[29]
ref_hepatocyte CYP4F2
Mean 30.2
Standard deviation 38
Values 11 87 51 1.2 0.054
[30]
HepG2 CYP4F2
Mean 0.677
Standard deviation 0.5
Values 0.32 1
[31]
HepG2.C3A CYP4F2
Mean 7.41
Standard deviation 4.8
Values 4 11
[32]
HuH.7 CYP4F2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[33]
SNU475 CYP4F2
Mean 0.00464
Standard deviation 0.0066
Values 0 0.0093
[34]
THLE CYP4F2
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[35]
liver CYP4F2
Mean 75.6
Standard deviation 42
Values 36 50 86 1.3e+02
[36]
ref_hepatocyte CYP4F12
Mean 7.85
Standard deviation 7.8
Values 0.73 19 8.4 11 0.13
[37]
HepG2 CYP4F12
Mean 2.67
Standard deviation 0.39
Values 2.4 2.9
[38]
HepG2.C3A CYP4F12
Mean 5.98
Standard deviation 2.1
Values 4.5 7.5
[39]
HuH.7 CYP4F12
Mean 13
Standard deviation 3.4
Values 14 16 9.3
[40]
SNU475 CYP4F12
Mean 0.47
Standard deviation 0.47
Values 0.14 0.8
[41]
THLE CYP4F12
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[42]
liver CYP4F12
Mean 12.8
Standard deviation 14
Values 3.9 5.3 34 8.3
[43]
ref_hepatocyte PPARA
Mean 3.95
Standard deviation 2.1
Values 1.6 6.2 5.5 4.6 1.9
[44]
HepG2 PPARA
Mean 13.9
Standard deviation 0.43
Values 14 14
[45]
HepG2.C3A PPARA
Mean 24.4
Standard deviation 5.6
Values 20 28
[46]
HuH.7 PPARA
Mean 42.3
Standard deviation 18
Values 25 60 42
[47]
SNU475 PPARA
Mean 7.44
Standard deviation 1.6
Values 6.3 8.5
[48]
THLE PPARA
Mean 4.68
Standard deviation 0.38
Values 4.9 4.4
[49]
liver PPARA
Mean 99.6
Standard deviation 24
Values 79 1.3e+02 88 97
[50]
ref_hepatocyte PPARG
Mean 3.66
Standard deviation 0.37
Values 3.1 3.9 3.6 3.6 4.1
[51]
HepG2 PPARG
Mean 7.61
Standard deviation 0.54
Values 7.2 8
[52]
HepG2.C3A PPARG
Mean 20.7
Standard deviation 6.8
Values 16 26
[53]
HuH.7 PPARG
Mean 28.4
Standard deviation 6.2
Values 26 35 24
[54]
SNU475 PPARG
Mean 12.1
Standard deviation 2.4
Values 14 10
[55]
THLE PPARG
Mean 13.2
Standard deviation 1.2
Values 12 14
[56]
liver PPARG
Mean 4
Standard deviation 1.3
Values 2.5 4 3.8 5.7
[57]
ref_hepatocyte CYP4A22
Mean 3.13
Standard deviation 4
Values 0.49 7.8 7.2 0 0.14
[58]
HepG2 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 CYP4A22
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[63]
liver CYP4A22
Mean 21.4
Standard deviation 17
Values 18 6.3 46 15