WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | EIF4E2 | Eukaryotic translation initiation factor 4E type 2 | [8] | -2.25[9] | -2.17[10] | -1.89[11] | -1.65[12] | -1.93[13] | -2.04[14] |
3 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [15] | -0.67[16] | -0.88[17] | -0.33[18] | -2.65[19] | -1.07[20] | -1.23[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | 0.40[23] | 0.28[24] | -0.86[25] | 0.60[26] | 0.65[27] | 0.12[28] |
5 | RRAS2 | Ras-related protein R-Ras2 | [29] | -1.67[30] | -1.41[31] | -1.30[32] | -0.91[33] | -1.09[34] | -1.43[35] |
6 | STAT3 | Signal transducer and activator of transcription 3 | [36] | 0.87[37] | -0.52[38] | 0.16[39] | 0.90[40] | 0.19[41] | 2.77[42] |
7 | MYC | Myc proto-oncogene protein | [43] | 0.75[44] | 0.52[45] | -1.56[46] | -2.14[47] | 0.26[48] | -1.63[49] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [50] | -0.61[51] | -0.83[52] | -0.31[53] | 0.11[54] | 0.64[55] | -0.83[56] |
9 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [57] | 0.37[58] | 0.16[59] | 0.97[60] | -0.19[61] | 0.32[62] | -1.34[63] |
10 | BCL2L1 | Bcl-2-like protein 1 | [64] | 2.46[65] | 1.96[66] | 2.86[67] | 0.04[68] | 0.45[69] | -0.45[70] |
11 | BAX | Apoptosis regulator BAX | [71] | 0.65[72] | -0.03[73] | -0.56[74] | -0.95[75] | -0.54[76] | -3.59[77] |
12 | CCND1 | G1/S-specific cyclin-D1 | [78] | 3.37[79] | 0.98[80] | 1.75[81] | 2.53[82] | 1.08[83] | 1.42[84] |
13 | GRB2 | Growth factor receptor-bound protein 2 | [85] | 1.51[86] | 1.46[87] | 1.52[88] | 1.21[89] | 1.15[90] | 0.66[91] |
14 | IGF1 | Insulin-like growth factor I | [92] | -8.10[93] | -8.93[94] | -7.20[95] | -0.89[96] | -8.69[97] | 1.28[98] |
15 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [99] | [100] | [101] | [102] | [103] | [104] | [105] |
16 | BAD | Bcl2-associated agonist of cell death | [106] | -1.35[107] | -1.11[108] | -2.12[109] | -0.41[110] | 0.01[111] | -1.06[112] |
17 | SHC1 | SHC-transforming protein 1 | [113] | 1.48[114] | 1.81[115] | 1.83[116] | 3.30[117] | 2.82[118] | 1.14[119] |
18 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [120] | 0.26[121] | 0.77[122] | 1.98[123] | 0.47[124] | 1.36[125] | 1.46[126] |
19 | VEGFA | Vascular endothelial growth factor A | [127] | 1.54[128] | 2.99[129] | 1.53[130] | 1.09[131] | 1.83[132] | 1.14[133] |
20 | JAK1 | Tyrosine-protein kinase JAK1 | [134] | 0.83[135] | 0.43[136] | 0.55[137] | 1.28[138] | 1.95[139] | 1.89[140] |
21 | EIF4E | Eukaryotic translation initiation factor 4E | [141] | 0.46[142] | 1.40[143] | 0.70[144] | 0.38[145] | 1.43[146] | 0.53[147] |
22 | NRAS | GTPase NRas | [148] | 0.95[149] | 1.49[150] | 1.84[151] | 1.65[152] | 1.25[153] | 0.11[154] |
23 | RRAS | Ras-related protein R-Ras | [155] | -1.17[156] | -2.04[157] | -1.52[158] | 0.37[159] | 0.41[160] | -1.82[161] |
24 | MET | Hepatocyte growth factor receptor | [162] | 0.40[163] | 0.55[164] | 1.11[165] | 2.19[166] | 0.93[167] | 1.33[168] |
25 | ARAF | Serine/threonine-protein kinase A-Raf | [169] | -0.14[170] | -0.33[171] | -0.12[172] | 0.56[173] | 0.62[174] | 1.24[175] |
26 | HRAS | GTPase HRas | [176] | -0.69[177] | -1.28[178] | -2.13[179] | -0.29[180] | -0.49[181] | -2.30[182] |
27 | MAPK1 | Mitogen-activated protein kinase 1 | [183] | 2.03[184] | 2.28[185] | 2.05[186] | 2.50[187] | 2.18[188] | 2.14[189] |
28 | AKT2 | RAC-beta serine/threonine-protein kinase | [190] | 1.28[191] | 1.67[192] | 1.73[193] | 1.51[194] | 1.33[195] | 1.49[196] |
29 | IL6R | Interleukin-6 receptor subunit alpha | [197] | 0.10[198] | 0.54[199] | -0.34[200] | -0.22[201] | -4.29[202] | 2.02[203] |
30 | SHC2 | SHC-transforming protein 2 | [204] | -1.06[205] | -0.60[206] | -1.50[207] | -4.01[208] | -3.62[209] | -0.01[210] |
31 | KRAS | GTPase KRas | [211] | -0.20[212] | -0.10[213] | 1.43[214] | 1.46[215] | 1.14[216] | 1.04[217] |
32 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [218] | 2.32[219] | 3.81[220] | 2.80[221] | -5.22[222] | -4.94[223] | 2.67[224] |
33 | FGFR3 | Fibroblast growth factor receptor 3 | [225] | 3.05[226] | 3.07[227] | 3.34[228] | -2.64[229] | -1.27[230] | 0.81[231] |
34 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [232] | -0.15[233] | 0.08[234] | 1.11[235] | 2.72[236] | 2.25[237] | 3.37[238] |
35 | SOS1 | Son of sevenless homolog 1 | [239] | 0.22[240] | 1.86[241] | 1.31[242] | 1.50[243] | 0.76[244] | 0.90[245] |
36 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.22[246] | 1.28[247] | 1.42[248] | 0.09[249] | 1.36[250] | 2.84[251] | |
37 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [252] | 2.69[253] | 1.62[254] | 2.73[255] | 1.91[256] | 1.54[257] | 0.52[258] |
38 | EGFR | Epidermal growth factor receptor | [259] | -0.38[260] | -0.64[261] | 2.18[262] | 1.09[263] | 1.73[264] | 3.02[265] |
39 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [266] | 2.19[267] | 2.53[268] | 3.08[269] | 1.36[270] | 1.94[271] | 0.07[272] |
40 | PDGFC | Platelet-derived growth factor C | [273] | -0.96[274] | 0.10[275] | -0.03[276] | 1.56[277] | 1.82[278] | 0.56[279] |
41 | MAPK3 | Mitogen-activated protein kinase 3 | [280] | 2.17[281] | 2.33[282] | 2.31[283] | 1.08[284] | 1.12[285] | -0.68[286] |
42 | GSK3B | Glycogen synthase kinase-3 beta | [287] | 1.58[288] | 1.33[289] | 1.84[290] | 2.47[291] | 2.32[292] | 1.53[293] |
43 | FGF2 | Fibroblast growth factor 2 | [294] | -6.37[295] | -6.00[296] | -1.91[297] | 1.59[298] | 3.19[299] | -1.30[300] |
44 | SRC | Proto-oncogene tyrosine-protein kinase Src | [301] | 3.34[302] | 3.44[303] | 2.38[304] | 3.05[305] | 2.25[306] | -0.49[307] |
45 | GAS6 | Growth arrest-specific protein 6 | [308] | -1.96[309] | -4.45[310] | -8.11[311] | -0.66[312] | 2.90[313] | 0.87[314] |
46 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [315] | 2.65[316] | 3.95[317] | 2.60[318] | 2.09[319] | 2.51[320] | 2.87[321] |
47 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.81[322] | 3.54[323] | 2.81[324] | 3.47[325] | 2.99[326] | 0.70[327] | |
48 | MTOR | Serine/threonine-protein kinase mTOR | [328] | 2.85[329] | 3.98[330] | 3.48[331] | 3.34[332] | 3.44[333] | 3.81[334] |
49 | MRAS | Ras-related protein M-Ras | [335] | 2.07[336] | -3.48[337] | -2.37[338] | 1.11[339] | 1.44[340] | -1.30[341] |
50 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [342] | [343] | [344] | [345] | [346] | [347] | [348] |
51 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.53[349] | 2.15[350] | 2.25[351] | 1.70[352] | 1.89[353] | 1.52[354] | |
52 | FOXO3 | Forkhead box protein O3 | [355] | 0.77[356] | 0.98[357] | 1.55[358] | 1.05[359] | 2.32[360] | 2.70[361] |
53 | SOS2 | Son of sevenless homolog 2 | [362] | 0.29[363] | 1.53[364] | 0.70[365] | 2.34[366] | 2.23[367] | 2.20[368] |
54 | PRKCA | Protein kinase C alpha type | [369] | 3.15[370] | 3.31[371] | 3.61[372] | 2.80[373] | 3.19[374] | 2.28[375] |
55 | TGFA | Protransforming growth factor alpha | [376] | 2.11[377] | 3.29[378] | -7.82[379] | -0.31[380] | -1.51[381] | -0.03[382] |
56 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.06[383] | 1.69[384] | 1.82[385] | 1.78[386] | 2.01[387] | 2.28[388] | |
57 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.20[389] | 3.40[390] | -0.47[391] | 0.93[392] | 1.72[393] | 0.66[394] | |
58 | NF1 | Neurofibromin | [395] | 2.78[396] | 3.23[397] | 3.98[398] | 4.62[399] | 4.09[400] | 4.47[401] |
59 | PDGFA | Platelet-derived growth factor subunit A | [402] | -0.69[403] | -0.36[404] | 1.66[405] | 0.31[406] | -0.58[407] | -0.39[408] |
60 | BCL2L11 | Bcl-2-like protein 11 | [409] | 1.82[410] | 1.94[411] | 2.21[412] | 2.52[413] | 1.52[414] | 2.35[415] |
61 | IL6 | Interleukin-6 | [416] | -8.12[417] | [418] | -4.46[419] | -0.20[420] | 2.34[421] | [422] |
62 | FGFR2 | Fibroblast growth factor receptor 2 | [423] | -2.19[424] | -0.87[425] | 3.01[426] | 2.11[427] | -2.71[428] | 3.79[429] |
63 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [430] | 0.65[431] | -5.37[432] | -2.54[433] | 2.70[434] | -4.75[435] | 1.13[436] |
64 | BRAF | Serine/threonine-protein kinase B-raf | [437] | 0.57[438] | 0.41[439] | 2.38[440] | 1.39[441] | 1.11[442] | 2.22[443] |
65 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -0.96[444] | -6.60[445] | 0.79[446] | -2.08[447] | -0.90[448] | 3.08[449] | |
66 | AXL | Tyrosine-protein kinase receptor UFO | [450] | 3.02[451] | 0.73[452] | -2.95[453] | 5.22[454] | 5.99[455] | 3.73[456] |
67 | GAB1 | GRB2-associated-binding protein 1 | [457] | 1.62[458] | 2.82[459] | 2.88[460] | 2.59[461] | 2.47[462] | 3.24[463] |
68 | JAK2 | Tyrosine-protein kinase JAK2 | [464] | 0.55[465] | 0.65[466] | 0.15[467] | 1.42[468] | 2.04[469] | 3.07[470] |
69 | IGF1R | Insulin-like growth factor 1 receptor | [471] | 5.06[472] | 4.48[473] | 3.09[474] | 5.12[475] | 4.70[476] | 2.45[477] |
70 | PDGFB | Platelet-derived growth factor subunit B | [478] | 3.37[479] | 3.35[480] | 0.48[481] | 0.72[482] | 0.32[483] | 0.74[484] |
71 | PDGFRA | Platelet-derived growth factor receptor alpha | [485] | -3.30[486] | -4.17[487] | 3.41[488] | 1.18[489] | 5.88[490] | 5.68[491] |
72 | PDGFRB | Platelet-derived growth factor receptor beta | [492] | 1.62[493] | 2.13[494] | -0.39[495] | 2.51[496] | 3.09[497] | 3.78[498] |
73 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [499] | 2.04[500] | 2.16[501] | 2.95[502] | 3.82[503] | 2.86[504] | 3.04[505] |
74 | AKT3 | RAC-gamma serine/threonine-protein kinase | [506] | -1.52[507] | -3.97[508] | -3.34[509] | 6.50[510] | 5.47[511] | 3.97[512] |
75 | KDR | Vascular endothelial growth factor receptor 2 | [513] | -5.31[514] | -6.85[515] | -6.20[516] | -1.09[517] | 5.40[518] | 6.66[519] |
76 | PRKCB | Protein kinase C beta type | [520] | -6.49[521] | -5.19[522] | [523] | 3.14[524] | -2.14[525] | 3.90[526] |
77 | BCL2 | Apoptosis regulator Bcl-2 | [527] | -2.54[528] | 2.98[529] | -4.48[530] | 2.43[531] | 2.17[532] | 3.59[533] |
78 | SHC4 | SHC-transforming protein 4 | [534] | -1.94[535] | [536] | -1.33[537] | 3.18[538] | 3.58[539] | -0.33[540] |
79 | SHC3 | SHC-transforming protein 3 | [541] | 2.43[542] | 4.92[543] | -2.63[544] | 4.11[545] | 8.04[546] | 2.18[547] |
80 | PRKCG | Protein kinase C gamma type | [548] | -0.50[549] | 0.28[550] | -2.16[551] | -0.41[552] | -0.47[553] | [554] |
81 | PDGFD | Platelet-derived growth factor D | [555] | 2.69[556] | -2.01[557] | -4.26[558] | 3.49[559] | 5.06[560] | 6.44[561] |
82 | HGF | Hepatocyte growth factor | [562] | [563] | [564] | -1.28[565] | 5.25[566] | 2.30[567] | 9.26[568] |
83 | EGF | Pro-epidermal growth factor | [569] | 2.29[570] | 4.19[571] | 7.74[572] | 9.68[573] | 7.12[574] | 1.94[575] |
84 | NRG2 | Pro-neuregulin-2, membrane-bound isoform | [576] | [577] | [578] | [579] | [580] | [581] | [582] |