WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SULT2A1 Bile salt sulfotransferase [1] -0.83[2] -0.92[3] -1.22[4] -8.76[5] -7.26[6] -0.60[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -9.31[9] -10.44[10] -11.20[11] -12.67[12] -9.82[13] -0.16[14]
3 BAAT Bile acid-CoA:amino acid N-acyltransferase [15] -3.08[16] -3.47[17] -4.87[18] -4.40[19] -4.42[20] 0.86[21]
4 SLC10A1 Sodium/bile acid cotransporter [22] -7.37[23] -8.76[24] -9.28[25] -8.13[26] -8.19[27] -1.29[28]
5 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [29] -12.74[30] -9.96[31] -3.78[32] -8.50[33] [34] 0.68[35]
6 ABCC2 Canalicular multispecific organic anion transporter 1 [36] 3.27[37] 3.83[38] 3.20[39] 3.60[40] -1.88[41] 1.06[42]
7 NR1I3 Nuclear receptor subfamily 1 group I member 3 [43] -5.63[44] -5.14[45] -4.09[46] -5.89[47] -3.88[48] -1.45[49]
8 NR1H4 Bile acid receptor [50] 0.84[51] 0.42[52] 3.16[53] -4.20[54] -2.93[55] -0.37[56]
9 ABCC3 Canalicular multispecific organic anion transporter 2 [57] 3.52[58] 1.83[59] 1.15[60] 4.12[61] 4.83[62] 1.75[63]
10 ABCB1 Multidrug resistance protein 1 [64] 1.85[65] 2.36[66] 1.70[67] -2.01[68] -2.37[69] -0.21[70]
11 NR1I2 Nuclear receptor subfamily 1 group I member 2 [71] 1.05[72] -0.21[73] -3.79[74] -6.17[75] -3.92[76] 0.80[77]
12 CYP7A1 Cholesterol 7-alpha-monooxygenase [78] -1.90[79] -5.25[80] -7.83[81] -6.12[82] [83] -3.84[84]
13 ABCB11 Bile salt export pump [85] -4.35[86] [87] -3.11[88] -1.68[89] [90] 3.90[91]
14 ABCC4 Multidrug resistance-associated protein 4 [92] 4.23[93] 2.30[94] 5.49[95] 6.55[96] 7.35[97] -0.42[98]
15 VDR Vitamin D3 receptor [99] 2.28[100] 1.69[101] 3.28[102] 6.18[103] 8.82[104] -0.41[105]
16 SLC51A Organic solute transporter subunit alpha [106] [107] [108] [109] [110] [111] [112]
17 SLC51B Organic solute transporter subunit beta [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte SULT2A1
Mean 281
Standard deviation 2.8e+02
Values 7.2 3e+02 6.4e+02 4.5e+02 5.2
[2]
HepG2 SULT2A1
Mean 64.4
Standard deviation 29
Values 85 44
[3]
HepG2.C3A SULT2A1
Mean 109
Standard deviation 37
Values 83 1.4e+02
[4]
HuH.7 SULT2A1
Mean 43.5
Standard deviation 18
Values 38 64 29
[5]
SNU475 SULT2A1
Mean 0.0827
Standard deviation 0.012
Values 0.091 0.074
[6]
THLE SULT2A1
Mean 0.106
Standard deviation 0.0079
Values 0.1 0.11
[7]
liver SULT2A1
Mean 489
Standard deviation 2.7e+02
Values 2.3e+02 2.9e+02 8.1e+02 6.3e+02
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[15]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 17 84 89 1.6 59
[16]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 3 1.9
[17]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.1 3.5
[18]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.18 1.6 0.098
[19]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.11 0.49
[20]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[21]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 1.1e+02 1.7e+02 4.1e+02 2.7e+02
[22]
ref_hepatocyte SLC10A1
Mean 41.6
Standard deviation 64
Values 1.5 1.5e+02 60 0 0
[23]
HepG2 SLC10A1
Mean 0.102
Standard deviation 0.08
Values 0.16 0.046
[24]
HepG2.C3A SLC10A1
Mean 0.0701
Standard deviation 0.038
Values 0.043 0.097
[25]
HuH.7 SLC10A1
Mean 0.0242
Standard deviation 0.015
Values 0.019 0.013 0.041
[26]
SNU475 SLC10A1
Mean 0.019
Standard deviation 0.013
Values 0.01 0.028
[27]
THLE SLC10A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[28]
liver SLC10A1
Mean 44.8
Standard deviation 22
Values 29 22 64 63
[29]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 1.4 1e+02 37 0 40
[30]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[31]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.043 0.0097
[32]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.22 2.6 0.074
[33]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0.025 0
[34]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[35]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 95 1.8e+02 1.8e+02 1.5e+02
[36]
ref_hepatocyte ABCC2
Mean 31.6
Standard deviation 23
Values 16 17 17 68 40
[37]
HepG2 ABCC2
Mean 125
Standard deviation 1.3
Values 1.3e+02 1.2e+02
[38]
HepG2.C3A ABCC2
Mean 328
Standard deviation 1.2
Values 3.3e+02 3.3e+02
[39]
HuH.7 ABCC2
Mean 105
Standard deviation 48
Values 68 1.6e+02 88
[40]
SNU475 ABCC2
Mean 48.9
Standard deviation 12
Values 41 57
[41]
THLE ABCC2
Mean 0.497
Standard deviation 0.041
Values 0.53 0.47
[42]
liver ABCC2
Mean 174
Standard deviation 96
Values 1.9e+02 3e+02 89 1.1e+02
[43]
ref_hepatocyte NR1I3
Mean 21.5
Standard deviation 28
Values 3.1 56 46 0.98 0.67
[44]
HepG2 NR1I3
Mean 0.177
Standard deviation 0.0012
Values 0.18 0.18
[45]
HepG2.C3A NR1I3
Mean 0.446
Standard deviation 0.084
Values 0.39 0.51
[46]
HuH.7 NR1I3
Mean 0.459
Standard deviation 0.23
Values 0.34 0.72 0.32
[47]
SNU475 NR1I3
Mean 0.0462
Standard deviation 0.0063
Values 0.051 0.042
[48]
THLE NR1I3
Mean 0.0849
Standard deviation 0.022
Values 0.1 0.069
[49]
liver NR1I3
Mean 20.7
Standard deviation 18
Values 7.7 6.7 46 23
[50]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 3.8 33 43 15 9.3
[51]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 20 11
[52]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 21 19
[53]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 58 82 62
[54]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.17 0.12
[55]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[56]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 39 37 59 35
[57]
ref_hepatocyte ABCC3
Mean 14.4
Standard deviation 9.9
Values 5 9.7 31 14 12
[58]
HepG2 ABCC3
Mean 67.6
Standard deviation 20
Values 54 81
[59]
HepG2.C3A ABCC3
Mean 37.4
Standard deviation 7.2
Values 32 42
[60]
HuH.7 ABCC3
Mean 11.6
Standard deviation 4.6
Values 10 17 7.9
[61]
SNU475 ABCC3
Mean 31.8
Standard deviation 16
Values 21 43
[62]
THLE ABCC3
Mean 23.7
Standard deviation 5.8
Values 28 20
[63]
liver ABCC3
Mean 128
Standard deviation 23
Values 1.3e+02 1.4e+02 93 1.5e+02
[64]
ref_hepatocyte ABCB1
Mean 12.8
Standard deviation 7
Values 15 5.6 5.4 17 21
[65]
HepG2 ABCB1
Mean 18.8
Standard deviation 3.2
Values 21 17
[66]
HepG2.C3A ABCB1
Mean 47.9
Standard deviation 1.3
Values 49 47
[67]
HuH.7 ABCB1
Mean 15
Standard deviation 8.7
Values 9 25 11
[68]
SNU475 ABCB1
Mean 0.405
Standard deviation 0.094
Values 0.47 0.34
[69]
THLE ABCB1
Mean 0.143
Standard deviation 0.0068
Values 0.15 0.14
[70]
liver ABCB1
Mean 29
Standard deviation 14
Values 31 46 13 26
[71]
ref_hepatocyte NR1I2
Mean 9.56
Standard deviation 6.3
Values 6.4 18 15 5.2 3.7
[72]
HepG2 NR1I2
Mean 8.09
Standard deviation 2.1
Values 9.6 6.6
[73]
HepG2.C3A NR1I2
Mean 6.05
Standard deviation 2.4
Values 7.8 4.3
[74]
HuH.7 NR1I2
Mean 0.251
Standard deviation 0.064
Values 0.23 0.32 0.2
[75]
SNU475 NR1I2
Mean 0.0169
Standard deviation 0.0024
Values 0.015 0.019
[76]
THLE NR1I2
Mean 0.0367
Standard deviation 0.0067
Values 0.041 0.032
[77]
liver NR1I2
Mean 43.7
Standard deviation 13
Values 38 37 63 37
[78]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 0 9.7 0.69 9.8 0
[79]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.77 0.11
[80]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.097 0.058
[81]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[82]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.01 0.0046
[83]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[84]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 0.079 0.94 1.1 0.82
[85]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 1.8 4.1 3 0 1
[86]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.021 0.057
[87]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.037 0.096 0.11
[89]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.11 0.051
[90]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[91]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 71 1.9e+02 17 36
[92]
ref_hepatocyte ABCC4
Mean 1.25
Standard deviation 1.2
Values 0.52 0.16 0.41 2.7 2.4
[93]
HepG2 ABCC4
Mean 9.57
Standard deviation 0.89
Values 8.9 10
[94]
HepG2.C3A ABCC4
Mean 4.52
Standard deviation 0.047
Values 4.5 4.5
[95]
HuH.7 ABCC4
Mean 20.4
Standard deviation 3.5
Values 16 23 22
[96]
SNU475 ABCC4
Mean 14.9
Standard deviation 1.9
Values 14 16
[97]
THLE ABCC4
Mean 11.8
Standard deviation 2.1
Values 10 13
[98]
liver ABCC4
Mean 2.46
Standard deviation 0.72
Values 3 3.1 2.2 1.6
[99]
ref_hepatocyte VDR
Mean 0.333
Standard deviation 0.23
Values 0.19 0.39 0.41 0.038 0.63
[100]
HepG2 VDR
Mean 0.657
Standard deviation 0.019
Values 0.64 0.67
[101]
HepG2.C3A VDR
Mean 0.783
Standard deviation 0.23
Values 0.94 0.62
[102]
HuH.7 VDR
Mean 1.17
Standard deviation 0.57
Values 1.3 0.56 1.7
[103]
SNU475 VDR
Mean 3.08
Standard deviation 3
Values 5.2 0.97
[104]
THLE VDR
Mean 8.71
Standard deviation 1.4
Values 7.8 9.7
[105]
liver VDR
Mean 0.658
Standard deviation 0.17
Values 0.54 0.56 0.63 0.9
[106]
ref_hepatocyte SLC51A
Missing
[107]
HepG2 SLC51A
Mean 2.9
Standard deviation 0.024
Values 2.9 2.9
[108]
HepG2.C3A SLC51A
Mean 10.5
Standard deviation 3.2
Values 8.2 13
[109]
HuH.7 SLC51A
Mean 4.67
Standard deviation 0.7
Values 4.7 5.3 4
[110]
SNU475 SLC51A
Mean 0.0895
Standard deviation 0.0047
Values 0.086 0.093
[111]
THLE SLC51A
Mean 0.0943
Standard deviation 0.025
Values 0.077 0.11
[112]
liver SLC51A
Mean 12.1
Standard deviation 5.5
Values 11 5.5 19 14
[113]
ref_hepatocyte SLC51B
Missing
[114]
HepG2 SLC51B
Mean 5.2
Standard deviation 0.49
Values 4.9 5.5
[115]
HepG2.C3A SLC51B
Mean 6.12
Standard deviation 2.1
Values 7.6 4.6
[116]
HuH.7 SLC51B
Mean 13.2
Standard deviation 4
Values 17 13 9.5
[117]
SNU475 SLC51B
Mean 0.158
Standard deviation 0.18
Values 0.28 0.032
[118]
THLE SLC51B
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[119]
liver SLC51B
Mean 0.29
Standard deviation 0.29
Values 0.093 0.19 0.16 0.72