WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | XRCC6 | X-ray repair cross-complementing protein 6 | [1] | -0.10[2] | -0.68[3] | -0.77[4] | -1.07[5] | -0.89[6] | -1.16[7] |
2 | HMGB1 | High mobility group protein B1 | [8] | -0.40[9] | 0.12[10] | -0.43[11] | 0.25[12] | -0.34[13] | -0.25[14] |
3 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [15] | -2.16[16] | -1.95[17] | -2.35[18] | -2.91[19] | -2.56[20] | -1.79[21] |
4 | CETN2 | Centrin-2 | [22] | -2.71[23] | -2.55[24] | -4.00[25] | -2.87[26] | -3.36[27] | -3.18[28] |
5 | XRCC5 | X-ray repair cross-complementing protein 5 | [29] | 0.96[30] | 0.85[31] | 0.44[32] | 0.61[33] | 0.77[34] | 0.45[35] |
6 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | [36] | -0.01[37] | -0.58[38] | 0.06[39] | -1.02[40] | -1.44[41] | -1.37[42] |
7 | MGMT | Methylated-DNA--protein-cysteine methyltransferase | [43] | -3.38[44] | -3.24[45] | -3.05[46] | -4.59[47] | -4.96[48] | -0.57[49] |
8 | PARP1 | Poly [ADP-ribose] polymerase 1 | [50] | 0.02[51] | -0.44[52] | 0.01[53] | 0.32[54] | -0.23[55] | -0.11[56] |
9 | PCNA | Proliferating cell nuclear antigen | [57] | 0.78[58] | 0.55[59] | -1.15[60] | -0.42[61] | -0.21[62] | -2.77[63] |
10 | RAD23B | UV excision repair protein RAD23 homolog B | [64] | 0.51[65] | 0.14[66] | 0.16[67] | 0.36[68] | 0.79[69] | 0.33[70] |
11 | POLD2 | DNA polymerase delta subunit 2 | [71] | -0.71[72] | -0.75[73] | -0.52[74] | -1.07[75] | -0.77[76] | 0.18[77] |
12 | POLD4 | DNA polymerase delta subunit 4 | [78] | -2.24[79] | -2.80[80] | -1.00[81] | 1.24[82] | -2.42[83] | -0.17[84] |
13 | RAD23A | UV excision repair protein RAD23 homolog A | [85] | -0.51[86] | -0.81[87] | -0.03[88] | -1.14[89] | -0.27[90] | -0.13[91] |
14 | DDB1 | DNA damage-binding protein 1 | [92] | 1.51[93] | 0.65[94] | 1.50[95] | 0.63[96] | 0.60[97] | 0.90[98] |
15 | POLE3 | DNA polymerase epsilon subunit 3 | [99] | -0.89[100] | -1.25[101] | -1.24[102] | -1.26[103] | -0.30[104] | -1.27[105] |
16 | POLE4 | DNA polymerase epsilon subunit 4 | [106] | -1.15[107] | -0.63[108] | -4.37[109] | -1.83[110] | -2.37[111] | -1.50[112] |
17 | RPA2 | Replication protein A 32 kDa subunit | [113] | -1.56[114] | -1.71[115] | -1.43[116] | -0.95[117] | -0.94[118] | -2.09[119] |
18 | MPG | DNA-3-methyladenine glycosylase | [120] | -0.78[121] | -0.27[122] | -1.64[123] | -2.53[124] | -2.05[125] | -1.20[126] |
19 | RAP1A | Ras-related protein Rap-1A | [127] | -1.15[128] | -1.43[129] | -0.88[130] | -0.42[131] | -0.73[132] | -0.98[133] |
20 | CUL4A | Cullin-4A | [134] | 0.13[135] | 0.19[136] | -0.79[137] | -0.28[138] | -0.54[139] | 0.89[140] |
21 | CCNH | Cyclin-H | [141] | -1.77[142] | -1.14[143] | -2.03[144] | -1.98[145] | -0.66[146] | -0.62[147] |
22 | ERCC3 | TFIIH basal transcription factor complex helicase XPB subunit | [148] | -0.22[149] | -0.19[150] | -1.06[151] | -0.65[152] | -0.27[153] | -0.39[154] |
23 | NTHL1 | Endonuclease III-like protein 1 | [155] | -1.31[156] | -1.12[157] | -2.14[158] | -2.47[159] | -2.75[160] | -0.12[161] |
24 | UNG | Uracil-DNA glycosylase | [162] | 0.40[163] | 0.15[164] | 0.29[165] | -1.32[166] | -0.63[167] | -0.79[168] |
25 | ERCC1 | DNA excision repair protein ERCC-1 | [169] | -0.60[170] | -0.96[171] | -1.08[172] | -0.86[173] | -0.51[174] | -0.76[175] |
26 | CDK7 | Cyclin-dependent kinase 7 | [176] | -0.75[177] | 0.04[178] | -0.52[179] | -0.77[180] | -1.16[181] | -2.05[182] |
27 | SMUG1 | Single-strand selective monofunctional uracil DNA glycosylase | [183] | -0.88[184] | -0.87[185] | -1.10[186] | -0.79[187] | -1.33[188] | -0.29[189] |
28 | RFC4 | Replication factor C subunit 4 | [190] | -1.08[191] | -0.67[192] | -0.37[193] | -1.17[194] | 0.09[195] | -2.45[196] |
29 | MSH6 | DNA mismatch repair protein Msh6 | [197] | 0.21[198] | 0.48[199] | 0.40[200] | 0.69[201] | 1.04[202] | 0.60[203] |
30 | POLB | DNA polymerase beta | [204] | -1.04[205] | -1.21[206] | -1.44[207] | -2.49[208] | -2.37[209] | -1.20[210] |
31 | GTF2H2 | General transcription factor IIH subunit 2 | [211] | -5.51[212] | -4.78[213] | -5.27[214] | -5.39[215] | -6.71[216] | -4.37[217] |
32 | RAD51C | DNA repair protein RAD51 homolog 3 | [218] | -0.52[219] | -0.50[220] | -0.95[221] | -2.39[222] | -0.92[223] | -1.95[224] |
33 | PARP2 | Poly [ADP-ribose] polymerase 2 | [225] | -0.18[226] | -0.77[227] | -0.30[228] | -0.48[229] | 0.22[230] | -1.17[231] |
34 | RFC1 | Replication factor C subunit 1 | [232] | 0.04[233] | 1.11[234] | 1.20[235] | 0.12[236] | 0.89[237] | 1.08[238] |
35 | RFC2 | Replication factor C subunit 2 | [239] | -0.37[240] | -0.73[241] | -0.97[242] | -0.03[243] | 0.36[244] | -0.47[245] |
36 | FEN1 | Flap endonuclease 1 | [246] | 0.92[247] | 0.49[248] | 1.07[249] | 0.47[250] | 1.30[251] | -0.79[252] |
37 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [253] | 1.21[254] | 0.72[255] | 0.72[256] | 1.64[257] | 1.59[258] | 0.31[259] |
38 | RPA3 | Replication protein A 14 kDa subunit | [260] | -0.47[261] | 0.11[262] | 0.55[263] | -1.11[264] | -0.90[265] | -0.39[266] |
39 | GTF2H1 | General transcription factor IIH subunit 1 | [267] | 0.12[268] | 0.08[269] | -0.26[270] | 0.39[271] | -0.13[272] | 0.47[273] |
40 | NEIL2 | Endonuclease 8-like 2 | [274] | -1.33[275] | -1.62[276] | -2.38[277] | -3.20[278] | -3.22[279] | -0.72[280] |
41 | GTF2H4 | General transcription factor IIH subunit 4 | [281] | -0.35[282] | -0.10[283] | -0.29[284] | 0.11[285] | -0.73[286] | -1.36[287] |
42 | XPA | DNA repair protein complementing XP-A cells | [288] | -2.44[289] | -1.78[290] | -2.39[291] | -2.13[292] | -2.03[293] | -0.38[294] |
43 | APEX2 | DNA-(apurinic or apyrimidinic site) lyase 2 | [295] | 0.42[296] | -0.70[297] | -1.18[298] | -0.09[299] | -0.30[300] | -0.39[301] |
44 | CUL4B | Cullin-4B | [302] | -0.20[303] | 0.97[304] | 2.16[305] | 2.10[306] | 2.97[307] | 1.18[308] |
45 | PNKP | Bifunctional polynucleotide phosphatase/kinase | [309] | -1.09[310] | -0.96[311] | -0.31[312] | -1.14[313] | -0.75[314] | 0.00[315] |
46 | MLH1 | DNA mismatch repair protein Mlh1 | [316] | 0.75[317] | 0.65[318] | 1.11[319] | -0.06[320] | 0.52[321] | 0.73[322] |
47 | DDB2 | DNA damage-binding protein 2 | [323] | 0.98[324] | 0.28[325] | -1.31[326] | -1.81[327] | -1.30[328] | -1.22[329] |
48 | NBN | Nibrin | [330] | -0.52[331] | 0.44[332] | -0.09[333] | 1.30[334] | 0.35[335] | 1.58[336] |
49 | MBD4 | Methyl-CpG-binding domain protein 4 | [337] | -0.81[338] | -0.30[339] | -0.15[340] | 0.16[341] | 0.86[342] | 1.07[343] |
50 | TDG | G/T mismatch-specific thymine DNA glycosylase | [344] | -0.43[345] | 0.39[346] | -0.16[347] | 1.31[348] | 0.61[349] | 0.22[350] |
51 | RFC5 | Replication factor C subunit 5 | [351] | 0.02[352] | 0.27[353] | 0.18[354] | 0.06[355] | 0.52[356] | -0.57[357] |
52 | ERCC5 | DNA repair protein complementing XP-G cells | [358] | -4.88[359] | -4.31[360] | -4.60[361] | -3.95[362] | -4.21[363] | -1.93[364] |
53 | MNAT1 | CDK-activating kinase assembly factor MAT1 | [365] | -0.72[366] | 0.36[367] | -0.74[368] | 0.18[369] | -0.35[370] | -0.65[371] |
54 | PMS2 | Mismatch repair endonuclease PMS2 | [372] | -1.52[373] | -2.00[374] | -1.38[375] | -0.80[376] | -1.18[377] | -1.11[378] |
55 | XPC | DNA repair protein complementing XP-C cells | [379] | 0.80[380] | 0.35[381] | 0.95[382] | 0.24[383] | 0.42[384] | 1.55[385] |
56 | OGG1 | N-glycosylase/DNA lyase | [386] | 0.31[387] | 0.21[388] | 0.03[389] | -0.79[390] | -1.00[391] | -0.42[392] |
57 | USP1 | Ubiquitin carboxyl-terminal hydrolase 1 | [393] | 0.43[394] | 1.61[395] | 1.44[396] | 1.57[397] | 1.86[398] | 0.64[399] |
58 | RAD51 | DNA repair protein RAD51 homolog 1 | [400] | -0.36[401] | -0.76[402] | -0.95[403] | -0.39[404] | -0.49[405] | -3.64[406] |
59 | GTF2H3 | General transcription factor IIH subunit 3 | [407] | 1.10[408] | 1.30[409] | 0.98[410] | 1.15[411] | 0.86[412] | 0.43[413] |
60 | ERCC2 | TFIIH basal transcription factor complex helicase XPD subunit | [414] | 1.01[415] | 0.85[416] | 1.00[417] | 1.11[418] | 0.96[419] | -0.52[420] |
61 | GTF2H2C | General transcription factor IIH subunit 2-like protein | [421] | -6.77[422] | -6.19[423] | -5.69[424] | -6.12[425] | -7.19[426] | -6.03[427] |
62 | TERF2 | Telomeric repeat-binding factor 2 | [428] | 0.20[429] | -0.01[430] | 0.48[431] | -0.29[432] | 0.04[433] | -0.13[434] |
63 | MSH2 | DNA mismatch repair protein Msh2 | [435] | 0.72[436] | 1.79[437] | 0.95[438] | 1.93[439] | 1.22[440] | -0.39[441] |
64 | RAD50 | DNA repair protein RAD50 | [442] | 0.05[443] | 1.96[444] | 0.83[445] | 1.06[446] | 1.48[447] | 2.51[448] |
65 | XRCC1 | DNA repair protein XRCC1 | [449] | 0.53[450] | 0.50[451] | 1.29[452] | 0.56[453] | 0.47[454] | -0.62[455] |
66 | WDR48 | WD repeat-containing protein 48 | [456] | 0.94[457] | 1.58[458] | 1.50[459] | 0.29[460] | 0.81[461] | 1.53[462] |
67 | FANCL | E3 ubiquitin-protein ligase FANCL | [463] | -1.08[464] | 0.69[465] | -0.69[466] | -0.55[467] | -0.50[468] | 0.21[469] |
68 | NHEJ1 | Non-homologous end-joining factor 1 | [470] | 0.43[471] | 0.48[472] | 0.27[473] | -0.28[474] | -0.51[475] | 0.16[476] |
69 | PRKDC | DNA-dependent protein kinase catalytic subunit | [477] | 4.11[478] | 3.36[479] | 4.96[480] | 4.69[481] | 4.70[482] | 4.54[483] |
70 | RFC3 | Replication factor C subunit 3 | [484] | 1.07[485] | 1.71[486] | 1.57[487] | 1.05[488] | 1.57[489] | -0.56[490] |
71 | LIG3 | DNA ligase 3 | [491] | 1.07[492] | 0.90[493] | 1.69[494] | 0.87[495] | -0.15[496] | 1.17[497] |
72 | LIG1 | DNA ligase 1 | [498] | 1.52[499] | 1.33[500] | 1.68[501] | 0.30[502] | 0.97[503] | -0.06[504] |
73 | GTF2H5 | General transcription factor IIH subunit 5 | [505] | 1.49[506] | 1.67[507] | 1.21[508] | 1.07[509] | 1.16[510] | 1.33[511] |
74 | CHEK1 | Serine/threonine-protein kinase Chk1 | [512] | 1.43[513] | 1.57[514] | 0.86[515] | 1.94[516] | 2.10[517] | -1.72[518] |
75 | POLD1 | DNA polymerase delta catalytic subunit | [519] | 1.75[520] | 1.76[521] | 2.29[522] | 1.62[523] | 2.31[524] | 0.97[525] |
76 | POLL | DNA polymerase lambda | [526] | 0.89[527] | 1.62[528] | 1.90[529] | -0.16[530] | 0.36[531] | 0.54[532] |
77 | LIG4 | DNA ligase 4 | [533] | -1.31[534] | 0.38[535] | -1.01[536] | 0.57[537] | 0.30[538] | 1.79[539] |
78 | FAN1 | Fanconi-associated nuclease 1 | [540] | 0.90[541] | 0.97[542] | 0.52[543] | 1.33[544] | 1.34[545] | 2.39[546] |
79 | FANCA | Fanconi anemia group A protein | [547] | 1.56[548] | 2.02[549] | 1.45[550] | 1.11[551] | 1.38[552] | -0.06[553] |
80 | REV1 | DNA repair protein REV1 | [554] | 1.33[555] | 2.32[556] | 1.32[557] | 1.63[558] | 1.52[559] | 2.11[560] |
81 | POLK | DNA polymerase kappa | [561] | -0.95[562] | 0.31[563] | 0.28[564] | 1.62[565] | 1.29[566] | 2.40[567] |
82 | POLH | DNA polymerase eta | [568] | 2.01[569] | 1.28[570] | -0.43[571] | 1.79[572] | 1.51[573] | 1.64[574] |
83 | FANCF | Fanconi anemia group F protein | [575] | 0.89[576] | 0.42[577] | 1.32[578] | 0.62[579] | -0.69[580] | 1.51[581] |
84 | ERCC8 | DNA excision repair protein ERCC-8 | [582] | 0.67[583] | 1.58[584] | 0.44[585] | -0.62[586] | 0.62[587] | 0.36[588] |
85 | MUTYH | Adenine DNA glycosylase | [589] | 0.17[590] | 0.99[591] | 1.58[592] | -0.29[593] | -0.18[594] | 0.24[595] |
86 | XRCC4 | DNA repair protein XRCC4 | [596] | -0.69[597] | 0.69[598] | 0.19[599] | -0.01[600] | -0.10[601] | -0.44[602] |
87 | PALB2 | Partner and localizer of BRCA2 | [603] | 1.66[604] | 1.74[605] | 1.09[606] | 0.49[607] | 0.91[608] | 0.98[609] |
88 | BRCA1 | Breast cancer type 1 susceptibility protein | [610] | 1.56[611] | 2.59[612] | 2.70[613] | 1.94[614] | 2.39[615] | 1.98[616] |
89 | POLM | DNA-directed DNA/RNA polymerase mu | [617] | -0.41[618] | -0.24[619] | 0.26[620] | -0.03[621] | -0.35[622] | 1.50[623] |
90 | FANCI | Fanconi anemia group I protein | [624] | 2.33[625] | 2.55[626] | 2.76[627] | 3.14[628] | 3.37[629] | 0.14[630] |
91 | MSH3 | DNA mismatch repair protein Msh3 | [631] | 0.64[632] | 1.04[633] | 0.54[634] | 1.27[635] | 1.09[636] | 2.73[637] |
92 | FANCC | Fanconi anemia group C protein | [638] | 0.91[639] | 1.02[640] | -0.88[641] | 1.33[642] | 1.43[643] | 3.23[644] |
93 | ATR | Serine/threonine-protein kinase ATR | [645] | 0.99[646] | 1.77[647] | 1.56[648] | 2.32[649] | 2.21[650] | 3.85[651] |
94 | POLD3 | DNA polymerase delta subunit 3 | [652] | 1.07[653] | 0.72[654] | 1.41[655] | 1.91[656] | 2.32[657] | 1.29[658] |
95 | POLE | DNA polymerase epsilon catalytic subunit A | [659] | 2.94[660] | 3.34[661] | 3.11[662] | 2.53[663] | 3.47[664] | 3.24[665] |
96 | FANCE | Fanconi anemia group E protein | [666] | 0.68[667] | 0.78[668] | 0.34[669] | 0.61[670] | 0.53[671] | -2.27[672] |
97 | WRN | Werner syndrome ATP-dependent helicase | [673] | 0.50[674] | 1.75[675] | 3.40[676] | 1.49[677] | 1.24[678] | 2.27[679] |
98 | RAD52 | DNA repair protein RAD52 homolog | [680] | 0.27[681] | 0.82[682] | 0.65[683] | -0.62[684] | -0.24[685] | 1.06[686] |
99 | POLE2 | DNA polymerase epsilon subunit 2 | [687] | 0.60[688] | 1.18[689] | 1.88[690] | 0.95[691] | 1.42[692] | -0.85[693] |
100 | FANCG | Fanconi anemia group G protein | [694] | 1.86[695] | 2.46[696] | 2.96[697] | 1.51[698] | 2.32[699] | 0.19[700] |
101 | FANCD2 | Fanconi anemia group D2 protein | [701] | 2.33[702] | 2.25[703] | 3.04[704] | 2.21[705] | 2.83[706] | 0.33[707] |
102 | ATM | Serine-protein kinase ATM | [708] | 2.92[709] | 4.31[710] | 3.75[711] | 3.95[712] | 3.36[713] | 5.29[714] |
103 | DCLRE1C | Protein artemis | [715] | 0.17[716] | 1.45[717] | 0.32[718] | 2.44[719] | 1.16[720] | 1.76[721] |
104 | REV3L | DNA polymerase zeta catalytic subunit | [722] | 2.30[723] | 3.65[724] | 1.98[725] | 2.79[726] | 2.86[727] | 4.77[728] |
105 | RAD54B | DNA repair and recombination protein RAD54B | [729] | 0.64[730] | 2.25[731] | 2.70[732] | 2.48[733] | 1.84[734] | -0.03[735] |
106 | ERCC4 | DNA repair endonuclease XPF | [736] | 2.11[737] | 1.57[738] | 1.46[739] | 2.02[740] | 2.10[741] | 2.72[742] |
107 | EXO1 | Exonuclease 1 | [743] | 1.80[744] | 1.87[745] | 2.75[746] | 3.57[747] | 2.78[748] | -1.17[749] |
108 | ERCC6 | DNA excision repair protein ERCC-6 | [750] | 1.18[751] | 1.74[752] | -0.39[753] | 3.11[754] | 2.12[755] | 3.53[756] |
109 | POLI | DNA polymerase iota | [757] | 1.48[758] | 2.64[759] | 2.27[760] | 2.06[761] | 1.78[762] | 3.18[763] |
110 | BRIP1 | Fanconi anemia group J protein | [764] | 2.04[765] | 3.22[766] | 2.95[767] | 3.00[768] | 2.97[769] | 2.26[770] |
111 | FANCM | Fanconi anemia group M protein | [771] | 0.76[772] | 2.74[773] | 2.97[774] | 2.77[775] | 2.77[776] | 3.00[777] |
112 | NEIL3 | Endonuclease 8-like 3 | [778] | 2.33[779] | 2.38[780] | 3.29[781] | 4.08[782] | 4.11[783] | -0.94[784] |
113 | BRCA2 | Breast cancer type 2 susceptibility protein | [785] | 2.69[786] | 4.97[787] | 4.86[788] | 4.27[789] | 4.35[790] | 3.74[791] |
114 | FANCB | Fanconi anemia group B protein | [792] | 2.14[793] | 2.48[794] | 3.41[795] | 3.89[796] | 3.78[797] | 1.52[798] |
115 | H2AX | [799] | [800] | [801] | [802] | [803] | [804] | [805] | |
116 | CENPS | Centromere protein S | [806] | [807] | [808] | [809] | [810] | [811] | [812] |
117 | MIR6838 | [813] | [814] | [815] | [816] | [817] | [818] | [819] | |
118 | FAAP24 | Fanconi anemia core complex-associated protein 24 | [820] | [821] | [822] | [823] | [824] | [825] | [826] |
119 | CENPX | Centromere protein X | [827] | [828] | [829] | [830] | [831] | [832] | [833] |
120 | FAAP100 | Fanconi anemia core complex-associated protein 100 | [834] | [835] | [836] | [837] | [838] | [839] | [840] |
121 | MRE11 | Double-strand break repair protein MRE11 | [841] | [842] | [843] | [844] | [845] | [846] | [847] |