WP_DNA_IRDOUBLE_STRAND_BREAKS_AND_CELLULAR_RESPONSE_VIA_ATM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PARP1 | Poly [ADP-ribose] polymerase 1 | [1] | -0.88[2] | -1.33[3] | -0.86[4] | -0.64[5] | -1.19[6] | -0.86[7] |
2 | PCNA | Proliferating cell nuclear antigen | [8] | -0.12[9] | -0.34[10] | -2.02[11] | -1.38[12] | -1.16[13] | -3.53[14] |
3 | TRIM28 | Transcription intermediary factor 1-beta | [15] | 0.45[16] | 0.02[17] | 0.77[18] | -0.15[19] | -0.48[20] | -1.12[21] |
4 | BAX | Apoptosis regulator BAX | [22] | -0.68[23] | -1.68[24] | -2.41[25] | -2.77[26] | -2.45[27] | -4.41[28] |
5 | ACTL6A | Actin-like protein 6A | [29] | -0.71[30] | -0.81[31] | -1.02[32] | -0.96[33] | -0.79[34] | -1.60[35] |
6 | CASP3 | Caspase-3 | [36] | -0.88[37] | -0.41[38] | -3.22[39] | -2.06[40] | -1.13[41] | -1.26[42] |
7 | HSF1 | Heat shock factor protein 1 | [43] | -0.65[44] | -1.28[45] | -1.29[46] | -0.65[47] | -1.13[48] | -1.29[49] |
8 | BID | BH3-interacting domain death agonist | [50] | -1.28[51] | -1.38[52] | -2.03[53] | -1.45[54] | -2.06[55] | -0.28[56] |
9 | RASSF1 | Ras association domain-containing protein 1 | [57] | -2.07[58] | -2.13[59] | -2.78[60] | -2.66[61] | -1.30[62] | -2.36[63] |
10 | YAP1 | Transcriptional coactivator YAP1 | [64] | 0.96[65] | 0.21[66] | -0.43[67] | 1.12[68] | 0.47[69] | -0.10[70] |
11 | SMC3 | Structural maintenance of chromosomes protein 3 | [71] | -2.18[72] | 0.27[73] | 0.46[74] | -0.75[75] | -0.39[76] | -0.40[77] |
12 | UPF1 | Regulator of nonsense transcripts 1 | [78] | 0.71[79] | 0.31[80] | 0.80[81] | -0.37[82] | 0.22[83] | 0.07[84] |
13 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [85] | -0.37[86] | 0.47[87] | 0.43[88] | -0.38[89] | -0.67[90] | 0.57[91] |
14 | RAD17 | Cell cycle checkpoint protein RAD17 | [92] | -1.86[93] | -0.98[94] | -1.20[95] | -1.51[96] | -1.22[97] | -0.88[98] |
15 | KAT5 | Histone acetyltransferase KAT5 | [99] | -1.79[100] | -1.58[101] | -2.88[102] | -2.00[103] | -2.15[104] | -1.52[105] |
16 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [106] | 1.10[107] | 2.31[108] | -0.72[109] | -0.65[110] | 0.16[111] | 1.71[112] |
17 | BAK1 | Bcl-2 homologous antagonist/killer | [113] | -0.12[114] | -0.78[115] | -1.08[116] | 0.02[117] | -0.56[118] | -2.24[119] |
18 | NBN | Nibrin | [120] | -1.43[121] | -0.45[122] | -0.97[123] | 0.34[124] | -0.61[125] | 0.82[126] |
19 | CHEK2 | Serine/threonine-protein kinase Chk2 | [127] | -0.91[128] | -0.67[129] | -0.54[130] | -1.41[131] | -1.85[132] | -3.73[133] |
20 | TP53 | Cellular tumor antigen p53 | [134] | 0.63[135] | -0.02[136] | 0.47[137] | 0.13[138] | -0.27[139] | -0.49[140] |
21 | RAD51 | DNA repair protein RAD51 homolog 1 | [141] | -1.26[142] | -1.65[143] | -1.82[144] | -1.35[145] | -1.44[146] | -4.40[147] |
22 | CDK5 | Cyclin-dependent-like kinase 5 | [148] | -0.77[149] | -1.67[150] | -1.89[151] | -0.54[152] | -1.81[153] | -1.33[154] |
23 | SMC1A | Structural maintenance of chromosomes protein 1A | [155] | 1.09[156] | 0.75[157] | 1.49[158] | 1.85[159] | 2.63[160] | 1.99[161] |
24 | TERF2 | Telomeric repeat-binding factor 2 | [162] | -0.71[163] | -0.90[164] | -0.40[165] | -1.25[166] | -0.91[167] | -0.89[168] |
25 | ABL1 | Tyrosine-protein kinase ABL1 | [169] | 1.22[170] | 0.41[171] | 0.93[172] | 0.91[173] | 1.53[174] | 0.49[175] |
26 | RAD50 | DNA repair protein RAD50 | [176] | -0.86[177] | 1.07[178] | -0.05[179] | 0.10[180] | 0.53[181] | 1.75[182] |
27 | PRKDC | DNA-dependent protein kinase catalytic subunit | [183] | 3.20[184] | 2.46[185] | 4.08[186] | 3.73[187] | 3.75[188] | 3.79[189] |
28 | RNF8 | E3 ubiquitin-protein ligase RNF8 | [190] | 0.33[191] | 0.20[192] | -1.42[193] | 0.11[194] | -0.47[195] | -0.54[196] |
29 | STK3 | Serine/threonine-protein kinase 3 | [197] | -2.09[198] | -1.44[199] | -1.50[200] | 0.16[201] | -1.24[202] | 0.73[203] |
30 | CASP9 | Caspase-9 | [204] | -0.85[205] | -0.10[206] | -1.25[207] | -0.92[208] | -1.67[209] | -0.99[210] |
31 | E2F1 | Transcription factor E2F1 | [211] | 0.94[212] | 0.59[213] | 0.44[214] | 0.70[215] | 1.08[216] | -4.07[217] |
32 | CHEK1 | Serine/threonine-protein kinase Chk1 | [218] | 0.52[219] | 0.68[220] | -0.02[221] | 0.99[222] | 1.15[223] | -2.48[224] |
33 | MCPH1 | Microcephalin | [225] | -0.12[226] | 0.26[227] | 0.45[228] | -1.74[229] | -0.75[230] | 0.68[231] |
34 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [232] | 1.48[233] | 1.68[234] | 1.74[235] | 1.73[236] | 1.59[237] | 1.00[238] |
35 | RAD9A | Cell cycle checkpoint control protein RAD9A | [239] | -0.94[240] | -0.86[241] | 0.68[242] | 1.16[243] | -1.07[244] | -0.62[245] |
36 | BRCA1 | Breast cancer type 1 susceptibility protein | [246] | 0.66[247] | 1.70[248] | 1.82[249] | 0.98[250] | 1.44[251] | 1.22[252] |
37 | RIF1 | Telomere-associated protein RIF1 | [253] | 0.50[254] | 2.44[255] | 1.31[256] | 1.74[257] | 2.12[258] | 3.10[259] |
38 | LATS1 | Serine/threonine-protein kinase LATS1 | [260] | 0.37[261] | 0.71[262] | 1.13[263] | 1.52[264] | 1.04[265] | 1.81[266] |
39 | ATR | Serine/threonine-protein kinase ATR | [267] | 0.08[268] | 0.88[269] | 0.69[270] | 1.36[271] | 1.26[272] | 3.10[273] |
40 | TP53BP1 | TP53-binding protein 1 | [274] | 1.57[275] | 0.87[276] | 1.57[277] | 2.77[278] | 2.16[279] | 1.83[280] |
41 | APAF1 | Apoptotic protease-activating factor 1 | [281] | 0.65[282] | 0.87[283] | 0.85[284] | 1.46[285] | 0.50[286] | 1.04[287] |
42 | RAD52 | DNA repair protein RAD52 homolog | [288] | -0.63[289] | -0.07[290] | -0.23[291] | -1.58[292] | -1.19[293] | 0.30[294] |
43 | FANCD2 | Fanconi anemia group D2 protein | [295] | 1.42[296] | 1.36[297] | 2.16[298] | 1.25[299] | 1.87[300] | -0.43[301] |
44 | ATM | Serine-protein kinase ATM | [302] | 2.02[303] | 3.42[304] | 2.87[305] | 2.99[306] | 2.41[307] | 4.54[308] |
45 | TRAF6 | TNF receptor-associated factor 6 | [309] | 0.08[310] | -0.24[311] | 0.06[312] | 0.50[313] | -0.11[314] | 2.46[315] |
46 | DCLRE1C | Protein artemis | [316] | -0.74[317] | 0.56[318] | -0.56[319] | 1.48[320] | 0.21[321] | 1.01[322] |
47 | CDC25C | M-phase inducer phosphatase 3 | [323] | 0.92[324] | 1.87[325] | 1.63[326] | 0.76[327] | 1.55[328] | -1.87[329] |
48 | EXO1 | Exonuclease 1 | [330] | 0.89[331] | 0.97[332] | 1.87[333] | 2.61[334] | 1.83[335] | -1.92[336] |
49 | BLM | Bloom syndrome protein | [337] | 0.53[338] | 1.68[339] | 2.22[340] | 1.73[341] | 1.74[342] | -0.83[343] |
50 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [344] | 3.07[345] | 0.63[346] | 3.77[347] | 4.04[348] | 5.76[349] | -2.60[350] |
51 | TP73 | Tumor protein p73 | [351] | -0.29[352] | 2.06[353] | 0.71[354] | -0.49[355] | 0.58[356] | 0.20[357] |
52 | BRCA2 | Breast cancer type 2 susceptibility protein | [358] | 1.79[359] | 4.07[360] | 3.98[361] | 3.31[362] | 3.40[363] | 2.98[364] |
53 | H2AX | [365] | [366] | [367] | [368] | [369] | [370] | [371] | |
54 | NABP2 | SOSS complex subunit B1 | [372] | [373] | [374] | [375] | [376] | [377] | [378] |
55 | MRE11 | Double-strand break repair protein MRE11 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |