WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [1] | -1.70[2] | -1.67[3] | -1.68[4] | -1.77[5] | -1.51[6] | -0.47[7] |
2 | XRCC5 | X-ray repair cross-complementing protein 5 | [8] | 0.19[9] | 0.01[10] | -0.37[11] | -0.21[12] | -0.20[13] | -0.19[14] |
3 | PARP1 | Poly [ADP-ribose] polymerase 1 | [15] | -0.74[16] | -1.28[17] | -0.80[18] | -0.50[19] | -1.20[20] | -0.74[21] |
4 | PCNA | Proliferating cell nuclear antigen | [22] | 0.02[23] | -0.29[24] | -1.95[25] | -1.25[26] | -1.18[27] | -3.41[28] |
5 | TRIM28 | Transcription intermediary factor 1-beta | [29] | 0.59[30] | 0.07[31] | 0.84[32] | -0.01[33] | -0.50[34] | -1.01[35] |
6 | RPA2 | Replication protein A 32 kDa subunit | [36] | -2.33[37] | -2.55[38] | -2.24[39] | -1.77[40] | -1.91[41] | -2.73[42] |
7 | IKBKG | NF-kappa-B essential modulator | [43] | -1.76[44] | -1.90[45] | -4.41[46] | -1.88[47] | -3.31[48] | -0.94[49] |
8 | EEF1E1 | Eukaryotic translation elongation factor 1 epsilon-1 | [50] | -2.13[51] | -1.57[52] | -3.12[53] | -3.56[54] | -3.58[55] | -3.00[56] |
9 | CDK2 | Cyclin-dependent kinase 2 | [57] | -1.28[58] | -1.41[59] | -1.29[60] | -1.05[61] | -0.68[62] | -2.52[63] |
10 | POLB | DNA polymerase beta | [64] | -1.80[65] | -2.05[66] | -2.25[67] | -3.32[68] | -3.34[69] | -1.83[70] |
11 | UPF1 | Regulator of nonsense transcripts 1 | [71] | 0.85[72] | 0.36[73] | 0.87[74] | -0.24[75] | 0.20[76] | 0.19[77] |
12 | FEN1 | Flap endonuclease 1 | [78] | 0.16[79] | -0.34[80] | 0.26[81] | -0.35[82] | 0.33[83] | -1.43[84] |
13 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [85] | 0.44[86] | -0.11[87] | -0.09[88] | 0.82[89] | 0.62[90] | -0.33[91] |
14 | BCL6 | B-cell lymphoma 6 protein | [92] | -1.77[93] | 0.19[94] | -1.58[95] | -1.57[96] | -1.05[97] | -0.30[98] |
15 | RAD17 | Cell cycle checkpoint protein RAD17 | [99] | -1.72[100] | -0.92[101] | -1.13[102] | -1.37[103] | -1.24[104] | -0.76[105] |
16 | XPA | DNA repair protein complementing XP-A cells | [106] | -3.20[107] | -2.62[108] | -3.20[109] | -2.95[110] | -3.00[111] | -1.02[112] |
17 | MLH1 | DNA mismatch repair protein Mlh1 | [113] | -0.02[114] | -0.19[115] | 0.30[116] | -0.89[117] | -0.45[118] | 0.09[119] |
18 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [120] | 1.24[121] | 2.37[122] | -0.65[123] | -0.52[124] | 0.14[125] | 1.83[126] |
19 | NBN | Nibrin | [127] | -1.29[128] | -0.40[129] | -0.90[130] | 0.47[131] | -0.62[132] | 0.94[133] |
20 | CDK1 | Cyclin-dependent kinase 1 | [134] | 0.38[135] | 2.15[136] | 0.63[137] | 1.24[138] | 1.84[139] | -2.80[140] |
21 | CHEK2 | Serine/threonine-protein kinase Chk2 | [141] | -0.77[142] | -0.62[143] | -0.47[144] | -1.28[145] | -1.87[146] | -3.61[147] |
22 | RECQL | ATP-dependent DNA helicase Q1 | [148] | -1.69[149] | -0.91[150] | -0.78[151] | -0.46[152] | -0.05[153] | -0.38[154] |
23 | TP53 | Cellular tumor antigen p53 | [155] | 0.77[156] | 0.04[157] | 0.54[158] | 0.26[159] | -0.29[160] | -0.37[161] |
24 | SMARCC2 | SWI/SNF complex subunit SMARCC2 | [162] | 0.36[163] | 0.01[164] | 0.24[165] | 1.08[166] | 0.81[167] | 1.13[168] |
25 | UIMC1 | BRCA1-A complex subunit RAP80 | [169] | -0.50[170] | -0.56[171] | -0.37[172] | -0.96[173] | -1.02[174] | -0.63[175] |
26 | BRCC3 | Lys-63-specific deubiquitinase BRCC36 | [176] | -1.34[177] | -0.69[178] | -1.65[179] | -1.26[180] | -1.31[181] | 0.10[182] |
27 | PLK1 | Serine/threonine-protein kinase PLK1 | [183] | 1.62[184] | 1.07[185] | 0.68[186] | 0.22[187] | 1.04[188] | -2.96[189] |
28 | USP1 | Ubiquitin carboxyl-terminal hydrolase 1 | [190] | -0.34[191] | 0.77[192] | 0.63[193] | 0.74[194] | 0.89[195] | 0.00[196] |
29 | RAD51 | DNA repair protein RAD51 homolog 1 | [197] | -1.12[198] | -1.60[199] | -1.75[200] | -1.21[201] | -1.46[202] | -4.28[203] |
30 | SMC1A | Structural maintenance of chromosomes protein 1A | [204] | 1.23[205] | 0.80[206] | 1.56[207] | 1.99[208] | 2.61[209] | 2.11[210] |
31 | CLK2 | Dual specificity protein kinase CLK2 | [211] | -1.16[212] | -0.64[213] | -0.01[214] | -0.45[215] | -0.91[216] | -0.56[217] |
32 | MCM2 | DNA replication licensing factor MCM2 | [218] | 2.05[219] | 1.21[220] | 2.25[221] | 1.10[222] | 1.89[223] | -1.95[224] |
33 | MSH2 | DNA mismatch repair protein Msh2 | [225] | -0.05[226] | 0.95[227] | 0.14[228] | 1.10[229] | 0.25[230] | -1.02[231] |
34 | RAD50 | DNA repair protein RAD50 | [232] | -0.72[233] | 1.12[234] | 0.02[235] | 0.24[236] | 0.51[237] | 1.87[238] |
35 | PML | Protein PML | [239] | -0.64[240] | -1.94[241] | -0.49[242] | 0.86[243] | 0.13[244] | -0.09[245] |
36 | RBBP8 | DNA endonuclease RBBP8 | [246] | -0.68[247] | 0.45[248] | -1.18[249] | 0.41[250] | 0.39[251] | -0.09[252] |
37 | SP1 | Transcription factor Sp1 | [253] | 0.95[254] | 0.90[255] | 1.71[256] | 1.64[257] | 1.11[258] | 1.82[259] |
38 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [260] | 0.15[261] | 0.89[262] | 0.80[263] | 1.10[264] | 1.29[265] | 0.55[266] |
39 | PRKDC | DNA-dependent protein kinase catalytic subunit | [267] | 3.34[268] | 2.52[269] | 4.15[270] | 3.86[271] | 3.73[272] | 3.91[273] |
40 | HUS1 | Checkpoint protein HUS1 | [274] | -1.59[275] | -1.60[276] | -1.32[277] | -1.14[278] | -1.55[279] | 1.04[280] |
41 | RFWD3 | E3 ubiquitin-protein ligase RFWD3 | [281] | 1.74[282] | 1.34[283] | 1.25[284] | 1.59[285] | 1.66[286] | 0.39[287] |
42 | PPM1D | Protein phosphatase 1D | [288] | 0.38[289] | 0.33[290] | -0.72[291] | -1.52[292] | -0.67[293] | -0.23[294] |
43 | SMARCAL | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 0.41[295] | 0.21[296] | -0.04[297] | 0.15[298] | -0.49[299] | -0.55[300] | |
44 | RECQL5 | ATP-dependent DNA helicase Q5 | [301] | 0.39[302] | 0.46[303] | -0.17[304] | -0.13[305] | -0.53[306] | 0.59[307] |
45 | CDC45 | Cell division control protein 45 homolog | [308] | 0.33[309] | -0.01[310] | 0.40[311] | 0.23[312] | 0.35[313] | -3.24[314] |
46 | E2F1 | Transcription factor E2F1 | [315] | 1.07[316] | 0.64[317] | 0.51[318] | 0.84[319] | 1.06[320] | -3.95[321] |
47 | CHEK1 | Serine/threonine-protein kinase Chk1 | [322] | 0.66[323] | 0.74[324] | 0.05[325] | 1.12[326] | 1.13[327] | -2.36[328] |
48 | MCPH1 | Microcephalin | [329] | 0.02[330] | 0.31[331] | 0.52[332] | -1.61[333] | -0.77[334] | 0.80[335] |
49 | FANCA | Fanconi anemia group A protein | [336] | 0.79[337] | 1.18[338] | 0.64[339] | 0.28[340] | 0.41[341] | -0.69[342] |
50 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [343] | 1.62[344] | 1.73[345] | 1.81[346] | 1.86[347] | 1.57[348] | 1.12[349] |
51 | TOP3A | DNA topoisomerase 3-alpha | [350] | 1.09[351] | 0.48[352] | 0.52[353] | 0.82[354] | 0.99[355] | 1.46[356] |
52 | RAD1 | Cell cycle checkpoint protein RAD1 | [357] | 0.49[358] | 0.88[359] | 1.16[360] | 0.77[361] | 1.45[362] | 0.57[363] |
53 | PALB2 | Partner and localizer of BRCA2 | [364] | 0.89[365] | 0.90[366] | 0.28[367] | -0.33[368] | -0.05[369] | 0.34[370] |
54 | RAD9A | Cell cycle checkpoint control protein RAD9A | [371] | -0.80[372] | -0.81[373] | 0.75[374] | 1.30[375] | -1.09[376] | -0.51[377] |
55 | BRCA1 | Breast cancer type 1 susceptibility protein | [378] | 0.80[379] | 1.76[380] | 1.89[381] | 1.12[382] | 1.42[383] | 1.34[384] |
56 | FANCI | Fanconi anemia group I protein | [385] | 1.56[386] | 1.71[387] | 1.95[388] | 2.31[389] | 2.40[390] | -0.50[391] |
57 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [392] | 1.59[393] | 0.99[394] | 1.29[395] | 2.06[396] | 1.91[397] | 3.83[398] |
58 | DCLRE1A | DNA cross-link repair 1A protein | [399] | -0.11[400] | 1.55[401] | 0.91[402] | 0.12[403] | 0.26[404] | 1.31[405] |
59 | ATRIP | ATR-interacting protein | [406] | -0.63[407] | -0.67[408] | -0.05[409] | -1.37[410] | -0.51[411] | -0.50[412] |
60 | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | [413] | 0.71[414] | 0.53[415] | 0.02[416] | 0.87[417] | 0.20[418] | 0.08[419] |
61 | ATR | Serine/threonine-protein kinase ATR | [420] | 0.22[421] | 0.93[422] | 0.76[423] | 1.50[424] | 1.25[425] | 3.22[426] |
62 | TP53BP1 | TP53-binding protein 1 | [427] | 1.71[428] | 0.93[429] | 1.64[430] | 2.91[431] | 2.14[432] | 1.95[433] |
63 | CEP164 | Centrosomal protein of 164 kDa | [434] | 1.25[435] | 1.01[436] | 0.52[437] | 1.41[438] | 0.87[439] | 1.02[440] |
64 | FOXM1 | Forkhead box protein M1 | [441] | 2.35[442] | 1.96[443] | 2.50[444] | 1.88[445] | 3.18[446] | -0.95[447] |
65 | WRN | Werner syndrome ATP-dependent helicase | [448] | -0.26[449] | 0.91[450] | 2.59[451] | 0.67[452] | 0.27[453] | 1.64[454] |
66 | RAD52 | DNA repair protein RAD52 homolog | [455] | -0.49[456] | -0.02[457] | -0.16[458] | -1.44[459] | -1.21[460] | 0.42[461] |
67 | CLSPN | Claspin | [462] | 0.49[463] | 0.63[464] | 0.65[465] | 1.72[466] | 1.89[467] | -1.47[468] |
68 | RMI1 | RecQ-mediated genome instability protein 1 | [469] | -0.29[470] | 0.66[471] | 0.85[472] | 1.05[473] | 1.68[474] | 0.65[475] |
69 | FANCD2 | Fanconi anemia group D2 protein | [476] | 1.56[477] | 1.42[478] | 2.23[479] | 1.39[480] | 1.86[481] | -0.31[482] |
70 | ATM | Serine-protein kinase ATM | [483] | 2.16[484] | 3.47[485] | 2.94[486] | 3.13[487] | 2.39[488] | 4.65[489] |
71 | CDC25C | M-phase inducer phosphatase 3 | [490] | 1.06[491] | 1.93[492] | 1.70[493] | 0.90[494] | 1.53[495] | -1.75[496] |
72 | EXO1 | Exonuclease 1 | [497] | 1.03[498] | 1.03[499] | 1.94[500] | 2.75[501] | 1.81[502] | -1.80[503] |
73 | BRIP1 | Fanconi anemia group J protein | [504] | 1.27[505] | 2.38[506] | 2.14[507] | 2.18[508] | 2.00[509] | 1.63[510] |
74 | BARD1 | BRCA1-associated RING domain protein 1 | [511] | 0.44[512] | 1.14[513] | 0.91[514] | 1.67[515] | 1.53[516] | 1.54[517] |
75 | BRCA2 | Breast cancer type 2 susceptibility protein | [518] | 1.93[519] | 4.13[520] | 4.05[521] | 3.44[522] | 3.38[523] | 3.10[524] |
76 | POLN | DNA polymerase nu | [525] | -1.84[526] | -0.11[527] | 1.92[528] | 1.68[529] | 0.64[530] | 2.46[531] |
77 | ABRAXAS | BRCA1-A complex subunit Abraxas 1 | [532] | [533] | [534] | [535] | [536] | [537] | [538] |
78 | H2AX | [539] | [540] | [541] | [542] | [543] | [544] | [545] | |
79 | MIR4741 | [546] | [547] | [548] | [549] | [550] | [551] | [552] | |
80 | MRE11 | Double-strand break repair protein MRE11 | [553] | [554] | [555] | [556] | [557] | [558] | [559] |
81 | SEM1 | Putative protein SEM1, isoform 2 | [560] | [561] | [562] | [563] | [564] | [565] | [566] |