WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SOD2 | Superoxide dismutase [Mn], mitochondrial | [1] | -4.34[2] | -3.61[3] | -4.44[4] | -5.26[5] | -3.20[6] | -2.43[7] |
2 | SCP2 | Non-specific lipid-transfer protein | [8] | -3.25[9] | -2.06[10] | -1.81[11] | -2.69[12] | -2.90[13] | 0.73[14] |
3 | RHOA | Transforming protein RhoA | [15] | -0.35[16] | -0.78[17] | -0.57[18] | -0.49[19] | -0.08[20] | -0.93[21] |
4 | CAT | Catalase | [22] | -1.47[23] | -1.71[24] | -1.22[25] | -2.51[26] | -3.19[27] | 0.89[28] |
5 | CDC42 | Cell division control protein 42 homolog | [29] | -0.24[30] | 0.54[31] | -0.47[32] | 0.20[33] | -0.57[34] | -1.69[35] |
6 | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | [36] | 0.02[37] | -1.33[38] | -0.66[39] | -4.65[40] | -2.67[41] | 0.12[42] |
7 | HMGB1 | High mobility group protein B1 | [43] | 0.29[44] | 1.10[45] | 0.82[46] | 1.20[47] | 0.63[48] | -0.16[49] |
8 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [50] | 0.20[51] | -0.07[52] | 0.63[53] | 0.75[54] | 0.68[55] | -0.57[56] |
9 | JUN | Transcription factor AP-1 | [57] | 0.10[58] | -1.38[59] | -1.12[60] | -0.97[61] | -0.45[62] | -1.41[63] |
10 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [64] | 1.43[65] | 0.10[66] | -2.60[67] | -1.25[68] | 1.25[69] | -1.44[70] |
11 | AKT1 | RAC-alpha serine/threonine-protein kinase | [71] | 0.67[72] | 0.50[73] | -0.59[74] | 0.68[75] | 0.65[76] | 0.15[77] |
12 | CTNNB1 | Catenin beta-1 | [78] | 2.21[79] | 1.76[80] | 2.65[81] | 1.49[82] | 1.67[83] | 1.50[84] |
13 | MYC | Myc proto-oncogene protein | [85] | 1.02[86] | 0.74[87] | -1.29[88] | -2.05[89] | 0.27[90] | -1.60[91] |
14 | BAX | Apoptosis regulator BAX | [92] | 0.92[93] | 0.19[94] | -0.29[95] | -0.87[96] | -0.53[97] | -3.56[98] |
15 | CCND1 | G1/S-specific cyclin-D1 | [99] | 3.64[100] | 1.20[101] | 2.02[102] | 2.61[103] | 1.09[104] | 1.45[105] |
16 | GRB2 | Growth factor receptor-bound protein 2 | [106] | 1.79[107] | 1.69[108] | 1.80[109] | 1.29[110] | 1.15[111] | 0.70[112] |
17 | FOSL1 | Fos-related antigen 1 | [113] | -1.15[114] | -2.55[115] | -5.40[116] | -0.12[117] | 0.60[118] | -6.73[119] |
18 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [120] | -0.18[121] | 0.19[122] | 0.62[123] | -0.65[124] | 0.16[125] | -2.62[126] |
19 | BAD | Bcl2-associated agonist of cell death | [127] | -1.08[128] | -0.89[129] | -1.85[130] | -0.33[131] | 0.02[132] | -1.02[133] |
20 | SHC1 | SHC-transforming protein 1 | [134] | 1.75[135] | 2.04[136] | 2.10[137] | 3.39[138] | 2.82[139] | 1.18[140] |
21 | NRAS | GTPase NRas | [141] | 1.22[142] | 1.71[143] | 2.11[144] | 1.73[145] | 1.25[146] | 0.15[147] |
22 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isofor | 0.28[148] | 1.22[149] | 0.91[150] | 1.67[151] | 1.43[152] | 0.20[153] | |
23 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [154] | 0.51[155] | 1.01[156] | 1.20[157] | -0.37[158] | 0.04[159] | -0.51[160] |
24 | LDLR | Low-density lipoprotein receptor | [161] | 0.78[162] | 1.68[163] | 2.68[164] | -0.16[165] | 0.98[166] | 1.63[167] |
25 | DVL1 | Segment polarity protein dishevelled homolog DVL-1 | [168] | 1.39[169] | 1.91[170] | 0.78[171] | 0.80[172] | 0.79[173] | -0.36[174] |
26 | HRAS | GTPase HRas | [175] | -0.42[176] | -1.06[177] | -1.86[178] | -0.21[179] | -0.48[180] | -2.26[181] |
27 | MAPK1 | Mitogen-activated protein kinase 1 | [182] | 2.30[183] | 2.50[184] | 2.32[185] | 2.58[186] | 2.18[187] | 2.17[188] |
28 | AKT2 | RAC-beta serine/threonine-protein kinase | [189] | 1.55[190] | 1.89[191] | 2.01[192] | 1.59[193] | 1.33[194] | 1.53[195] |
29 | KRAS | GTPase KRas | [196] | 0.07[197] | 0.12[198] | 1.71[199] | 1.54[200] | 1.14[201] | 1.07[202] |
30 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [203] | 0.49[204] | 1.62[205] | 1.48[206] | 1.22[207] | 1.35[208] | 0.65[209] |
31 | WNT11 | Protein Wnt-11 | [210] | -0.83[211] | -6.48[212] | -5.46[213] | -5.80[214] | -6.28[215] | -2.69[216] |
32 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [217] | 0.12[218] | 0.30[219] | 1.38[220] | 2.80[221] | 2.25[222] | 3.40[223] |
33 | BCL6 | B-cell lymphoma 6 protein | [224] | -0.31[225] | 2.01[226] | 0.47[227] | 0.19[228] | 0.88[229] | 0.43[230] |
34 | MAPK8 | Mitogen-activated protein kinase 8 | [231] | -0.86[232] | 0.62[233] | -0.52[234] | -0.17[235] | -0.36[236] | -0.11[237] |
35 | SOS1 | Son of sevenless homolog 1 | [238] | 0.49[239] | 2.08[240] | 1.58[241] | 1.58[242] | 0.76[243] | 0.94[244] |
36 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | 0.05[245] | 1.51[246] | 1.69[247] | 0.17[248] | 1.37[249] | 2.88[250] | |
37 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [251] | 2.96[252] | 1.85[253] | 3.00[254] | 1.99[255] | 1.54[256] | 0.55[257] |
38 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [258] | 2.70[259] | 4.18[260] | 1.41[261] | 1.25[262] | 2.07[263] | 2.56[264] |
39 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [265] | 1.26[266] | 1.00[267] | 0.78[268] | 0.49[269] | 1.35[270] | 0.85[271] |
40 | RBL2 | Retinoblastoma-like protein 2 | [272] | 1.43[273] | 2.34[274] | 2.38[275] | 1.96[276] | 1.62[277] | 2.54[278] |
41 | BAK1 | Bcl-2 homologous antagonist/killer | [279] | 1.48[280] | 1.09[281] | 1.04[282] | 1.92[283] | 1.35[284] | -1.39[285] |
42 | SMAD3 | Mothers against decapentaplegic homolog 3 | [286] | 2.52[287] | 1.98[288] | 2.19[289] | 2.53[290] | 3.36[291] | 0.61[292] |
43 | DVL3 | Segment polarity protein dishevelled homolog DVL-3 | [293] | 2.08[294] | 2.35[295] | 1.74[296] | 2.20[297] | 2.23[298] | 0.71[299] |
44 | INSR | Insulin receptor | [300] | 1.05[301] | 1.76[302] | 3.18[303] | -2.35[304] | 0.20[305] | 4.40[306] |
45 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isofor | 0.70[307] | 0.94[308] | 0.47[309] | 1.60[310] | 1.33[311] | 0.59[312] | |
46 | TP53 | Cellular tumor antigen p53 | [313] | 2.23[314] | 1.85[315] | 2.60[316] | 2.03[317] | 1.64[318] | 0.36[319] |
47 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [320] | 2.46[321] | 2.75[322] | 3.35[323] | 1.44[324] | 1.95[325] | 0.11[326] |
48 | AXIN1 | Axin-1 | [327] | 1.94[328] | 2.32[329] | 0.75[330] | -7.96[331] | 0.84[332] | -0.25[333] |
49 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | [334] | 0.97[335] | 1.66[336] | 0.74[337] | 1.54[338] | 1.70[339] | 1.03[340] |
50 | MAPK9 | Mitogen-activated protein kinase 9 | [341] | 1.82[342] | 2.11[343] | 2.16[344] | 2.45[345] | 1.85[346] | 0.91[347] |
51 | GSK3B | Glycogen synthase kinase-3 beta | [348] | 1.86[349] | 1.55[350] | 2.12[351] | 2.55[352] | 2.33[353] | 1.56[354] |
52 | BBC3 | Bcl-2-binding component 3 | [355] | 1.33[356] | 1.28[357] | 0.76[358] | -2.07[359] | -1.36[360] | -3.94[361] |
53 | ABL1 | Tyrosine-protein kinase ABL1 | [362] | 2.82[363] | 2.28[364] | 3.06[365] | 2.81[366] | 3.44[367] | 1.34[368] |
54 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [369] | -1.12[370] | -7.05[371] | -7.67[372] | -0.65[373] | 3.10[374] | -0.83[375] |
55 | CCND3 | G1/S-specific cyclin-D3 | [376] | 1.54[377] | 0.54[378] | -1.10[379] | 4.40[380] | 3.52[381] | 1.05[382] |
56 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.80[383] | 2.37[384] | 2.52[385] | 1.79[386] | 1.89[387] | 1.55[388] | |
57 | SMAD4 | Mothers against decapentaplegic homolog 4 | [389] | 1.98[390] | 2.68[391] | 2.63[392] | 2.65[393] | 2.96[394] | 3.19[395] |
58 | IRS1 | Insulin receptor substrate 1 | [396] | 2.68[397] | 2.19[398] | 3.60[399] | 2.44[400] | 1.97[401] | 2.51[402] |
59 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [403] | 0.22[404] | 3.34[405] | 2.17[406] | 0.84[407] | -0.69[408] | -3.08[409] |
60 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | [410] | 1.54[411] | 2.28[412] | 1.41[413] | 1.59[414] | 1.84[415] | 1.79[416] |
61 | FOXO3 | Forkhead box protein O3 | [417] | 1.04[418] | 1.20[419] | 1.82[420] | 1.14[421] | 2.32[422] | 2.73[423] |
62 | SOS2 | Son of sevenless homolog 2 | [424] | 0.56[425] | 1.75[426] | 0.97[427] | 2.42[428] | 2.24[429] | 2.24[430] |
63 | PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | 2.25[431] | 3.89[432] | 4.02[433] | 3.79[434] | 3.03[435] | 4.05[436] | |
64 | TCF7L2 | Transcription factor 7-like 2 | [437] | 1.46[438] | 2.29[439] | 2.48[440] | 1.43[441] | 1.36[442] | 2.12[443] |
65 | DVL2 | Segment polarity protein dishevelled homolog DVL-2 | [444] | 2.71[445] | 2.52[446] | 3.49[447] | 2.96[448] | 2.55[449] | 0.41[450] |
66 | TGFB1 | Transforming growth factor beta-1 | [451] | 4.06[452] | 3.09[453] | 0.33[454] | 4.57[455] | 3.75[456] | -0.83[457] |
67 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [458] | 0.64[459] | -2.66[460] | 0.88[461] | 3.02[462] | 2.19[463] | -3.90[464] |
68 | MLKL | Mixed lineage kinase domain-like protein | [465] | 0.43[466] | 0.38[467] | -1.29[468] | 0.22[469] | 0.56[470] | 0.18[471] |
69 | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | [472] | 1.75[473] | 1.87[474] | 2.83[475] | 2.40[476] | 2.82[477] | 3.27[478] |
70 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.21[479] | 1.91[480] | 2.09[481] | 1.86[482] | 2.02[483] | 2.31[484] | |
71 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.48[485] | 3.63[486] | -0.20[487] | 1.02[488] | 1.73[489] | 0.70[490] | |
72 | PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | 2.96[491] | 3.74[492] | 3.34[493] | 3.35[494] | 1.53[495] | 2.46[496] | |
73 | TCF7L1 | Transcription factor 7-like 1 | [497] | -2.46[498] | -0.59[499] | 1.59[500] | -1.08[501] | -1.01[502] | 0.69[503] |
74 | TCF7 | Transcription factor 7 | [504] | 3.03[505] | 1.74[506] | 0.79[507] | 0.90[508] | 0.54[509] | 0.03[510] |
75 | CCNG2 | Cyclin-G2 | [511] | 1.47[512] | 2.20[513] | 3.12[514] | 1.06[515] | 2.48[516] | 0.52[517] |
76 | BCL2L11 | Bcl-2-like protein 11 | [518] | 2.09[519] | 2.17[520] | 2.48[521] | 2.60[522] | 1.53[523] | 2.38[524] |
77 | FRAT1 | Proto-oncogene FRAT1 | [525] | 1.28[526] | 1.10[527] | 3.20[528] | -1.82[529] | -0.68[530] | 0.87[531] |
78 | PLAU | Urokinase-type plasminogen activator | [532] | 0.86[533] | -3.20[534] | -2.06[535] | 3.06[536] | 1.03[537] | -1.60[538] |
79 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [539] | 3.24[540] | 3.02[541] | 2.73[542] | 3.06[543] | 1.89[544] | 3.20[545] |
80 | PIK3C2G | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma | -7.44[546] | [547] | 1.30[548] | -2.61[549] | -8.90[550] | 4.78[551] | |
81 | APC | Adenomatous polyposis coli protein | [552] | 1.16[553] | 2.89[554] | 2.72[555] | 2.96[556] | 3.55[557] | 4.13[558] |
82 | BIK | Bcl-2-interacting killer | [559] | 1.06[560] | 1.20[561] | -3.04[562] | -1.75[563] | -2.54[564] | -2.33[565] |
83 | ATM | Serine-protein kinase ATM | [566] | 3.62[567] | 5.29[568] | 5.00[569] | 4.89[570] | 4.32[571] | 5.38[572] |
84 | WNT3 | Proto-oncogene Wnt-3 | [573] | 0.21[574] | 1.22[575] | -0.71[576] | 0.17[577] | -1.22[578] | 0.58[579] |
85 | WNT5B | Protein Wnt-5b | [580] | -4.35[581] | -5.46[582] | 1.09[583] | 2.31[584] | -1.55[585] | -0.81[586] |
86 | CCND2 | G1/S-specific cyclin-D2 | [587] | 3.73[588] | 2.38[589] | -3.84[590] | -3.71[591] | -0.86[592] | 2.25[593] |
87 | PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | 2.38[594] | 0.67[595] | 3.45[596] | 3.68[597] | 1.04[598] | 3.24[599] | |
88 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [600] | 2.31[601] | 2.38[602] | 3.22[603] | 3.90[604] | 2.87[605] | 3.07[606] |
89 | AKT3 | RAC-gamma serine/threonine-protein kinase | [607] | -1.25[608] | -3.75[609] | -3.07[610] | 6.58[611] | 5.48[612] | 4.01[613] |
90 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [614] | -6.58[615] | [616] | -1.89[617] | -3.19[618] | -2.90[619] | 2.74[620] |
91 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [621] | 4.67[622] | 2.50[623] | 5.90[624] | 5.94[625] | 7.68[626] | -1.76[627] |
92 | WNT4 | Protein Wnt-4 | [628] | -3.10[629] | -2.18[630] | -3.30[631] | -0.63[632] | -2.00[633] | 0.61[634] |
93 | WNT5A | Protein Wnt-5a | [635] | -2.60[636] | -2.53[637] | -1.37[638] | 7.33[639] | 8.85[640] | 1.71[641] |
94 | TP73 | Tumor protein p73 | [642] | 1.31[643] | 3.93[644] | 2.84[645] | 1.41[646] | 2.50[647] | 1.05[648] |
95 | WNT7B | Protein Wnt-7b | [649] | 3.28[650] | 1.52[651] | 1.26[652] | 1.07[653] | 0.07[654] | -0.43[655] |
96 | BCL2 | Apoptosis regulator Bcl-2 | [656] | -2.26[657] | 3.20[658] | -4.21[659] | 2.51[660] | 2.17[661] | 3.63[662] |
97 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [663] | -3.22[664] | -1.29[665] | -5.27[666] | [667] | [668] | 0.98[669] |
98 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [670] | [671] | [672] | 2.08[673] | -2.86[674] | 4.50[675] | |
99 | WNT2B | Protein Wnt-2b | [676] | -0.04[677] | 0.80[678] | 0.78[679] | 3.34[680] | 2.60[681] | 1.33[682] |
100 | LEF1 | Lymphoid enhancer-binding factor 1 | [683] | 3.24[684] | -3.62[685] | 4.29[686] | 1.82[687] | 0.06[688] | 1.48[689] |
101 | WNT16 | Protein Wnt-16 | [690] | [691] | [692] | [693] | 2.08[694] | -1.85[695] | 0.55[696] |
102 | WNT10A | Protein Wnt-10a | [697] | 1.84[698] | -1.44[699] | -4.16[700] | 4.28[701] | -1.54[702] | -1.08[703] |
103 | WNT2 | Protein Wnt-2 | [704] | [705] | [706] | -1.36[707] | 1.67[708] | -2.32[709] | 6.62[710] |
104 | MAPK10 | Mitogen-activated protein kinase 10 | [711] | -0.89[712] | [713] | [714] | 9.64[715] | 5.33[716] | 7.64[717] |
105 | G6PC1 | [718] | [719] | [720] | [721] | [722] | [723] | [724] | |
106 | SOD2-OT1 | [725] | [726] | [727] | [728] | [729] | [730] | [731] | |
107 | MIR3191 | [732] | [733] | [734] | [735] | [736] | [737] | [738] | |
108 | WNT7A | Protein Wnt-7a | [739] | [740] | [741] | [742] | [743] | [744] | [745] |
109 | WNT10B | Protein Wnt-10b | [746] | [747] | [748] | [749] | [750] | [751] | [752] |
110 | WNT6 | Protein Wnt-6 | [753] | [754] | [755] | [756] | [757] | [758] | [759] |
111 | WNT3A | Protein Wnt-3a | [760] | [761] | [762] | [763] | [764] | [765] | [766] |
112 | MIR6886 | [767] | [768] | [769] | [770] | [771] | [772] | [773] | |
113 | WNT1 | Proto-oncogene Wnt-1 | [774] | [775] | [776] | [777] | [778] | [779] | [780] |
114 | MIR6808 | [781] | [782] | [783] | [784] | [785] | [786] | [787] |