WP_DNA_DAMAGE_RESPONSE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [1] | -4.74[2] | -5.48[3] | -4.23[4] | -4.27[5] | -3.59[6] | -1.92[7] |
2 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [8] | -3.04[9] | -4.10[10] | -3.87[11] | -4.24[12] | -2.80[13] | -2.76[14] |
3 | SFN | 14-3-3 protein sigma | [15] | -2.93[16] | -3.27[17] | -2.84[18] | -8.08[19] | -9.31[20] | -9.84[21] |
4 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [22] | -10.49[23] | [24] | -8.91[25] | -8.08[26] | -8.32[27] | -1.47[28] |
5 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [29] | 0.27[30] | -1.10[31] | -3.76[32] | -2.24[33] | 0.02[34] | -1.58[35] |
6 | MYC | Myc proto-oncogene protein | [36] | -0.14[37] | -0.46[38] | -2.45[39] | -3.04[40] | -0.97[41] | -1.75[42] |
7 | BAX | Apoptosis regulator BAX | [43] | -0.24[44] | -1.02[45] | -1.44[46] | -1.85[47] | -1.77[48] | -3.70[49] |
8 | RPA2 | Replication protein A 32 kDa subunit | [50] | -2.03[51] | -1.94[52] | -1.34[53] | -1.00[54] | -1.22[55] | -2.15[56] |
9 | CCND1 | G1/S-specific cyclin-D1 | [57] | 2.48[58] | -0.01[59] | 0.86[60] | 1.63[61] | -0.15[62] | 1.31[63] |
10 | CDK4 | Cyclin-dependent kinase 4 | [64] | 0.76[65] | 1.36[66] | 1.03[67] | -0.07[68] | 0.28[69] | -0.58[70] |
11 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [71] | 1.42[72] | 1.31[73] | 1.15[74] | -0.58[75] | 0.73[76] | 0.29[77] |
12 | CYCS | Cytochrome c | [78] | 0.76[79] | 0.98[80] | 1.09[81] | 1.08[82] | 1.18[83] | 1.57[84] |
13 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [85] | -0.65[86] | -0.20[87] | 0.04[88] | -1.36[89] | -1.20[90] | -0.66[91] |
14 | CASP3 | Caspase-3 | [92] | -0.43[93] | 0.26[94] | -2.25[95] | -1.15[96] | -0.45[97] | -0.55[98] |
15 | BID | BH3-interacting domain death agonist | [99] | -0.84[100] | -0.72[101] | -1.06[102] | -0.54[103] | -1.38[104] | 0.43[105] |
16 | CDK2 | Cyclin-dependent kinase 2 | [106] | -0.98[107] | -0.80[108] | -0.39[109] | -0.27[110] | 0.02[111] | -1.94[112] |
17 | FAS | Tumor necrosis factor receptor superfamily member 6 | [113] | -2.17[114] | -1.38[115] | -9.35[116] | -2.00[117] | -1.78[118] | -1.47[119] |
18 | RFC1 | Replication factor C subunit 1 | [120] | -0.43[121] | 0.88[122] | 1.30[123] | 0.07[124] | 0.61[125] | 1.03[126] |
19 | CASP8 | Caspase-8 | [127] | -0.55[128] | 0.04[129] | -0.75[130] | -0.33[131] | -1.38[132] | -1.17[133] |
20 | CCNB1 | G2/mitotic-specific cyclin-B1 | [134] | 1.28[135] | 1.53[136] | 1.75[137] | 1.35[138] | 2.03[139] | -2.09[140] |
21 | TLK1 | Serine/threonine-protein kinase tousled-like 1 | [141] | -0.81[142] | 0.80[143] | 0.15[144] | 0.52[145] | -0.46[146] | 1.54[147] |
22 | RAD17 | Cell cycle checkpoint protein RAD17 | [148] | -1.42[149] | -0.31[150] | -0.23[151] | -0.60[152] | -0.54[153] | -0.18[154] |
23 | DDB2 | DNA damage-binding protein 2 | [155] | 0.51[156] | 0.05[157] | -1.22[158] | -1.86[159] | -1.58[160] | -1.27[161] |
24 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [162] | 1.54[163] | 2.98[164] | 0.25[165] | 0.26[166] | 0.83[167] | 2.42[168] |
25 | NBN | Nibrin | [169] | -0.99[170] | 0.21[171] | 0.00[172] | 1.25[173] | 0.07[174] | 1.52[175] |
26 | CDK1 | Cyclin-dependent kinase 1 | [176] | 0.68[177] | 2.76[178] | 1.53[179] | 2.02[180] | 2.54[181] | -2.22[182] |
27 | CHEK2 | Serine/threonine-protein kinase Chk2 | [183] | -0.47[184] | -0.01[185] | 0.43[186] | -0.50[187] | -1.17[188] | -3.03[189] |
28 | TP53 | Cellular tumor antigen p53 | [190] | 1.07[191] | 0.65[192] | 1.44[193] | 1.04[194] | 0.40[195] | 0.21[196] |
29 | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | [197] | 0.67[198] | 0.85[199] | -0.29[200] | 0.76[201] | 0.25[202] | 0.70[203] |
30 | RAD51 | DNA repair protein RAD51 homolog 1 | [204] | -0.82[205] | -0.99[206] | -0.85[207] | -0.44[208] | -0.77[209] | -3.70[210] |
31 | CDK5 | Cyclin-dependent-like kinase 5 | [211] | -0.33[212] | -1.01[213] | -0.92[214] | 0.38[215] | -1.13[216] | -0.63[217] |
32 | SMC1A | Structural maintenance of chromosomes protein 1A | [218] | 1.53[219] | 1.41[220] | 2.46[221] | 2.76[222] | 3.31[223] | 2.69[224] |
33 | BBC3 | Bcl-2-binding component 3 | [225] | 0.17[226] | 0.07[227] | -0.39[228] | -3.05[229] | -2.60[230] | -4.08[231] |
34 | CDK6 | Cyclin-dependent kinase 6 | [232] | 1.48[233] | 2.19[234] | 0.63[235] | 0.67[236] | 1.17[237] | 2.32[238] |
35 | ABL1 | Tyrosine-protein kinase ABL1 | [239] | 1.66[240] | 1.07[241] | 1.90[242] | 1.82[243] | 2.20[244] | 1.19[245] |
36 | RAD50 | DNA repair protein RAD50 | [246] | -0.42[247] | 1.73[248] | 0.92[249] | 1.02[250] | 1.20[251] | 2.46[252] |
37 | PML | Protein PML | [253] | -0.33[254] | -1.33[255] | 0.41[256] | 1.64[257] | 0.83[258] | 0.49[259] |
38 | CCND3 | G1/S-specific cyclin-D3 | [260] | 0.38[261] | -0.66[262] | -2.25[263] | 3.41[264] | 2.29[265] | 0.91[266] |
39 | CCNE1 | G1/S-specific cyclin-E1 | [267] | 0.67[268] | 0.80[269] | -0.98[270] | -0.66[271] | -0.36[272] | -4.38[273] |
40 | PRKDC | DNA-dependent protein kinase catalytic subunit | [274] | 3.64[275] | 3.13[276] | 5.05[277] | 4.64[278] | 4.42[279] | 4.49[280] |
41 | SESN1 | Sestrin-1 | [281] | 0.72[282] | 1.06[283] | -1.42[284] | -1.13[285] | -0.22[286] | 0.95[287] |
42 | RB1 | Retinoblastoma-associated protein | [288] | 0.65[289] | 1.17[290] | 1.76[291] | 2.03[292] | 2.05[293] | 1.73[294] |
43 | TLK2 | Serine/threonine-protein kinase tousled-like 2 | [295] | 1.24[296] | 1.54[297] | 1.07[298] | 1.73[299] | 1.19[300] | 1.69[301] |
44 | CASP9 | Caspase-9 | [302] | -0.41[303] | 0.56[304] | -0.28[305] | -0.01[306] | -0.99[307] | -0.29[308] |
45 | E2F1 | Transcription factor E2F1 | [309] | 1.38[310] | 1.25[311] | 1.41[312] | 1.61[313] | 1.75[314] | -3.36[315] |
46 | CHEK1 | Serine/threonine-protein kinase Chk1 | [316] | 0.97[317] | 1.35[318] | 0.95[319] | 1.90[320] | 1.83[321] | -1.78[322] |
47 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [323] | -0.52[324] | -3.87[325] | -0.28[326] | 2.03[327] | 0.95[328] | -4.05[329] |
48 | CDC25A | M-phase inducer phosphatase 1 | [330] | 0.86[331] | 1.51[332] | 1.90[333] | 0.09[334] | 1.25[335] | -2.41[336] |
49 | CCNB2 | G2/mitotic-specific cyclin-B2 | [337] | 1.52[338] | 2.30[339] | 2.72[340] | 2.27[341] | 2.95[342] | -1.35[343] |
50 | RAD1 | Cell cycle checkpoint protein RAD1 | [344] | 0.80[345] | 1.49[346] | 2.07[347] | 1.55[348] | 2.14[349] | 1.16[350] |
51 | RAD9A | Cell cycle checkpoint control protein RAD9A | [351] | -0.50[352] | -0.20[353] | 1.65[354] | 2.08[355] | -0.40[356] | 0.08[357] |
52 | BRCA1 | Breast cancer type 1 susceptibility protein | [358] | 1.10[359] | 2.37[360] | 2.79[361] | 1.89[362] | 2.12[363] | 1.92[364] |
53 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [365] | 1.15[366] | 2.33[367] | 2.85[368] | 2.29[369] | 1.93[370] | 2.59[371] |
54 | ATRIP | ATR-interacting protein | [372] | -0.33[373] | -0.06[374] | 0.85[375] | -0.60[376] | 0.18[377] | 0.09[378] |
55 | ATR | Serine/threonine-protein kinase ATR | [379] | 0.52[380] | 1.54[381] | 1.66[382] | 2.28[383] | 1.94[384] | 3.80[385] |
56 | APAF1 | Apoptotic protease-activating factor 1 | [386] | 1.09[387] | 1.53[388] | 1.82[389] | 2.37[390] | 1.18[391] | 1.74[392] |
57 | RAD52 | DNA repair protein RAD52 homolog | [393] | -0.19[394] | 0.59[395] | 0.74[396] | -0.67[397] | -0.51[398] | 1.00[399] |
58 | FANCD2 | Fanconi anemia group D2 protein | [400] | 1.86[401] | 2.03[402] | 3.13[403] | 2.16[404] | 2.55[405] | 0.28[406] |
59 | ATM | Serine-protein kinase ATM | [407] | 2.46[408] | 4.08[409] | 3.84[410] | 3.90[411] | 3.09[412] | 5.24[413] |
60 | CCNE2 | G1/S-specific cyclin-E2 | [414] | -0.15[415] | 0.27[416] | -0.16[417] | 2.79[418] | 2.39[419] | -0.10[420] |
61 | CDC25C | M-phase inducer phosphatase 3 | [421] | 1.36[422] | 2.53[423] | 2.60[424] | 1.68[425] | 2.23[426] | -1.17[427] |
62 | CCND2 | G1/S-specific cyclin-D2 | [428] | 2.57[429] | 1.17[430] | -5.00[431] | -4.70[432] | -2.09[433] | 2.11[434] |
63 | CCNB3 | G2/mitotic-specific cyclin-B3 | [435] | -2.23[436] | -2.96[437] | -3.18[438] | -2.15[439] | 0.40[440] | 2.09[441] |
64 | HUS1B | Checkpoint protein HUS1B | [442] | -1.38[443] | -2.35[444] | -1.90[445] | 0.82[446] | -0.89[447] | 1.47[448] |
65 | TP53AIP1 | p53-regulated apoptosis-inducing protein 1 | [449] | -0.64[450] | -0.50[451] | -1.20[452] | -0.78[453] | -1.43[454] | 0.59[455] |
66 | PIDD1 | p53-induced death domain-containing protein 1 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | MRE11 | Double-strand break repair protein MRE11 | [463] | [464] | [465] | [466] | [467] | [468] | [469] |
68 | MIR3191 | [470] | [471] | [472] | [473] | [474] | [475] | [476] | |
69 | H2AX | [477] | [478] | [479] | [480] | [481] | [482] | [483] |