WP_DISORDERS_OF_FOLATE_METABOLISM_AND_TRANSPORT Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FTCD Formimidoyltransferase-cyclodeaminase [1] -2.02[2] -1.18[3] -7.43[4] -8.48[5] -11.20[6] -0.60[7]
2 SHMT2 Serine hydroxymethyltransferase, mitochondrial [8] 0.38[9] 1.02[10] 0.89[11] -0.29[12] 0.47[13] -0.21[14]
3 ALDH1L1 Cytosolic 10-formyltetrahydrofolate dehydrogenase [15] -3.62[16] -12.67[17] -13.30[18] -6.67[19] -7.00[20] 0.90[21]
4 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic [22] 0.16[23] -0.84[24] -0.59[25] 0.47[26] 0.62[27] 0.89[28]
5 MTHFS 5-formyltetrahydrofolate cyclo-ligase [29] -4.06[30] -3.77[31] -4.09[32] -4.31[33] -4.20[34] -2.59[35]
6 ATIC Bifunctional purine biosynthesis protein PURH [36] 1.64[37] 1.05[38] 1.35[39] 0.99[40] 0.81[41] -1.34[42]
7 TYMS Thymidylate synthase [43] -0.77[44] -0.80[45] -0.62[46] 0.06[47] -0.39[48] -6.01[49]
8 GART Trifunctional purine biosynthetic protein adenosine-3 [50] 1.31[51] 0.65[52] 0.42[53] 1.53[54] 1.34[55] -0.59[56]
9 DHFR Dihydrofolate reductase [57] 2.04[58] 2.31[59] 3.00[60] 2.62[61] 2.97[62] 0.04[63]
10 SLC46A1 Proton-coupled folate transporter [64] 0.42[65] 0.36[66] 0.45[67] 0.04[68] -0.89[69] 1.13[70]
11 MTR Methionine synthase [71] 2.77[72] 3.01[73] 3.51[74] 4.52[75] 3.34[76] 3.28[77]
12 MTHFR Methylenetetrahydrofolate reductase [78] 1.83[79] 2.75[80] 3.35[81] 4.07[82] 2.33[83] 3.73[84]
13 FOLR1 Folate receptor alpha [85] 2.67[86] -3.27[87] -0.41[88] 5.71[89] -4.05[90] -0.72[91]
[1]
ref_hepatocyte FTCD
Mean 68.2
Standard deviation 89
Values 7.2 2.1e+02 1e+02 16 4.8
[2]
HepG2 FTCD
Mean 26.2
Standard deviation 1.2
Values 25 27
[3]
HepG2.C3A FTCD
Mean 57.1
Standard deviation 32
Values 34 80
[4]
HuH.7 FTCD
Mean 0.564
Standard deviation 0.18
Values 0.64 0.69 0.36
[5]
SNU475 FTCD
Mean 0.136
Standard deviation 0.057
Values 0.096 0.18
[6]
THLE FTCD
Mean 0.0331
Standard deviation 0.013
Values 0.024 0.043
[7]
liver FTCD
Mean 67.7
Standard deviation 27
Values 58 43 1.1e+02 64
[8]
ref_hepatocyte SHMT2
Mean 66.5
Standard deviation 44
Values 61 78 1.4e+02 27 32
[9]
HepG2 SHMT2
Mean 135
Standard deviation 40
Values 1.1e+02 1.6e+02
[10]
HepG2.C3A SHMT2
Mean 256
Standard deviation 1e+02
Values 1.8e+02 3.3e+02
[11]
HuH.7 SHMT2
Mean 175
Standard deviation 6.4
Values 1.8e+02 1.8e+02 1.7e+02
[12]
SNU475 SHMT2
Mean 38.7
Standard deviation 3
Values 41 37
[13]
THLE SHMT2
Mean 105
Standard deviation 2.1
Values 1.1e+02 1e+02
[14]
liver SHMT2
Mean 86.4
Standard deviation 29
Values 59 67 1e+02 1.2e+02
[15]
ref_hepatocyte ALDH1L1
Mean 53.8
Standard deviation 57
Values 4.3 1.3e+02 1.1e+02 22 12
[16]
HepG2 ALDH1L1
Mean 6.81
Standard deviation 2.3
Values 5.2 8.4
[17]
HepG2.C3A ALDH1L1
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[18]
HuH.7 ALDH1L1
Mean 0.00761
Standard deviation 0.0083
Values 0 0.0064 0.016
[19]
SNU475 ALDH1L1
Mean 0.375
Standard deviation 0.16
Values 0.49 0.26
[20]
THLE ALDH1L1
Mean 0.478
Standard deviation 0.039
Values 0.45 0.51
[21]
liver ALDH1L1
Mean 151
Standard deviation 64
Values 90 1.5e+02 1.2e+02 2.4e+02
[22]
ref_hepatocyte MTHFD1
Mean 38.3
Standard deviation 33
Values 7.6 88 54 17 24
[23]
HepG2 MTHFD1
Mean 66.6
Standard deviation 5.5
Values 70 63
[24]
HepG2.C3A MTHFD1
Mean 40.6
Standard deviation 9.4
Values 47 34
[25]
HuH.7 MTHFD1
Mean 36.1
Standard deviation 17
Values 42 17 50
[26]
SNU475 MTHFD1
Mean 37.7
Standard deviation 1.4
Values 37 39
[27]
THLE MTHFD1
Mean 67.1
Standard deviation 15
Values 56 78
[28]
liver MTHFD1
Mean 106
Standard deviation 16
Values 1.1e+02 99 90 1.3e+02
[29]
ref_hepatocyte MTHFS
Mean 33.8
Standard deviation 36
Values 12 71 75 4.8 6.2
[30]
HepG2 MTHFS
Mean 3.16
Standard deviation 0.23
Values 3.3 3
[31]
HepG2.C3A MTHFS
Mean 4.68
Standard deviation 1.1
Values 5.5 3.9
[32]
HuH.7 MTHFS
Mean 2.82
Standard deviation 0.4
Values 2.8 3.2 2.4
[33]
SNU475 MTHFS
Mean 1.22
Standard deviation 0.081
Values 1.2 1.3
[34]
THLE MTHFS
Mean 2.1
Standard deviation 0.12
Values 2 2.2
[35]
liver MTHFS
Mean 8.42
Standard deviation 9.4
Values 0.46 0.66 19 13
[36]
ref_hepatocyte ATIC
Mean 24.9
Standard deviation 8.1
Values 28 14 19 32 32
[37]
HepG2 ATIC
Mean 121
Standard deviation 12
Values 1.1e+02 1.3e+02
[38]
HepG2.C3A ATIC
Mean 97.3
Standard deviation 10
Values 90 1e+02
[39]
HuH.7 ATIC
Mean 90.3
Standard deviation 22
Values 1.1e+02 65 1e+02
[40]
SNU475 ATIC
Mean 35.2
Standard deviation 3.4
Values 38 33
[41]
THLE ATIC
Mean 49.5
Standard deviation 10
Values 42 57
[42]
liver ATIC
Mean 14.7
Standard deviation 12
Values 4.1 5.3 21 29
[43]
ref_hepatocyte TYMS
Mean 24.8
Standard deviation 32
Values 2.5 0.91 3.3 69 49
[44]
HepG2 TYMS
Mean 22.7
Standard deviation 7.9
Values 28 17
[45]
HepG2.C3A TYMS
Mean 26.9
Standard deviation 18
Values 40 14
[46]
HuH.7 TYMS
Mean 23
Standard deviation 12
Values 32 9.1 28
[47]
SNU475 TYMS
Mean 18.5
Standard deviation 1.2
Values 19 18
[48]
THLE TYMS
Mean 21.5
Standard deviation 4.9
Values 18 25
[49]
liver TYMS
Mean 0.58
Standard deviation 0.68
Values 0 0.4 0.35 1.6
[50]
ref_hepatocyte GART
Mean 21.4
Standard deviation 16
Values 33 7.1 8 17 43
[51]
HepG2 GART
Mean 83.2
Standard deviation 13
Values 74 92
[52]
HepG2.C3A GART
Mean 63.6
Standard deviation 1.3
Values 65 63
[53]
HuH.7 GART
Mean 40.7
Standard deviation 14
Values 50 25 48
[54]
SNU475 GART
Mean 44.2
Standard deviation 5.5
Values 48 40
[55]
THLE GART
Mean 61.8
Standard deviation 11
Values 54 69
[56]
liver GART
Mean 21.4
Standard deviation 7.5
Values 20 26 12 29
[57]
ref_hepatocyte DHFR
Mean 6.89
Standard deviation 3.8
Values 0.65 9.3 6.3 10 7.9
[58]
HepG2 DHFR
Mean 44.3
Standard deviation 17
Values 56 32
[59]
HepG2.C3A DHFR
Mean 64.7
Standard deviation 42
Values 95 35
[60]
HuH.7 DHFR
Mean 78.4
Standard deviation 42
Values 96 31 1.1e+02
[61]
SNU475 DHFR
Mean 30.2
Standard deviation 0.92
Values 30 31
[62]
THLE DHFR
Mean 61.5
Standard deviation 17
Values 50 73
[63]
liver DHFR
Mean 10.7
Standard deviation 3.8
Values 12 9.2 15 6.4
[64]
ref_hepatocyte SLC46A1
Mean 4.01
Standard deviation 2.2
Values 1.7 5.3 6.2 5.3 1.5
[65]
HepG2 SLC46A1
Mean 8.35
Standard deviation 1.4
Values 9.4 7.4
[66]
HepG2.C3A SLC46A1
Mean 9.72
Standard deviation 1.6
Values 8.6 11
[67]
HuH.7 SLC46A1
Mean 7.78
Standard deviation 1.9
Values 6.3 9.9 7.2
[68]
SNU475 SLC46A1
Mean 2.94
Standard deviation 0.048
Values 3 2.9
[69]
THLE SLC46A1
Mean 2.47
Standard deviation 0.27
Values 2.3 2.7
[70]
liver SLC46A1
Mean 13.2
Standard deviation 3.5
Values 16 9.6 16 11
[71]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 1.2 0.48 0.53 2.9 2.1
[72]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 18 12
[73]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 21 22
[74]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 20 21 29
[75]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 18 29
[76]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[77]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 24 34 12 14
[78]
ref_hepatocyte MTHFR
Mean 0.857
Standard deviation 0.14
Values 0.91 0.6 0.95 0.9 0.92
[79]
HepG2 MTHFR
Mean 4.76
Standard deviation 0.36
Values 5 4.5
[80]
HepG2.C3A MTHFR
Mean 10.9
Standard deviation 2
Values 9.5 12
[81]
HuH.7 MTHFR
Mean 12.4
Standard deviation 3.7
Values 9.7 17 11
[82]
SNU475 MTHFR
Mean 10.2
Standard deviation 3.7
Values 7.6 13
[83]
THLE MTHFR
Mean 4.9
Standard deviation 0.19
Values 5 4.8
[84]
liver MTHFR
Mean 17.1
Standard deviation 4.4
Values 19 21 17 11
[85]
ref_hepatocyte FOLR1
Mean 0.0819
Standard deviation 0.12
Values 0 0 0.16 0.25 0
[86]
HepG2 FOLR1
Mean 0.813
Standard deviation 0.26
Values 1 0.63
[87]
HepG2.C3A FOLR1
Mean 0.0161
Standard deviation 0.023
Values 0.032 0
[88]
HuH.7 FOLR1
Mean 0.0878
Standard deviation 0.025
Values 0.084 0.064 0.11
[89]
SNU475 FOLR1
Mean 3.05
Standard deviation 0.94
Values 2.4 3.7
[90]
THLE FOLR1
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[91]
liver FOLR1
Mean 0.0746
Standard deviation 0.0043
Values 0.079 0.071 0.071 0.077