WP_CORTICOTROPINRELEASING_HORMONE_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90AA1 | Heat shock protein HSP 90-alpha | [1] | -0.43[2] | 0.46[3] | -0.30[4] | 0.18[5] | -0.04[6] | -0.92[7] |
2 | SULT2A1 | Bile salt sulfotransferase | [8] | -3.06[9] | -2.21[10] | -3.47[11] | -12.51[12] | -12.23[13] | 0.63[14] |
3 | RHOA | Transforming protein RhoA | [15] | -0.73[16] | -1.30[17] | -1.08[18] | -1.13[19] | -0.58[20] | -0.99[21] |
4 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.64[22] | 0.60[23] | 0.26[24] | 0.94[25] | 0.27[26] | -1.00[27] | |
5 | RAP1B | Ras-related protein Rap-1b | [28] | -2.09[29] | -1.55[30] | -1.77[31] | -0.43[32] | -0.58[33] | -1.56[34] |
6 | NFKBIA | NF-kappa-B inhibitor alpha | [35] | -0.84[36] | -2.71[37] | -3.09[38] | -3.43[39] | -1.45[40] | -0.80[41] |
7 | JUND | Transcription factor jun-D | [42] | -0.48[43] | -0.61[44] | -0.80[45] | -3.24[46] | -2.17[47] | -2.53[48] |
8 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [49] | 1.23[50] | 1.17[51] | 0.69[52] | 1.38[53] | 1.26[54] | -0.90[55] |
9 | FOS | Proto-oncogene c-Fos | [56] | -5.80[57] | -4.61[58] | -5.27[59] | -6.07[60] | -4.92[61] | -0.97[62] |
10 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | [63] | -0.39[64] | -0.72[65] | -0.38[66] | -0.27[67] | -0.12[68] | -1.27[69] |
11 | JUNB | Transcription factor jun-B | [70] | -1.74[71] | -2.68[72] | -1.97[73] | -2.07[74] | -1.14[75] | -1.05[76] |
12 | AKT1 | RAC-alpha serine/threonine-protein kinase | [77] | 0.29[78] | -0.01[79] | -1.09[80] | 0.04[81] | 0.16[82] | 0.09[83] |
13 | CTNNB1 | Catenin beta-1 | [84] | 1.83[85] | 1.25[86] | 2.14[87] | 0.85[88] | 1.17[89] | 1.44[90] |
14 | PARP1 | Poly [ADP-ribose] polymerase 1 | [91] | 0.34[92] | 0.02[93] | 0.76[94] | 0.62[95] | 0.23[96] | -0.08[97] |
15 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [98] | 0.28[99] | -0.86[100] | -0.69[101] | -0.08[102] | 1.08[103] | 0.14[104] |
16 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [105] | -0.72[106] | -1.12[107] | -0.54[108] | -0.45[109] | 0.15[110] | -0.86[111] |
17 | TRIM28 | Transcription intermediary factor 1-beta | [112] | 1.68[113] | 1.37[114] | 2.40[115] | 1.11[116] | 0.93[117] | -0.34[118] |
18 | JUP | Junction plakoglobin | [119] | 1.20[120] | -0.09[121] | 0.19[122] | -0.46[123] | -1.05[124] | 0.74[125] |
19 | FOSL1 | Fos-related antigen 1 | [126] | -1.52[127] | -3.06[128] | -5.90[129] | -0.77[130] | 0.11[131] | -6.80[132] |
20 | RELA | Transcription factor p65 | [133] | 0.35[134] | -0.23[135] | -0.10[136] | 0.04[137] | 0.04[138] | -0.55[139] |
21 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [140] | 0.15[141] | 0.48[142] | 1.75[143] | -0.09[144] | 0.86[145] | 1.43[146] |
22 | IL18 | Interleukin-18 | [147] | -0.65[148] | -4.56[149] | -0.43[150] | -1.08[151] | -1.65[152] | -3.83[153] |
23 | CASP3 | Caspase-3 | [154] | 0.35[155] | 0.95[156] | -1.60[157] | -0.80[158] | 0.28[159] | -0.47[160] |
24 | MAPK1 | Mitogen-activated protein kinase 1 | [161] | 1.92[162] | 1.98[163] | 1.81[164] | 1.94[165] | 1.68[166] | 2.11[167] |
25 | ECE1 | Endothelin-converting enzyme 1 | [168] | 1.98[169] | 1.66[170] | 1.41[171] | 0.59[172] | 2.18[173] | 1.99[174] |
26 | GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | [175] | -0.46[176] | -0.61[177] | -0.65[178] | -1.09[179] | -0.20[180] | -0.92[181] |
27 | PTK2 | Focal adhesion kinase 1 | [182] | 0.95[183] | 1.36[184] | 1.74[185] | 2.04[186] | 1.33[187] | 1.09[188] |
28 | MAPK14 | Mitogen-activated protein kinase 14 | [189] | 1.69[190] | 1.68[191] | 1.26[192] | 1.78[193] | 1.34[194] | 1.62[195] |
29 | ARRB2 | Beta-arrestin-2 | [196] | 0.38[197] | 0.69[198] | 0.65[199] | -1.22[200] | -0.33[201] | -0.54[202] |
30 | MAPK8 | Mitogen-activated protein kinase 8 | [203] | -1.23[204] | 0.10[205] | -1.02[206] | -0.81[207] | -0.86[208] | -0.18[209] |
31 | ELK1 | ETS domain-containing protein Elk-1 | [210] | -0.10[211] | -2.31[212] | 0.11[213] | 0.37[214] | 1.04[215] | 0.17[216] |
32 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [217] | -1.43[218] | -2.45[219] | -0.31[220] | 1.31[221] | 0.77[222] | 1.17[223] |
33 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [224] | 0.88[225] | 0.48[226] | 0.28[227] | -0.15[228] | 0.85[229] | 0.78[230] |
34 | CYP21A2 | Steroid 21-hydroxylase | [231] | -5.65[232] | -3.80[233] | -8.17[234] | -4.14[235] | -9.36[236] | 0.06[237] |
35 | GNB5 | Guanine nucleotide-binding protein subunit beta-5 | [238] | 0.31[239] | 0.28[240] | 1.29[241] | 0.88[242] | 1.09[243] | 1.22[244] |
36 | MAPK9 | Mitogen-activated protein kinase 9 | [245] | 1.44[246] | 1.59[247] | 1.65[248] | 1.81[249] | 1.36[250] | 0.84[251] |
37 | PRKCI | Protein kinase C iota type | [252] | 1.27[253] | 1.87[254] | 3.48[255] | 1.25[256] | 1.75[257] | 0.59[258] |
38 | MAPK3 | Mitogen-activated protein kinase 3 | [259] | 2.06[260] | 2.03[261] | 2.07[262] | 0.52[263] | 0.63[264] | -0.71[265] |
39 | GSK3B | Glycogen synthase kinase-3 beta | [266] | 1.48[267] | 1.04[268] | 1.61[269] | 1.91[270] | 1.83[271] | 1.50[272] |
40 | PRKCD | Protein kinase C delta type | [273] | 1.31[274] | 1.48[275] | 0.96[276] | -0.41[277] | 0.84[278] | -0.73[279] |
41 | FOSB | Protein fosB | [280] | -4.42[281] | -3.21[282] | -2.51[283] | -4.03[284] | -2.43[285] | -4.28[286] |
42 | SP1 | Transcription factor Sp1 | [287] | 2.03[288] | 2.20[289] | 3.27[290] | 2.77[291] | 2.54[292] | 2.49[293] |
43 | GRK6 | G protein-coupled receptor kinase 6 | [294] | 1.38[295] | 1.41[296] | 2.32[297] | 0.84[298] | 1.71[299] | 0.02[300] |
44 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.70[301] | 3.25[302] | 2.58[303] | 2.92[304] | 2.50[305] | 0.67[306] | |
45 | ACACA | Acetyl-CoA carboxylase 1 | [307] | 2.67[308] | 2.93[309] | 3.85[310] | 2.67[311] | 1.96[312] | 3.69[313] |
46 | FOSL2 | Fos-related antigen 2 | [314] | 2.09[315] | 1.37[316] | 0.60[317] | 3.37[318] | 3.57[319] | 0.42[320] |
47 | GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | [321] | -6.21[322] | -7.87[323] | -7.03[324] | -2.49[325] | -6.27[326] | 0.82[327] |
48 | CASP9 | Caspase-9 | [328] | 0.37[329] | 1.25[330] | 0.37[331] | 0.34[332] | -0.25[333] | -0.20[334] |
49 | PRKCA | Protein kinase C alpha type | [335] | 3.05[336] | 3.02[337] | 3.38[338] | 2.24[339] | 2.70[340] | 2.25[341] |
50 | TGFB1 | Transforming growth factor beta-1 | [342] | 3.69[343] | 2.57[344] | -0.18[345] | 3.93[346] | 3.25[347] | -0.90[348] |
51 | CACNA1H | Voltage-dependent T-type calcium channel subunit alpha-1H | [349] | 3.75[350] | 1.61[351] | -0.65[352] | 3.15[353] | -5.03[354] | 1.89[355] |
52 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | [356] | 0.04[357] | 0.55[358] | 0.54[359] | -0.88[360] | 0.54[361] | 2.50[362] |
53 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [363] | 0.29[364] | 0.99[365] | 1.50[366] | 1.68[367] | 1.99[368] | 1.77[369] |
54 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [370] | 1.94[371] | 3.02[372] | 3.51[373] | 2.64[374] | 2.67[375] | 2.67[376] |
55 | CRHBP | Corticotropin-releasing factor-binding protein | [377] | [378] | -9.37[379] | [380] | -10.26[381] | -10.26[382] | 4.15[383] |
56 | GNAZ | Guanine nucleotide-binding protein G(z) subunit alpha | [384] | 2.11[385] | 2.50[386] | 1.78[387] | -1.91[388] | -1.39[389] | -2.98[390] |
57 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | [391] | -4.08[392] | -7.09[393] | -1.20[394] | -1.77[395] | 2.72[396] | 3.38[397] |
58 | STAR | Steroidogenic acute regulatory protein, mitochondrial | [398] | 0.98[399] | 0.31[400] | -3.34[401] | -3.06[402] | -0.55[403] | -3.16[404] |
59 | NCOA2 | Nuclear receptor coactivator 2 | [405] | 1.79[406] | 2.53[407] | 4.36[408] | 3.29[409] | 1.68[410] | 4.94[411] |
60 | BRAF | Serine/threonine-protein kinase B-raf | [412] | 0.46[413] | 0.11[414] | 2.15[415] | 0.83[416] | 0.62[417] | 2.19[418] |
61 | NR4A1 | Nuclear receptor subfamily 4 group A member 1 | [419] | 1.43[420] | 1.90[421] | 2.04[422] | 0.24[423] | 1.42[424] | 0.86[425] |
62 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -1.07[426] | -6.89[427] | 0.56[428] | -2.64[429] | -1.40[430] | 3.05[431] | |
63 | GJA1 | Gap junction alpha-1 protein | [432] | -2.64[433] | -2.42[434] | 4.80[435] | 5.05[436] | 5.23[437] | -0.01[438] |
64 | POMC | Pro-opiomelanocortin | [439] | [440] | -8.23[441] | [442] | [443] | -6.93[444] | -1.86[445] |
65 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [446] | 3.25[447] | 3.62[448] | 3.65[449] | 3.14[450] | 1.27[451] | 2.18[452] |
66 | ARRB1 | Beta-arrestin-1 | [453] | 3.80[454] | 3.53[455] | 2.82[456] | 2.25[457] | 2.14[458] | 3.60[459] |
67 | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial | [460] | -0.44[461] | -3.04[462] | [463] | -3.17[464] | 0.97[465] | 0.80[466] |
68 | TLR4 | Toll-like receptor 4 | [467] | 0.48[468] | -4.74[469] | -5.63[470] | -5.00[471] | 5.51[472] | 4.80[473] |
69 | NR4A2 | Nuclear receptor subfamily 4 group A member 2 | [474] | -3.08[475] | -5.02[476] | 3.53[477] | -1.36[478] | -0.59[479] | -0.10[480] |
70 | PRKCB | Protein kinase C beta type | [481] | -6.60[482] | -5.48[483] | [484] | 2.58[485] | -2.64[486] | 3.87[487] |
71 | NOS3 | Nitric oxide synthase, endothelial | [488] | 4.98[489] | 2.01[490] | 1.48[491] | 0.15[492] | 1.58[493] | 3.10[494] |
72 | TCF4 | Transcription factor 4 | [495] | -2.02[496] | -1.16[497] | 5.21[498] | 5.42[499] | 4.98[500] | 5.65[501] |
73 | HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | [502] | -4.90[503] | -5.63[504] | 1.43[505] | [506] | -2.84[507] | -2.60[508] |
74 | TBX19 | T-box transcription factor TBX19 | [509] | 1.19[510] | 0.72[511] | 2.20[512] | 2.85[513] | 0.92[514] | 1.60[515] |
75 | KRT14 | Keratin, type I cytoskeletal 14 | [516] | -3.70[517] | [518] | [519] | -3.52[520] | [521] | [522] |
76 | CRHR1 | Corticotropin-releasing factor receptor 1 | [523] | [524] | -5.34[525] | -5.91[526] | [527] | [528] | [529] |
77 | BCL2 | Apoptosis regulator Bcl-2 | [530] | -2.64[531] | 2.69[532] | -4.72[533] | 1.87[534] | 1.67[535] | 3.56[536] |
78 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | [537] | 2.04[538] | 1.64[539] | 1.07[540] | 1.98[541] | 0.72[542] | 4.15[543] |
79 | PRKCQ | Protein kinase C theta type | [544] | 1.12[545] | -2.52[546] | [547] | 2.22[548] | 3.81[549] | 2.42[550] |
80 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [551] | 1.80[552] | 3.98[553] | 3.28[554] | 1.10[555] | 3.91[556] | -1.35[557] |
81 | HSD3B2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | [558] | -3.36[559] | [560] | -0.70[561] | [562] | -2.04[563] | 1.11[564] |
82 | CRHR2 | Corticotropin-releasing factor receptor 2 | [565] | -2.92[566] | [567] | 0.25[568] | -2.01[569] | 0.43[570] | 0.41[571] |
83 | CRH | Corticoliberin | [572] | [573] | [574] | [575] | [576] | [577] | [578] |
84 | CASP12 | Inactive caspase-12 | [579] | [580] | [581] | [582] | [583] | [584] | [585] |
85 | TFAP2A | Transcription factor AP-2-alpha | [586] | [587] | [588] | [589] | [590] | [591] | [592] |
86 | CYP11B1 | Cytochrome P450 11B1, mitochondrial | [593] | [594] | [595] | [596] | [597] | [598] | [599] |
87 | IVL | Involucrin | [600] | [601] | [602] | [603] | [604] | [605] | [606] |
88 | CXCL8 | Interleukin-8 | [607] | [608] | [609] | [610] | [611] | [612] | [613] |
89 | KRT1 | Keratin, type II cytoskeletal 1 | [614] | [615] | [616] | [617] | [618] | [619] | [620] |
90 | IL2 | Interleukin-2 | [621] | [622] | [623] | [624] | [625] | [626] | [627] |
91 | GRK3 | Beta-adrenergic receptor kinase 2 | [628] | [629] | [630] | [631] | [632] | [633] | [634] |
92 | LINC02210-CRHR1 | [635] | [636] | [637] | [638] | [639] | [640] | [641] | |
93 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [642] | [643] | [644] | [645] | [646] | [647] | [648] |