WP_COPPER_HOMEOSTASIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MT2A Metallothionein-2 [1] -2.85[2] -2.79[3] -6.66[4] -4.85[5] 0.04[6] -0.50[7]
2 MT1G Metallothionein-1G [8] -7.26[9] -4.24[10] -9.90[11] -13.67[12] -9.66[13] -1.33[14]
3 MT1X Metallothionein-1X [15] -3.84[16] -5.14[17] -6.90[18] -6.08[19] -3.08[20] -0.47[21]
4 SOD1 Superoxide dismutase [Cu-Zn] [22] 0.22[23] 0.30[24] -0.23[25] 0.28[26] -0.75[27] 0.82[28]
5 MT1E Metallothionein-1E [29] -2.18[30] -0.96[31] -4.39[32] -7.82[33] -0.29[34] -0.67[35]
6 MT1F Metallothionein-1F [36] -4.73[37] -2.21[38] -4.11[39] -9.48[40] -5.13[41] -0.84[42]
7 MT1H Metallothionein-1H [43] -14.14[44] -12.56[45] [46] [47] -10.72[48] -0.71[49]
8 MT1A Metallothionein-1A [50] -3.43[51] -7.13[52] -4.74[53] -5.26[54] -4.95[55] -1.08[56]
9 COX17 Cytochrome c oxidase copper chaperone [57] -0.18[58] 0.50[59] -0.19[60] -0.20[61] -0.71[62] -0.07[63]
10 ATOX1 Copper transport protein ATOX1 [64] 0.77[65] 0.81[66] 1.03[67] 0.92[68] 0.37[69] 0.59[70]
11 APP Amyloid-beta A4 protein [71] 4.01[72] 3.55[73] 4.66[74] 4.75[75] 4.29[76] 2.48[77]
12 JUN Transcription factor AP-1 [78] 3.14[79] 1.69[80] 2.41[81] 2.27[82] 1.97[83] 0.53[84]
13 AKT1 RAC-alpha serine/threonine-protein kinase [85] 3.71[86] 3.57[87] 2.94[88] 3.92[89] 3.07[90] 2.10[91]
14 STEAP3 Metalloreductase STEAP3 [92] 2.16[93] 1.53[94] -0.20[95] 2.58[96] 0.81[97] 4.05[98]
15 COMMD1 COMM domain-containing protein 1 [99] 1.04[100] 0.77[101] -0.15[102] 0.66[103] -0.25[104] -0.05[105]
16 CCS Copper chaperone for superoxide dismutase [106] 1.40[107] 1.21[108] 3.04[109] 1.68[110] -0.15[111] 1.23[112]
17 COX11 Cytochrome c oxidase assembly protein COX11, mitochondrial [113] 3.03[114] 4.04[115] 3.84[116] 1.48[117] 1.74[118] 1.01[119]
18 SCO1 Protein SCO1 homolog, mitochondrial [120] 2.42[121] 2.15[122] 2.57[123] 2.38[124] 1.66[125] 1.03[126]
19 CCND1 G1/S-specific cyclin-D1 [127] 6.68[128] 4.26[129] 5.55[130] 5.85[131] 3.50[132] 3.40[133]
20 STEAP1 Metalloreductase STEAP1 [134] 1.27[135] 2.57[136] 2.07[137] 0.68[138] 0.97[139] 1.07[140]
21 PRNP Major prion protein [141] 5.10[142] 4.91[143] -1.07[144] 5.37[145] 5.16[146] 2.41[147]
22 SLC31A1 High affinity copper uptake protein 1 [148] 4.20[149] 4.95[150] 5.12[151] 3.59[152] 3.75[153] 4.22[154]
23 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 [155] 4.98[156] 5.55[157] 5.89[158] 6.00[159] 5.46[160] 2.01[161]
24 SCO2 Protein SCO2 homolog, mitochondrial [162] -0.58[163] -0.32[164] 0.76[165] -1.21[166] -2.73[167] -2.04[168]
25 CASP3 Caspase-3 [169] 3.76[170] 4.53[171] 2.44[172] 3.08[173] 3.20[174] 1.54[175]
26 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 [176] 4.61[177] 5.18[178] 5.66[179] 5.25[180] 4.79[181] 3.14[182]
27 SLC11A2 Natural resistance-associated macrophage protein 2 [183] 5.29[184] 6.18[185] 4.79[186] 3.97[187] 3.86[188] 4.02[189]
28 PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 3.09[190] 4.57[191] 5.23[192] 3.41[193] 3.79[194] 4.82[195]
29 SLC31A2 Probable low affinity copper uptake protein 2 [196] 1.70[197] 2.34[198] 1.73[199] 1.74[200] 3.27[201] 3.09[202]
30 MDM2 E3 ubiquitin-protein ligase Mdm2 [203] 5.74[204] 7.25[205] 4.94[206] 4.48[207] 4.49[208] 4.51[209]
31 TP53 Cellular tumor antigen p53 [210] 5.26[211] 4.92[212] 6.13[213] 5.26[214] 4.06[215] 2.30[216]
32 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 [217] 4.30[218] 4.28[219] 4.47[220] 5.71[221] 3.98[222] 2.42[223]
33 XAF1 XIAP-associated factor 1 [224] -0.24[225] 0.12[226] -2.72[227] 2.35[228] 1.15[229] 4.17[230]
34 GSK3B Glycogen synthase kinase-3 beta [231] 4.89[232] 4.62[233] 5.65[234] 5.79[235] 4.75[236] 3.51[237]
35 BACE1 Beta-secretase 1 [238] 3.90[239] 4.34[240] 5.21[241] 5.54[242] 5.14[243] 3.98[244]
36 SP1 Transcription factor Sp1 [245] 5.45[246] 5.78[247] 7.30[248] 6.64[249] 5.46[250] 4.50[251]
37 ATP7B Copper-transporting ATPase 2 [252] 6.11[253] 6.49[254] 6.74[255] 2.14[256] 1.40[257] 5.08[258]
38 FOXO3 Forkhead box protein O3 [259] 4.08[260] 4.26[261] 5.36[262] 4.37[263] 4.74[264] 4.68[265]
39 XIAP E3 ubiquitin-protein ligase XIAP [266] 5.15[267] 5.83[268] 6.74[269] 6.56[270] 5.12[271] 5.03[272]
40 MTF2 Metal-response element-binding transcription factor 2 [273] 4.96[274] 5.76[275] 6.62[276] 5.96[277] 4.62[278] 3.49[279]
41 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 3.25[280] 4.98[281] 5.62[282] 5.10[283] 4.43[284] 4.26[285]
42 STEAP2 Metalloreductase STEAP2 [286] 2.99[287] 5.10[288] 5.38[289] 4.60[290] 4.70[291] 3.50[292]
43 FOXO1 Forkhead box protein O1 [293] 5.32[294] 5.08[295] 5.67[296] 5.15[297] 6.29[298] 5.43[299]
44 MTF1 Metal regulatory transcription factor 1 [300] 5.14[301] 5.09[302] 6.12[303] 6.12[304] 5.27[305] 4.32[306]
45 MT1B Metallothionein-1B [307] -0.06[308] 1.88[309] [310] [311] -4.37[312] -4.26[313]
46 APC Adenomatous polyposis coli protein [314] 4.20[315] 5.96[316] 6.25[317] 6.20[318] 5.96[319] 6.08[320]
47 MAPT Microtubule-associated protein tau [321] 6.15[322] 6.18[323] 5.94[324] 5.31[325] 1.38[326] 2.68[327]
48 ATP7A Copper-transporting ATPase 1 [328] 6.38[329] 6.25[330] 6.99[331] 8.90[332] 6.41[333] 5.64[334]
49 STEAP4 Metalloreductase STEAP4 [335] -0.98[336] 0.39[337] 0.85[338] -0.76[339] 2.34[340] 9.02[341]
50 SOD3 Extracellular superoxide dismutase [Cu-Zn] [342] 0.45[343] 1.42[344] [345] 6.27[346] 1.83[347] 6.74[348]
51 MT3 Metallothionein-3 [349] [350] [351] [352] 7.14[353] 6.39[354] 0.85[355]
52 MT1L Metallothionein-1L [356] [357] [358] [359] [360] [361] [362]
53 MT4 Metallothionein-4 [363] [364] [365] [366] [367] [368] [369]
54 MT1JP [370] [371] [372] [373] [374] [375] [376]
[1]
ref_hepatocyte MT2A
Mean 3.23e+03
Standard deviation 2.9e+03
Values 1.8e+03 7.3e+03 4.9e+03 3.3e+02 1.7e+03
[2]
HepG2 MT2A
Mean 80
Standard deviation 16
Values 69 91
[3]
HepG2.C3A MT2A
Mean 70
Standard deviation 92
Values 1.3e+02 4.9
[4]
HuH.7 MT2A
Mean 3.35
Standard deviation 0.65
Values 3.7 2.6 3.7
[5]
SNU475 MT2A
Mean 13.1
Standard deviation 7.9
Values 19 7.5
[6]
THLE MT2A
Mean 796
Standard deviation 79
Values 7.4e+02 8.5e+02
[7]
liver MT2A
Mean 640
Standard deviation 7.3e+02
Values 4.2 8.7 1.3e+03 1.3e+03
[8]
ref_hepatocyte MT1G
Mean 2.8e+03
Standard deviation 4.6e+03
Values 2.3e+02 1.1e+04 2.6e+03 54 2.3e+02
[9]
HepG2 MT1G
Mean 3.25
Standard deviation 2
Values 4.7 1.8
[10]
HepG2.C3A MT1G
Mean 22.2
Standard deviation 31
Values 44 0.078
[11]
HuH.7 MT1G
Mean 0.306
Standard deviation 0.11
Values 0.4 0.18 0.34
[12]
SNU475 MT1G
Mean 0.0251
Standard deviation 0.029
Values 0.046 0.0046
[13]
THLE MT1G
Mean 0.831
Standard deviation 0.12
Values 0.92 0.74
[14]
liver MT1G
Mean 311
Standard deviation 4.9e+02
Values 3.5 4.7 1e+03 2.1e+02
[15]
ref_hepatocyte MT1X
Mean 1.36e+03
Standard deviation 1.8e+03
Values 74 3.8e+03 2.7e+03 1.3e+02 83
[16]
HepG2 MT1X
Mean 16.9
Standard deviation 13
Values 7.8 26
[17]
HepG2.C3A MT1X
Mean 5.77
Standard deviation 7.8
Values 11 0.25
[18]
HuH.7 MT1X
Mean 1.19
Standard deviation 0.48
Values 1.7 0.76 1.1
[19]
SNU475 MT1X
Mean 2.36
Standard deviation 0.026
Values 2.3 2.4
[20]
THLE MT1X
Mean 38.6
Standard deviation 8.7
Values 45 32
[21]
liver MT1X
Mean 276
Standard deviation 3.3e+02
Values 11 21 7.1e+02 3.6e+02
[22]
ref_hepatocyte SOD1
Mean 597
Standard deviation 4e+02
Values 1.7e+02 1.2e+03 7.2e+02 2.9e+02 6.1e+02
[23]
HepG2 SOD1
Mean 125
Standard deviation 15
Values 1.4e+02 1.1e+02
[24]
HepG2.C3A SOD1
Mean 110
Standard deviation 30
Values 1.3e+02 89
[25]
HuH.7 SOD1
Mean 53.3
Standard deviation 20
Values 71 31 57
[26]
SNU475 SOD1
Mean 84.9
Standard deviation 18
Values 72 97
[27]
THLE SOD1
Mean 85.3
Standard deviation 11
Values 78 93
[28]
liver SOD1
Mean 296
Standard deviation 2.4e+02
Values 63 1.1e+02 5.3e+02 4.8e+02
[29]
ref_hepatocyte MT1E
Mean 596
Standard deviation 5.3e+02
Values 2.7e+02 1.3e+03 1e+03 54 3.5e+02
[30]
HepG2 MT1E
Mean 23.5
Standard deviation 13
Values 32 15
[31]
HepG2.C3A MT1E
Mean 45.8
Standard deviation 63
Values 91 0.98
[32]
HuH.7 MT1E
Mean 2.96
Standard deviation 0.41
Values 3.2 2.5 3.2
[33]
SNU475 MT1E
Mean 0.309
Standard deviation 0.035
Values 0.28 0.33
[34]
THLE MT1E
Mean 117
Standard deviation 26
Values 98 1.4e+02
[35]
liver MT1E
Mean 105
Standard deviation 1.5e+02
Values 16 8.5 3.3e+02 61
[36]
ref_hepatocyte MT1F
Mean 435
Standard deviation 6.9e+02
Values 37 1.6e+03 4.4e+02 51 8.4
[37]
HepG2 MT1F
Mean 2.92
Standard deviation 1.1
Values 3.7 2.2
[38]
HepG2.C3A MT1F
Mean 14.1
Standard deviation 19
Values 28 0.3
[39]
HuH.7 MT1F
Mean 2.63
Standard deviation 0.45
Values 3.1 2.5 2.2
[40]
SNU475 MT1F
Mean 0.0711
Standard deviation 0.028
Values 0.091 0.051
[41]
THLE MT1F
Mean 2.98
Standard deviation 0.2
Values 3.1 2.8
[42]
liver MT1F
Mean 68.1
Standard deviation 1.2e+02
Values 0.49 0.61 2.5e+02 21
[43]
ref_hepatocyte MT1H
Mean 434
Standard deviation 7.2e+02
Values 33 1.7e+03 3.7e+02 0 76
[44]
HepG2 MT1H
Mean 0.00429
Standard deviation 0.0061
Values 0.0086 0
[45]
HepG2.C3A MT1H
Mean 0.0107
Standard deviation 0.015
Values 0.021 0
[46]
HuH.7 MT1H
Mean 0
Standard deviation 0
Values 0 0 0
[47]
SNU475 MT1H
Mean 0
Standard deviation 0
Values 0 0
[48]
THLE MT1H
Mean 0.0618
Standard deviation 0.0046
Values 0.065 0.059
[49]
liver MT1H
Mean 74.4
Standard deviation 1.3e+02
Values 0.11 1.3 2.7e+02 31
[50]
ref_hepatocyte MT1A
Mean 109
Standard deviation 1e+02
Values 58 1.4e+02 2.7e+02 1.4 79
[51]
HepG2 MT1A
Mean 1.82
Standard deviation 1.6
Values 0.7 2.9
[52]
HepG2.C3A MT1A
Mean 0.117
Standard deviation 0.14
Values 0.21 0.019
[53]
HuH.7 MT1A
Mean 0.43
Standard deviation 0.14
Values 0.57 0.28 0.43
[54]
SNU475 MT1A
Mean 0.334
Standard deviation 0.16
Values 0.45 0.22
[55]
THLE MT1A
Mean 0.85
Standard deviation 0.2
Values 0.71 0.99
[56]
liver MT1A
Mean 14.5
Standard deviation 17
Values 0.5 2.6 19 36
[57]
ref_hepatocyte COX17
Mean 69
Standard deviation 57
Values 40 1.2e+02 1.4e+02 16 28
[58]
HepG2 COX17
Mean 10.9
Standard deviation 0.57
Values 11 10
[59]
HepG2.C3A COX17
Mean 14.5
Standard deviation 5.5
Values 18 11
[60]
HuH.7 COX17
Mean 6.32
Standard deviation 1.8
Values 8.3 4.7 5.9
[61]
SNU475 COX17
Mean 7.04
Standard deviation 2.5
Values 5.3 8.8
[62]
THLE COX17
Mean 10.1
Standard deviation 1.3
Values 9.1 11
[63]
liver COX17
Mean 18.4
Standard deviation 21
Values 0.52 0.93 42 30
[64]
ref_hepatocyte ATOX1
Mean 60.5
Standard deviation 62
Values 25 1.5e+02 99 18 9.7
[65]
HepG2 ATOX1
Mean 18.4
Standard deviation 2.9
Values 20 16
[66]
HepG2.C3A ATOX1
Mean 15.8
Standard deviation 3.2
Values 18 14
[67]
HuH.7 ATOX1
Mean 12.9
Standard deviation 4.5
Values 18 8.5 13
[68]
SNU475 ATOX1
Mean 13.4
Standard deviation 2.3
Values 12 15
[69]
THLE ATOX1
Mean 18.7
Standard deviation 2.5
Values 17 21
[70]
liver ATOX1
Mean 25.5
Standard deviation 29
Values 1.1 1.2 58 42
[71]
ref_hepatocyte APP
Mean 58.3
Standard deviation 28
Values 46 59 51 31 1e+02
[72]
HepG2 APP
Mean 167
Standard deviation 49
Values 1.3e+02 2e+02
[73]
HepG2.C3A APP
Mean 102
Standard deviation 27
Values 83 1.2e+02
[74]
HuH.7 APP
Mean 154
Standard deviation 13
Values 1.4e+02 1.7e+02 1.6e+02
[75]
SNU475 APP
Mean 184
Standard deviation 28
Values 1.6e+02 2e+02
[76]
THLE APP
Mean 273
Standard deviation 68
Values 2.3e+02 3.2e+02
[77]
liver APP
Mean 91
Standard deviation 73
Values 1.3e+02 1.7e+02 32 28
[78]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 66 20 73 26 30
[79]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 42 93
[80]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 13 28
[81]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 14 46 11
[82]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 27 21
[83]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[84]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 12 24 25 8.4
[85]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[86]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[87]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[88]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[89]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[90]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[91]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[92]
ref_hepatocyte STEAP3
Mean 29.1
Standard deviation 31
Values 7.5 63 62 2.5 10
[93]
HepG2 STEAP3
Mean 23.2
Standard deviation 1.8
Values 22 24
[94]
HepG2.C3A STEAP3
Mean 12.5
Standard deviation 1.6
Values 14 11
[95]
HuH.7 STEAP3
Mean 2.64
Standard deviation 1.2
Values 3 1.3 3.6
[96]
SNU475 STEAP3
Mean 20.3
Standard deviation 7.9
Values 15 26
[97]
THLE STEAP3
Mean 12.2
Standard deviation 1.5
Values 11 13
[98]
liver STEAP3
Mean 135
Standard deviation 39
Values 1.2e+02 95 1.4e+02 1.9e+02
[99]
ref_hepatocyte COMMD1
Mean 28.4
Standard deviation 11
Values 11 35 26 32 38
[100]
HepG2 COMMD1
Mean 10.4
Standard deviation 2.2
Values 12 8.8
[101]
HepG2.C3A COMMD1
Mean 7.22
Standard deviation 1.1
Values 8 6.4
[102]
HuH.7 COMMD1
Mean 2.67
Standard deviation 0.35
Values 2.9 2.3 2.8
[103]
SNU475 COMMD1
Mean 5.23
Standard deviation 1.6
Values 4.1 6.3
[104]
THLE COMMD1
Mean 5.72
Standard deviation 0.1
Values 5.8 5.6
[105]
liver COMMD1
Mean 7.69
Standard deviation 6.1
Values 2.3 3.2 15 9.9
[106]
ref_hepatocyte CCS
Mean 26.9
Standard deviation 25
Values 19 62 44 6.3 3.2
[107]
HepG2 CCS
Mean 12.7
Standard deviation 0.52
Values 13 12
[108]
HepG2.C3A CCS
Mean 9.27
Standard deviation 1.8
Values 8 11
[109]
HuH.7 CCS
Mean 23
Standard deviation 6.1
Values 29 17 23
[110]
SNU475 CCS
Mean 10.1
Standard deviation 0.53
Values 9.7 10
[111]
THLE CCS
Mean 5.81
Standard deviation 0.14
Values 5.9 5.7
[112]
liver CCS
Mean 17.6
Standard deviation 12
Values 9.6 5.8 31 24
[113]
ref_hepatocyte COX11
Mean 23.2
Standard deviation 18
Values 4.3 18 8.1 46 39
[114]
HepG2 COX11
Mean 33.8
Standard deviation 6.4
Values 38 29
[115]
HepG2.C3A COX11
Mean 57.1
Standard deviation 19
Values 70 44
[116]
HuH.7 COX11
Mean 34.8
Standard deviation 7.9
Values 41 26 37
[117]
SNU475 COX11
Mean 7.56
Standard deviation 0.11
Values 7.5 7.6
[118]
THLE COX11
Mean 18.5
Standard deviation 0.84
Values 18 19
[119]
liver COX11
Mean 13.1
Standard deviation 5.6
Values 8.2 8.6 20 16
[120]
ref_hepatocyte SCO1
Mean 23.1
Standard deviation 11
Values 15 15 14 33 38
[121]
HepG2 SCO1
Mean 22.1
Standard deviation 5.2
Values 26 18
[122]
HepG2.C3A SCO1
Mean 15.3
Standard deviation 6.6
Values 20 11
[123]
HuH.7 SCO1
Mean 14.4
Standard deviation 4.3
Values 16 9.4 17
[124]
SNU475 SCO1
Mean 14
Standard deviation 1.6
Values 13 15
[125]
THLE SCO1
Mean 17.5
Standard deviation 2.6
Values 16 19
[126]
liver SCO1
Mean 13.2
Standard deviation 3.8
Values 9.2 12 13 18
[127]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 19 12 11 44 28
[128]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 3.9e+02 4.5e+02
[129]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 74 58
[130]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.2e+02 79 1.4e+02
[131]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 2e+02 1.1e+02
[132]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[133]
liver CCND1
Mean 67.8
Standard deviation 49
Values 25 1.1e+02 26 1.1e+02
[134]
ref_hepatocyte STEAP1
Mean 19.3
Standard deviation 13
Values 24 12 40 7.6 12
[135]
HepG2 STEAP1
Mean 8.31
Standard deviation 1.5
Values 7.3 9.3
[136]
HepG2.C3A STEAP1
Mean 17.1
Standard deviation 4.9
Values 21 14
[137]
HuH.7 STEAP1
Mean 8.46
Standard deviation 2.4
Values 11 7.5 6.7
[138]
SNU475 STEAP1
Mean 3.6
Standard deviation 2.6
Values 5.4 1.8
[139]
THLE STEAP1
Mean 9.01
Standard deviation 0.46
Values 9.3 8.7
[140]
liver STEAP1
Mean 11.3
Standard deviation 4.7
Values 6.1 8.6 16 15
[141]
ref_hepatocyte PRNP
Mean 19.1
Standard deviation 12
Values 39 20 18 9.9 8.6
[142]
HepG2 PRNP
Mean 117
Standard deviation 11
Values 1.1e+02 1.2e+02
[143]
HepG2.C3A PRNP
Mean 86
Standard deviation 14
Values 96 76
[144]
HuH.7 PRNP
Mean 0.95
Standard deviation 0.22
Values 0.81 0.85 1.2
[145]
SNU475 PRNP
Mean 92.4
Standard deviation 29
Values 1.1e+02 72
[146]
THLE PRNP
Mean 163
Standard deviation 47
Values 1.3e+02 2e+02
[147]
liver PRNP
Mean 28.5
Standard deviation 5.5
Values 21 29 31 34
[148]
ref_hepatocyte SLC31A1
Mean 17.4
Standard deviation 7.3
Values 7.1 23 23 22 12
[149]
HepG2 SLC31A1
Mean 56.9
Standard deviation 10
Values 64 50
[150]
HepG2.C3A SLC31A1
Mean 80.5
Standard deviation 17
Values 68 93
[151]
HuH.7 SLC31A1
Mean 63.2
Standard deviation 5.1
Values 59 61 69
[152]
SNU475 SLC31A1
Mean 24.5
Standard deviation 1.6
Values 23 26
[153]
THLE SLC31A1
Mean 56.2
Standard deviation 2
Values 58 55
[154]
liver SLC31A1
Mean 90.8
Standard deviation 16
Values 90 71 1.1e+02 93
[155]
ref_hepatocyte ADAM9
Mean 14.2
Standard deviation 13
Values 12 1.6 1.6 28 27
[156]
HepG2 ADAM9
Mean 79.8
Standard deviation 11
Values 87 72
[157]
HepG2.C3A ADAM9
Mean 99.4
Standard deviation 24
Values 1.2e+02 83
[158]
HuH.7 ADAM9
Mean 87.6
Standard deviation 12
Values 75 99 88
[159]
SNU475 ADAM9
Mean 106
Standard deviation 34
Values 82 1.3e+02
[160]
THLE ADAM9
Mean 149
Standard deviation 0.94
Values 1.5e+02 1.5e+02
[161]
liver ADAM9
Mean 15.9
Standard deviation 4.2
Values 14 21 12 17
[162]
ref_hepatocyte SCO2
Mean 13
Standard deviation 8.9
Values 22 14 22 2.3 5.8
[163]
HepG2 SCO2
Mean 1.56
Standard deviation 0.044
Values 1.6 1.5
[164]
HepG2.C3A SCO2
Mean 1.56
Standard deviation 0.15
Values 1.7 1.4
[165]
HuH.7 SCO2
Mean 2.3
Standard deviation 0.8
Values 3 1.4 2.5
[166]
SNU475 SCO2
Mean 0.655
Standard deviation 0.11
Values 0.58 0.73
[167]
THLE SCO2
Mean 0.47
Standard deviation 0.16
Values 0.35 0.59
[168]
liver SCO2
Mean 0.882
Standard deviation 0.89
Values 0.17 0.057 1.6 1.7
[169]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 6.8 5.1 4.9 33 13
[170]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 36 25
[171]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 59 27
[172]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 7.8 7.5 5.9
[173]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 12 13
[174]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[175]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 6.1 9 9.5 16
[176]
ref_hepatocyte ADAM10
Mean 8.78
Standard deviation 8.3
Values 2.8 3.4 3.4 21 13
[177]
HepG2 ADAM10
Mean 38.3
Standard deviation 10
Values 46 31
[178]
HepG2.C3A ADAM10
Mean 47.7
Standard deviation 4.9
Values 51 44
[179]
HuH.7 ADAM10
Mean 46.6
Standard deviation 9
Values 36 53 51
[180]
SNU475 ADAM10
Mean 39.1
Standard deviation 5.2
Values 35 43
[181]
THLE ADAM10
Mean 58.2
Standard deviation 3.8
Values 56 61
[182]
liver ADAM10
Mean 21.7
Standard deviation 10
Values 26 34 13 14
[183]
ref_hepatocyte SLC11A2
Mean 7.42
Standard deviation 2.2
Values 9.1 9.8 6.4 7.3 4.4
[184]
HepG2 SLC11A2
Mean 51.9
Standard deviation 3
Values 50 54
[185]
HepG2.C3A SLC11A2
Mean 80.2
Standard deviation 5.6
Values 84 76
[186]
HuH.7 SLC11A2
Mean 21.4
Standard deviation 1.3
Values 21 23 21
[187]
SNU475 SLC11A2
Mean 13.6
Standard deviation 0.2
Values 13 14
[188]
THLE SLC11A2
Mean 25.8
Standard deviation 1.4
Values 25 27
[189]
liver SLC11A2
Mean 33.8
Standard deviation 8
Values 45 34 31 26
[190]
ref_hepatocyte PTEN
Mean 6.57
Standard deviation 2.4
Values 5.2 11 7 4.2 5.9
[191]
HepG2 PTEN
Mean 9.98
Standard deviation 2.3
Values 12 8.4
[192]
HepG2.C3A PTEN
Mean 23.3
Standard deviation 3.3
Values 21 26
[193]
HuH.7 PTEN
Mean 25.7
Standard deviation 12
Values 19 39 19
[194]
SNU475 PTEN
Mean 8.16
Standard deviation 1.8
Values 6.9 9.4
[195]
THLE PTEN
Mean 21.8
Standard deviation 0.98
Values 22 21
[196]
liver PTEN
Mean 52
Standard deviation 9.3
Values 53 55 61 39
[197]
ref_hepatocyte SLC31A2
Mean 6.48
Standard deviation 5.1
Values 4.1 3.7 15 1.9 7.9
[198]
HepG2 SLC31A2
Mean 3.77
Standard deviation 0.69
Values 4.3 3.3
[199]
HepG2.C3A SLC31A2
Mean 4.92
Standard deviation 0.57
Values 4.5 5.3
[200]
HuH.7 SLC31A2
Mean 2.25
Standard deviation 0.37
Values 2.1 2.7 2
[201]
SNU475 SLC31A2
Mean 2.54
Standard deviation 0.11
Values 2.5 2.6
[202]
THLE SLC31A2
Mean 15
Standard deviation 0.34
Values 15 15
[203]
liver SLC31A2
Mean 15.5
Standard deviation 7.8
Values 9.3 9.3 25 18
[204]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 5 4.8 3.6 11 7.6
[205]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 70 51
[206]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.8e+02 1.1e+02
[207]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 20 20 21
[208]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 15 18
[209]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[210]
liver MDM2
Mean 40.5
Standard deviation 11
Values 45 54 29 35
[211]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[212]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[213]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[214]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[215]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[216]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[217]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[218]
ref_hepatocyte ADAM17
Mean 5.04
Standard deviation 4.3
Values 4.3 1.1 1 10 8.5
[219]
HepG2 ADAM17
Mean 17.8
Standard deviation 0.96
Values 17 18
[220]
HepG2.C3A ADAM17
Mean 14.6
Standard deviation 0.94
Values 15 14
[221]
HuH.7 ADAM17
Mean 11.7
Standard deviation 1.5
Values 10 12 13
[222]
SNU475 ADAM17
Mean 31
Standard deviation 2.8
Values 29 33
[223]
THLE ADAM17
Mean 19
Standard deviation 2.3
Values 17 21
[224]
liver ADAM17
Mean 7.57
Standard deviation 0.72
Values 7.4 8.6 7.2 7
[225]
ref_hepatocyte XAF1
Mean 4.86
Standard deviation 3
Values 6.3 5.3 8.8 0.83 3.2
[226]
HepG2 XAF1
Mean 0.738
Standard deviation 0.22
Values 0.9 0.58
[227]
HepG2.C3A XAF1
Mean 0.79
Standard deviation 0.01
Values 0.78 0.8
[228]
HuH.7 XAF1
Mean 0.077
Standard deviation 0.031
Values 0.094 0.096 0.041
[229]
SNU475 XAF1
Mean 2.9
Standard deviation 0.92
Values 2.3 3.6
[230]
THLE XAF1
Mean 2.58
Standard deviation 1.3
Values 3.5 1.7
[231]
liver XAF1
Mean 24.5
Standard deviation 12
Values 7.5 29 28 34
[232]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[233]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[234]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[235]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[236]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[237]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[238]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[239]
ref_hepatocyte BACE1
Mean 3.65
Standard deviation 3.1
Values 1.1 7.7 6.3 1.5 1.6
[240]
HepG2 BACE1
Mean 9.71
Standard deviation 0.36
Values 9.5 10
[241]
HepG2.C3A BACE1
Mean 11.1
Standard deviation 1.2
Values 10 12
[242]
HuH.7 BACE1
Mean 14.1
Standard deviation 1.8
Values 12 15 15
[243]
SNU475 BACE1
Mean 19.9
Standard deviation 7.2
Values 15 25
[244]
THLE BACE1
Mean 30.8
Standard deviation 2.2
Values 29 32
[245]
liver BACE1
Mean 16.1
Standard deviation 3.6
Values 19 16 19 11
[246]
ref_hepatocyte SP1
Mean 3.57
Standard deviation 0.42
Values 4.3 3.6 3.5 3.2 3.3
[247]
HepG2 SP1
Mean 27.8
Standard deviation 1
Values 29 27
[248]
HepG2.C3A SP1
Mean 29.3
Standard deviation 0.25
Values 29 29
[249]
HuH.7 SP1
Mean 58.8
Standard deviation 12
Values 46 59 71
[250]
SNU475 SP1
Mean 41.7
Standard deviation 2.6
Values 40 44
[251]
THLE SP1
Mean 37.5
Standard deviation 7.4
Values 32 43
[252]
liver SP1
Mean 22.6
Standard deviation 13
Values 36 31 14 9.1
[253]
ref_hepatocyte ATP7B
Mean 2.93
Standard deviation 1.9
Values 1.3 3.8 2.6 5.8 1.2
[254]
HepG2 ATP7B
Mean 36.2
Standard deviation 8.1
Values 42 30
[255]
HepG2.C3A ATP7B
Mean 39.4
Standard deviation 2.6
Values 38 41
[256]
HuH.7 ATP7B
Mean 32.8
Standard deviation 5.6
Values 27 34 38
[257]
SNU475 ATP7B
Mean 1.51
Standard deviation 0.36
Values 1.3 1.8
[258]
THLE ATP7B
Mean 1.85
Standard deviation 0.41
Values 1.6 2.1
[259]
liver ATP7B
Mean 27.8
Standard deviation 15
Values 48 32 18 14
[260]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 2.3 2.9 2.8 3.3 2.7
[261]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 9.2 7.7
[262]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 6.3 9.7
[263]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 7.9 15 13
[264]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 6.2 7.3
[265]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[266]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 23 21 24 12
[267]
ref_hepatocyte XIAP
Mean 2.63
Standard deviation 0.63
Values 2.1 3.2 1.9 2.6 3.3
[268]
HepG2 XIAP
Mean 16.7
Standard deviation 3.8
Values 19 14
[269]
HepG2.C3A XIAP
Mean 22.3
Standard deviation 5.6
Values 26 18
[270]
HuH.7 XIAP
Mean 29.4
Standard deviation 6.2
Values 22 31 34
[271]
SNU475 XIAP
Mean 29.2
Standard deviation 5.9
Values 25 33
[272]
THLE XIAP
Mean 21.9
Standard deviation 3.4
Values 19 24
[273]
liver XIAP
Mean 24
Standard deviation 7.9
Values 27 34 19 16
[274]
ref_hepatocyte MTF2
Mean 2.26
Standard deviation 1.6
Values 1.4 1.8 0.64 4.6 2.9
[275]
HepG2 MTF2
Mean 12.6
Standard deviation 4
Values 15 9.8
[276]
HepG2.C3A MTF2
Mean 18.4
Standard deviation 3.3
Values 21 16
[277]
HuH.7 MTF2
Mean 23.3
Standard deviation 5.2
Values 27 17 26
[278]
SNU475 MTF2
Mean 16.5
Standard deviation 1
Values 17 16
[279]
THLE MTF2
Mean 13.4
Standard deviation 1.9
Values 15 12
[280]
liver MTF2
Mean 7.13
Standard deviation 1.3
Values 5.7 7.3 8.8 6.8
[281]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[282]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[283]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[284]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[285]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[286]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[287]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[288]
ref_hepatocyte STEAP2
Mean 1.85
Standard deviation 0.65
Values 2.2 1 1.6 1.6 2.7
[289]
HepG2 STEAP2
Mean 2.61
Standard deviation 0.35
Values 2.4 2.9
[290]
HepG2.C3A STEAP2
Mean 9.47
Standard deviation 0.48
Values 9.8 9.1
[291]
HuH.7 STEAP2
Mean 8.07
Standard deviation 0.6
Values 7.6 7.8 8.8
[292]
SNU475 STEAP2
Mean 5.25
Standard deviation 1.4
Values 6.2 4.3
[293]
THLE STEAP2
Mean 11.5
Standard deviation 3.4
Values 14 9.1
[294]
liver STEAP2
Mean 5.84
Standard deviation 0.91
Values 7.2 5.6 5.4 5.2
[295]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 2 2.6 1.9 0.71 1.7
[296]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 14 11
[297]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 7.9 10
[298]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 7.6 10 10
[299]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 6 8.6
[300]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[301]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 29 19 25 13
[302]
ref_hepatocyte MTF1
Mean 1.32
Standard deviation 0.88
Values 2.5 0.46 0.7 0.97 1.9
[303]
HepG2 MTF1
Mean 8.32
Standard deviation 1.5
Values 9.4 7.2
[304]
HepG2.C3A MTF1
Mean 6.72
Standard deviation 0.89
Values 7.3 6.1
[305]
HuH.7 MTF1
Mean 9.61
Standard deviation 1.8
Values 7.7 9.9 11
[306]
SNU475 MTF1
Mean 10.7
Standard deviation 1.8
Values 12 9.5
[307]
THLE MTF1
Mean 12.2
Standard deviation 1.1
Values 11 13
[308]
liver MTF1
Mean 7.36
Standard deviation 1.8
Values 6.7 5.3 7.9 9.6
[309]
ref_hepatocyte MT1B
Mean 1.25
Standard deviation 1.5
Values 0.92 3.7 1.6 0 0
[310]
HepG2 MT1B
Mean 0.213
Standard deviation 0.29
Values 0.0086 0.42
[311]
HepG2.C3A MT1B
Mean 0.686
Standard deviation 0.96
Values 1.4 0.0097
[312]
HuH.7 MT1B
Mean 0
Standard deviation 0
Values 0 0 0
[313]
SNU475 MT1B
Mean 0
Standard deviation 0
Values 0 0
[314]
THLE MT1B
Mean 0.0145
Standard deviation 0.013
Values 0.024 0.0053
[315]
liver MT1B
Mean 0.0182
Standard deviation 0.023
Values 0 0 0.047 0.026
[316]
ref_hepatocyte APC
Mean 1.09
Standard deviation 0.39
Values 1 0.97 0.53 1.4 1.5
[317]
HepG2 APC
Mean 3.57
Standard deviation 1.5
Values 4.6 2.5
[318]
HepG2.C3A APC
Mean 10.1
Standard deviation 2.6
Values 12 8.3
[319]
HuH.7 APC
Mean 8.67
Standard deviation 2.6
Values 5.7 11 9.7
[320]
SNU475 APC
Mean 9.33
Standard deviation 3.4
Values 12 6.9
[321]
THLE APC
Mean 16.3
Standard deviation 4.6
Values 20 13
[322]
liver APC
Mean 20.6
Standard deviation 6.3
Values 22 28 20 12
[323]
ref_hepatocyte MAPT
Mean 0.398
Standard deviation 0.55
Values 0 0.057 0.29 1.3 0.29
[324]
HepG2 MAPT
Mean 5.07
Standard deviation 2.9
Values 3 7.1
[325]
HepG2.C3A MAPT
Mean 4.33
Standard deviation 2.4
Values 2.6 6
[326]
HuH.7 MAPT
Mean 2.56
Standard deviation 0.37
Values 2.1 2.8 2.8
[327]
SNU475 MAPT
Mean 1.84
Standard deviation 0.65
Values 2.3 1.4
[328]
THLE MAPT
Mean 0.248
Standard deviation 0.12
Values 0.33 0.16
[329]
liver MAPT
Mean 0.713
Standard deviation 0.37
Values 1.2 0.4 0.82 0.44
[330]
ref_hepatocyte ATP7A
Mean 0.324
Standard deviation 0.26
Values 0.11 0.12 0.21 0.47 0.72
[331]
HepG2 ATP7A
Mean 4.83
Standard deviation 1.1
Values 5.6 4
[332]
HepG2.C3A ATP7A
Mean 3.69
Standard deviation 0.64
Values 4.1 3.2
[333]
HuH.7 ATP7A
Mean 4.32
Standard deviation 1.1
Values 3 4.9 5
[334]
SNU475 ATP7A
Mean 18.1
Standard deviation 5.2
Values 14 22
[335]
THLE ATP7A
Mean 6.59
Standard deviation 0.53
Values 6.2 7
[336]
liver ATP7A
Mean 4.51
Standard deviation 2.4
Values 6.9 6.2 2.8 2.1
[337]
ref_hepatocyte STEAP4
Mean 0.283
Standard deviation 0.34
Values 0.092 0.46 0.8 0 0.06
[338]
HepG2 STEAP4
Mean 0.0258
Standard deviation 0.012
Values 0.034 0.017
[339]
HepG2.C3A STEAP4
Mean 0.0555
Standard deviation 0.018
Values 0.043 0.068
[340]
HuH.7 STEAP4
Mean 0.0534
Standard deviation 0.014
Values 0.056 0.039 0.066
[341]
SNU475 STEAP4
Mean 0.0196
Standard deviation 0.0081
Values 0.025 0.014
[342]
THLE STEAP4
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[343]
liver STEAP4
Mean 41.2
Standard deviation 16
Values 42 61 20 42
[344]
ref_hepatocyte SOD3
Mean 0.0499
Standard deviation 0.071
Values 0 0.15 0.095 0 0
[345]
HepG2 SOD3
Mean 0.0122
Standard deviation 0.001
Values 0.013 0.011
[346]
HepG2.C3A SOD3
Mean 0.0199
Standard deviation 0.013
Values 0.011 0.029
[347]
HuH.7 SOD3
Mean 0
Standard deviation 0
Values 0 0 0
[348]
SNU475 SOD3
Mean 0.45
Standard deviation 0.13
Values 0.54 0.36
[349]
THLE SOD3
Mean 0.0426
Standard deviation 0.015
Values 0.053 0.032
[350]
liver SOD3
Mean 1.49
Standard deviation 0.55
Values 1.5 0.96 2.3 1.3
[351]
ref_hepatocyte MT3
Mean 0.0244
Standard deviation 0.055
Values 0 0.12 0 0 0
[352]
HepG2 MT3
Mean 0
Standard deviation 0
Values 0 0
[353]
HepG2.C3A MT3
Mean 0
Standard deviation 0
Values 0 0
[354]
HuH.7 MT3
Mean 0
Standard deviation 0
Values 0 0 0
[355]
SNU475 MT3
Mean 0.402
Standard deviation 0.38
Values 0.67 0.13
[356]
THLE MT3
Mean 0.489
Standard deviation 0.2
Values 0.63 0.35
[357]
liver MT3
Mean 0.0123
Standard deviation 0.014
Values 0 0 0.024 0.026
[358]
ref_hepatocyte MT1L
Missing
[359]
HepG2 MT1L
Mean 0.124
Standard deviation 0.13
Values 0.03 0.22
[360]
HepG2.C3A MT1L
Mean 0
Standard deviation 0
Values 0 0
[361]
HuH.7 MT1L
Mean 0.632
Standard deviation 0.18
Values 0.84 0.53 0.52
[362]
SNU475 MT1L
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[363]
THLE MT1L
Mean 8.87
Standard deviation 1.3
Values 7.9 9.8
[364]
liver MT1L
Mean 4.48
Standard deviation 5.4
Values 0.45 0.17 12 5.7
[365]
ref_hepatocyte MT4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[366]
HepG2 MT4
Missing
[367]
HepG2.C3A MT4
Missing
[368]
HuH.7 MT4
Missing
[369]
SNU475 MT4
Missing
[370]
THLE MT4
Missing
[371]
liver MT4
Missing
[372]
ref_hepatocyte MT1JP
Missing
[373]
HepG2 MT1JP
Mean 0
Standard deviation 0
Values 0 0
[374]
HepG2.C3A MT1JP
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[375]
HuH.7 MT1JP
Mean 0.00526
Standard deviation 0.0048
Values 0.0094 0.0064 0
[376]
SNU475 MT1JP
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[377]
THLE MT1JP
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[378]
liver MT1JP
Mean 0.309
Standard deviation 0.25
Values 0.15 0.1 0.66 0.33