WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90AA1 | Heat shock protein HSP 90-alpha | [1] | 1.74[2] | 1.90[3] | 1.80[4] | 2.25[5] | 2.20[6] | -1.56[7] |
2 | CYP2C9 | Cytochrome P450 2C9 | [8] | [9] | -15.10[10] | -7.53[11] | -14.05[12] | -12.97[13] | 0.72[14] |
3 | SULT2A1 | Bile salt sulfotransferase | [15] | -0.89[16] | -0.77[17] | -1.36[18] | -10.45[19] | -9.98[20] | -0.01[21] |
4 | CYP3A4 | Cytochrome P450 3A4 | [22] | -9.36[23] | -10.29[24] | -11.34[25] | -14.36[26] | -12.54[27] | 0.43[28] |
5 | UGT1A6 | UDP-glucuronosyltransferase 1-6 | [29] | -6.45[30] | -15.00[31] | -8.44[32] | -5.71[33] | -11.28[34] | -4.19[35] |
6 | CYP2A6 | Cytochrome P450 2A6 | [36] | -15.47[37] | [38] | -7.77[39] | -11.12[40] | -13.28[41] | -1.91[42] |
7 | GSTA2 | Glutathione S-transferase A2 | [43] | -4.36[44] | -7.66[45] | -2.60[46] | -7.29[47] | -10.56[48] | -3.73[49] |
8 | CYP3A5 | Cytochrome P450 3A5 | [50] | -4.42[51] | -3.01[52] | -5.09[53] | -6.93[54] | -8.88[55] | 0.80[56] |
9 | CYP4A11 | Cytochrome P450 4A11 | [57] | -12.28[58] | -10.46[59] | -11.66[60] | -10.17[61] | -10.92[62] | 0.58[63] |
10 | SULT1A1 | Sulfotransferase 1A1 | [64] | 0.88[65] | 0.71[66] | -2.10[67] | -1.44[68] | -1.10[69] | -2.45[70] |
11 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | [71] | -3.98[72] | -11.04[73] | -5.22[74] | -0.19[75] | -9.92[76] | -0.35[77] |
12 | UGT1A4 | UDP-glucuronosyltransferase 1-4 | [78] | -11.35[79] | [80] | -11.12[81] | -9.46[82] | [83] | -0.16[84] |
13 | CYP2B6 | Cytochrome P450 2B6 | [85] | -7.25[86] | -4.63[87] | -2.59[88] | -8.91[89] | -9.65[90] | 2.10[91] |
14 | ALAS1 | 5-aminolevulinate synthase, nonspecific, mitochondrial | [92] | 0.69[93] | -0.50[94] | 0.88[95] | 0.26[96] | 0.81[97] | 0.78[98] |
15 | EHHADH | Peroxisomal bifunctional enzyme | [99] | -0.49[100] | -0.53[101] | 0.73[102] | -1.08[103] | -1.50[104] | 1.34[105] |
16 | DNAJC7 | DnaJ homolog subfamily C member 7 | [106] | 1.82[107] | 0.25[108] | 1.79[109] | 0.94[110] | 1.59[111] | -2.30[112] |
17 | ABCC2 | Canalicular multispecific organic anion transporter 1 | [113] | 3.22[114] | 3.98[115] | 3.06[116] | 1.91[117] | -4.60[118] | 1.65[119] |
18 | NR1I3 | Nuclear receptor subfamily 1 group I member 3 | [120] | -5.69[121] | -4.99[122] | -4.22[123] | -7.58[124] | -6.60[125] | -0.86[126] |
19 | CYP2C19 | Cytochrome P450 2C19 | [127] | [128] | [129] | -4.67[130] | -11.73[131] | -11.27[132] | 1.28[133] |
20 | UGT1A9 | UDP-glucuronosyltransferase 1-9 | [134] | -5.32[135] | -11.01[136] | -6.53[137] | -4.52[138] | -9.51[139] | -0.93[140] |
21 | RXRA | Retinoic acid receptor RXR-alpha | [141] | 2.33[142] | 1.32[143] | 2.83[144] | 2.17[145] | 2.11[146] | 1.85[147] |
22 | ABCC3 | Canalicular multispecific organic anion transporter 2 | [148] | 3.47[149] | 1.98[150] | 1.01[151] | 2.42[152] | 2.11[153] | 2.34[154] |
23 | ABCB1 | Multidrug resistance protein 1 | [155] | 1.80[156] | 2.51[157] | 1.56[158] | -3.70[159] | -5.09[160] | 0.38[161] |
24 | SMC1A | Structural maintenance of chromosomes protein 1A | [162] | 4.48[163] | 3.54[164] | 5.22[165] | 5.17[166] | 6.29[167] | 2.14[168] |
25 | UGT1A3 | UDP-glucuronosyltransferase 1-3 | [169] | -0.58[170] | [171] | -7.38[172] | -4.26[173] | -9.10[174] | 0.94[175] |
26 | SP1 | Transcription factor Sp1 | [176] | 4.20[177] | 3.64[178] | 5.37[179] | 4.83[180] | 4.78[181] | 1.85[182] |
27 | NCOA6 | Nuclear receptor coactivator 6 | [183] | 4.59[184] | 3.63[185] | 4.50[186] | 4.72[187] | 4.24[188] | 1.11[189] |
28 | NCOA1 | Nuclear receptor coactivator 1 | [190] | 2.85[191] | 2.61[192] | 3.47[193] | 3.95[194] | 3.67[195] | 2.35[196] |
29 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | 1.30[197] | 3.38[198] | -6.73[199] | 2.92[200] | -0.11[201] | 3.13[202] | |
30 | FOXO1 | Forkhead box protein O1 | [203] | 4.08[204] | 2.94[205] | 3.74[206] | 3.33[207] | 5.62[208] | 2.79[209] |
31 | NCOA2 | Nuclear receptor coactivator 2 | [210] | 3.96[211] | 3.97[212] | 6.47[213] | 5.36[214] | 3.92[215] | 4.30[216] |
32 | PTPA | Serine/threonine-protein phosphatase 2A activator | [217] | [218] | [219] | [220] | [221] | [222] | [223] |