WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ACTB | Actin, cytoplasmic 1 | [1] | -0.67[2] | -0.97[3] | -0.48[4] | -0.33[5] | -0.47[6] | -0.11[7] |
2 | ACTG1 | Actin, cytoplasmic 2 | [8] | 0.61[9] | -0.33[10] | -0.37[11] | -0.52[12] | 0.12[13] | -0.86[14] |
3 | CALM2 | Calmodulin-2 | [15] | -0.79[16] | 0.47[17] | -1.15[18] | -1.09[19] | -0.55[20] | -0.65[21] |
4 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 1.15[22] | 1.57[23] | 1.08[24] | 1.51[25] | 0.99[26] | -0.27[27] | |
5 | RAP1B | Ras-related protein Rap-1b | [28] | -1.58[29] | -0.58[30] | -0.95[31] | 0.14[32] | 0.14[33] | -0.82[34] |
6 | GJB1 | Gap junction beta-1 protein | [35] | -1.50[36] | 0.18[37] | -0.73[38] | -10.82[39] | -10.22[40] | 1.22[41] |
7 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [42] | 0.70[43] | 0.81[44] | 1.88[45] | 2.20[46] | 0.04[47] | 0.12[48] |
8 | PPP1R1A | Protein phosphatase 1 regulatory subunit 1A | [49] | -9.13[50] | [51] | -8.20[52] | -11.77[53] | -12.18[54] | 0.89[55] |
9 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [56] | 0.48[57] | 1.43[58] | 1.38[59] | 1.42[60] | 1.49[61] | 1.57[62] |
10 | CALM1 | Calmodulin-1 | [63] | 0.80[64] | 1.22[65] | 1.54[66] | 2.25[67] | 1.76[68] | 2.69[69] |
11 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [70] | -0.21[71] | -0.15[72] | 0.28[73] | 0.12[74] | 0.87[75] | -0.12[76] |
12 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [77] | 0.78[78] | 0.84[79] | 1.56[80] | -0.18[81] | 0.55[82] | -0.63[83] |
13 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.40[84] | 2.57[85] | 2.65[86] | 0.90[87] | 1.25[88] | -0.01[89] | |
14 | RAP1A | Ras-related protein Rap-1A | [90] | -0.33[91] | 0.00[92] | 0.69[93] | 0.45[94] | 0.45[95] | -0.22[96] |
15 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [97] | 0.56[98] | 0.77[99] | 0.62[100] | 0.20[101] | 1.03[102] | 0.29[103] |
16 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [104] | 0.66[105] | 1.45[106] | 2.57[107] | 0.48[108] | 1.59[109] | 2.17[110] |
17 | ARAF | Serine/threonine-protein kinase A-Raf | [111] | 0.27[112] | 0.35[113] | 0.47[114] | 0.57[115] | 0.84[116] | 1.95[117] |
18 | MAPK1 | Mitogen-activated protein kinase 1 | [118] | 2.43[119] | 2.95[120] | 2.64[121] | 2.51[122] | 2.40[123] | 2.85[124] |
19 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [125] | -0.93[126] | -1.48[127] | 0.51[128] | 1.88[129] | 1.49[130] | 1.90[131] |
20 | MAPK3 | Mitogen-activated protein kinase 3 | [132] | 2.57[133] | 3.00[134] | 2.90[135] | 1.09[136] | 1.35[137] | 0.03[138] |
21 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [139] | -0.11[140] | 1.05[141] | 2.19[142] | 2.90[143] | 2.00[144] | 2.78[145] |
22 | PRKCA | Protein kinase C alpha type | [146] | 3.56[147] | 3.99[148] | 4.20[149] | 2.81[150] | 3.42[151] | 2.99[152] |
23 | GRIA3 | Glutamate receptor 3 | [153] | -7.72[154] | -6.20[155] | 1.95[156] | -7.28[157] | -1.49[158] | 0.28[159] |
24 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [160] | 2.44[161] | 3.99[162] | 4.33[163] | 3.21[164] | 3.39[165] | 3.41[166] |
25 | ADCY1 | Adenylate cyclase type 1 | [167] | -0.11[168] | -1.60[169] | -1.94[170] | -1.44[171] | -1.22[172] | 6.06[173] |
26 | PRKCB | Protein kinase C beta type | [174] | -6.09[175] | -4.51[176] | [177] | 3.15[178] | -1.92[179] | 4.61[180] |
27 | DRD4 | D(4) dopamine receptor | [181] | 0.15[182] | 1.75[183] | 1.22[184] | 0.56[185] | -0.43[186] | -0.36[187] |
28 | ACTG2 | Actin, gamma-enteric smooth muscle | [188] | 0.55[189] | 1.20[190] | 0.16[191] | 10.45[192] | 1.33[193] | 6.34[194] |
29 | PRKCG | Protein kinase C gamma type | [195] | -0.10[196] | 0.96[197] | -1.57[198] | -0.40[199] | -0.25[200] | [201] |
30 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | [202] | [203] | -0.66[204] | -1.46[205] | 2.11[206] | 4.42[207] | 5.32[208] |
31 | GRIA4 | Glutamate receptor 4 | [209] | [210] | 0.51[211] | 2.03[212] | 2.18[213] | 2.13[214] | 2.73[215] |
32 | GRIA1 | Glutamate receptor 1 | [216] | -1.60[217] | [218] | [219] | 0.01[220] | 0.69[221] | 1.21[222] |
33 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | [223] | [224] | [225] | 0.36[226] | 9.72[227] | 2.49[228] | 9.10[229] |
34 | GRM1 | Metabotropic glutamate receptor 1 | [230] | 2.98[231] | [232] | 1.38[233] | 6.24[234] | 4.22[235] | 4.20[236] |
35 | ADCY8 | Adenylate cyclase type 8 | [237] | [238] | [239] | [240] | [241] | [242] | [243] |
36 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [244] | [245] | [246] | [247] | [248] | [249] | [250] |
37 | DRD2 | D(2) dopamine receptor | [251] | [252] | [253] | [254] | [255] | [256] | [257] |
38 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | [258] | [259] | [260] | [261] | [262] | [263] | [264] |
39 | GRM5 | Metabotropic glutamate receptor 5 | [265] | [266] | [267] | [268] | [269] | [270] | [271] |
40 | GRIA2 | Glutamate receptor 2 | [272] | [273] | [274] | [275] | [276] | [277] | [278] |
41 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [279] | [280] | [281] | [282] | [283] | [284] | [285] |
42 | DRD1 | D(1A) dopamine receptor | [286] | [287] | [288] | [289] | [290] | [291] | [292] |