WP_CODEINE_AND_MORPHINE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2C8 Cytochrome P450 2C8 [1] -12.84[2] -9.14[3] -5.48[4] -8.96[5] [6] 0.07[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -8.09[9] -9.25[10] -9.51[11] -11.96[12] -8.12[13] 0.29[14]
3 UGT1A6 UDP-glucuronosyltransferase 1-6 [15] -5.18[16] -13.96[17] -6.61[18] -3.32[19] -6.85[20] -4.33[21]
4 UGT2B4 UDP-glucuronosyltransferase 2B4 [22] -5.79[23] -7.00[24] -0.30[25] -6.55[26] -7.74[27] 0.33[28]
5 UGT2B7 UDP-glucuronosyltransferase 2B7 [29] 0.31[30] -0.58[31] -4.59[32] -7.77[33] -7.03[34] -0.96[35]
6 UGT1A1 UDP-glucuronosyltransferase 1-1 [36] -2.71[37] -10.00[38] -3.38[39] 2.21[40] -5.49[41] -0.49[42]
7 CYP2D6 Cytochrome P450 2D6 [43] -4.25[44] -2.80[45] -3.88[46] -5.03[47] -3.24[48] 0.78[49]
8 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [50] -11.52[51] -8.77[52] -2.08[53] -7.79[54] [55] 1.13[56]
9 ABCC2 Canalicular multispecific organic anion transporter 1 [57] 4.49[58] 5.02[59] 4.89[60] 4.30[61] -0.17[62] 1.51[63]
10 UGT1A9 UDP-glucuronosyltransferase 1-9 [64] -4.06[65] -9.96[66] -4.69[67] -2.13[68] -5.08[69] -1.08[70]
11 ABCC3 Canalicular multispecific organic anion transporter 2 [71] 4.74[72] 3.02[73] 2.84[74] 4.82[75] 6.53[76] 2.20[77]
12 ABCB1 Multidrug resistance protein 1 [78] 3.07[79] 3.55[80] 3.39[81] -1.30[82] -0.66[83] 0.24[84]
13 UGT1A3 UDP-glucuronosyltransferase 1-3 [85] 0.69[86] [87] -5.55[88] -1.87[89] -4.67[90] 0.80[91]
14 UGT1A10 UDP-glucuronosyltransferase 1-10 [92] [93] [94] [95] [96] [97] [98]
15 UGT1A8 UDP-glucuronosyltransferase 1-8 [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 19 9.1e+02 7.1e+02 0 1.2
[2]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[3]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.24 0.14
[4]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.3 2 0.16
[5]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.066 0.037
[6]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[7]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 2e+02 6.2e+02 6.8e+02 1.2e+03
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[15]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 11 5.9e+02 4.3e+02 0.45 1.7e+02
[16]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 0.56 1.8
[17]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[18]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.14 0.65 0.041
[19]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 1.8 2
[20]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[21]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 8.2 34 9 42
[22]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 15 5e+02 4.6e+02 0.056 68
[23]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.37 0.96
[24]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.69 0.36
[25]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 12 34 11
[26]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.15 0.2
[27]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[28]
liver UGT2B4
Mean 509
Standard deviation 93
Values 4.3e+02 5.3e+02 4.5e+02 6.3e+02
[29]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 5.3 4.3e+02 1.6e+02 3.3 8.1
[30]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 20 33
[31]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 35 17
[32]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.34 1.1 0.3
[33]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.051 0.037
[34]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[35]
liver UGT2B7
Mean 121
Standard deviation 61
Values 61 77 1.7e+02 1.7e+02
[36]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 15 96 2.1e+02 0.52 12
[37]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.7 1.9
[38]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[39]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.31 1.3 0.57
[40]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 9.8 39
[41]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[42]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 34 83 1.1e+02 1.4e+02
[43]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 3.7 87 1.1e+02 0.24 0.47
[44]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.4 0.36
[45]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 1.2 2.6
[46]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.31 0.4 0.23
[47]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.096 0.1
[48]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[49]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 57 53 3.1e+02 1.3e+02
[50]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 1.4 1e+02 37 0 40
[51]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[52]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.043 0.0097
[53]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.22 2.6 0.074
[54]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0.025 0
[55]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[56]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 95 1.8e+02 1.8e+02 1.5e+02
[57]
ref_hepatocyte ABCC2
Mean 31.6
Standard deviation 23
Values 16 17 17 68 40
[58]
HepG2 ABCC2
Mean 125
Standard deviation 1.3
Values 1.3e+02 1.2e+02
[59]
HepG2.C3A ABCC2
Mean 328
Standard deviation 1.2
Values 3.3e+02 3.3e+02
[60]
HuH.7 ABCC2
Mean 105
Standard deviation 48
Values 68 1.6e+02 88
[61]
SNU475 ABCC2
Mean 48.9
Standard deviation 12
Values 41 57
[62]
THLE ABCC2
Mean 0.497
Standard deviation 0.041
Values 0.53 0.47
[63]
liver ABCC2
Mean 174
Standard deviation 96
Values 1.9e+02 3e+02 89 1.1e+02
[64]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 2.6 27 26 0 21
[65]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.12 0.2
[66]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[67]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.0094 0.12 0.066
[68]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.03 0.51
[69]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[70]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 3 22 8.7 22
[71]
ref_hepatocyte ABCC3
Mean 14.4
Standard deviation 9.9
Values 5 9.7 31 14 12
[72]
HepG2 ABCC3
Mean 67.6
Standard deviation 20
Values 54 81
[73]
HepG2.C3A ABCC3
Mean 37.4
Standard deviation 7.2
Values 32 42
[74]
HuH.7 ABCC3
Mean 11.6
Standard deviation 4.6
Values 10 17 7.9
[75]
SNU475 ABCC3
Mean 31.8
Standard deviation 16
Values 21 43
[76]
THLE ABCC3
Mean 23.7
Standard deviation 5.8
Values 28 20
[77]
liver ABCC3
Mean 128
Standard deviation 23
Values 1.3e+02 1.4e+02 93 1.5e+02
[78]
ref_hepatocyte ABCB1
Mean 12.8
Standard deviation 7
Values 15 5.6 5.4 17 21
[79]
HepG2 ABCB1
Mean 18.8
Standard deviation 3.2
Values 21 17
[80]
HepG2.C3A ABCB1
Mean 47.9
Standard deviation 1.3
Values 49 47
[81]
HuH.7 ABCB1
Mean 15
Standard deviation 8.7
Values 9 25 11
[82]
SNU475 ABCB1
Mean 0.405
Standard deviation 0.094
Values 0.47 0.34
[83]
THLE ABCB1
Mean 0.143
Standard deviation 0.0068
Values 0.15 0.14
[84]
liver ABCB1
Mean 29
Standard deviation 14
Values 31 46 13 26
[85]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0.37 11 7.9 0 2.3
[86]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.1 1.3
[87]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0094 0.013 0.0082
[89]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.071 0.11
[90]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[91]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 5.8 21 2.5 28
[92]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[94]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.075 0.21 0.066
[96]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.01 0.014
[97]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[98]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0
[99]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.019 0.071 0.033
[103]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.13 0.17
[104]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[105]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0