WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
GAPDH |
Glyceraldehyde-3-phosphate dehydrogenase |
[1] |
-0.27[2] |
-0.41[3] |
0.31[4] |
-0.55[5] |
-0.18[6] |
-0.90[7] |
2 |
SQSTM1 |
Sequestosome-1 |
[8] |
-1.98[9] |
-2.91[10] |
-2.43[11] |
-1.20[12] |
-1.16[13] |
-1.62[14] |
3 |
ALDOB |
Fructose-bisphosphate aldolase B |
[15] |
-11.36[16] |
-10.98[17] |
-11.07[18] |
-14.93[19] |
-15.79[20] |
0.35[21] |
4 |
ENO1 |
Alpha-enolase |
[22] |
0.49[23] |
1.07[24] |
0.15[25] |
0.61[26] |
-0.01[27] |
-1.18[28] |
5 |
LDHA |
L-lactate dehydrogenase A chain |
[29] |
0.09[30] |
0.15[31] |
0.24[32] |
-0.05[33] |
-0.52[34] |
0.42[35] |
6 |
TPI1 |
Triosephosphate isomerase |
[36] |
-0.17[37] |
-0.17[38] |
0.35[39] |
-0.83[40] |
0.14[41] |
-0.25[42] |
7 |
PLOD2 |
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 |
[43] |
-1.58[44] |
-1.13[45] |
-1.36[46] |
-1.35[47] |
-0.68[48] |
-2.56[49] |
8 |
ALDOA |
Fructose-bisphosphate aldolase A |
[50] |
1.98[51] |
1.72[52] |
0.71[53] |
1.12[54] |
0.80[55] |
-1.00[56] |
9 |
PGK1 |
Phosphoglycerate kinase 1 |
[57] |
1.13[58] |
0.40[59] |
0.18[60] |
1.34[61] |
0.82[62] |
-0.07[63] |
10 |
SHMT1 |
Serine hydroxymethyltransferase, cytosolic |
[64] |
-3.22[65] |
-3.17[66] |
-2.77[67] |
-2.87[68] |
-3.01[69] |
1.35[70] |
11 |
MDH1 |
Malate dehydrogenase, cytoplasmic |
[71] |
-0.86[72] |
-0.13[73] |
-0.77[74] |
-0.55[75] |
-0.78[76] |
-0.41[77] |
12 |
SDS |
L-serine dehydratase/L-threonine deaminase |
[78] |
-12.37[79] |
[80] |
-12.41[81] |
-7.10[82] |
-10.78[83] |
0.44[84] |
13 |
RHEB |
GTP-binding protein Rheb |
[85] |
-2.17[86] |
-1.48[87] |
-1.62[88] |
-1.14[89] |
-0.89[90] |
-0.91[91] |
14 |
SHMT2 |
Serine hydroxymethyltransferase, mitochondrial |
[92] |
-0.35[93] |
0.86[94] |
0.31[95] |
-1.69[96] |
-0.29[97] |
0.05[98] |
15 |
PGM1 |
Phosphoglucomutase-1 |
[99] |
-1.64[100] |
-0.71[101] |
-0.26[102] |
-1.20[103] |
-1.60[104] |
0.90[105] |
16 |
PSAT1 |
Phosphoserine aminotransferase |
[106] |
0.33[107] |
0.49[108] |
0.49[109] |
-2.75[110] |
-0.08[111] |
0.32[112] |
17 |
PHGDH |
D-3-phosphoglycerate dehydrogenase |
[113] |
-0.61[114] |
-0.12[115] |
1.08[116] |
-2.18[117] |
-0.28[118] |
-0.17[119] |
18 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[120] |
-0.14[121] |
-0.26[122] |
-1.41[123] |
-0.09[124] |
0.07[125] |
-0.07[126] |
19 |
STAT3 |
Signal transducer and activator of transcription 3 |
[127] |
0.33[128] |
-1.06[129] |
-0.39[130] |
0.21[131] |
-0.39[132] |
2.58[133] |
20 |
ACLY |
ATP-citrate synthase |
[134] |
0.96[135] |
0.74[136] |
1.59[137] |
1.03[138] |
0.92[139] |
-0.18[140] |
21 |
LDHD |
Probable D-lactate dehydrogenase, mitochondrial |
[141] |
-4.52[142] |
-2.73[143] |
-5.05[144] |
-9.10[145] |
-9.55[146] |
0.35[147] |
22 |
HIF1A |
Hypoxia-inducible factor 1-alpha |
[148] |
-0.38[149] |
-0.59[150] |
0.14[151] |
2.25[152] |
2.77[153] |
-0.63[154] |
23 |
GPI |
Glucose-6-phosphate isomerase |
[155] |
1.55[156] |
0.92[157] |
1.64[158] |
1.66[159] |
1.49[160] |
2.01[161] |
24 |
ENO3 |
Beta-enolase |
[162] |
-2.48[163] |
-2.24[164] |
-4.38[165] |
-2.18[166] |
-5.49[167] |
-0.66[168] |
25 |
PFKL |
ATP-dependent 6-phosphofructokinase, liver type |
[169] |
0.86[170] |
1.03[171] |
0.82[172] |
0.54[173] |
0.24[174] |
0.88[175] |
26 |
SDSL |
Serine dehydratase-like |
[176] |
-3.76[177] |
-3.89[178] |
-3.43[179] |
-2.37[180] |
-2.88[181] |
-0.26[182] |
27 |
FASN |
Fatty acid synthase |
[183] |
2.18[184] |
2.93[185] |
3.43[186] |
0.70[187] |
0.86[188] |
2.68[189] |
28 |
LDHB |
L-lactate dehydrogenase B chain |
[190] |
-9.18[191] |
-9.15[192] |
-7.63[193] |
-3.28[194] |
3.19[195] |
-0.96[196] |
29 |
AKT1S1 |
Proline-rich AKT1 substrate 1 |
[197] |
-0.69[198] |
-0.72[199] |
-0.44[200] |
-0.79[201] |
-0.03[202] |
-1.01[203] |
30 |
ALDOC |
Fructose-bisphosphate aldolase C |
[204] |
-1.77[205] |
-0.13[206] |
0.57[207] |
-1.01[208] |
-2.56[209] |
0.52[210] |
31 |
VEGFA |
Vascular endothelial growth factor A |
[211] |
0.99[212] |
2.45[213] |
0.98[214] |
0.40[215] |
1.25[216] |
0.96[217] |
32 |
PSPH |
Phosphoserine phosphatase |
[218] |
0.54[219] |
1.43[220] |
1.75[221] |
-0.95[222] |
-0.39[223] |
-1.81[224] |
33 |
MLST8 |
Target of rapamycin complex subunit LST8 |
[225] |
-0.40[226] |
0.05[227] |
0.35[228] |
-1.01[229] |
-0.53[230] |
-0.39[231] |
34 |
PFKP |
ATP-dependent 6-phosphofructokinase, platelet type |
[232] |
-0.42[233] |
-2.06[234] |
-6.78[235] |
3.51[236] |
2.30[237] |
-2.77[238] |
35 |
CAMK1 |
Calcium/calmodulin-dependent protein kinase type 1 |
[239] |
-1.47[240] |
0.09[241] |
-0.06[242] |
-1.50[243] |
-0.74[244] |
-0.78[245] |
36 |
BAP1 |
Ubiquitin carboxyl-terminal hydrolase BAP1 |
[246] |
0.86[247] |
1.16[248] |
0.22[249] |
0.42[250] |
1.37[251] |
0.57[252] |
37 |
PKLR |
Pyruvate kinase PKLR |
[253] |
-2.09[254] |
-0.10[255] |
-1.89[256] |
-10.21[257] |
-9.98[258] |
1.13[259] |
38 |
PTEN |
Phosphatidylinositol
3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
-0.76[260] |
0.75[261] |
0.88[262] |
-0.60[263] |
0.78[264] |
2.65[265] |
39 |
ARNT |
Aryl hydrocarbon receptor nuclear translocator |
[266] |
0.19[267] |
0.10[268] |
0.90[269] |
1.33[270] |
1.23[271] |
1.71[272] |
40 |
KDM5C |
Lysine-specific demethylase 5C |
[273] |
1.71[274] |
1.77[275] |
2.03[276] |
2.34[277] |
2.79[278] |
1.98[279] |
41 |
EGFR |
Epidermal growth factor receptor |
[280] |
-0.92[281] |
-1.18[282] |
1.63[283] |
0.40[284] |
1.15[285] |
2.83[286] |
42 |
ACACB |
Acetyl-CoA carboxylase 2 |
[287] |
-1.09[288] |
0.00[289] |
0.05[290] |
-1.80[291] |
-1.38[292] |
4.36[293] |
43 |
VHL |
von Hippel-Lindau disease tumor suppressor |
[294] |
1.72[295] |
1.96[296] |
2.67[297] |
0.81[298] |
1.63[299] |
1.15[300] |
44 |
PGM2 |
Phosphoglucomutase-2 |
[301] |
0.54[302] |
0.77[303] |
0.89[304] |
0.79[305] |
1.94[306] |
0.18[307] |
45 |
ME1 |
NADP-dependent malic enzyme |
[308] |
-6.57[309] |
-5.82[310] |
2.25[311] |
2.86[312] |
1.48[313] |
0.70[314] |
46 |
GRB10 |
Growth factor receptor-bound protein 10 |
[315] |
2.28[316] |
-0.68[317] |
1.63[318] |
0.65[319] |
1.65[320] |
2.12[321] |
47 |
SETD2 |
Histone-lysine N-methyltransferase SETD2 |
[322] |
0.83[323] |
2.05[324] |
2.60[325] |
1.75[326] |
2.36[327] |
3.02[328] |
48 |
MTOR |
Serine/threonine-protein kinase mTOR |
[329] |
2.31[330] |
3.44[331] |
2.94[332] |
2.65[333] |
2.86[334] |
3.63[335] |
49 |
TSC2 |
Tuberin |
[336] |
1.59[337] |
1.23[338] |
1.85[339] |
1.17[340] |
1.82[341] |
2.26[342] |
50 |
ENPP3 |
Ectonucleotide
pyrophosphatase/phosphodiesterase family member 3 |
-0.15[343] |
2.08[344] |
-3.36[345] |
-4.10[346] |
-6.11[347] |
-1.81[348] |
51 |
TGFB2 |
Transforming growth factor beta-2 |
[349] |
-4.51[350] |
-6.93[351] |
-1.19[352] |
3.42[353] |
2.15[354] |
-2.59[355] |
52 |
ACACA |
Acetyl-CoA carboxylase 1 |
[356] |
2.23[357] |
2.68[358] |
3.53[359] |
2.55[360] |
1.87[361] |
3.53[362] |
53 |
DEPTOR |
DEP domain-containing mTOR-interacting protein |
[363] |
-3.55[364] |
-2.24[365] |
1.74[366] |
-4.29[367] |
-1.51[368] |
1.03[369] |
54 |
PBRM1 |
Protein polybromo-1 |
[370] |
0.88[371] |
1.48[372] |
1.02[373] |
1.99[374] |
2.31[375] |
3.03[376] |
55 |
EP300 |
Histone acetyltransferase p300 |
[377] |
2.50[378] |
2.21[379] |
3.03[380] |
2.54[381] |
2.72[382] |
2.93[383] |
56 |
SLC2A1 |
Solute carrier family 2, facilitated glucose transporter member 1 |
[384] |
6.42[385] |
3.55[386] |
2.55[387] |
3.41[388] |
2.68[389] |
-1.17[390] |
57 |
TGFB1 |
Transforming growth factor beta-1 |
[391] |
3.25[392] |
2.33[393] |
-0.49[394] |
3.80[395] |
3.17[396] |
-1.05[397] |
58 |
RPTOR |
Regulatory-associated protein of mTOR |
[398] |
2.86[399] |
2.21[400] |
2.24[401] |
1.81[402] |
2.18[403] |
2.51[404] |
59 |
ZEB1 |
Zinc finger E-box-binding homeobox 1 |
[405] |
-0.54[406] |
0.89[407] |
1.71[408] |
3.29[409] |
2.09[410] |
2.01[411] |
60 |
HK1 |
Hexokinase-1 |
[412] |
0.69[413] |
-4.09[414] |
-5.42[415] |
4.50[416] |
4.68[417] |
1.09[418] |
61 |
TSC1 |
Hamartin |
[419] |
1.66[420] |
2.44[421] |
2.52[422] |
2.02[423] |
2.37[424] |
2.93[425] |
62 |
CREBBP |
CREB-binding protein |
[426] |
2.68[427] |
2.01[428] |
2.55[429] |
2.72[430] |
2.86[431] |
3.41[432] |
63 |
ENO2 |
Gamma-enolase |
[433] |
4.38[434] |
3.26[435] |
0.99[436] |
2.62[437] |
3.72[438] |
-1.55[439] |
64 |
PFKM |
ATP-dependent 6-phosphofructokinase, muscle type |
[440] |
-1.80[441] |
-1.08[442] |
3.86[443] |
3.31[444] |
3.84[445] |
1.08[446] |
65 |
TGFB3 |
Transforming growth factor beta-3 |
[447] |
-1.77[448] |
-2.53[449] |
-2.83[450] |
0.13[451] |
-0.80[452] |
0.63[453] |
66 |
PGBD5 |
PiggyBac transposable element-derived protein 5 |
[454] |
-5.05[455] |
[456] |
-2.89[457] |
-1.83[458] |
-4.07[459] |
1.14[460] |
67 |
CEP290 |
Centrosomal protein of 290 kDa |
[461] |
0.04[462] |
3.22[463] |
2.07[464] |
2.11[465] |
2.20[466] |
2.03[467] |
68 |
PDGFB |
Platelet-derived growth factor subunit B |
[468] |
2.83[469] |
2.81[470] |
-0.07[471] |
0.03[472] |
-0.27[473] |
0.55[474] |
69 |
HK2 |
Hexokinase-2 |
[475] |
5.66[476] |
6.13[477] |
5.13[478] |
3.83[479] |
4.74[480] |
0.72[481] |
70 |
HK3 |
Hexokinase-3 |
[482] |
-8.06[483] |
-7.88[484] |
-8.86[485] |
-5.54[486] |
-8.59[487] |
3.14[488] |
71 |
PDGFRA |
Platelet-derived growth factor receptor alpha |
[489] |
-3.84[490] |
-4.71[491] |
2.86[492] |
0.49[493] |
5.30[494] |
5.50[495] |
72 |
LDHC |
L-lactate dehydrogenase C chain |
[496] |
[497] |
-7.77[498] |
-6.95[499] |
-1.56[500] |
-5.22[501] |
-0.28[502] |
73 |
PDGFRB |
Platelet-derived growth factor receptor beta |
[503] |
1.07[504] |
1.59[505] |
-0.93[506] |
1.82[507] |
2.51[508] |
3.59[509] |
74 |
RAPGEF5 |
Rap guanine nucleotide exchange factor 5 |
[510] |
2.58[511] |
4.38[512] |
4.06[513] |
-0.58[514] |
-2.31[515] |
4.80[516] |
75 |
KSR1 |
Kinase suppressor of Ras 1 |
[517] |
3.04[518] |
2.86[519] |
-0.30[520] |
2.01[521] |
2.64[522] |
0.91[523] |
76 |
KDR |
Vascular endothelial growth factor receptor 2 |
[524] |
-5.85[525] |
-7.39[526] |
-6.75[527] |
-1.77[528] |
4.82[529] |
6.47[530] |
77 |
FLT1 |
Vascular endothelial growth factor receptor 1 |
[531] |
-1.74[532] |
-1.25[533] |
-1.76[534] |
-0.33[535] |
-1.13[536] |
6.27[537] |
78 |
TOX2 |
TOX high mobility group box family member 2 |
[538] |
-2.72[539] |
-5.43[540] |
-5.79[541] |
4.64[542] |
5.02[543] |
1.99[544] |
79 |
BHLHE41 |
Class E basic helix-loop-helix protein 41 |
[545] |
1.02[546] |
-4.19[547] |
-0.45[548] |
5.63[549] |
3.84[550] |
-0.09[551] |
80 |
CDH13 |
Cadherin-13 |
[552] |
-4.46[553] |
-3.73[554] |
-4.74[555] |
0.10[556] |
7.56[557] |
3.91[558] |
81 |
KCNJ2 |
Inward rectifier potassium channel 2 |
[559] |
-2.57[560] |
[561] |
[562] |
3.25[563] |
3.53[564] |
6.05[565] |
82 |
EFCAB3 |
EF-hand calcium-binding domain-containing protein 3 |
[566] |
2.90[567] |
3.11[568] |
4.70[569] |
2.79[570] |
2.56[571] |
1.39[572] |
83 |
SSPN |
Sarcospan |
[573] |
0.91[574] |
-0.95[575] |
2.67[576] |
9.45[577] |
5.64[578] |
6.21[579] |
84 |
MIR1281 |
|
[580] |
[581] |
[582] |
[583] |
[584] |
[585] |
[586] |
85 |
PGK2 |
Phosphoglycerate kinase 2 |
[587] |
[588] |
[589] |
[590] |
[591] |
[592] |
[593] |
86 |
PKM |
Pyruvate kinase PKM |
[594] |
[595] |
[596] |
[597] |
[598] |
[599] |
[600] |
87 |
MIR6778 |
|
[601] |
[602] |
[603] |
[604] |
[605] |
[606] |
[607] |
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