WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYB5A Cytochrome b5 [1] -1.60[2] -1.74[3] -1.71[4] -1.80[5] -2.35[6] -0.83[7]
2 HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1 [8] -10.90[9] -11.37[10] -12.35[11] -5.56[12] 0.50[13] -0.36[14]
3 POR NADPH--cytochrome P450 reductase [15] 1.98[16] 1.94[17] 1.93[18] 2.04[19] 1.06[20] 1.26[21]
4 SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 [22] -5.79[23] -5.58[24] -4.44[25] -8.53[26] -8.45[27] -0.37[28]
5 H6PD GDH/6PGL endoplasmic bifunctional protein [29] 4.32[30] 4.58[31] 4.88[32] 4.78[33] 5.10[34] 4.16[35]
6 CYP21A2 Steroid 21-hydroxylase [36] -2.96[37] -1.64[38] -4.80[39] -0.41[40] -5.68[41] -0.37[42]
7 STAR Steroidogenic acute regulatory protein, mitochondrial [43] 3.66[44] 2.46[45] 0.03[46] 0.67[47] 3.12[48] -3.59[49]
8 CYP19A1 Aromatase [50] 4.83[51] 5.24[52] 0.00[53] 2.16[54] -0.25[55] -6.44[56]
9 CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial [57] 2.24[58] -0.88[59] [60] 0.56[61] 4.65[62] 0.37[63]
10 HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 [64] 5.10[65] 4.53[66] 4.91[67] 1.54[68] -0.77[69] 0.54[70]
11 HSD17B3 Testosterone 17-beta-dehydrogenase 3 [71] -0.30[72] -0.95[73] 4.86[74] 3.75[75] -2.12[76] 0.78[77]
12 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase [78] 0.16[79] 3.60[80] 1.38[81] -1.92[82] -1.83[83] 1.54[84]
13 HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 [85] -2.21[86] -3.47[87] 4.80[88] [89] 0.83[90] -3.04[91]
14 HSD3B2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [92] -0.68[93] [94] 2.67[95] [96] 1.63[97] 0.68[98]
15 CYP11B2 Cytochrome P450 11B2, mitochondrial [99] [100] [101] [102] [103] [104] [105]
16 MIR4651 [106] [107] [108] [109] [110] [111] [112]
17 CYP11B1 Cytochrome P450 11B1, mitochondrial [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte CYB5A
Mean 485
Standard deviation 5e+02
Values 86 1.2e+03 8.6e+02 1.7e+02 1.3e+02
[2]
HepG2 CYB5A
Mean 47.2
Standard deviation 8.3
Values 53 41
[3]
HepG2.C3A CYB5A
Mean 58.3
Standard deviation 3.9
Values 61 55
[4]
HuH.7 CYB5A
Mean 24.7
Standard deviation 6.7
Values 32 20 22
[5]
SNU475 CYB5A
Mean 18.2
Standard deviation 3.3
Values 16 21
[6]
THLE CYB5A
Mean 13.5
Standard deviation 0.22
Values 14 13
[7]
liver CYB5A
Mean 416
Standard deviation 2.9e+02
Values 92 2.7e+02 5.6e+02 7.4e+02
[8]
ref_hepatocyte HSD11B1
Mean 134
Standard deviation 1.2e+02
Values 1.4e+02 2.9e+02 2.2e+02 0 27
[9]
HepG2 HSD11B1
Mean 0.0208
Standard deviation 0.011
Values 0.013 0.029
[10]
HepG2.C3A HSD11B1
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[11]
HuH.7 HSD11B1
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[12]
SNU475 HSD11B1
Mean 0.372
Standard deviation 0.36
Values 0.62 0.12
[13]
THLE HSD11B1
Mean 27
Standard deviation 6.9
Values 32 22
[14]
liver HSD11B1
Mean 160
Standard deviation 98
Values 51 1e+02 2.4e+02 2.4e+02
[15]
ref_hepatocyte POR
Mean 97
Standard deviation 75
Values 26 1.3e+02 2.1e+02 90 32
[16]
HepG2 POR
Mean 113
Standard deviation 40
Values 85 1.4e+02
[17]
HepG2.C3A POR
Mean 150
Standard deviation 87
Values 88 2.1e+02
[18]
HuH.7 POR
Mean 61.3
Standard deviation 8.5
Values 56 71 57
[19]
SNU475 POR
Mean 52.1
Standard deviation 1.3
Values 53 51
[20]
THLE POR
Mean 28.6
Standard deviation 2.7
Values 27 31
[21]
liver POR
Mean 355
Standard deviation 1.6e+02
Values 2.3e+02 3.2e+02 2.7e+02 5.9e+02
[22]
ref_hepatocyte SRD5A2
Mean 6.56
Standard deviation 6.6
Values 1.5 17 5.8 0.19 8.5
[23]
HepG2 SRD5A2
Mean 0.0351
Standard deviation 0.031
Values 0.013 0.057
[24]
HepG2.C3A SRD5A2
Mean 0.055
Standard deviation 0.032
Values 0.032 0.078
[25]
HuH.7 SRD5A2
Mean 0.0502
Standard deviation 0.057
Values 0.019 0.12 0.016
[26]
SNU475 SRD5A2
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[27]
THLE SRD5A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[28]
liver SRD5A2
Mean 7.73
Standard deviation 6.8
Values 18 3.3 5.4 4.4
[29]
ref_hepatocyte H6PD
Mean 6.55
Standard deviation 4.5
Values 3.3 11 12 2.6 4
[30]
HepG2 H6PD
Mean 38.6
Standard deviation 6.9
Values 34 44
[31]
HepG2.C3A H6PD
Mean 63
Standard deviation 17
Values 51 75
[32]
HuH.7 H6PD
Mean 31.9
Standard deviation 5.4
Values 26 36 33
[33]
SNU475 H6PD
Mean 23.5
Standard deviation 15
Values 13 34
[34]
THLE H6PD
Mean 31.8
Standard deviation 0.33
Values 32 32
[35]
liver H6PD
Mean 179
Standard deviation 61
Values 2.3e+02 2.2e+02 1e+02 1.6e+02
[36]
ref_hepatocyte CYP21A2
Mean 5.14
Standard deviation 5.5
Values 2.4 9.3 13 0.5 0.83
[37]
HepG2 CYP21A2
Mean 0.195
Standard deviation 0.0088
Values 0.2 0.19
[38]
HepG2.C3A CYP21A2
Mean 0.66
Standard deviation 0.51
Values 0.3 1
[39]
HuH.7 CYP21A2
Mean 0.0306
Standard deviation 0.027
Values 0.047 0.045 0
[40]
SNU475 CYP21A2
Mean 0.502
Standard deviation 0.11
Values 0.58 0.43
[41]
THLE CYP21A2
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[42]
liver CYP21A2
Mean 6.05
Standard deviation 3.4
Values 5.9 6 2 10
[43]
ref_hepatocyte STAR
Mean 1.18
Standard deviation 2
Values 0.17 0.33 0.13 4.8 0.5
[44]
HepG2 STAR
Mean 4.43
Standard deviation 2.3
Values 6 2.8
[45]
HepG2.C3A STAR
Mean 2.62
Standard deviation 0.42
Values 2.3 2.9
[46]
HuH.7 STAR
Mean 0.2
Standard deviation 0.04
Values 0.24 0.17 0.19
[47]
SNU475 STAR
Mean 0.245
Standard deviation 0.084
Values 0.3 0.19
[48]
THLE STAR
Mean 1.46
Standard deviation 0.0069
Values 1.5 1.5
[49]
liver STAR
Mean 0.149
Standard deviation 0.075
Values 0.2 0.23 0.094 0.077
[50]
ref_hepatocyte CYP19A1
Mean 1.13
Standard deviation 2.3
Values 0.28 0 0 5.3 0.08
[51]
HepG2 CYP19A1
Mean 9.51
Standard deviation 0.87
Values 10 8.9
[52]
HepG2.C3A CYP19A1
Mean 17.1
Standard deviation 5.6
Values 13 21
[53]
HuH.7 CYP19A1
Mean 0.188
Standard deviation 0.27
Values 0.047 0.5 0.016
[54]
SNU475 CYP19A1
Mean 0.66
Standard deviation 0.58
Values 1.1 0.25
[55]
THLE CYP19A1
Mean 0.135
Standard deviation 0.018
Values 0.15 0.12
[56]
liver CYP19A1
Mean 0.0199
Standard deviation 0.04
Values 0.079 0 0 0
[57]
ref_hepatocyte CYP11A1
Mean 0.602
Standard deviation 0.44
Values 0.44 1.3 0.59 0.18 0.47
[58]
HepG2 CYP11A1
Mean 0.843
Standard deviation 0.49
Values 0.49 1.2
[59]
HepG2.C3A CYP11A1
Mean 0.131
Standard deviation 0.049
Values 0.097 0.17
[60]
HuH.7 CYP11A1
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 CYP11A1
Mean 0.115
Standard deviation 0.045
Values 0.15 0.083
[62]
THLE CYP11A1
Mean 2.14
Standard deviation 0.87
Values 2.8 1.5
[63]
liver CYP11A1
Mean 1.18
Standard deviation 0.65
Values 0.75 0.57 1.4 2
[64]
ref_hepatocyte HSD11B2
Mean 0.44
Standard deviation 0.31
Values 0.47 0.81 0.6 0.31 0
[65]
HepG2 HSD11B2
Mean 4.48
Standard deviation 0.0009
Values 4.5 4.5
[66]
HepG2.C3A HSD11B2
Mean 4.1
Standard deviation 0.84
Values 3.5 4.7
[67]
HuH.7 HSD11B2
Mean 2.2
Standard deviation 1.5
Values 3.3 0.48 2.8
[68]
SNU475 HSD11B2
Mean 0.167
Standard deviation 0.079
Values 0.11 0.22
[69]
THLE HSD11B2
Mean 0.0367
Standard deviation 0.0067
Values 0.041 0.032
[70]
liver HSD11B2
Mean 0.978
Standard deviation 0.63
Values 1.5 0.3 1.6 0.59
[71]
ref_hepatocyte HSD17B3
Mean 0.262
Standard deviation 0.31
Values 0 0.58 0.63 0 0.1
[72]
HepG2 HSD17B3
Mean 0.063
Standard deviation 0.032
Values 0.086 0.04
[73]
HepG2.C3A HSD17B3
Mean 0.0545
Standard deviation 0.047
Values 0.021 0.087
[74]
HuH.7 HSD17B3
Mean 1.27
Standard deviation 0.54
Values 1.6 1.5 0.65
[75]
SNU475 HSD17B3
Mean 0.46
Standard deviation 0.0054
Values 0.46 0.46
[76]
THLE HSD17B3
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[77]
liver HSD17B3
Mean 0.686
Standard deviation 0.23
Values 0.87 0.54 0.89 0.44
[78]
ref_hepatocyte CYP17A1
Mean 0.208
Standard deviation 0.25
Values 0.31 0.13 0.6 0 0
[79]
HepG2 CYP17A1
Mean 0.0687
Standard deviation 0.024
Values 0.051 0.086
[80]
HepG2.C3A CYP17A1
Mean 1.01
Standard deviation 0.19
Values 0.88 1.1
[81]
HuH.7 CYP17A1
Mean 0.0898
Standard deviation 0.047
Values 0.094 0.13 0.041
[82]
SNU475 CYP17A1
Mean 0.00717
Standard deviation 0.003
Values 0.0051 0.0093
[83]
THLE CYP17A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[84]
liver CYP17A1
Mean 0.926
Standard deviation 1.4
Values 0.5 0.057 2.9 0.21
[85]
ref_hepatocyte HSD3B1
Mean 0.134
Standard deviation 0.3
Values 0 0 0.67 0 0
[86]
HepG2 HSD3B1
Mean 0.0086
Standard deviation 0.012
Values 0 0.017
[87]
HepG2.C3A HSD3B1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[88]
HuH.7 HSD3B1
Mean 0.62
Standard deviation 0.19
Values 0.77 0.41 0.68
[89]
SNU475 HSD3B1
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE HSD3B1
Mean 0.034
Standard deviation 0.01
Values 0.041 0.027
[91]
liver HSD3B1
Mean 0.025
Standard deviation 0.029
Values 0.053 0 0.047 0
[92]
ref_hepatocyte HSD3B2
Mean 0.031
Standard deviation 0.065
Values 0 0.15 0.0086 0 0
[93]
HepG2 HSD3B2
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[94]
HepG2.C3A HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 HSD3B2
Mean 0.0327
Standard deviation 0.028
Values 0.0094 0.064 0.025
[96]
SNU475 HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE HSD3B2
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[98]
liver HSD3B2
Mean 0.0756
Standard deviation 0.044
Values 0.053 0.057 0.14 0.051
[99]
ref_hepatocyte CYP11B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 CYP11B2
Missing
[101]
HepG2.C3A CYP11B2
Missing
[102]
HuH.7 CYP11B2
Missing
[103]
SNU475 CYP11B2
Missing
[104]
THLE CYP11B2
Missing
[105]
liver CYP11B2
Missing
[106]
ref_hepatocyte MIR4651
Missing
[107]
HepG2 MIR4651
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[108]
HepG2.C3A MIR4651
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[109]
HuH.7 MIR4651
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 MIR4651
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE MIR4651
Mean 0
Standard deviation 0
Values 0 0
[112]
liver MIR4651
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 CYP11B1
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[115]
HepG2.C3A CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE CYP11B1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[119]
liver CYP11B1
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0