WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.22[2] | -1.31[3] | -1.13[4] | -1.11[5] | -0.88[6] | -1.01[7] |
2 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [8] | -4.45[9] | -4.81[10] | -3.63[11] | -3.90[12] | -3.14[13] | -1.85[14] |
3 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [15] | -2.75[16] | -3.42[17] | -3.27[18] | -3.87[19] | -2.36[20] | -2.69[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | -0.67[23] | -0.60[24] | 0.07[25] | 0.13[26] | -0.11[27] | -0.65[28] |
5 | JUN | Transcription factor AP-1 | [29] | -0.77[30] | -1.91[31] | -1.68[32] | -1.59[33] | -1.24[34] | -1.49[35] |
6 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [36] | -10.20[37] | [38] | -8.30[39] | -7.72[40] | -7.88[41] | -1.40[42] |
7 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [43] | 0.56[44] | -0.43[45] | -3.15[46] | -1.87[47] | 0.46[48] | -1.52[49] |
8 | FOS | Proto-oncogene c-Fos | [50] | -6.29[51] | -4.63[52] | -5.33[53] | -6.06[54] | -5.21[55] | -0.99[56] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [57] | -0.20[58] | -0.03[59] | -1.15[60] | 0.06[61] | -0.14[62] | 0.07[63] |
10 | CTNNB1 | Catenin beta-1 | [64] | 1.34[65] | 1.24[66] | 2.09[67] | 0.87[68] | 0.88[69] | 1.42[70] |
11 | RALB | Ras-related protein Ral-B | [71] | -1.51[72] | -1.13[73] | -2.00[74] | -1.22[75] | -1.77[76] | -1.67[77] |
12 | MYC | Myc proto-oncogene protein | [78] | 0.15[79] | 0.21[80] | -1.85[81] | -2.68[82] | -0.53[83] | -1.68[84] |
13 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [85] | -1.21[86] | -1.14[87] | -0.59[88] | -0.43[89] | -0.14[90] | -0.88[91] |
14 | BAX | Apoptosis regulator BAX | [92] | 0.05[93] | -0.34[94] | -0.84[95] | -1.49[96] | -1.33[97] | -3.64[98] |
15 | CCND1 | G1/S-specific cyclin-D1 | [99] | 2.77[100] | 0.67[101] | 1.46[102] | 1.99[103] | 0.30[104] | 1.37[105] |
16 | RALA | Ras-related protein Ral-A | [106] | -1.47[107] | -0.32[108] | -0.19[109] | -0.46[110] | -0.39[111] | -1.42[112] |
17 | CSNK1A1 | Casein kinase I isoform alpha | [113] | 0.06[114] | 0.45[115] | 0.19[116] | 0.95[117] | 0.82[118] | 1.01[119] |
18 | BAD | Bcl2-associated agonist of cell death | [120] | -1.95[121] | -1.42[122] | -2.40[123] | -0.95[124] | -0.77[125] | -1.10[126] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [127] | -0.34[128] | 0.47[129] | 1.70[130] | -0.07[131] | 0.57[132] | 1.41[133] |
20 | CYCS | Cytochrome c | [134] | 1.05[135] | 1.65[136] | 1.69[137] | 1.44[138] | 1.63[139] | 1.63[140] |
21 | CASP3 | Caspase-3 | [141] | -0.15[142] | 0.93[143] | -1.65[144] | -0.78[145] | -0.01[146] | -0.49[147] |
22 | ARAF | Serine/threonine-protein kinase A-Raf | [148] | -0.74[149] | -0.64[150] | -0.40[151] | 0.02[152] | -0.17[153] | 1.19[154] |
23 | TGFBR2 | TGF-beta receptor type-2 | [155] | 2.54[156] | 2.41[157] | 2.03[158] | 1.18[159] | 2.67[160] | 1.82[161] |
24 | MSH6 | DNA mismatch repair protein Msh6 | [162] | 0.03[163] | 0.93[164] | 1.10[165] | 1.01[166] | 1.21[167] | 0.61[168] |
25 | MAPK1 | Mitogen-activated protein kinase 1 | [169] | 1.43[170] | 1.97[171] | 1.76[172] | 1.96[173] | 1.39[174] | 2.09[175] |
26 | AKT2 | RAC-beta serine/threonine-protein kinase | [176] | 0.68[177] | 1.36[178] | 1.45[179] | 0.97[180] | 0.54[181] | 1.45[182] |
27 | KRAS | GTPase KRas | [183] | -0.79[184] | -0.41[185] | 1.15[186] | 0.91[187] | 0.35[188] | 0.99[189] |
28 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [190] | 1.30[191] | 2.15[192] | 2.07[193] | 0.79[194] | 1.40[195] | -2.00[196] |
29 | MAPK8 | Mitogen-activated protein kinase 8 | [197] | -1.72[198] | 0.09[199] | -1.08[200] | -0.79[201] | -1.15[202] | -0.19[203] |
30 | TBK1 | Serine/threonine-protein kinase TBK1 | [204] | -0.91[205] | 1.16[206] | 0.27[207] | 0.60[208] | 0.47[209] | 0.79[210] |
31 | MLH1 | DNA mismatch repair protein Mlh1 | [211] | 0.57[212] | 1.10[213] | 1.81[214] | 0.25[215] | 0.69[216] | 0.74[217] |
32 | DDB2 | DNA damage-binding protein 2 | [218] | 0.80[219] | 0.73[220] | -0.62[221] | -1.50[222] | -1.13[223] | -1.20[224] |
33 | BAK1 | Bcl-2 homologous antagonist/killer | [225] | 0.61[226] | 0.56[227] | 0.49[228] | 1.30[229] | 0.56[230] | -1.47[231] |
34 | SMAD3 | Mothers against decapentaplegic homolog 3 | [232] | 1.65[233] | 1.45[234] | 1.64[235] | 1.91[236] | 2.57[237] | 0.53[238] |
35 | TP53 | Cellular tumor antigen p53 | [239] | 1.36[240] | 1.32[241] | 2.05[242] | 1.40[243] | 0.85[244] | 0.28[245] |
36 | AXIN1 | Axin-1 | [246] | 1.07[247] | 1.79[248] | 0.19[249] | -8.58[250] | 0.05[251] | -0.33[252] |
37 | TGFBR1 | TGF-beta receptor type-1 | [253] | 0.05[254] | 0.68[255] | 0.14[256] | 0.46[257] | 1.34[258] | 1.65[259] |
38 | APPL1 | DCC-interacting protein 13-alpha | [260] | -0.23[261] | 1.36[262] | 0.55[263] | 0.88[264] | 1.16[265] | 2.12[266] |
39 | MAPK9 | Mitogen-activated protein kinase 9 | [267] | 0.95[268] | 1.58[269] | 1.60[270] | 1.83[271] | 1.06[272] | 0.83[273] |
40 | MAPK3 | Mitogen-activated protein kinase 3 | [274] | 1.57[275] | 2.02[276] | 2.02[277] | 0.54[278] | 0.34[279] | -0.72[280] |
41 | GSK3B | Glycogen synthase kinase-3 beta | [281] | 0.99[282] | 1.03[283] | 1.56[284] | 1.93[285] | 1.54[286] | 1.48[287] |
42 | BBC3 | Bcl-2-binding component 3 | [288] | 0.46[289] | 0.75[290] | 0.21[291] | -2.69[292] | -2.15[293] | -4.02[294] |
43 | MSH2 | DNA mismatch repair protein Msh2 | [295] | 0.54[296] | 2.23[297] | 1.64[298] | 2.24[299] | 1.39[300] | -0.37[301] |
44 | AXIN2 | Axin-2 | [302] | 3.19[303] | 1.19[304] | -2.89[305] | -0.98[306] | -1.57[307] | -2.03[308] |
45 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [309] | -1.99[310] | -7.58[311] | -8.22[312] | -1.28[313] | 2.31[314] | -0.91[315] |
46 | EXOC2 | Exocyst complex component 2 | [316] | 1.34[317] | 1.76[318] | 1.30[319] | 2.52[320] | 0.99[321] | 1.99[322] |
47 | SMAD4 | Mothers against decapentaplegic homolog 4 | [323] | 1.11[324] | 2.15[325] | 2.08[326] | 2.02[327] | 2.17[328] | 3.11[329] |
48 | TGFB2 | Transforming growth factor beta-2 | [330] | -4.57[331] | -6.70[332] | -0.93[333] | 3.57[334] | 1.95[335] | -2.45[336] |
49 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [337] | -0.65[338] | 2.81[339] | 1.61[340] | 0.22[341] | -1.48[342] | -3.16[343] |
50 | CASP9 | Caspase-9 | [344] | -0.12[345] | 1.24[346] | 0.32[347] | 0.36[348] | -0.55[349] | -0.22[350] |
51 | SMAD2 | Mothers against decapentaplegic homolog 2 | [351] | 1.74[352] | 2.40[353] | 1.86[354] | 2.49[355] | 2.47[356] | 2.89[357] |
52 | TCF7L2 | Transcription factor 7-like 2 | [358] | 0.59[359] | 1.76[360] | 1.92[361] | 0.81[362] | 0.57[363] | 2.04[364] |
53 | TGFB1 | Transforming growth factor beta-1 | [365] | 3.19[366] | 2.56[367] | -0.23[368] | 3.95[369] | 2.96[370] | -0.91[371] |
54 | POLK | DNA polymerase kappa | [372] | -1.12[373] | 0.75[374] | 0.97[375] | 1.94[376] | 1.46[377] | 2.41[378] |
55 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [379] | -0.23[380] | -3.19[381] | 0.32[382] | 2.40[383] | 1.40[384] | -3.98[385] |
56 | TCF7L1 | Transcription factor 7-like 1 | [386] | -3.33[387] | -1.12[388] | 1.04[389] | -1.71[390] | -1.80[391] | 0.61[392] |
57 | TCF7 | Transcription factor 7 | [393] | 2.16[394] | 1.22[395] | 0.24[396] | 0.27[397] | -0.25[398] | -0.05[399] |
58 | MSH3 | DNA mismatch repair protein Msh3 | [400] | 0.47[401] | 1.48[402] | 1.23[403] | 1.59[404] | 1.26[405] | 2.74[406] |
59 | BCL2L11 | Bcl-2-like protein 11 | [407] | 1.23[408] | 1.64[409] | 1.93[410] | 1.98[411] | 0.73[412] | 2.30[413] |
60 | TGFB3 | Transforming growth factor beta-3 | [414] | -1.82[415] | -2.30[416] | -2.57[417] | 0.28[418] | -1.00[419] | 0.77[420] |
61 | APC | Adenomatous polyposis coli protein | [421] | 0.29[422] | 2.36[423] | 2.17[424] | 2.34[425] | 2.75[426] | 4.05[427] |
62 | BRAF | Serine/threonine-protein kinase B-raf | [428] | -0.03[429] | 0.10[430] | 2.10[431] | 0.85[432] | 0.33[433] | 2.17[434] |
63 | RALGDS | Ral guanine nucleotide dissociation stimulator | [435] | 2.77[436] | 2.82[437] | 1.58[438] | 2.89[439] | 2.24[440] | 1.59[441] |
64 | NTN1 | Netrin-1 | [442] | -2.44[443] | -2.72[444] | 0.81[445] | -4.54[446] | -2.47[447] | 3.59[448] |
65 | REL | Proto-oncogene c-Rel | [449] | -0.79[450] | 1.37[451] | 1.27[452] | 0.26[453] | 0.19[454] | 2.66[455] |
66 | AKT3 | RAC-gamma serine/threonine-protein kinase | [456] | -2.12[457] | -4.28[458] | -3.63[459] | 5.95[460] | 4.69[461] | 3.93[462] |
67 | BCL2 | Apoptosis regulator Bcl-2 | [463] | -3.13[464] | 2.67[465] | -4.77[466] | 1.89[467] | 1.38[468] | 3.55[469] |
68 | LEF1 | Lymphoid enhancer-binding factor 1 | [470] | 2.37[471] | -4.15[472] | 3.73[473] | 1.19[474] | -0.73[475] | 1.40[476] |
69 | APC2 | Adenomatous polyposis coli protein 2 | [477] | 3.34[478] | 3.75[479] | 3.73[480] | 2.98[481] | 2.79[482] | 4.73[483] |
70 | PTGS2 | Prostaglandin G/H synthase 2 | [484] | [485] | -2.50[486] | -2.28[487] | 2.98[488] | 8.58[489] | 3.15[490] |
71 | MAPK10 | Mitogen-activated protein kinase 10 | [491] | -1.76[492] | [493] | [494] | 9.02[495] | 4.54[496] | 7.56[497] |
72 | DCC | Netrin receptor DCC | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | MIR3191 | [505] | [506] | [507] | [508] | [509] | [510] | [511] | |
74 | CSNK1A1L | Casein kinase I isoform alpha-like | [512] | [513] | [514] | [515] | [516] | [517] | [518] |