WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FDPS Farnesyl pyrophosphate synthase [1] -0.58[2] -1.30[3] -1.13[4] -0.24[5] -0.20[6] -1.55[7]
2 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [8] -1.42[9] -0.52[10] 0.75[11] -1.58[12] -1.66[13] -0.20[14]
3 MSMO1 Methylsterol monooxygenase 1 [15] -1.18[16] -0.51[17] -0.28[18] -1.52[19] -0.56[20] 0.56[21]
4 FDFT1 Squalene synthase [22] 0.63[23] 0.24[24] -0.33[25] -1.06[26] 0.15[27] -0.91[28]
5 CYP51A1 Lanosterol 14-alpha demethylase [29] -0.32[30] -0.26[31] -0.45[32] 0.28[33] 0.09[34] 0.85[35]
6 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 [36] -0.46[37] 0.69[38] -0.85[39] 1.14[40] 0.09[41] 0.36[42]
7 SQLE Squalene monooxygenase [43] 0.51[44] 0.76[45] 0.37[46] 0.56[47] 0.14[48] -0.27[49]
8 DHCR7 7-dehydrocholesterol reductase [50] 1.37[51] 0.76[52] 0.90[53] 0.07[54] 0.47[55] 1.17[56]
9 PMVK Phosphomevalonate kinase [57] -0.15[58] -2.42[59] -1.31[60] 0.65[61] 0.56[62] -2.13[63]
10 MVD Diphosphomevalonate decarboxylase [64] 1.14[65] 1.28[66] 0.35[67] 0.30[68] 0.49[69] -0.39[70]
11 NSDHL Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [71] 0.57[72] -0.80[73] -1.53[74] 0.93[75] 0.53[76] -0.62[77]
12 LSS Lanosterol synthase [78] 1.75[79] 1.51[80] 0.33[81] 1.81[82] 1.57[83] 1.11[84]
13 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase [85] 1.83[86] 2.24[87] 2.39[88] 2.40[89] 2.25[90] 1.42[91]
14 MVK Mevalonate kinase [92] 0.07[93] 0.10[94] -0.57[95] -0.52[96] -0.57[97] 0.29[98]
15 SC5D Lathosterol oxidase [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte FDPS
Mean 168
Standard deviation 1.2e+02
Values 65 1.3e+02 1e+02 1.8e+02 3.6e+02
[2]
HepG2 FDPS
Mean 47.3
Standard deviation 9.8
Values 54 40
[3]
HepG2.C3A FDPS
Mean 130
Standard deviation 36
Values 1e+02 1.5e+02
[4]
HuH.7 FDPS
Mean 153
Standard deviation 26
Values 1.8e+02 1.3e+02 1.4e+02
[5]
SNU475 FDPS
Mean 40
Standard deviation 13
Values 31 49
[6]
THLE FDPS
Mean 41.3
Standard deviation 7.5
Values 36 47
[7]
liver FDPS
Mean 78.7
Standard deviation 39
Values 50 54 76 1.3e+02
[8]
ref_hepatocyte HMGCS1
Mean 128
Standard deviation 1e+02
Values 58 72 32 2.5e+02 2.3e+02
[9]
HepG2 HMGCS1
Mean 20.3
Standard deviation 12
Values 28 12
[10]
HepG2.C3A HMGCS1
Mean 170
Standard deviation 81
Values 1.1e+02 2.3e+02
[11]
HuH.7 HMGCS1
Mean 427
Standard deviation 1.7e+02
Values 3.3e+02 6.2e+02 3.3e+02
[12]
SNU475 HMGCS1
Mean 12.1
Standard deviation 4.1
Values 9.2 15
[13]
THLE HMGCS1
Mean 11.4
Standard deviation 0.78
Values 11 12
[14]
liver HMGCS1
Mean 154
Standard deviation 63
Values 2.2e+02 1.9e+02 79 1.3e+02
[15]
ref_hepatocyte MSMO1
Mean 108
Standard deviation 90
Values 21 2.6e+02 1e+02 88 72
[16]
HepG2 MSMO1
Mean 20.1
Standard deviation 11
Values 28 12
[17]
HepG2.C3A MSMO1
Mean 144
Standard deviation 56
Values 1e+02 1.8e+02
[18]
HuH.7 MSMO1
Mean 177
Standard deviation 63
Values 1.6e+02 2.5e+02 1.3e+02
[19]
SNU475 MSMO1
Mean 10.6
Standard deviation 4
Values 7.8 13
[20]
THLE MSMO1
Mean 20.7
Standard deviation 3.4
Values 18 23
[21]
liver MSMO1
Mean 219
Standard deviation 94
Values 1.7e+02 1.9e+02 1.6e+02 3.6e+02
[22]
ref_hepatocyte FDFT1
Mean 87.4
Standard deviation 77
Values 41 38 48 2.2e+02 91
[23]
HepG2 FDFT1
Mean 56.9
Standard deviation 24
Values 74 40
[24]
HepG2.C3A FDFT1
Mean 196
Standard deviation 63
Values 1.5e+02 2.4e+02
[25]
HuH.7 FDFT1
Mean 138
Standard deviation 16
Values 1.6e+02 1.3e+02 1.3e+02
[26]
SNU475 FDFT1
Mean 11.8
Standard deviation 4
Values 9 15
[27]
THLE FDFT1
Mean 27.4
Standard deviation 0.93
Values 27 28
[28]
liver FDFT1
Mean 64.1
Standard deviation 23
Values 52 45 62 98
[29]
ref_hepatocyte CYP51A1
Mean 63
Standard deviation 38
Values 38 46 27 1.2e+02 88
[30]
HepG2 CYP51A1
Mean 21.2
Standard deviation 5.5
Values 25 17
[31]
HepG2.C3A CYP51A1
Mean 99.9
Standard deviation 49
Values 66 1.3e+02
[32]
HuH.7 CYP51A1
Mean 91.5
Standard deviation 23
Values 78 1.2e+02 79
[33]
SNU475 CYP51A1
Mean 21.5
Standard deviation 2.5
Values 20 23
[34]
THLE CYP51A1
Mean 19
Standard deviation 1.2
Values 18 20
[35]
liver CYP51A1
Mean 156
Standard deviation 52
Values 1.5e+02 1.8e+02 89 2.1e+02
[36]
ref_hepatocyte IDI1
Mean 49.3
Standard deviation 26
Values 14 62 33 79 59
[37]
HepG2 IDI1
Mean 15.1
Standard deviation 12
Values 23 6.9
[38]
HepG2.C3A IDI1
Mean 151
Standard deviation 3.5
Values 1.5e+02 1.5e+02
[39]
HuH.7 IDI1
Mean 54.3
Standard deviation 7.2
Values 59 58 46
[40]
SNU475 IDI1
Mean 30.7
Standard deviation 8.7
Values 24 37
[41]
THLE IDI1
Mean 14.8
Standard deviation 3.6
Values 12 17
[42]
liver IDI1
Mean 87.2
Standard deviation 46
Values 55 57 84 1.5e+02
[43]
ref_hepatocyte SQLE
Mean 34.4
Standard deviation 33
Values 17 9.9 12 86 47
[44]
HepG2 SQLE
Mean 20.7
Standard deviation 9.1
Values 27 14
[45]
HepG2.C3A SQLE
Mean 111
Standard deviation 44
Values 80 1.4e+02
[46]
HuH.7 SQLE
Mean 88.5
Standard deviation 14
Values 75 1e+02 88
[47]
SNU475 SQLE
Mean 14.3
Standard deviation 3.6
Values 12 17
[48]
THLE SQLE
Mean 10.7
Standard deviation 4.6
Values 7.4 14
[49]
liver SQLE
Mean 39.4
Standard deviation 14
Values 49 28 27 54
[50]
ref_hepatocyte DHCR7
Mean 31.8
Standard deviation 19
Values 23 59 43 21 13
[51]
HepG2 DHCR7
Mean 34.7
Standard deviation 11
Values 43 27
[52]
HepG2.C3A DHCR7
Mean 103
Standard deviation 68
Values 54 1.5e+02
[53]
HuH.7 DHCR7
Mean 117
Standard deviation 29
Values 90 1.5e+02 1.1e+02
[54]
SNU475 DHCR7
Mean 9.4
Standard deviation 1.9
Values 8 11
[55]
THLE DHCR7
Mean 12.4
Standard deviation 3.1
Values 10 15
[56]
liver DHCR7
Mean 98.2
Standard deviation 72
Values 68 50 69 2.1e+02
[57]
ref_hepatocyte PMVK
Mean 22.4
Standard deviation 12
Values 20 34 33 3.4 22
[58]
HepG2 PMVK
Mean 8.49
Standard deviation 1
Values 7.8 9.2
[59]
HepG2.C3A PMVK
Mean 7.97
Standard deviation 0.74
Values 7.4 8.5
[60]
HuH.7 PMVK
Mean 17.9
Standard deviation 3.9
Values 22 14 18
[61]
SNU475 PMVK
Mean 9.92
Standard deviation 2.1
Values 8.5 11
[62]
THLE PMVK
Mean 9.34
Standard deviation 1.8
Values 8 11
[63]
liver PMVK
Mean 7.06
Standard deviation 5.2
Values 3.4 2.4 13 9
[64]
ref_hepatocyte MVD
Mean 20.1
Standard deviation 9.1
Values 15 24 17 34 10
[65]
HepG2 MVD
Mean 18.7
Standard deviation 5.5
Values 23 15
[66]
HepG2.C3A MVD
Mean 92.8
Standard deviation 59
Values 51 1.3e+02
[67]
HuH.7 MVD
Mean 50.8
Standard deviation 5.1
Values 56 45 51
[68]
SNU475 MVD
Mean 7
Standard deviation 2.5
Values 5.2 8.8
[69]
THLE MVD
Mean 7.96
Standard deviation 0.012
Values 8 8
[70]
liver MVD
Mean 21.1
Standard deviation 12
Values 19 14 12 39
[71]
ref_hepatocyte NSDHL
Mean 19.7
Standard deviation 8
Values 12 24 31 14 17
[72]
HepG2 NSDHL
Mean 12.3
Standard deviation 4.3
Values 15 9.2
[73]
HepG2.C3A NSDHL
Mean 21.5
Standard deviation 0.63
Values 21 22
[74]
HuH.7 NSDHL
Mean 13.6
Standard deviation 1.6
Values 15 12 14
[75]
SNU475 NSDHL
Mean 10.5
Standard deviation 1
Values 9.8 11
[76]
THLE NSDHL
Mean 8.01
Standard deviation 1.5
Values 6.9 9.1
[77]
liver NSDHL
Mean 17.7
Standard deviation 6.5
Values 15 11 18 26
[78]
ref_hepatocyte LSS
Mean 16.9
Standard deviation 8
Values 11 14 12 31 16
[79]
HepG2 LSS
Mean 23.9
Standard deviation 12
Values 32 15
[80]
HepG2.C3A LSS
Mean 91.2
Standard deviation 46
Values 59 1.2e+02
[81]
HuH.7 LSS
Mean 42.1
Standard deviation 4.8
Values 39 48 40
[82]
SNU475 LSS
Mean 16.7
Standard deviation 8.9
Values 10 23
[83]
THLE LSS
Mean 14.1
Standard deviation 4.1
Values 11 17
[84]
liver LSS
Mean 49.9
Standard deviation 22
Values 83 44 39 34
[85]
ref_hepatocyte HMGCR
Mean 14.8
Standard deviation 13
Values 9.1 9.8 5.9 37 12
[86]
HepG2 HMGCR
Mean 22.2
Standard deviation 14
Values 32 12
[87]
HepG2.C3A HMGCR
Mean 133
Standard deviation 31
Values 1.1e+02 1.5e+02
[88]
HuH.7 HMGCR
Mean 154
Standard deviation 61
Values 1.1e+02 2.2e+02 1.3e+02
[89]
SNU475 HMGCR
Mean 22
Standard deviation 2.5
Values 20 24
[90]
THLE HMGCR
Mean 19.8
Standard deviation 3.5
Values 17 22
[91]
liver HMGCR
Mean 54.5
Standard deviation 28
Values 81 71 20 46
[92]
ref_hepatocyte MVK
Mean 14.5
Standard deviation 7.2
Values 7.9 24 20 12 8.7
[93]
HepG2 MVK
Mean 6.45
Standard deviation 1.7
Values 7.6 5.3
[94]
HepG2.C3A MVK
Mean 29.6
Standard deviation 8.4
Values 24 36
[95]
HuH.7 MVK
Mean 19.4
Standard deviation 2
Values 22 18 19
[96]
SNU475 MVK
Mean 2.86
Standard deviation 0.47
Values 2.5 3.2
[97]
THLE MVK
Mean 2.76
Standard deviation 0.64
Values 2.3 3.2
[98]
liver MVK
Mean 24.4
Standard deviation 13
Values 16 11 36 35
[99]
ref_hepatocyte SC5D
Missing
[100]
HepG2 SC5D
Missing
[101]
HepG2.C3A SC5D
Missing
[102]
HuH.7 SC5D
Missing
[103]
SNU475 SC5D
Missing
[104]
THLE SC5D
Missing
[105]
liver SC5D
Missing