WP_CELL_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -1.56[2] | -1.54[3] | -1.26[4] | -1.36[5] | -1.38[6] | -1.06[7] |
2 | YWHAZ | 14-3-3 protein zeta/delta | [8] | -0.89[9] | -1.14[10] | -0.89[11] | 0.40[12] | -1.07[13] | -1.15[14] |
3 | SKP1 | S-phase kinase-associated protein 1 | [15] | -1.30[16] | -1.00[17] | -1.94[18] | -1.00[19] | -0.84[20] | -0.20[21] |
4 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [22] | -4.49[23] | -5.34[24] | -4.20[25] | -4.52[26] | -3.59[27] | -1.67[28] |
5 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [29] | -2.79[30] | -3.96[31] | -3.84[32] | -4.49[33] | -2.81[34] | -2.51[35] |
6 | YWHAH | 14-3-3 protein eta | [36] | -1.69[37] | -2.19[38] | -2.29[39] | -1.69[40] | -2.15[41] | -1.46[42] |
7 | YWHAQ | 14-3-3 protein theta | [43] | -0.06[44] | -0.33[45] | -0.70[46] | 0.86[47] | 0.12[48] | -0.10[49] |
8 | SFN | 14-3-3 protein sigma | [50] | -2.68[51] | -3.13[52] | -2.80[53] | -8.33[54] | -9.32[55] | -9.60[56] |
9 | ANAPC11 | Anaphase-promoting complex subunit 11 | [57] | -2.16[58] | -1.80[59] | -2.29[60] | -2.82[61] | -2.49[62] | -0.90[63] |
10 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [64] | -2.38[65] | -2.04[66] | -2.22[67] | -3.20[68] | -2.84[69] | -1.60[70] |
11 | YWHAG | 14-3-3 protein gamma | [71] | -0.12[72] | -0.74[73] | -0.76[74] | 0.22[75] | -0.53[76] | -0.85[77] |
12 | YWHAB | 14-3-3 protein beta/alpha | [78] | 0.72[79] | 0.34[80] | -0.45[81] | 0.80[82] | 0.18[83] | 0.40[84] |
13 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [85] | -10.24[86] | [87] | -8.87[88] | -8.33[89] | -8.33[90] | -1.22[91] |
14 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [92] | 0.52[93] | -0.96[94] | -3.72[95] | -2.49[96] | 0.01[97] | -1.34[98] |
15 | PCNA | Proliferating cell nuclear antigen | [99] | 0.57[100] | 0.46[101] | -1.02[102] | -0.72[103] | -0.49[104] | -2.58[105] |
16 | MYC | Myc proto-oncogene protein | [106] | 0.11[107] | -0.32[108] | -2.42[109] | -3.29[110] | -0.98[111] | -1.50[112] |
17 | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B | [113] | -1.86[114] | -0.53[115] | -1.88[116] | -2.17[117] | -2.01[118] | -0.92[119] |
18 | CCND1 | G1/S-specific cyclin-D1 | [120] | 2.73[121] | 0.14[122] | 0.90[123] | 1.38[124] | -0.15[125] | 1.55[126] |
19 | BUB3 | Mitotic checkpoint protein BUB3 | [127] | -0.01[128] | 0.78[129] | 0.10[130] | -0.81[131] | 0.59[132] | -0.10[133] |
20 | ANAPC13 | Anaphase-promoting complex subunit 13 | [134] | -1.15[135] | -0.79[136] | -0.88[137] | -1.37[138] | -1.39[139] | 0.33[140] |
21 | HDAC1 | Histone deacetylase 1 | [141] | 0.18[142] | 0.11[143] | 0.73[144] | 0.14[145] | -0.13[146] | 0.03[147] |
22 | CDK4 | Cyclin-dependent kinase 4 | [148] | 1.01[149] | 1.50[150] | 1.06[151] | -0.32[152] | 0.27[153] | -0.34[154] |
23 | RAD21 | Double-strand-break repair protein rad21 homolog | [155] | 0.12[156] | 1.42[157] | 1.44[158] | 1.56[159] | 1.13[160] | 0.87[161] |
24 | ANAPC5 | Anaphase-promoting complex subunit 5 | [162] | 0.55[163] | 1.13[164] | 1.22[165] | -0.16[166] | 0.24[167] | 1.21[168] |
25 | CCNH | Cyclin-H | [169] | -1.99[170] | -1.22[171] | -1.90[172] | -2.28[173] | -0.94[174] | -0.43[175] |
26 | TFDP1 | Transcription factor Dp-1 | [176] | 0.34[177] | -0.41[178] | -0.42[179] | 0.10[180] | 0.62[181] | -0.65[182] |
27 | CUL1 | Cullin-1 | [183] | -0.71[184] | -0.12[185] | -0.64[186] | 0.08[187] | -0.32[188] | 1.24[189] |
28 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [190] | -0.41[191] | -0.05[192] | 0.07[193] | -1.61[194] | -1.20[195] | -0.41[196] |
29 | CDC27 | Cell division cycle protein 27 homolog | [197] | -0.11[198] | 0.64[199] | -0.08[200] | 0.68[201] | 0.17[202] | 0.64[203] |
30 | MCM7 | DNA replication licensing factor MCM7 | [204] | 1.59[205] | 1.30[206] | 2.46[207] | 0.79[208] | 1.29[209] | -0.30[210] |
31 | MCM3 | DNA replication licensing factor MCM3 | [211] | 1.98[212] | 1.74[213] | 1.78[214] | 0.48[215] | 1.51[216] | -0.19[217] |
32 | CDC16 | Cell division cycle protein 16 homolog | [218] | -0.82[219] | -0.68[220] | -1.40[221] | -0.92[222] | -0.53[223] | 0.37[224] |
33 | CDK2 | Cyclin-dependent kinase 2 | [225] | -0.74[226] | -0.66[227] | -0.35[228] | -0.52[229] | 0.01[230] | -1.69[231] |
34 | CDK7 | Cyclin-dependent kinase 7 | [232] | -0.97[233] | -0.04[234] | -0.39[235] | -1.07[236] | -1.44[237] | -1.86[238] |
35 | SMC3 | Structural maintenance of chromosomes protein 3 | [239] | -1.49[240] | 1.07[241] | 1.47[242] | -0.09[243] | 0.28[244] | 0.55[245] |
36 | E2F4 | Transcription factor E2F4 | [246] | 0.81[247] | 0.83[248] | -0.21[249] | -0.08[250] | -0.14[251] | 0.25[252] |
37 | MCM4 | DNA replication licensing factor MCM4 | [253] | 1.74[254] | 1.54[255] | 2.19[256] | 1.50[257] | 2.08[258] | -0.49[259] |
38 | MCM5 | DNA replication licensing factor MCM5 | [260] | 0.89[261] | 0.67[262] | 1.23[263] | 0.02[264] | 0.89[265] | -0.42[266] |
39 | CCNB1 | G2/mitotic-specific cyclin-B1 | [267] | 1.53[268] | 1.67[269] | 1.78[270] | 1.11[271] | 2.03[272] | -1.85[273] |
40 | ORC4 | Origin recognition complex subunit 4 | [274] | -0.26[275] | 0.83[276] | 0.48[277] | 0.87[278] | 0.07[279] | 3.47[280] |
41 | CDC23 | Cell division cycle protein 23 homolog | [281] | 0.05[282] | 0.17[283] | 0.35[284] | 0.53[285] | 0.18[286] | 0.69[287] |
42 | HDAC2 | Histone deacetylase 2 | [288] | 1.40[289] | 2.64[290] | 1.94[291] | 1.66[292] | 1.74[293] | 0.70[294] |
43 | ORC5 | Origin recognition complex subunit 5 | [295] | -1.30[296] | -1.05[297] | -0.54[298] | -0.65[299] | -0.94[300] | 0.32[301] |
44 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [302] | 1.79[303] | 3.12[304] | 0.28[305] | 0.01[306] | 0.83[307] | 2.66[308] |
45 | RBL2 | Retinoblastoma-like protein 2 | [309] | 0.52[310] | 1.27[311] | 1.26[312] | 0.73[313] | 0.38[314] | 2.64[315] |
46 | SMAD3 | Mothers against decapentaplegic homolog 3 | [316] | 1.61[317] | 0.92[318] | 1.07[319] | 1.30[320] | 2.12[321] | 0.71[322] |
47 | FZR1 | Fizzy-related protein homolog | [323] | 0.43[324] | -0.02[325] | 0.00[326] | -0.46[327] | 0.07[328] | 1.12[329] |
48 | CDK1 | Cyclin-dependent kinase 1 | [330] | 0.93[331] | 2.90[332] | 1.57[333] | 1.77[334] | 2.53[335] | -1.97[336] |
49 | ANAPC7 | Anaphase-promoting complex subunit 7 | [337] | 0.68[338] | 0.99[339] | 0.39[340] | 0.40[341] | 0.60[342] | 0.68[343] |
50 | CHEK2 | Serine/threonine-protein kinase Chk2 | [344] | -0.22[345] | 0.13[346] | 0.46[347] | -0.75[348] | -1.18[349] | -2.78[350] |
51 | ANAPC2 | Anaphase-promoting complex subunit 2 | [351] | 0.29[352] | -0.36[353] | 0.18[354] | -0.46[355] | -0.56[356] | 0.54[357] |
52 | TP53 | Cellular tumor antigen p53 | [358] | 1.31[359] | 0.79[360] | 1.48[361] | 0.79[362] | 0.40[363] | 0.46[364] |
53 | STAG2 | Cohesin subunit SA-2 | [365] | -0.04[366] | 1.88[367] | 2.83[368] | 2.04[369] | 1.46[370] | 2.45[371] |
54 | ORC2 | Origin recognition complex subunit 2 | [372] | 0.14[373] | 1.01[374] | 0.67[375] | -0.19[376] | 0.04[377] | 0.06[378] |
55 | MAD1L1 | Mitotic spindle assembly checkpoint protein MAD1 | [379] | 0.32[380] | -0.29[381] | -0.25[382] | -1.15[383] | -0.67[384] | 0.21[385] |
56 | PLK1 | Serine/threonine-protein kinase PLK1 | [386] | 2.17[387] | 1.82[388] | 1.61[389] | 0.75[390] | 1.73[391] | -2.13[392] |
57 | WEE1 | Wee1-like protein kinase | [393] | -0.02[394] | 0.31[395] | 0.98[396] | 0.22[397] | -0.31[398] | -0.04[399] |
58 | CDC14B | Dual specificity protein phosphatase CDC14B | [400] | 0.49[401] | 0.53[402] | 0.45[403] | -0.32[404] | 0.28[405] | 1.91[406] |
59 | CDC6 | Cell division control protein 6 homolog | [407] | 1.54[408] | 1.02[409] | 1.55[410] | 1.06[411] | 1.28[412] | -1.57[413] |
60 | SMC1A | Structural maintenance of chromosomes protein 1A | [414] | 1.78[415] | 1.56[416] | 2.49[417] | 2.51[418] | 3.30[419] | 2.94[420] |
61 | ORC6 | Origin recognition complex subunit 6 | [421] | 0.44[422] | 0.91[423] | 0.07[424] | 0.29[425] | 0.48[426] | -3.20[427] |
62 | MCM6 | DNA replication licensing factor MCM6 | [428] | 0.88[429] | 0.50[430] | 2.45[431] | 1.92[432] | 2.66[433] | -0.79[434] |
63 | MCM2 | DNA replication licensing factor MCM2 | [435] | 2.60[436] | 1.96[437] | 3.19[438] | 1.63[439] | 2.58[440] | -1.12[441] |
64 | GSK3B | Glycogen synthase kinase-3 beta | [442] | 0.94[443] | 0.49[444] | 0.99[445] | 1.31[446] | 1.09[447] | 1.66[448] |
65 | CDK6 | Cyclin-dependent kinase 6 | [449] | 1.72[450] | 2.34[451] | 0.67[452] | 0.42[453] | 1.16[454] | 2.57[455] |
66 | ABL1 | Tyrosine-protein kinase ABL1 | [456] | 1.91[457] | 1.21[458] | 1.94[459] | 1.57[460] | 2.20[461] | 1.44[462] |
67 | ORC3 | Origin recognition complex subunit 3 | [463] | -0.24[464] | 0.88[465] | 0.95[466] | 0.04[467] | 0.96[468] | 0.75[469] |
68 | CDC20 | Cell division cycle protein 20 homolog | [470] | 2.04[471] | 1.97[472] | 2.26[473] | 2.01[474] | 2.60[475] | -1.81[476] |
69 | CDC25B | M-phase inducer phosphatase 2 | [477] | 1.54[478] | 1.64[479] | 0.94[480] | 2.22[481] | 2.32[482] | 0.84[483] |
70 | PTTG1 | Securin | [484] | 1.17[485] | 1.75[486] | 2.28[487] | 0.92[488] | 2.15[489] | -1.57[490] |
71 | ANAPC1 | Anaphase-promoting complex subunit 1 | [491] | 2.09[492] | 2.18[493] | 2.00[494] | 1.42[495] | 1.39[496] | 1.95[497] |
72 | CCND3 | G1/S-specific cyclin-D3 | [498] | 0.63[499] | -0.52[500] | -2.22[501] | 3.16[502] | 2.28[503] | 1.15[504] |
73 | SKP2 | S-phase kinase-associated protein 2 | [505] | 0.99[506] | 1.36[507] | 2.43[508] | 0.76[509] | 0.79[510] | 1.58[511] |
74 | CCNE1 | G1/S-specific cyclin-E1 | [512] | 0.92[513] | 0.94[514] | -0.95[515] | -0.90[516] | -0.36[517] | -4.13[518] |
75 | PRKDC | DNA-dependent protein kinase catalytic subunit | [519] | 3.89[520] | 3.27[521] | 5.09[522] | 4.39[523] | 4.42[524] | 4.74[525] |
76 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | [526] | 0.33[527] | 0.87[528] | 0.02[529] | 0.18[530] | -0.06[531] | 0.63[532] |
77 | CCNA2 | Cyclin-A2 | [533] | 1.88[534] | 2.81[535] | 2.08[536] | 1.50[537] | 2.84[538] | -0.73[539] |
78 | SMAD4 | Mothers against decapentaplegic homolog 4 | [540] | 1.07[541] | 1.61[542] | 1.51[543] | 1.41[544] | 1.72[545] | 3.29[546] |
79 | TGFB2 | Transforming growth factor beta-2 | [547] | -4.61[548] | -7.23[549] | -1.50[550] | 2.96[551] | 1.50[552] | -2.27[553] |
80 | RB1 | Retinoblastoma-associated protein | [554] | 0.90[555] | 1.31[556] | 1.80[557] | 1.78[558] | 2.04[559] | 1.97[560] |
81 | STAG1 | Cohesin subunit SA-1 | [561] | 0.13[562] | 1.33[563] | 0.45[564] | 1.08[565] | 1.12[566] | 2.67[567] |
82 | ANAPC4 | Anaphase-promoting complex subunit 4 | [568] | -0.13[569] | 0.71[570] | 0.97[571] | 0.69[572] | 0.11[573] | 1.48[574] |
83 | SMAD2 | Mothers against decapentaplegic homolog 2 | [575] | 1.70[576] | 1.87[577] | 1.30[578] | 1.88[579] | 2.02[580] | 3.07[581] |
84 | CDC45 | Cell division control protein 45 homolog | [582] | 0.88[583] | 0.74[584] | 1.33[585] | 0.76[586] | 1.04[587] | -2.41[588] |
85 | E2F1 | Transcription factor E2F1 | [589] | 1.62[590] | 1.39[591] | 1.45[592] | 1.37[593] | 1.75[594] | -3.12[595] |
86 | EP300 | Histone acetyltransferase p300 | [596] | 2.40[597] | 1.91[598] | 2.73[599] | 2.07[600] | 2.07[601] | 3.25[602] |
87 | CHEK1 | Serine/threonine-protein kinase Chk1 | [603] | 1.21[604] | 1.49[605] | 0.98[606] | 1.65[607] | 1.82[608] | -1.53[609] |
88 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [610] | 0.04[611] | -4.51[612] | -0.73[613] | 0.66[614] | 0.90[615] | -1.59[616] |
89 | TGFB1 | Transforming growth factor beta-1 | [617] | 3.15[618] | 2.02[619] | -0.80[620] | 3.34[621] | 2.51[622] | -0.73[623] |
90 | E2F3 | Transcription factor E2F3 | [624] | 1.39[625] | 1.14[626] | 0.32[627] | 2.13[628] | 1.52[629] | 0.33[630] |
91 | ANAPC10 | Anaphase-promoting complex subunit 10 | [631] | -0.56[632] | 0.24[633] | -0.44[634] | -0.72[635] | 0.00[636] | 0.62[637] |
92 | CDC25A | M-phase inducer phosphatase 1 | [638] | 1.10[639] | 1.65[640] | 1.93[641] | -0.16[642] | 1.24[643] | -2.16[644] |
93 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C | [645] | -0.10[646] | 0.42[647] | 0.50[648] | 1.68[649] | 1.75[650] | -0.32[651] |
94 | CCNB2 | G2/mitotic-specific cyclin-B2 | [652] | 1.77[653] | 2.44[654] | 2.75[655] | 2.02[656] | 2.95[657] | -1.10[658] |
95 | TFDP2 | Transcription factor Dp-2 | [659] | 1.59[660] | 2.19[661] | 2.13[662] | 1.89[663] | 2.06[664] | 2.85[665] |
96 | BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1 | [666] | 1.87[667] | 2.93[668] | 2.49[669] | 2.59[670] | 2.89[671] | -0.82[672] |
97 | CDKN2D | Cyclin-dependent kinase 4 inhibitor D | [673] | -0.83[674] | -0.53[675] | -0.85[676] | -1.33[677] | 0.07[678] | -1.22[679] |
98 | PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | 0.99[680] | 0.68[681] | 0.74[682] | 0.14[683] | 1.28[684] | -2.06[685] | |
99 | DBF4 | Protein DBF4 homolog A | [686] | 0.17[687] | 1.72[688] | 1.39[689] | 1.08[690] | 1.29[691] | 0.03[692] |
100 | ORC1 | Origin recognition complex subunit 1 | [693] | 1.23[694] | 1.17[695] | 2.61[696] | 0.78[697] | 1.29[698] | -1.61[699] |
101 | ATR | Serine/threonine-protein kinase ATR | [700] | 0.77[701] | 1.68[702] | 1.69[703] | 2.03[704] | 1.93[705] | 4.05[706] |
102 | TGFB3 | Transforming growth factor beta-3 | [707] | -1.86[708] | -2.83[709] | -3.13[710] | -0.33[711] | -1.45[712] | 0.95[713] |
103 | CDC7 | Cell division cycle 7-related protein kinase | [714] | 0.17[715] | 1.05[716] | 1.79[717] | 1.92[718] | 2.58[719] | -0.29[720] |
104 | E2F5 | Transcription factor E2F5 | [721] | 1.20[722] | 2.08[723] | 2.41[724] | -0.47[725] | -2.07[726] | -1.19[727] |
105 | TTK | Dual specificity protein kinase TTK | [728] | 0.53[729] | 2.94[730] | 2.87[731] | 2.46[732] | 2.96[733] | -0.62[734] |
106 | ATM | Serine-protein kinase ATM | [735] | 2.71[736] | 4.22[737] | 3.88[738] | 3.66[739] | 3.08[740] | 5.48[741] |
107 | CCNE2 | G1/S-specific cyclin-E2 | [742] | 0.10[743] | 0.41[744] | -0.13[745] | 2.54[746] | 2.38[747] | 0.14[748] |
108 | RBL1 | Retinoblastoma-like protein 1 | [749] | 1.46[750] | 2.24[751] | 0.79[752] | 2.31[753] | 2.59[754] | 1.18[755] |
109 | CDC25C | M-phase inducer phosphatase 3 | [756] | 1.61[757] | 2.68[758] | 2.63[759] | 1.43[760] | 2.22[761] | -0.92[762] |
110 | CCND2 | G1/S-specific cyclin-D2 | [763] | 2.82[764] | 1.32[765] | -4.96[766] | -4.95[767] | -2.10[768] | 2.35[769] |
111 | CDC14A | Dual specificity protein phosphatase CDC14A | [770] | 0.52[771] | 1.22[772] | 1.76[773] | 1.14[774] | 0.75[775] | 1.67[776] |
112 | ESPL1 | Separin | [777] | 3.60[778] | 3.87[779] | 3.76[780] | 3.99[781] | 3.96[782] | 2.67[783] |
113 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [784] | 3.76[785] | 1.44[786] | 4.77[787] | 4.71[788] | 6.43[789] | -1.66[790] |
114 | CDKN1C | Cyclin-dependent kinase inhibitor 1C | [791] | [792] | -5.67[793] | 0.96[794] | 0.67[795] | -0.02[796] | 1.96[797] |
115 | E2F2 | Transcription factor E2F2 | [798] | 3.92[799] | 4.73[800] | 4.17[801] | 3.55[802] | 3.82[803] | 1.92[804] |
116 | CCNB3 | G2/mitotic-specific cyclin-B3 | [805] | -1.99[806] | -2.82[807] | -3.15[808] | -2.40[809] | 0.39[810] | 2.34[811] |
117 | CCNA1 | Cyclin-A1 | [812] | [813] | -3.80[814] | [815] | -1.29[816] | 6.06[817] | [818] |
118 | WEE2 | Wee1-like protein kinase 2 | [819] | -1.64[820] | -0.96[821] | 1.27[822] | 0.53[823] | -1.36[824] | 1.73[825] |
119 | PTTG2 | Securin-2 | [826] | [827] | [828] | [829] | [830] | [831] | [832] |
120 | SMC1B | Structural maintenance of chromosomes protein 1B | [833] | [834] | [835] | [836] | [837] | [838] | [839] |
121 | MIR3610 | [840] | [841] | [842] | [843] | [844] | [845] | [846] | |
122 | MIR1281 | [847] | [848] | [849] | [850] | [851] | [852] | [853] |