WP_CANCER_IMMUNOTHERAPY_BY_PD1_BLOCKADE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HLA-A HLA class I histocompatibility antigen, A-68 alpha chain [1] -0.63[2] -0.37[3] -5.50[4] -0.04[5] -0.77[6] -2.04[7]
2 JUN Transcription factor AP-1 [8] 0.05[9] -1.47[10] -0.35[11] -1.49[12] -0.63[13] -1.77[14]
3 STAT3 Signal transducer and activator of transcription 3 [15] 1.09[16] -0.39[17] 1.20[18] 0.45[19] 0.02[20] 2.45[21]
4 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [22] 0.99[23] 1.44[24] 2.24[25] 1.10[26] 2.03[27] 1.30[28]
5 HLA-DRB1 HLA class II histocompatibility antigen, DRB1-15 beta chain [29] -7.90[30] [31] [32] -5.90[33] -10.67[34] -1.61[35]
6 NFKB1 Nuclear factor NF-kappa-B p105 subunit [36] 1.21[37] 0.91[38] 1.55[39] -0.04[40] 1.17[41] 0.49[42]
7 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 [43] 2.01[44] 2.81[45] 3.55[46] 1.07[47] 1.75[48] 2.44[49]
8 BATF Basic leucine zipper transcriptional factor ATF-like [50] 0.27[51] -0.72[52] -7.20[53] -9.54[54] [55] -2.97[56]
9 NFAT5 Nuclear factor of activated T-cells 5 [57] 4.13[58] 4.93[59] 5.79[60] 4.10[61] 4.02[62] 4.68[63]
10 CD3E T-cell surface glycoprotein CD3 epsilon chain [64] -8.32[65] [66] -3.98[67] [68] [69] -0.56[70]
11 CD274 Programmed cell death 1 ligand 1 [71] -2.60[72] -3.85[73] -4.44[74] -0.04[75] 4.66[76] 0.70[77]
12 NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1 [78] -1.41[79] -3.91[80] 3.55[81] -5.77[82] 2.94[83] 0.77[84]
13 CD3D T-cell surface glycoprotein CD3 delta chain [85] 1.94[86] -0.05[87] -1.57[88] -6.29[89] -4.00[90] -0.28[91]
14 NFATC2 Nuclear factor of activated T-cells, cytoplasmic 2 [92] 3.13[93] 4.40[94] 4.66[95] 0.39[96] 1.64[97] 3.33[98]
15 LCK Tyrosine-protein kinase Lck [99] 3.32[100] 3.42[101] -5.73[102] -4.87[103] -4.78[104] 1.28[105]
16 CD8A T-cell surface glycoprotein CD8 alpha chain [106] -0.08[107] -3.82[108] 2.16[109] -4.47[110] -2.81[111] 0.88[112]
17 CD3G T-cell surface glycoprotein CD3 gamma chain [113] -3.05[114] -2.28[115] -2.49[116] -4.40[117] -3.52[118] -0.30[119]
18 PDCD1LG2 Programmed cell death 1 ligand 2 [120] -5.95[121] [122] [123] -0.21[124] 4.69[125] 1.55[126]
19 ZAP70 Tyrosine-protein kinase ZAP-70 [127] 1.54[128] 1.78[129] -3.60[130] -5.33[131] -3.69[132] 2.20[133]
20 IFNG Interferon gamma [134] [135] [136] [137] -0.48[138] [139] -2.25[140]
21 NFATC4 Nuclear factor of activated T-cells, cytoplasmic 4 [141] 3.20[142] 0.49[143] 4.33[144] 2.95[145] 9.08[146] 5.27[147]
22 CD8B T-cell surface glycoprotein CD8 beta chain [148] 1.54[149] -0.09[150] 9.36[151] [152] -1.51[153] 3.16[154]
23 PDCD1 Programmed cell death protein 1 [155] 5.37[156] 2.08[157] [158] -0.02[159] [160] 2.66[161]
[1]
ref_hepatocyte HLA-A
Mean 230
Standard deviation 75
Values 1.9e+02 2.5e+02 3.5e+02 2e+02 1.6e+02
[2]
HepG2 HLA-A
Mean 225
Standard deviation 68
Values 1.8e+02 2.7e+02
[3]
HepG2.C3A HLA-A
Mean 238
Standard deviation 65
Values 1.9e+02 2.8e+02
[4]
HuH.7 HLA-A
Mean 3.61
Standard deviation 1.9
Values 2.7 5.8 2.4
[5]
SNU475 HLA-A
Mean 354
Standard deviation 9.1
Values 3.6e+02 3.5e+02
[6]
THLE HLA-A
Mean 195
Standard deviation 20
Values 2.1e+02 1.8e+02
[7]
liver HLA-A
Mean 77.2
Standard deviation 46
Values 33 45 1.3e+02 1e+02
[8]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 66 20 73 26 30
[9]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 42 93
[10]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 13 28
[11]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 14 46 11
[12]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 27 21
[13]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[14]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 12 24 25 8.4
[15]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 18 36 46 26 25
[16]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 1e+02 90
[17]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 27 34
[18]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 35 65 47
[19]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 57 74
[20]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[21]
liver STAT3
Mean 227
Standard deviation 42
Values 2e+02 2.3e+02 1.9e+02 2.8e+02
[22]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 10 7.4 7.5 33 53
[23]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 76 58
[24]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 92 68
[25]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 61 77 86
[26]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 76 75
[27]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[28]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 80 99 60 62
[29]
ref_hepatocyte HLA-DRB1
Mean 19
Standard deviation 28
Values 4 66 24 0 0.7
[30]
HepG2 HLA-DRB1
Mean 0.121
Standard deviation 0.017
Values 0.13 0.11
[31]
HepG2.C3A HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0
[32]
HuH.7 HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0 0
[33]
SNU475 HLA-DRB1
Mean 0.506
Standard deviation 0.45
Values 0.83 0.19
[34]
THLE HLA-DRB1
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[35]
liver HLA-DRB1
Mean 8.55
Standard deviation 3.8
Values 4.6 6.5 10 13
[36]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 12 4.7 5.3 3 6.7
[37]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 26 18
[38]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 17 15
[39]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 13 12 14
[40]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 10 9.6
[41]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[42]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 17 15 9.7 7.2
[43]
ref_hepatocyte NFATC3
Mean 4.32
Standard deviation 2.8
Values 2.2 4.5 4.8 8.6 1.5
[44]
HepG2 NFATC3
Mean 26.4
Standard deviation 8
Values 32 21
[45]
HepG2.C3A NFATC3
Mean 40.3
Standard deviation 0.21
Values 40 40
[46]
HuH.7 NFATC3
Mean 36
Standard deviation 7.7
Values 30 33 45
[47]
SNU475 NFATC3
Mean 14.4
Standard deviation 0.48
Values 15 14
[48]
THLE NFATC3
Mean 21
Standard deviation 0.15
Values 21 21
[49]
liver NFATC3
Mean 32.4
Standard deviation 6.8
Values 26 27 40 36
[50]
ref_hepatocyte BATF
Mean 1.09
Standard deviation 1.4
Values 1.6 0.27 0.31 0 3.3
[51]
HepG2 BATF
Mean 1.99
Standard deviation 0.38
Values 1.7 2.3
[52]
HepG2.C3A BATF
Mean 0.886
Standard deviation 0.11
Values 0.97 0.81
[53]
HuH.7 BATF
Mean 0.00526
Standard deviation 0.0048
Values 0.0094 0.0064 0
[54]
SNU475 BATF
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[55]
THLE BATF
Mean 0
Standard deviation 0
Values 0 0
[56]
liver BATF
Mean 0.192
Standard deviation 0.15
Values 0.17 0.043 0.4 0.15
[57]
ref_hepatocyte NFAT5
Mean 0.959
Standard deviation 0.93
Values 0.56 0.55 0.47 2.6 0.59
[58]
HepG2 NFAT5
Mean 25.5
Standard deviation 5.7
Values 30 21
[59]
HepG2.C3A NFAT5
Mean 39
Standard deviation 0.7
Values 38 39
[60]
HuH.7 NFAT5
Mean 37.6
Standard deviation 15
Values 23 53 37
[61]
SNU475 NFAT5
Mean 26.1
Standard deviation 1.2
Values 25 27
[62]
THLE NFAT5
Mean 22.5
Standard deviation 4.9
Values 26 19
[63]
liver NFAT5
Mean 33.8
Standard deviation 13
Values 42 46 32 16
[64]
ref_hepatocyte CD3E
Mean 0.605
Standard deviation 0.94
Values 0 2.2 0.75 0 0.078
[65]
HepG2 CD3E
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[66]
HepG2.C3A CD3E
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 CD3E
Mean 0.0273
Standard deviation 0.032
Values 0.0094 0.064 0.0082
[68]
SNU475 CD3E
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE CD3E
Mean 0
Standard deviation 0
Values 0 0
[70]
liver CD3E
Mean 0.564
Standard deviation 0.34
Values 0.36 0.21 0.94 0.74
[71]
ref_hepatocyte CD274
Mean 0.501
Standard deviation 0.62
Values 1.5 0.13 0.23 0 0.6
[72]
HepG2 CD274
Mean 0.125
Standard deviation 0.025
Values 0.11 0.14
[73]
HepG2.C3A CD274
Mean 0.0463
Standard deviation 0.01
Values 0.054 0.039
[74]
HuH.7 CD274
Mean 0.0164
Standard deviation 0.01
Values 0.028 0.013 0.0082
[75]
SNU475 CD274
Mean 0.776
Standard deviation 0.17
Values 0.9 0.65
[76]
THLE CD274
Mean 18.4
Standard deviation 4.5
Values 22 15
[77]
liver CD274
Mean 1.12
Standard deviation 0.24
Values 1.1 1.5 0.99 0.92
[78]
ref_hepatocyte NFATC1
Mean 0.405
Standard deviation 0.28
Values 0.43 0.7 0.28 0 0.61
[79]
HepG2 NFATC1
Mean 0.231
Standard deviation 0.27
Values 0.039 0.42
[80]
HepG2.C3A NFATC1
Mean 0.036
Standard deviation 0.0097
Values 0.043 0.029
[81]
HuH.7 NFATC1
Mean 3.36
Standard deviation 0.62
Values 3 3 4.1
[82]
SNU475 NFATC1
Mean 0.0118
Standard deviation 0.0095
Values 0.0051 0.019
[83]
THLE NFATC1
Mean 4.5
Standard deviation 0.49
Values 4.1 4.8
[84]
liver NFATC1
Mean 0.95
Standard deviation 0.21
Values 1.1 0.7 0.85 1.2
[85]
ref_hepatocyte CD3D
Mean 0.343
Standard deviation 0.47
Values 0 1.1 0.2 0 0.4
[86]
HepG2 CD3D
Mean 2
Standard deviation 2.2
Values 0.42 3.6
[87]
HepG2.C3A CD3D
Mean 0.441
Standard deviation 0.23
Values 0.6 0.28
[88]
HuH.7 CD3D
Mean 0.082
Standard deviation 0.059
Values 0.066 0.15 0.033
[89]
SNU475 CD3D
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[90]
THLE CD3D
Mean 0.031
Standard deviation 0.0063
Values 0.035 0.027
[91]
liver CD3D
Mean 0.389
Standard deviation 0.39
Values 0.093 0.11 0.42 0.92
[92]
ref_hepatocyte NFATC2
Mean 0.322
Standard deviation 0.29
Values 0.8 0.21 0.095 0.36 0.15
[93]
HepG2 NFATC2
Mean 4.27
Standard deviation 1.6
Values 5.4 3.1
[94]
HepG2.C3A NFATC2
Mean 9.11
Standard deviation 2.4
Values 7.4 11
[95]
HuH.7 NFATC2
Mean 5.8
Standard deviation 2.3
Values 3.8 8.2 5.4
[96]
SNU475 NFATC2
Mean 0.671
Standard deviation 0.23
Values 0.83 0.51
[97]
THLE NFATC2
Mean 1.46
Standard deviation 0.081
Values 1.4 1.5
[98]
liver NFATC2
Mean 4.46
Standard deviation 1.2
Values 4.7 3.9 5.9 3.3
[99]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.49 0.99 0 0.11 0
[100]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 1.7 8
[101]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.7 4.4
[102]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[103]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.025 0.0093
[104]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[105]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 0.91 0.49 1.2 1.7
[106]
ref_hepatocyte CD8A
Mean 0.274
Standard deviation 0.36
Values 0.2 0.91 0.095 0.082 0.078
[107]
HepG2 CD8A
Mean 0.392
Standard deviation 0.19
Values 0.26 0.53
[108]
HepG2.C3A CD8A
Mean 0.0258
Standard deviation 0.009
Values 0.032 0.019
[109]
HuH.7 CD8A
Mean 0.869
Standard deviation 0.17
Values 0.86 1 0.71
[110]
SNU475 CD8A
Mean 0.0196
Standard deviation 0.0081
Values 0.025 0.014
[111]
THLE CD8A
Mean 0.0565
Standard deviation 0.012
Values 0.065 0.048
[112]
liver CD8A
Mean 0.696
Standard deviation 0.6
Values 0.19 0.24 0.92 1.4
[113]
ref_hepatocyte CD3G
Mean 0.262
Standard deviation 0.26
Values 0 0.54 0.49 0.28 0
[114]
HepG2 CD3G
Mean 0.048
Standard deviation 0.013
Values 0.039 0.057
[115]
HepG2.C3A CD3G
Mean 0.0721
Standard deviation 0.019
Values 0.086 0.058
[116]
HuH.7 CD3G
Mean 0.0331
Standard deviation 0.0052
Values 0.028 0.039 0.033
[117]
SNU475 CD3G
Mean 0.0196
Standard deviation 0.0081
Values 0.025 0.014
[118]
THLE CD3G
Mean 0.0331
Standard deviation 0.013
Values 0.024 0.043
[119]
liver CD3G
Mean 0.293
Standard deviation 0.14
Values 0.34 0.46 0.14 0.23
[120]
ref_hepatocyte PDCD1LG2
Mean 0.234
Standard deviation 0.35
Values 0.84 0.098 0.23 0 0
[121]
HepG2 PDCD1LG2
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[122]
HepG2.C3A PDCD1LG2
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 PDCD1LG2
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 PDCD1LG2
Mean 0.321
Standard deviation 0.19
Values 0.46 0.19
[125]
THLE PDCD1LG2
Mean 8.77
Standard deviation 0.85
Values 9.4 8.2
[126]
liver PDCD1LG2
Mean 0.941
Standard deviation 0.52
Values 0.57 1.6 0.52 1.1
[127]
ref_hepatocyte ZAP70
Mean 0.182
Standard deviation 0.23
Values 0 0.57 0.2 0.14 0
[128]
HepG2 ZAP70
Mean 0.806
Standard deviation 0.62
Values 0.37 1.2
[129]
HepG2.C3A ZAP70
Mean 0.835
Standard deviation 0.029
Values 0.82 0.86
[130]
HuH.7 ZAP70
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[131]
SNU475 ZAP70
Mean 0.00717
Standard deviation 0.003
Values 0.0051 0.0093
[132]
THLE ZAP70
Mean 0.0204
Standard deviation 0.021
Values 0.035 0.0053
[133]
liver ZAP70
Mean 1.16
Standard deviation 0.36
Values 1.3 0.87 0.85 1.6
[134]
ref_hepatocyte IFNG
Mean 0.182
Standard deviation 0.29
Values 0 0.67 0.23 0 0
[135]
HepG2 IFNG
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A IFNG
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 IFNG
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 IFNG
Mean 0.206
Standard deviation 0.22
Values 0.051 0.36
[139]
THLE IFNG
Mean 0
Standard deviation 0
Values 0 0
[140]
liver IFNG
Mean 0.0524
Standard deviation 0.037
Values 0.026 0.057 0.024 0.1
[141]
ref_hepatocyte NFATC4
Mean 0.0185
Standard deviation 0.03
Values 0.068 0.024 0 0 0
[142]
HepG2 NFATC4
Mean 0.258
Standard deviation 0.27
Values 0.069 0.45
[143]
HepG2.C3A NFATC4
Mean 0.0345
Standard deviation 0.034
Values 0.011 0.058
[144]
HuH.7 NFATC4
Mean 0.263
Standard deviation 0.25
Values 0.12 0.55 0.11
[145]
SNU475 NFATC4
Mean 0.227
Standard deviation 0.02
Values 0.21 0.24
[146]
THLE NFATC4
Mean 14.5
Standard deviation 0.74
Values 15 14
[147]
liver NFATC4
Mean 0.981
Standard deviation 0.66
Values 1.9 0.7 0.89 0.41
[148]
ref_hepatocyte CD8B
Mean 0.0163
Standard deviation 0.036
Values 0 0.081 0 0 0
[149]
HepG2 CD8B
Mean 0.0715
Standard deviation 0.044
Values 0.1 0.04
[150]
HepG2.C3A CD8B
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[151]
HuH.7 CD8B
Mean 7.57
Standard deviation 1.4
Values 9.2 6.5 7
[152]
SNU475 CD8B
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE CD8B
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[154]
liver CD8B
Mean 0.201
Standard deviation 0.15
Values 0.053 0.13 0.21 0.41
[155]
ref_hepatocyte PDCD1
Mean 0.0138
Standard deviation 0.031
Values 0 0 0.069 0 0
[156]
HepG2 PDCD1
Mean 0.867
Standard deviation 0.25
Values 0.69 1
[157]
HepG2.C3A PDCD1
Mean 0.0779
Standard deviation 0.041
Values 0.11 0.049
[158]
HuH.7 PDCD1
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 PDCD1
Mean 0.0215
Standard deviation 0.0089
Values 0.015 0.028
[160]
THLE PDCD1
Mean 0
Standard deviation 0
Values 0 0
[161]
liver PDCD1
Mean 0.12
Standard deviation 0.086
Values 0.15 0.057 0.047 0.23