WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.07[1] -0.20[2] -0.79[3] 0.14[4] 0.03[5] -0.98[6]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [7] 0.24[8] 0.31[9] 0.31[10] 0.28[11] 0.70[12] 0.38[13]
3 HLA-DRB1 HLA class II histocompatibility antigen, DRB1-15 beta chain [14] -8.64[15] [16] [17] -6.71[18] -12.00[19] -2.54[20]
4 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [21] -0.68[22] -0.92[23] 0.21[24] 1.46[25] 0.75[26] 2.12[27]
5 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [28] -0.67[29] -0.84[30] -0.22[31] -7.74[32] -2.94[33] -1.06[34]
6 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [35] 1.67[36] 1.53[37] 2.18[38] 0.10[39] 0.44[40] -1.17[41]
7 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1.01[42] 1.15[43] 1.35[44] 0.45[45] 0.39[46] 0.28[47]
8 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.58[48] 0.69[49] 0.92[50] 0.52[51] 0.51[52] 1.03[53]
9 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.68[54] 2.41[55] -1.36[56] -0.33[57] 0.22[58] -0.58[59]
10 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma [60] 1.52[61] 1.17[62] 2.05[63] 2.56[64] 1.36[65] 1.80[66]
11 CD86 T-lymphocyte activation antigen CD86 [67] [68] [69] -5.23[70] -4.70[71] -6.94[72] 0.47[73]
12 CD28 T-cell-specific surface glycoprotein CD28 [74] -4.21[75] -3.70[76] -3.63[77] -2.95[78] -3.22[79] 0.24[80]
13 CD80 T-lymphocyte activation antigen CD80 [81] [82] [83] -5.78[84] -1.76[85] -3.04[86] 1.74[87]
14 CTLA4 Cytotoxic T-lymphocyte protein 4 [88] [89] [90] [91] [92] [93] [94]
[1]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 22 25 24 27 38
[2]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 83 62
[3]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 83 55
[4]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 48 38 43
[5]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 87 81
[6]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[7]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 23 27 49 46
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 10 7.4 7.5 33 53
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 76 58
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 92 68
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 61 77 86
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 76 75
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 80 99 60 62
[15]
ref_hepatocyte HLA-DRB1
Mean 19
Standard deviation 28
Values 4 66 24 0 0.7
[16]
HepG2 HLA-DRB1
Mean 0.121
Standard deviation 0.017
Values 0.13 0.11
[17]
HepG2.C3A HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0 0
[19]
SNU475 HLA-DRB1
Mean 0.506
Standard deviation 0.45
Values 0.83 0.19
[20]
THLE HLA-DRB1
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[21]
liver HLA-DRB1
Mean 8.55
Standard deviation 3.8
Values 4.6 6.5 10 13
[22]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.2 14 8.1 4.1 7.4
[23]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 14 9.8
[24]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 13 9.6
[25]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 15 32 23
[26]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 35 80
[27]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[28]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 1.4e+02 1e+02 64 32
[29]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 4.4 9.3 7.6 2.2 3.1
[30]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.6 8.5
[31]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.8 8.6
[32]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 14 10 13
[33]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.051 0.088
[34]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[35]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 5.4 4.8 7.5 9.1
[36]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 3.1 3.8 4.9 11 3.2
[37]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 41 44
[38]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 35 53
[39]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 64 55 75
[40]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 13 18
[41]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[42]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 6.9 6 7.6 3.8
[43]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 2.6 2.1 1.8 5.2 4.2
[44]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 18 15
[45]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 19 23
[46]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 20 23 24
[47]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 10 14
[48]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[49]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 11 15 6.4 7.9
[50]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[51]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[52]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[53]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[54]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[55]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[56]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[57]
ref_hepatocyte PIK3CD
Mean 1.86
Standard deviation 1.7
Values 3.3 0.66 0.38 4.1 0.94
[58]
HepG2 PIK3CD
Mean 15.2
Standard deviation 3.8
Values 13 18
[59]
HepG2.C3A PIK3CD
Mean 28.8
Standard deviation 2.6
Values 27 31
[60]
HuH.7 PIK3CD
Mean 1.97
Standard deviation 0.32
Values 1.6 2.3 2
[61]
SNU475 PIK3CD
Mean 4.15
Standard deviation 0.57
Values 3.7 4.6
[62]
THLE PIK3CD
Mean 7.91
Standard deviation 1.1
Values 7.1 8.7
[63]
liver PIK3CD
Mean 3.25
Standard deviation 1.3
Values 5.1 3 2.4 2.6
[64]
ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.47 0.15 0.078 0.52 0.81
[65]
HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 4.7 1.2
[66]
HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 3.8 1.5
[67]
HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5 3.1 5.7
[68]
SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.8 6.5
[69]
THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4
[70]
liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 4 3.8 3.7 3.3
[71]
ref_hepatocyte CD86
Mean 0.389
Standard deviation 0.38
Values 0.61 0.85 0.48 0 0
[72]
HepG2 CD86
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A CD86
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 CD86
Mean 0.0281
Standard deviation 0.02
Values 0.0094 0.026 0.049
[75]
SNU475 CD86
Mean 0.0418
Standard deviation 0.02
Values 0.056 0.028
[76]
THLE CD86
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[77]
liver CD86
Mean 1.41
Standard deviation 0.3
Values 1.3 1.9 1.2 1.2
[78]
ref_hepatocyte CD28
Mean 0.0933
Standard deviation 0.1
Values 0 0.24 0.086 0.14 0
[79]
HepG2 CD28
Mean 0.0129
Standard deviation 0.018
Values 0.026 0
[80]
HepG2.C3A CD28
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[81]
HuH.7 CD28
Mean 0.0205
Standard deviation 0.023
Values 0.047 0.0064 0.0082
[82]
SNU475 CD28
Mean 0.0338
Standard deviation 0.0047
Values 0.03 0.037
[83]
THLE CD28
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[84]
liver CD28
Mean 0.288
Standard deviation 0.19
Values 0.56 0.27 0.094 0.23
[85]
ref_hepatocyte CD80
Mean 0.0435
Standard deviation 0.06
Values 0 0.11 0.1 0 0
[86]
HepG2 CD80
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A CD80
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 CD80
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[89]
SNU475 CD80
Mean 0.0359
Standard deviation 0.015
Values 0.025 0.046
[90]
THLE CD80
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[91]
liver CD80
Mean 0.381
Standard deviation 0.28
Values 0.61 0.64 0.12 0.15
[92]
ref_hepatocyte CTLA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 CTLA4
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[94]
HepG2.C3A CTLA4
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[95]
HuH.7 CTLA4
Mean 0.00487
Standard deviation 0.0043
Values 0 0.0064 0.0082
[96]
SNU475 CTLA4
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE CTLA4
Mean 0.0361
Standard deviation 0.0092
Values 0.03 0.043
[98]
liver CTLA4
Mean 0.0171
Standard deviation 0.02
Values 0.04 0.029 0 0