WP_CALORIC_RESTRICTION_AND_AGING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NAMPT Nicotinamide phosphoribosyltransferase [1] -2.20[2] -2.09[3] -1.34[4] -0.81[5] 0.51[6] -0.02[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] 0.59[9] -0.13[10] -1.04[11] 0.03[12] -1.00[13] -1.24[14]
3 IGF1 Insulin-like growth factor I [15] -7.91[16] -9.33[17] -7.38[18] -1.46[19] -10.34[20] -0.08[21]
4 PRKAB2 5'-AMP-activated protein kinase subunit beta-2 [22] 1.40[23] 2.10[24] 2.38[25] 1.11[26] -0.97[27] 0.41[28]
5 TP53 Cellular tumor antigen p53 [29] 2.15[30] 1.22[31] 2.15[32] 1.37[33] -0.01[34] -1.04[35]
6 MTOR Serine/threonine-protein kinase mTOR [36] 3.05[37] 3.57[38] 3.31[39] 2.76[40] 1.80[41] 2.45[42]
7 PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha -0.58[43] 1.82[44] -8.78[45] 0.84[46] -3.51[47] 2.44[48]
8 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [49] 1.01[50] 1.62[51] 1.35[52] 1.64[53] 0.84[54] 0.34[55]
[1]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[2]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[3]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[4]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[5]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[6]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[7]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[15]
ref_hepatocyte IGF1
Mean 17.2
Standard deviation 16
Values 5 39 24 0 18
[16]
HepG2 IGF1
Mean 0.111
Standard deviation 0.0052
Values 0.11 0.11
[17]
HepG2.C3A IGF1
Mean 0.0516
Standard deviation 0.018
Values 0.064 0.039
[18]
HuH.7 IGF1
Mean 0.171
Standard deviation 0.058
Values 0.19 0.22 0.11
[19]
SNU475 IGF1
Mean 10.9
Standard deviation 5.6
Values 6.9 15
[20]
THLE IGF1
Mean 0.0535
Standard deviation 0.008
Values 0.059 0.048
[21]
liver IGF1
Mean 46.3
Standard deviation 31
Values 39 24 92 31
[22]
ref_hepatocyte PRKAB2
Mean 7.76
Standard deviation 2.5
Values 8.8 7.4 4.5 11 6.7
[23]
HepG2 PRKAB2
Mean 31.7
Standard deviation 10
Values 39 25
[24]
HepG2.C3A PRKAB2
Mean 64.2
Standard deviation 12
Values 56 73
[25]
HuH.7 PRKAB2
Mean 66.5
Standard deviation 35
Values 46 1.1e+02 47
[26]
SNU475 PRKAB2
Mean 29
Standard deviation 6.7
Values 24 34
[27]
THLE PRKAB2
Mean 15.9
Standard deviation 0.88
Values 17 15
[28]
liver PRKAB2
Mean 29.3
Standard deviation 1.5
Values 28 30 28 31
[29]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[30]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[31]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[32]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[33]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[34]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[35]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[36]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 4.3 3.2 3.5 2.6 3.1
[37]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 47 38
[38]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 65 89
[39]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 41 50 73
[40]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 40 39
[41]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[42]
liver MTOR
Mean 51.8
Standard deviation 18
Values 62 72 34 39
[43]
ref_hepatocyte PPARGC1A
Mean 1.87
Standard deviation 1.7
Values 0.25 1.6 3.2 4 0.26
[44]
HepG2 PPARGC1A
Mean 1.94
Standard deviation 0.37
Values 2.2 1.7
[45]
HepG2.C3A PPARGC1A
Mean 12.8
Standard deviation 3.6
Values 10 15
[46]
HuH.7 PPARGC1A
Mean 0.00701
Standard deviation 0.0065
Values 0 0.013 0.0082
[47]
SNU475 PPARGC1A
Mean 5.83
Standard deviation 1.4
Values 4.9 6.8
[48]
THLE PPARGC1A
Mean 0.662
Standard deviation 0.1
Values 0.73 0.59
[49]
liver PPARGC1A
Mean 28.7
Standard deviation 18
Values 26 54 20 15
[50]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[51]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[52]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[53]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[54]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[55]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[56]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4