WP_B_CELL_RECEPTOR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CD81 | CD81 antigen | [1] | -10.09[2] | -11.36[3] | -3.00[4] | -2.09[5] | -2.61[6] | -1.86[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -0.70[9] | -0.09[10] | -1.08[11] | -0.50[12] | -1.23[13] | -2.02[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.93[16] | -2.83[17] | -3.19[18] | -3.49[19] | -1.61[20] | -1.07[21] |
4 | ILF2 | Interleukin enhancer-binding factor 2 | [22] | -0.05[23] | -0.05[24] | 0.59[25] | -0.30[26] | -0.23[27] | -1.86[28] |
5 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [29] | -0.27[30] | -0.70[31] | 0.02[32] | 0.04[33] | 0.03[34] | -0.90[35] |
6 | JUN | Transcription factor AP-1 | [36] | -0.36[37] | -2.01[38] | -1.73[39] | -1.67[40] | -1.11[41] | -1.74[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.21[44] | -0.13[45] | -1.19[46] | -0.02[47] | 0.00[48] | -0.18[49] |
8 | MYC | Myc proto-oncogene protein | [50] | 0.55[51] | 0.11[52] | -1.90[53] | -2.76[54] | -0.39[55] | -1.93[56] |
9 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [57] | -0.80[58] | -1.24[59] | -0.64[60] | -0.51[61] | -0.01[62] | -1.12[63] |
10 | GTF2I | General transcription factor II-I | [64] | -1.35[65] | -1.86[66] | -1.34[67] | -0.61[68] | -1.60[69] | -0.67[70] |
11 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [71] | 0.18[72] | -0.25[73] | 0.64[74] | -0.81[75] | -0.33[76] | -1.63[77] |
12 | IKBKG | NF-kappa-B essential modulator | [78] | -0.76[79] | -0.72[80] | -2.95[81] | -0.82[82] | -2.03[83] | -0.54[84] |
13 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [85] | 0.57[86] | 0.89[87] | 0.87[88] | 0.92[89] | 1.55[90] | 1.33[91] |
14 | GRB2 | Growth factor receptor-bound protein 2 | [92] | 1.32[93] | 1.05[94] | 1.19[95] | 0.58[96] | 0.50[97] | 0.37[98] |
15 | CRK | Adapter molecule crk | [99] | -0.08[100] | -0.25[101] | -0.17[102] | -0.21[103] | 0.19[104] | 0.91[105] |
16 | SHC1 | SHC-transforming protein 1 | [106] | 1.29[107] | 1.40[108] | 1.50[109] | 2.68[110] | 2.17[111] | 0.85[112] |
17 | RELA | Transcription factor p65 | [113] | 0.26[114] | -0.35[115] | -0.20[116] | -0.03[117] | -0.12[118] | -0.81[119] |
18 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [120] | 0.06[121] | 0.36[122] | 1.65[123] | -0.16[124] | 0.71[125] | 1.16[126] |
19 | PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 | [127] | -2.66[128] | -0.40[129] | 0.24[130] | -2.90[131] | -7.74[132] | 2.56[133] |
20 | MAX | Protein max | [134] | -0.81[135] | -0.94[136] | -1.60[137] | -0.73[138] | -0.21[139] | -1.17[140] |
21 | HRAS | GTPase HRas | [141] | -0.88[142] | -1.70[143] | -2.47[144] | -0.92[145] | -1.13[146] | -2.59[147] |
22 | ETS1 | Protein C-ets-1 | [148] | -2.68[149] | -12.13[150] | -9.31[151] | -0.06[152] | 0.79[153] | -0.02[154] |
23 | NCK1 | Cytoplasmic protein NCK1 | [155] | -1.47[156] | -1.47[157] | -1.35[158] | -0.53[159] | -0.42[160] | -0.40[161] |
24 | MAPK1 | Mitogen-activated protein kinase 1 | [162] | 1.83[163] | 1.87[164] | 1.71[165] | 1.88[166] | 1.53[167] | 1.84[168] |
25 | GSK3A | Glycogen synthase kinase-3 alpha | [169] | 0.75[170] | 0.38[171] | 0.50[172] | 0.11[173] | 0.87[174] | -1.77[175] |
26 | MAPK14 | Mitogen-activated protein kinase 14 | [176] | 1.60[177] | 1.56[178] | 1.16[179] | 1.71[180] | 1.19[181] | 1.35[182] |
27 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [183] | 0.02[184] | 0.99[185] | 0.88[186] | 0.52[187] | 0.70[188] | 0.32[189] |
28 | VAV2 | Guanine nucleotide exchange factor VAV2 | [190] | 1.42[191] | 1.57[192] | 1.08[193] | -0.50[194] | -0.08[195] | 0.58[196] |
29 | CRKL | Crk-like protein | [197] | 1.83[198] | 1.82[199] | 2.44[200] | 1.15[201] | 1.36[202] | 1.52[203] |
30 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [204] | 0.76[205] | 1.70[206] | 1.95[207] | 0.81[208] | 0.58[209] | 1.09[210] |
31 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [211] | -0.35[212] | -0.34[213] | 0.77[214] | 2.10[215] | 1.60[216] | 3.07[217] |
32 | BCL6 | B-cell lymphoma 6 protein | [218] | -0.77[219] | 1.37[220] | -0.13[221] | -0.51[222] | 0.23[223] | 0.10[224] |
33 | MAPK8 | Mitogen-activated protein kinase 8 | [225] | -1.32[226] | -0.02[227] | -1.13[228] | -0.87[229] | -1.02[230] | -0.44[231] |
34 | SOS1 | Son of sevenless homolog 1 | [232] | 0.02[233] | 1.45[234] | 0.97[235] | 0.87[236] | 0.11[237] | 0.61[238] |
35 | ELK1 | ETS domain-containing protein Elk-1 | [239] | -0.19[240] | -2.43[241] | 0.01[242] | 0.30[243] | 0.89[244] | -0.10[245] |
36 | BLNK | B-cell linker protein | [246] | -9.47[247] | -9.72[248] | -7.37[249] | -10.26[250] | -8.82[251] | -0.01[252] |
37 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [253] | 0.79[254] | 0.37[255] | 0.17[256] | -0.22[257] | 0.69[258] | 0.52[259] |
38 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | [260] | 1.22[261] | 1.17[262] | 1.31[263] | 2.32[264] | 2.01[265] | -0.02[266] |
39 | LYN | Tyrosine-protein kinase Lyn | [267] | -0.74[268] | -1.02[269] | -0.47[270] | 1.09[271] | -0.16[272] | 0.08[273] |
40 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [274] | -0.34[275] | -0.25[276] | 0.34[277] | -7.11[278] | -2.09[279] | -0.11[280] |
41 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [281] | 2.00[282] | 2.12[283] | 2.74[284] | 0.74[285] | 1.30[286] | -0.22[287] |
42 | PTPN18 | Tyrosine-protein phosphatase non-receptor type 18 | [288] | 0.10[289] | 0.51[290] | -0.85[291] | -2.05[292] | 0.23[293] | 0.54[294] |
43 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [295] | 2.21[296] | 1.94[297] | 1.67[298] | 1.29[299] | 0.96[300] | 1.24[301] |
44 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [302] | [303] | [304] | [305] | [306] | [307] | [308] |
45 | MAPK9 | Mitogen-activated protein kinase 9 | [309] | 1.35[310] | 1.47[311] | 1.55[312] | 1.74[313] | 1.20[314] | 0.58[315] |
46 | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 | [316] | 1.59[317] | 2.26[318] | 2.18[319] | 0.89[320] | 1.27[321] | 2.47[322] |
47 | GSK3B | Glycogen synthase kinase-3 beta | [323] | 1.39[324] | 0.92[325] | 1.51[326] | 1.84[327] | 1.67[328] | 1.23[329] |
48 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [330] | 1.03[331] | 2.14[332] | 2.12[333] | 0.68[334] | 1.49[335] | 1.58[336] |
49 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [337] | -1.59[338] | -7.68[339] | -8.27[340] | -1.36[341] | 2.44[342] | -1.16[343] |
50 | PRKCD | Protein kinase C delta type | [344] | 1.22[345] | 1.37[346] | 0.86[347] | -0.47[348] | 0.68[349] | -1.00[350] |
51 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [351] | 2.46[352] | 3.54[353] | 2.27[354] | 1.47[355] | 1.86[356] | 2.57[357] |
52 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.62[358] | 3.13[359] | 2.48[360] | 2.85[361] | 2.34[362] | 0.41[363] | |
53 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [364] | 0.64[365] | 0.60[366] | 0.72[367] | 0.29[368] | 0.38[369] | 1.25[370] |
54 | KLF11 | Krueppel-like factor 11 | [371] | 0.11[372] | 0.70[373] | -0.47[374] | 0.19[375] | 0.74[376] | 2.57[377] |
55 | BCL10 | B-cell lymphoma/leukemia 10 | [378] | 0.21[379] | -0.39[380] | 0.61[381] | 0.57[382] | 0.61[383] | 0.60[384] |
56 | SH3BP2 | SH3 domain-binding protein 2 | [385] | 1.53[386] | 2.00[387] | 1.45[388] | 3.27[389] | 1.67[390] | 3.00[391] |
57 | HCLS1 | Hematopoietic lineage cell-specific protein | [392] | -7.81[393] | -6.91[394] | -6.84[395] | -5.11[396] | -5.53[397] | 1.81[398] |
58 | MEF2D | Myocyte-specific enhancer factor 2D | [399] | 0.87[400] | 0.62[401] | 1.36[402] | 2.61[403] | 2.19[404] | 0.92[405] |
59 | E2F3 | Transcription factor E2F3 | [406] | 1.84[407] | 1.56[408] | 0.84[409] | 2.66[410] | 2.11[411] | -0.10[412] |
60 | FYN | Tyrosine-protein kinase Fyn | [413] | 1.07[414] | -7.64[415] | 0.95[416] | 1.50[417] | 3.03[418] | 1.04[419] |
61 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 2.98[420] | 2.72[421] | 2.16[422] | 2.07[423] | 1.35[424] | 2.33[425] | |
62 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [426] | 1.85[427] | 2.90[428] | 3.41[429] | 2.57[430] | 2.51[431] | 2.41[432] |
63 | FOXO1 | Forkhead box protein O1 | [433] | 1.82[434] | 1.38[435] | 1.53[436] | 1.20[437] | 3.22[438] | 3.16[439] |
64 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [440] | 0.41[441] | -2.91[442] | 1.97[443] | 1.04[444] | -3.00[445] | -1.55[446] |
65 | GAB2 | GRB2-associated-binding protein 2 | [447] | 1.69[448] | 1.37[449] | 1.64[450] | 0.95[451] | 1.04[452] | 0.61[453] |
66 | LAT2 | Linker for activation of T-cells family member 2 | [454] | -1.54[455] | -0.92[456] | -4.24[457] | -2.11[458] | -2.76[459] | 0.57[460] |
67 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [461] | 3.98[462] | 4.26[463] | -5.91[464] | -5.64[465] | -2.69[466] | 1.35[467] |
68 | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | [468] | 2.89[469] | 2.02[470] | 2.37[471] | 2.65[472] | 3.22[473] | 1.53[474] |
69 | BRAF | Serine/threonine-protein kinase B-raf | [475] | 0.37[476] | -0.01[477] | 2.05[478] | 0.77[479] | 0.46[480] | 1.92[481] |
70 | RASGRP3 | Ras guanyl-releasing protein 3 | [482] | -3.07[483] | -6.30[484] | 2.23[485] | 0.94[486] | -4.12[487] | 1.59[488] |
71 | PTPRC | Receptor-type tyrosine-protein phosphatase C | [489] | [490] | [491] | [492] | 0.40[493] | -8.52[494] | 3.21[495] |
72 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -1.16[496] | -7.01[497] | 0.46[498] | -2.70[499] | -1.55[500] | 2.78[501] | |
73 | GAB1 | GRB2-associated-binding protein 1 | [502] | 1.43[503] | 2.41[504] | 2.55[505] | 1.96[506] | 1.82[507] | 2.94[508] |
74 | CD79A | B-cell antigen receptor complex-associated protein alpha chain | [509] | -0.80[510] | -2.58[511] | -4.54[512] | -4.49[513] | -4.66[514] | -0.60[515] |
75 | TEC | Tyrosine-protein kinase Tec | [516] | -2.03[517] | -2.53[518] | -1.92[519] | 1.37[520] | -0.21[521] | 1.66[522] |
76 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | [523] | 0.56[524] | 2.87[525] | 2.41[526] | -3.80[527] | -5.39[528] | -2.82[529] |
77 | CBL | E3 ubiquitin-protein ligase CBL | [530] | 4.57[531] | 3.41[532] | 3.65[533] | 5.17[534] | 4.65[535] | 3.82[536] |
78 | REL | Proto-oncogene c-Rel | [537] | -0.39[538] | 1.27[539] | 1.22[540] | 0.18[541] | 0.33[542] | 2.41[543] |
79 | IRF4 | Interferon regulatory factor 4 | [544] | -4.71[545] | -4.47[546] | -5.08[547] | -4.27[548] | -5.39[549] | 0.68[550] |
80 | VAV1 | Proto-oncogene vav | [551] | -8.37[552] | -3.65[553] | -5.34[554] | -6.06[555] | -7.32[556] | 1.25[557] |
81 | CD79B | B-cell antigen receptor complex-associated protein beta chain | [558] | -1.38[559] | -5.40[560] | [561] | -4.67[562] | -3.73[563] | 0.75[564] |
82 | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 | [565] | 2.71[566] | 3.86[567] | 3.29[568] | 0.21[569] | 1.17[570] | 3.35[571] |
83 | LCK | Tyrosine-protein kinase Lck | [572] | 2.90[573] | 2.88[574] | -7.10[575] | -5.05[576] | -5.26[577] | 1.30[578] |
84 | CD22 | B-cell receptor CD22 | [579] | 2.94[580] | 1.41[581] | -8.05[582] | -0.16[583] | -0.89[584] | -0.91[585] |
85 | SYK | Tyrosine-protein kinase SYK | [586] | -8.04[587] | -2.28[588] | -5.27[589] | 0.13[590] | -3.39[591] | 3.43[592] |
86 | PRKCB | Protein kinase C beta type | [593] | -6.69[594] | -5.60[595] | [596] | 2.51[597] | -2.79[598] | 3.60[599] |
87 | MAPK4 | Mitogen-activated protein kinase 4 | [600] | -6.79[601] | -4.87[602] | 2.34[603] | -6.38[604] | -3.53[605] | 3.07[606] |
88 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | [607] | -2.27[608] | -0.67[609] | -1.28[610] | -0.12[611] | -1.52[612] | 1.40[613] |
89 | BTK | Tyrosine-protein kinase BTK | [614] | -7.26[615] | [616] | -0.50[617] | -2.98[618] | -5.21[619] | 1.89[620] |
90 | DAPP1 | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide | -1.71[621] | -0.86[622] | -1.15[623] | -1.27[624] | -1.51[625] | 1.55[626] | |
91 | BLK | Tyrosine-protein kinase Blk | [627] | -3.41[628] | -3.18[629] | [630] | [631] | -2.60[632] | 2.25[633] |
92 | MEF2C | Myocyte-specific enhancer factor 2C | [634] | -2.98[635] | -1.96[636] | 3.02[637] | 5.64[638] | 1.63[639] | 5.36[640] |
93 | CARD11 | Caspase recruitment domain-containing protein 11 | [641] | 1.26[642] | -5.36[643] | -6.11[644] | 1.28[645] | 5.78[646] | 2.34[647] |
94 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [648] | [649] | [650] | 1.37[651] | -3.52[652] | 4.17[653] | |
95 | CD19 | B-lymphocyte antigen CD19 | [654] | 2.23[655] | 3.82[656] | -0.99[657] | -1.44[658] | [659] | 1.13[660] |
96 | CR2 | Complement receptor type 2 | [661] | -3.01[662] | [663] | [664] | -1.43[665] | -3.11[666] | 2.22[667] |
97 | MIR5196 | [668] | [669] | [670] | [671] | [672] | [673] | [674] | |
98 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [675] | [676] | [677] | [678] | [679] | [680] | [681] |