WP_BIOMARKERS_FOR_UREA_CYCLE_DISORDERS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ASS1 Argininosuccinate synthase [1] 0.05[2] -0.63[3] -0.02[4] 0.33[5] 0.50[6] -1.16[7]
2 GATM Glycine amidinotransferase, mitochondrial [8] -6.64[9] -2.57[10] -2.70[11] -7.02[12] -7.65[13] 0.17[14]
3 ARG1 Arginase-1 [15] -6.53[16] -7.63[17] -0.94[18] -7.23[19] -7.75[20] 0.92[21]
4 GAMT Guanidinoacetate N-methyltransferase [22] 0.96[23] 0.60[24] 1.11[25] 0.94[26] 0.99[27] -0.44[28]
5 ASL Argininosuccinate lyase [29] 1.11[30] 0.18[31] 1.34[32] 2.31[33] 0.88[34] 0.00[35]
6 GOT1 Aspartate aminotransferase, cytoplasmic [36] 2.00[37] 2.63[38] 1.41[39] 1.40[40] 2.35[41] 0.26[42]
7 F10 Coagulation factor X [43] 1.55[44] 1.49[45] 0.37[46] -2.30[47] -4.74[48] -0.06[49]
8 GPT Alanine aminotransferase 1 [50] -2.73[51] -2.42[52] -3.32[53] -1.71[54] -4.44[55] -0.70[56]
9 OTC Ornithine carbamoyltransferase, mitochondrial [57] -6.87[58] -6.97[59] -1.37[60] -7.70[61] -6.40[62] -0.83[63]
10 F7 Coagulation factor VII [64] 0.51[65] 1.80[66] 0.92[67] -5.79[68] -5.63[69] 0.40[70]
11 GLS2 Glutaminase liver isoform, mitochondrial [71] 0.80[72] 0.38[73] -3.62[74] -1.86[75] -1.32[76] 0.34[77]
12 NAGS N-acetylglutamate synthase, mitochondrial [78] 0.48[79] 0.88[80] 1.26[81] -1.36[82] 0.25[83] 0.10[84]
[1]
ref_hepatocyte ASS1
Mean 312
Standard deviation 3.6e+02
Values 56 8.5e+02 5.1e+02 57 90
[2]
HepG2 ASS1
Mean 73
Standard deviation 14
Values 63 83
[3]
HepG2.C3A ASS1
Mean 81.4
Standard deviation 45
Values 50 1.1e+02
[4]
HuH.7 ASS1
Mean 94.9
Standard deviation 22
Values 86 1.2e+02 79
[5]
SNU475 ASS1
Mean 19.2
Standard deviation 7
Values 14 24
[6]
THLE ASS1
Mean 23.8
Standard deviation 0.31
Values 24 24
[7]
liver ASS1
Mean 218
Standard deviation 27
Values 1.9e+02 2.5e+02 2.3e+02 2e+02
[8]
ref_hepatocyte GATM
Mean 270
Standard deviation 4.7e+02
Values 12 1.1e+03 1.9e+02 0.68 50
[9]
HepG2 GATM
Mean 0.609
Standard deviation 0.19
Values 0.74 0.48
[10]
HepG2.C3A GATM
Mean 18.3
Standard deviation 1.2
Values 19 17
[11]
HuH.7 GATM
Mean 12.8
Standard deviation 4.6
Values 17 7.8 14
[12]
SNU475 GATM
Mean 0.101
Standard deviation 0.065
Values 0.15 0.056
[13]
THLE GATM
Mean 0.0721
Standard deviation 0.018
Values 0.059 0.085
[14]
liver GATM
Mean 474
Standard deviation 2.1e+02
Values 3.5e+02 3.2e+02 7.7e+02 4.5e+02
[15]
ref_hepatocyte ARG1
Mean 190
Standard deviation 2.6e+02
Values 15 5.4e+02 3.9e+02 0.48 1.9
[16]
HepG2 ARG1
Mean 0.462
Standard deviation 0.059
Values 0.42 0.5
[17]
HepG2.C3A ARG1
Mean 0.387
Standard deviation 0.27
Values 0.58 0.19
[18]
HuH.7 ARG1
Mean 30.5
Standard deviation 25
Values 18 60 14
[19]
SNU475 ARG1
Mean 0.062
Standard deviation 0.03
Values 0.041 0.083
[20]
THLE ARG1
Mean 0.0476
Standard deviation 0.00039
Values 0.047 0.048
[21]
liver ARG1
Mean 562
Standard deviation 3.3e+02
Values 1.8e+02 4.1e+02 7.7e+02 8.9e+02
[22]
ref_hepatocyte GAMT
Mean 94.4
Standard deviation 1.2e+02
Values 11 2.6e+02 1.8e+02 15 6
[23]
HepG2 GAMT
Mean 41.4
Standard deviation 4.1
Values 38 44
[24]
HepG2.C3A GAMT
Mean 57.7
Standard deviation 8.1
Values 52 63
[25]
HuH.7 GAMT
Mean 62.6
Standard deviation 22
Values 78 38 72
[26]
SNU475 GAMT
Mean 8.87
Standard deviation 1.8
Values 7.6 10
[27]
THLE GAMT
Mean 10.1
Standard deviation 0.71
Values 11 9.6
[28]
liver GAMT
Mean 108
Standard deviation 90
Values 32 31 2e+02 1.7e+02
[29]
ref_hepatocyte ASL
Mean 75.2
Standard deviation 60
Values 35 1.4e+02 1.3e+02 8.2 57
[30]
HepG2 ASL
Mean 36.6
Standard deviation 1.9
Values 38 35
[31]
HepG2.C3A ASL
Mean 34.4
Standard deviation 3
Values 32 37
[32]
HuH.7 ASL
Mean 58.5
Standard deviation 21
Values 77 36 63
[33]
SNU475 ASL
Mean 18.3
Standard deviation 1.6
Values 17 19
[34]
THLE ASL
Mean 7.49
Standard deviation 0.63
Values 7 7.9
[35]
liver ASL
Mean 118
Standard deviation 52
Values 81 67 1.7e+02 1.5e+02
[36]
ref_hepatocyte GOT1
Mean 75.1
Standard deviation 57
Values 62 1.1e+02 1.5e+02 6.4 44
[37]
HepG2 GOT1
Mean 67.6
Standard deviation 26
Values 49 86
[38]
HepG2.C3A GOT1
Mean 188
Standard deviation 68
Values 1.4e+02 2.4e+02
[39]
HuH.7 GOT1
Mean 61.7
Standard deviation 15
Values 75 45 65
[40]
SNU475 GOT1
Mean 9.68
Standard deviation 0.11
Values 9.8 9.6
[41]
THLE GOT1
Mean 20.6
Standard deviation 1.6
Values 20 22
[42]
liver GOT1
Mean 140
Standard deviation 1e+02
Values 51 1.1e+02 1.1e+02 2.8e+02
[43]
ref_hepatocyte F10
Mean 43.2
Standard deviation 44
Values 6.8 98 82 25 4.4
[44]
HepG2 F10
Mean 28.5
Standard deviation 7.1
Values 24 34
[45]
HepG2.C3A F10
Mean 49.1
Standard deviation 38
Values 22 76
[46]
HuH.7 F10
Mean 17.2
Standard deviation 3.7
Values 16 21 14
[47]
SNU475 F10
Mean 0.43
Standard deviation 0.042
Values 0.4 0.46
[48]
THLE F10
Mean 0.0869
Standard deviation 0.0026
Values 0.089 0.085
[49]
liver F10
Mean 64.8
Standard deviation 49
Values 28 29 1.3e+02 70
[50]
ref_hepatocyte GPT
Mean 40.1
Standard deviation 56
Values 1.4 1.3e+02 48 1.8 15
[51]
HepG2 GPT
Mean 1.37
Standard deviation 0.59
Values 1.8 0.95
[52]
HepG2.C3A GPT
Mean 3.02
Standard deviation 1.1
Values 2.2 3.8
[53]
HuH.7 GPT
Mean 1.23
Standard deviation 0.39
Values 1.3 1.6 0.81
[54]
SNU475 GPT
Mean 0.599
Standard deviation 0.6
Values 0.17 1
[55]
THLE GPT
Mean 0.0994
Standard deviation 0.035
Values 0.12 0.074
[56]
liver GPT
Mean 38.4
Standard deviation 12
Values 30 27 45 51
[57]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 2.1 1.2e+02 41 1.7 0.78
[58]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.073 0.052
[59]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.15 0.058
[60]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 3.7 3.6 4.3
[61]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[62]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[63]
liver OTC
Mean 28.5
Standard deviation 16
Values 19 19 52 24
[64]
ref_hepatocyte F7
Mean 18.8
Standard deviation 21
Values 1.9 47 37 8.2 0.65
[65]
HepG2 F7
Mean 6.03
Standard deviation 0.89
Values 5.4 6.7
[66]
HepG2.C3A F7
Mean 26.5
Standard deviation 18
Values 13 39
[67]
HuH.7 F7
Mean 10.9
Standard deviation 2.5
Values 9.9 14 9.1
[68]
SNU475 F7
Mean 0.0167
Standard deviation 0.0092
Values 0.01 0.023
[69]
THLE F7
Mean 0.0204
Standard deviation 0.021
Values 0.035 0.0053
[70]
liver F7
Mean 38.9
Standard deviation 13
Values 37 39 56 24
[71]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 2.5 43 36 1.3 3.2
[72]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 7.4 6.1
[73]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 10 7.9
[74]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.37 0.52 0.4
[75]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.19 0.27
[76]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[77]
liver GLS2
Mean 33.9
Standard deviation 12
Values 20 35 31 50
[78]
ref_hepatocyte NAGS
Mean 11.3
Standard deviation 9.6
Values 13 23 17 0.8 2.6
[79]
HepG2 NAGS
Mean 3.57
Standard deviation 2.1
Values 2.1 5
[80]
HepG2.C3A NAGS
Mean 8.44
Standard deviation 4.2
Values 5.5 11
[81]
HuH.7 NAGS
Mean 8.34
Standard deviation 1.5
Values 8.5 9.8 6.8
[82]
SNU475 NAGS
Mean 0.215
Standard deviation 0.075
Values 0.27 0.16
[83]
THLE NAGS
Mean 0.725
Standard deviation 0.054
Values 0.76 0.69
[84]
liver NAGS
Mean 19
Standard deviation 5.9
Values 13 15 26 21