WP_BIOMARKERS_FOR_PYRIMIDINE_METABOLISM_DISORDERS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DPYS Dihydropyrimidinase [1] [2] [3] -15.63[4] -12.07[5] [6] 0.57[7]
2 TYMP Thymidine phosphorylase [8] -3.79[9] -3.12[10] -6.72[11] -8.02[12] -5.54[13] -2.34[14]
3 UPB1 Beta-ureidopropionase [15] -7.63[16] -5.19[17] -4.14[18] -7.51[19] -12.69[20] -0.14[21]
4 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial [22] -2.28[23] -2.13[24] -2.17[25] -2.69[26] -2.79[27] 0.21[28]
5 TYMS Thymidylate synthase [29] -0.46[30] 0.02[31] -0.78[32] -0.37[33] -0.33[34] -6.10[35]
6 NT5C 5'(3')-deoxyribonucleotidase, cytosolic type [36] -0.57[37] 0.48[38] -1.23[39] -0.54[40] -0.55[41] -2.12[42]
7 RRM2 Ribonucleoside-diphosphate reductase subunit M2 [43] 2.39[44] 2.59[45] 1.45[46] 3.04[47] 3.07[48] -1.01[49]
8 PUS1 tRNA pseudouridine synthase A [50] 0.41[51] 0.80[52] -0.09[53] -0.69[54] -0.55[55] -2.13[56]
9 RRM1 Ribonucleoside-diphosphate reductase large subunit [57] 2.29[58] 1.88[59] 1.95[60] 2.98[61] 3.08[62] -0.08[63]
10 DPYD Dihydropyrimidine dehydrogenase [NADP(+)] [64] -4.16[65] -3.13[66] 1.88[67] 1.67[68] 0.98[69] 3.22[70]
11 UMPS Uridine 5'-monophosphate synthase [71] 2.35[72] 2.67[73] 1.53[74] 1.46[75] 2.07[76] 1.46[77]
12 RRM2B Ribonucleoside-diphosphate reductase subunit M2 B [78] 2.05[79] 2.28[80] 0.47[81] 1.94[82] 1.72[83] 0.28[84]
13 CKB Creatine kinase B-type [85] 4.17[86] 3.24[87] 4.99[88] 2.59[89] 1.50[90] -0.45[91]
14 TK2 Thymidine kinase 2, mitochondrial [92] 0.88[93] 1.37[94] -0.46[95] 1.25[96] 2.11[97] 1.94[98]
15 NT5C3A Cytosolic 5'-nucleotidase 3A [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte DPYS
Mean 68
Standard deviation 1e+02
Values 1.4 2.4e+02 96 0 3.8
[2]
HepG2 DPYS
Mean 0
Standard deviation 0
Values 0 0
[3]
HepG2.C3A DPYS
Mean 0
Standard deviation 0
Values 0 0
[4]
HuH.7 DPYS
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[5]
SNU475 DPYS
Mean 0.0152
Standard deviation 0.022
Values 0.03 0
[6]
THLE DPYS
Mean 0
Standard deviation 0
Values 0 0
[7]
liver DPYS
Mean 161
Standard deviation 36
Values 1.6e+02 2.1e+02 1.6e+02 1.2e+02
[8]
ref_hepatocyte TYMP
Mean 63.3
Standard deviation 55
Values 70 38 56 1.8 1.5e+02
[9]
HepG2 TYMP
Mean 5.73
Standard deviation 3.7
Values 3.1 8.4
[10]
HepG2.C3A TYMP
Mean 7.77
Standard deviation 1.5
Values 6.7 8.9
[11]
HuH.7 TYMP
Mean 0.958
Standard deviation 0.51
Values 1 1.4 0.41
[12]
SNU475 TYMP
Mean 0.235
Standard deviation 0.14
Values 0.14 0.33
[13]
THLE TYMP
Mean 1.49
Standard deviation 0.28
Values 1.3 1.7
[14]
liver TYMP
Mean 19.9
Standard deviation 5.7
Values 28 19 17 15
[15]
ref_hepatocyte UPB1
Mean 34.1
Standard deviation 46
Values 8 1.1e+02 52 0.23 4
[16]
HepG2 UPB1
Mean 0.216
Standard deviation 0.0023
Values 0.21 0.22
[17]
HepG2.C3A UPB1
Mean 1
Standard deviation 0.041
Values 1 0.97
[18]
HuH.7 UPB1
Mean 3.08
Standard deviation 0.98
Values 4 2 3.2
[19]
SNU475 UPB1
Mean 0.181
Standard deviation 0.11
Values 0.1 0.26
[20]
THLE UPB1
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[21]
liver UPB1
Mean 49.6
Standard deviation 25
Values 26 30 75 67
[22]
ref_hepatocyte DHODH
Mean 27.3
Standard deviation 31
Values 5.7 55 67 3.2 5.2
[23]
HepG2 DHODH
Mean 7.06
Standard deviation 1
Values 6.4 7.8
[24]
HepG2.C3A DHODH
Mean 6.66
Standard deviation 0.088
Values 6.7 6.6
[25]
HuH.7 DHODH
Mean 9.66
Standard deviation 4.2
Values 12 4.8 12
[26]
SNU475 DHODH
Mean 4.06
Standard deviation 0.45
Values 4.4 3.7
[27]
THLE DHODH
Mean 4.31
Standard deviation 0.19
Values 4.2 4.4
[28]
liver DHODH
Mean 50.3
Standard deviation 12
Values 53 38 46 65
[29]
ref_hepatocyte TYMS
Mean 24.8
Standard deviation 32
Values 2.5 0.91 3.3 69 49
[30]
HepG2 TYMS
Mean 22.7
Standard deviation 7.9
Values 28 17
[31]
HepG2.C3A TYMS
Mean 26.9
Standard deviation 18
Values 40 14
[32]
HuH.7 TYMS
Mean 23
Standard deviation 12
Values 32 9.1 28
[33]
SNU475 TYMS
Mean 18.5
Standard deviation 1.2
Values 19 18
[34]
THLE TYMS
Mean 21.5
Standard deviation 4.9
Values 18 25
[35]
liver TYMS
Mean 0.58
Standard deviation 0.68
Values 0 0.4 0.35 1.6
[36]
ref_hepatocyte NT5C
Mean 14.1
Standard deviation 2
Values 16 14 12 12 16
[37]
HepG2 NT5C
Mean 11.9
Standard deviation 0.64
Values 11 12
[38]
HepG2.C3A NT5C
Mean 21
Standard deviation 3.6
Values 19 24
[39]
HuH.7 NT5C
Mean 9.58
Standard deviation 3.9
Values 14 6.7 8.1
[40]
SNU475 NT5C
Mean 9.37
Standard deviation 2.2
Values 7.8 11
[41]
THLE NT5C
Mean 10.5
Standard deviation 0.81
Values 9.9 11
[42]
liver NT5C
Mean 5.18
Standard deviation 4
Values 1.5 1.9 8.2 9.2
[43]
ref_hepatocyte RRM2
Mean 11.3
Standard deviation 12
Values 0.89 2.6 4.7 21 27
[44]
HepG2 RRM2
Mean 74.3
Standard deviation 40
Values 1e+02 46
[45]
HepG2.C3A RRM2
Mean 72.7
Standard deviation 62
Values 1.2e+02 29
[46]
HuH.7 RRM2
Mean 49
Standard deviation 32
Values 68 12 67
[47]
SNU475 RRM2
Mean 89.3
Standard deviation 5.3
Values 93 86
[48]
THLE RRM2
Mean 103
Standard deviation 25
Values 85 1.2e+02
[49]
liver RRM2
Mean 8.94
Standard deviation 9.7
Values 0.81 9.4 3.1 22
[50]
ref_hepatocyte PUS1
Mean 9.63
Standard deviation 4.8
Values 17 6.2 11 7.1 6.4
[51]
HepG2 PUS1
Mean 16
Standard deviation 3.7
Values 13 19
[52]
HepG2.C3A PUS1
Mean 18
Standard deviation 3.1
Values 16 20
[53]
HuH.7 PUS1
Mean 14.5
Standard deviation 5.5
Values 19 8.5 15
[54]
SNU475 PUS1
Mean 5.76
Standard deviation 0.75
Values 6.3 5.2
[55]
THLE PUS1
Mean 7.18
Standard deviation 1.3
Values 6.3 8.1
[56]
liver PUS1
Mean 3.52
Standard deviation 0.71
Values 2.9 3 4.2 4
[57]
ref_hepatocyte RRM1
Mean 8.31
Standard deviation 6.1
Values 3.3 4.7 5 11 18
[58]
HepG2 RRM1
Mean 51
Standard deviation 21
Values 66 37
[59]
HepG2.C3A RRM1
Mean 32.9
Standard deviation 21
Values 47 18
[60]
HuH.7 RRM1
Mean 51
Standard deviation 15
Values 61 34 59
[61]
SNU475 RRM1
Mean 63.2
Standard deviation 3.6
Values 66 61
[62]
THLE RRM1
Mean 76.5
Standard deviation 23
Values 60 93
[63]
liver RRM1
Mean 12.6
Standard deviation 3.4
Values 10 15 9.3 16
[64]
ref_hepatocyte DPYD
Mean 5.41
Standard deviation 7.8
Values 0.79 19 5.5 0.66 1.2
[65]
HepG2 DPYD
Mean 0.381
Standard deviation 0.23
Values 0.54 0.22
[66]
HepG2.C3A DPYD
Mean 0.663
Standard deviation 0.13
Values 0.57 0.76
[67]
HuH.7 DPYD
Mean 31.7
Standard deviation 5.8
Values 28 38 29
[68]
SNU475 DPYD
Mean 16.6
Standard deviation 0.43
Values 16 17
[69]
THLE DPYD
Mean 11.6
Standard deviation 1
Values 11 12
[70]
liver DPYD
Mean 80.3
Standard deviation 30
Values 1.1e+02 93 69 45
[71]
ref_hepatocyte UMPS
Mean 5.13
Standard deviation 2
Values 4.2 3.3 3.6 7.5 7.1
[72]
HepG2 UMPS
Mean 32.8
Standard deviation 4.8
Values 36 29
[73]
HepG2.C3A UMPS
Mean 35
Standard deviation 4.5
Values 38 32
[74]
HuH.7 UMPS
Mean 23.6
Standard deviation 3.4
Values 25 20 26
[75]
SNU475 UMPS
Mean 13.6
Standard deviation 0.94
Values 14 13
[76]
THLE UMPS
Mean 23.4
Standard deviation 4.7
Values 20 27
[77]
liver UMPS
Mean 22.6
Standard deviation 3.3
Values 20 22 20 27
[78]
ref_hepatocyte RRM2B
Mean 5.12
Standard deviation 4.1
Values 2.8 2.6 1.6 7.3 11
[79]
HepG2 RRM2B
Mean 26.7
Standard deviation 1.8
Values 28 25
[80]
HepG2.C3A RRM2B
Mean 26.7
Standard deviation 5.2
Values 30 23
[81]
HuH.7 RRM2B
Mean 11.3
Standard deviation 1.7
Values 9.5 13 12
[82]
SNU475 RRM2B
Mean 18.9
Standard deviation 5.1
Values 15 23
[83]
THLE RRM2B
Mean 18.4
Standard deviation 0.84
Values 19 18
[84]
liver RRM2B
Mean 9.96
Standard deviation 2.3
Values 8.6 12 7.4 12
[85]
ref_hepatocyte CKB
Mean 4.4
Standard deviation 5.3
Values 4.9 0.89 1.8 13 1
[86]
HepG2 CKB
Mean 99.7
Standard deviation 12
Values 91 1.1e+02
[87]
HepG2.C3A CKB
Mean 44.6
Standard deviation 6.7
Values 49 40
[88]
HuH.7 CKB
Mean 222
Standard deviation 17
Values 2.4e+02 2.1e+02 2.1e+02
[89]
SNU475 CKB
Mean 25.4
Standard deviation 1.2
Values 25 26
[90]
THLE CKB
Mean 13.5
Standard deviation 1.3
Values 14 13
[91]
liver CKB
Mean 5.14
Standard deviation 6.3
Values 1.5 0.56 14 4.3
[92]
ref_hepatocyte TK2
Mean 4.07
Standard deviation 2.8
Values 2.1 7.7 6.5 1.9 2.1
[93]
HepG2 TK2
Mean 9.37
Standard deviation 2.7
Values 11 7.4
[94]
HepG2.C3A TK2
Mean 11.3
Standard deviation 0.3
Values 11 11
[95]
HuH.7 TK2
Mean 4.72
Standard deviation 0.87
Values 5.2 5.2 3.7
[96]
SNU475 TK2
Mean 9.29
Standard deviation 3.2
Values 7 12
[97]
THLE TK2
Mean 19.2
Standard deviation 0.11
Values 19 19
[98]
liver TK2
Mean 25
Standard deviation 6.3
Values 18 22 32 28
[99]
ref_hepatocyte NT5C3A
Missing
[100]
HepG2 NT5C3A
Missing
[101]
HepG2.C3A NT5C3A
Missing
[102]
HuH.7 NT5C3A
Missing
[103]
SNU475 NT5C3A
Missing
[104]
THLE NT5C3A
Missing
[105]
liver NT5C3A
Missing