WP_BILE_ACIDS_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SLC10A1 Sodium/bile acid cotransporter [1] -10.18[2] -11.07[3] -12.96[4] -11.44[5] -12.91[6] -1.50[7]
2 FGFR4 Fibroblast growth factor receptor 4 [8] 1.59[9] 1.42[10] 1.58[11] -3.70[12] -3.93[13] -0.61[14]
3 LDLR Low-density lipoprotein receptor [15] -0.18[16] 0.15[17] 0.74[18] -0.36[19] 0.73[20] 0.13[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 1.34[23] 0.97[24] 0.38[25] 2.38[26] 1.93[27] 0.67[28]
5 ABCG8 ATP-binding cassette sub-family G member 8 [29] -2.35[30] -1.91[31] -7.87[32] -12.15[33] -11.14[34] 0.68[35]
6 FXR1 Fragile X mental retardation syndrome-related protein 1 [36] 0.97[37] 1.64[38] 1.64[39] 2.38[40] 2.54[41] -0.29[42]
7 ABCG5 ATP-binding cassette sub-family G member 5 [43] -2.35[44] -0.71[45] -8.23[46] -11.73[47] -9.82[48] 0.72[49]
8 MAPK3 Mitogen-activated protein kinase 3 [50] 1.48[51] 1.02[52] 0.64[53] 0.96[54] 0.87[55] -2.14[56]
9 CYP7A1 Cholesterol 7-alpha-monooxygenase [57] -4.71[58] -7.56[59] -11.51[60] -9.43[61] [62] -4.06[63]
10 ABCB11 Bile salt export pump [64] -7.16[65] [66] -6.79[67] -4.99[68] [69] 3.69[70]
11 FGF19 Fibroblast growth factor 19 [71] -2.43[72] -1.79[73] 4.54[74] 1.36[75] -2.21[76] [77]
12 MIR6886 [78] [79] [80] [81] [82] [83] [84]
13 SLC10A2 Ileal sodium/bile acid cotransporter [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte SLC10A1
Mean 41.6
Standard deviation 64
Values 1.5 1.5e+02 60 0 0
[2]
HepG2 SLC10A1
Mean 0.102
Standard deviation 0.08
Values 0.16 0.046
[3]
HepG2.C3A SLC10A1
Mean 0.0701
Standard deviation 0.038
Values 0.043 0.097
[4]
HuH.7 SLC10A1
Mean 0.0242
Standard deviation 0.015
Values 0.019 0.013 0.041
[5]
SNU475 SLC10A1
Mean 0.019
Standard deviation 0.013
Values 0.01 0.028
[6]
THLE SLC10A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[7]
liver SLC10A1
Mean 44.8
Standard deviation 22
Values 29 22 64 63
[8]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 2.2 23 18 30 2.5
[9]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.4e+02 1.2e+02
[10]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.3e+02 1.6e+02
[11]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.5e+02 1.3e+02 2.4e+02
[12]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.8 1.2
[13]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[14]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 29 18 43 31
[15]
ref_hepatocyte LDLR
Mean 13.7
Standard deviation 8.6
Values 27 4.3 16 7.7 14
[16]
HepG2 LDLR
Mean 34.6
Standard deviation 16
Values 23 46
[17]
HepG2.C3A LDLR
Mean 55.1
Standard deviation 38
Values 29 82
[18]
HuH.7 LDLR
Mean 106
Standard deviation 31
Values 78 1.4e+02 1e+02
[19]
SNU475 LDLR
Mean 13.5
Standard deviation 6.6
Values 8.9 18
[20]
THLE LDLR
Mean 34.7
Standard deviation 13
Values 25 44
[21]
liver LDLR
Mean 45.8
Standard deviation 27
Values 84 24 45 30
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[29]
ref_hepatocyte ABCG8
Mean 8.3
Standard deviation 8.1
Values 1.2 17 17 5.6 0.83
[30]
HepG2 ABCG8
Mean 4.64
Standard deviation 1.2
Values 5.5 3.8
[31]
HepG2.C3A ABCG8
Mean 8.02
Standard deviation 1.9
Values 6.7 9.4
[32]
HuH.7 ABCG8
Mean 0.164
Standard deviation 0.19
Values 0.056 0.38 0.057
[33]
SNU475 ABCG8
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[34]
THLE ABCG8
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[35]
liver ABCG8
Mean 40.7
Standard deviation 8.7
Values 51 40 30 42
[36]
ref_hepatocyte FXR1
Mean 7.16
Standard deviation 2.6
Values 8.2 4 4.8 9.5 9.3
[37]
HepG2 FXR1
Mean 40
Standard deviation 10
Values 47 33
[38]
HepG2.C3A FXR1
Mean 81
Standard deviation 12
Values 72 90
[39]
HuH.7 FXR1
Mean 104
Standard deviation 15
Values 94 1.2e+02 97
[40]
SNU475 FXR1
Mean 47.3
Standard deviation 2.1
Values 46 49
[41]
THLE FXR1
Mean 63.5
Standard deviation 3.7
Values 66 61
[42]
liver FXR1
Mean 17.9
Standard deviation 5.3
Values 21 23 16 11
[43]
ref_hepatocyte ABCG5
Mean 6.81
Standard deviation 7.7
Values 0.43 18 12 3.9 0.22
[44]
HepG2 ABCG5
Mean 3.81
Standard deviation 0.63
Values 4.3 3.4
[45]
HepG2.C3A ABCG5
Mean 15.1
Standard deviation 4
Values 12 18
[46]
HuH.7 ABCG5
Mean 0.105
Standard deviation 0.098
Values 0.056 0.22 0.041
[47]
SNU475 ABCG5
Mean 0.00253
Standard deviation 0.0036
Values 0.0051 0
[48]
THLE ABCG5
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[49]
liver ABCG5
Mean 34.4
Standard deviation 19
Values 24 18 61 34
[50]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[51]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[52]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[53]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[54]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[55]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[56]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[57]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 0 9.7 0.69 9.8 0
[58]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.77 0.11
[59]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.097 0.058
[60]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[61]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.01 0.0046
[62]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[63]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 0.079 0.94 1.1 0.82
[64]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 1.8 4.1 3 0 1
[65]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.021 0.057
[66]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.037 0.096 0.11
[68]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.11 0.051
[69]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[70]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 71 1.9e+02 17 36
[71]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0.61 0 0 0 0
[72]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.06 0.069
[73]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[74]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 12 17 11
[75]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.29 0.51
[76]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[77]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[78]
ref_hepatocyte MIR6886
Missing
[79]
HepG2 MIR6886
Missing
[80]
HepG2.C3A MIR6886
Missing
[81]
HuH.7 MIR6886
Missing
[82]
SNU475 MIR6886
Missing
[83]
THLE MIR6886
Missing
[84]
liver MIR6886
Missing
[85]
ref_hepatocyte SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE SLC10A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[91]
liver SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0